{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T10:37:10Z","timestamp":1762339030090,"version":"build-2065373602"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Independent Exploration and Innovation Project of Central South University","award":["2025ZZTS0294"],"award-info":[{"award-number":["2025ZZTS0294"]}]},{"name":"the Graduate Research Innovation Project of Hunan Province","award":["CX20250421"],"award-info":[{"award-number":["CX20250421"]}]},{"name":"the Outstanding Youth Foundation of Hunan Province","award":["2022JJ20092"],"award-info":[{"award-number":["2022JJ20092"]}]},{"name":"the science and technology innovation Program of Hunan Province","award":["2024RC3065"],"award-info":[{"award-number":["2024RC3065"]}]},{"name":"the Wisdom Accumulation and Talent Cultivation Project of Third Xiangya Hospital of Central South University","award":["YX202103"],"award-info":[{"award-number":["YX202103"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82270594"],"award-info":[{"award-number":["82270594"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-025-04740-5","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T10:35:15Z","timestamp":1762338915000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic application of EUS-guided intraportal autologous bone marrow transplantation for decompensated liver cirrhosis"],"prefix":"10.1186","volume":"16","author":[{"given":"Ting","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aojian","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-cun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-er","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lun-xi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"4740_CR1","doi-asserted-by":"crossref","unstructured":"Higashiyama R, Inagaki Y, Hong YY, et al. Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice[J]. Volume 45. Hepatology; 2007. pp. 213\u201322. 1.","DOI":"10.1002\/hep.21477"},{"issue":"2","key":"4740_CR2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3350\/cmh.2015.21.2.141","volume":"21","author":"YO Jang","year":"2015","unstructured":"Jang YO, Jun BG, Baik SK, et al. Inhibition of hepatic stellate cells by bone marrow-derived mesenchymal stem cells in hepatic fibrosis[J]. Clin Mol Hepatol. 2015;21(2):141\u20139.","journal-title":"Clin Mol Hepatol"},{"key":"4740_CR3","doi-asserted-by":"crossref","unstructured":"Jangra A, Kothari A, Sarma P et al. Recent advancements in antifibrotic therapies for regression of liver Fibrosis[J]. Cells. 2022;11(9):1500.","DOI":"10.3390\/cells11091500"},{"key":"4740_CR4","doi-asserted-by":"crossref","unstructured":"Liu B, Cheng M, Lang L et al. Autologous bone marrow cell infusion for the treatment of decompensated liver cirrhosis patients with type 2 diabetes Mellitus[J]. Front Physiol. 2021;12:730797.","DOI":"10.3389\/fphys.2021.730797"},{"issue":"1","key":"4740_CR5","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13287-020-01627-5","volume":"11","author":"A Sun","year":"2020","unstructured":"Sun A, Gao W, Xiao T. Autologous bone marrow stem cell transplantation via the hepatic artery for the treatment of hepatitis B virus-related cirrhosis: a PRISMA-compliant meta-analysis based on the Chinese population[J]. Stem Cell Res Ther. 2020;11(1):104.","journal-title":"Stem Cell Res Ther"},{"issue":"28","key":"4740_CR6","doi-asserted-by":"publisher","first-page":"8697","DOI":"10.3748\/wjg.v21.i28.8697","volume":"21","author":"P Pankaj","year":"2015","unstructured":"Pankaj P, Zhang Q, Bai X, et al. Autologous bone marrow transplantation in decompensated liver: systematic review and meta-analysis[J]. World J Gastroenterol. 2015;21(28):8697\u2013710.","journal-title":"World J Gastroenterol"},{"issue":"6","key":"4740_CR7","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.3727\/096368917X694778","volume":"26","author":"JK Kim","year":"2017","unstructured":"Kim JK, Kim S, Kim Y, et al. Long-Term Follow-Up of patients after autologous bone marrow cell infusion for decompensated liver Cirrhosis[J]. Cell Transpl. 2017;26(6):1059\u201366.","journal-title":"Cell Transpl"},{"key":"4740_CR8","doi-asserted-by":"crossref","unstructured":"Gang M, Othus M, Olix A et al. CD34\u2009+ cell Dose, measurable residual Disease, and outcome after myeloablative HLA-Matched peripheral blood hematopoietic cell transplantation for adults with acute myeloid Leukemia[J]. Cancers (Basel).2025;17(14):2323.","DOI":"10.3390\/cancers17142323"},{"key":"4740_CR9","doi-asserted-by":"publisher","first-page":"107504","DOI":"10.1016\/j.phrs.2024.107504","volume":"210","author":"S Hu","year":"2024","unstructured":"Hu S, Wu C, Li D, et al. Pregnane X receptor activation promotes hematopoiesis during liver regeneration by inducing proliferation of hematopoietic stem and progenitor cells in mice[J]. Pharmacol Res. 2024;210:107504.","journal-title":"Pharmacol Res"},{"key":"4740_CR10","doi-asserted-by":"publisher","first-page":"1439510","DOI":"10.3389\/fimmu.2024.1439510","volume":"15","author":"N Nautiyal","year":"2024","unstructured":"Nautiyal N, Maheshwari D, Kumar D, et al. Rejuvenating bone marrow hematopoietic reserve prevents regeneration failure and hepatic decompensation in animal model of cirrhosis[J]. Front Immunol. 2024;15:1439510.","journal-title":"Front Immunol"},{"issue":"5","key":"4740_CR11","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.gie.2017.02.019","volume":"85","author":"G Trikudanathan","year":"2017","unstructured":"Trikudanathan G, Pannala R, Bhutani MS, et al. EUS-guided portal vein interventions[J]. Gastrointest Endosc. 2017;85(5):883\u20138.","journal-title":"Gastrointest Endosc"},{"key":"4740_CR12","doi-asserted-by":"crossref","unstructured":"Samarasena JB, Yu AR, Chang KJ. EUS-guided portal pressure measurement (with videos)[J]. Endosc Ultrasound.2018;7(4):257\u201362.","DOI":"10.4103\/eus.eus_35_18"},{"key":"4740_CR13","doi-asserted-by":"publisher","first-page":"86","DOI":"10.11604\/pamj.2015.21.86.6991","volume":"21","author":"Y Kayar","year":"2015","unstructured":"Kayar Y, Turkdogan KA, Baysal B, et al. EUS-guided FNA of a portal vein thrombus in hepatocellular carcinoma[J]. Pan Afr Med J. 2015;21:86.","journal-title":"Pan Afr Med J"},{"issue":"2","key":"4740_CR14","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.gie.2015.08.064","volume":"83","author":"DO Faigel","year":"2016","unstructured":"Faigel DO, Lake DF, Landreth TL, et al. EUS-guided portal injection chemotherapy for treatment of hepatic metastases: feasibility in the acute Porcine model[J]. Gastrointest Endosc. 2016;83(2):444\u20136.","journal-title":"Gastrointest Endosc"},{"issue":"4","key":"4740_CR15","doi-asserted-by":"publisher","first-page":"655","DOI":"10.4240\/wjgs.v15.i4.655","volume":"15","author":"S Zheng","year":"2023","unstructured":"Zheng S, Deng A, Zhou J, et al. Endoscopic ultrasound-guided intraportal injection of autologous bone marrow in patients with decompensated liver cirrhosis: A case series[J]. World J Gastrointest Surg. 2023;15(4):655\u201363.","journal-title":"World J Gastrointest Surg"},{"issue":"10","key":"4740_CR16","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1634\/stemcells.2005-0542","volume":"24","author":"S Terai","year":"2006","unstructured":"Terai S, Ishikawa T, Omori K, et al. Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy[J]. Stem Cells. 2006;24(10):2292\u20138.","journal-title":"Stem Cells"},{"issue":"6","key":"4740_CR17","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","volume":"22","author":"K Ishak","year":"1995","unstructured":"Ishak K, Baptista A, Bianchi L, et al. Histological grading and staging of chronic hepatitis[J]. J Hepatol. 1995;22(6):696\u20139.","journal-title":"J Hepatol"},{"key":"4740_CR18","doi-asserted-by":"crossref","unstructured":"Zhu J, Li X, Huang M et al. Application of Recombinant human superoxide dismutase in radical concurrent chemoradiotherapy for cervical cancer to prevent and treat Radiation-induced acute rectal injury: A Multicenter, Randomized, Open-label, prospective Trial[J]. Int J Radiat Oncol Biol Phys. 2024;120(3):720\u20139.","DOI":"10.1016\/j.ijrobp.2024.04.070"},{"key":"4740_CR19","doi-asserted-by":"crossref","unstructured":"Farina A, Villagr\u00e1n-Garc\u00eda M, Fourier A et al. Diagnostic and prognostic biomarkers in immune checkpoint inhibitor-related encephalitis: a retrospective cohort study[J]. Lancet Reg Health Eur. 2024;44:101011.","DOI":"10.1016\/j.lanepe.2024.101011"},{"issue":"1","key":"4740_CR20","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/s12967-021-02876-5","volume":"19","author":"W Sumner","year":"2021","unstructured":"Sumner W, Ray X, Sutton L, et al. Gene alterations as predictors of radiation-induced toxicity in head and neck squamous cell carcinoma[J]. J Transl Med. 2021;19(1):212.","journal-title":"J Transl Med"},{"key":"4740_CR21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/1748-717X-9-101","volume":"9","author":"SH Son","year":"2014","unstructured":"Son SH, Jang HS, Jo I, et al. Significance of an increase in the Child-Pugh score after radiotherapy in patients with unresectable hepatocellular carcinoma[J]. Radiat Oncol. 2014;9:101.","journal-title":"Radiat Oncol"},{"key":"4740_CR22","doi-asserted-by":"crossref","unstructured":"Gazdic M, Arsenijevic A, Markovic BS et al. Mesenchymal stem Cell-Dependent modulation of liver Diseases[J]. Int J Biol Sci. 2017;13(9):1109\u201317.","DOI":"10.7150\/ijbs.20240"},{"issue":"1","key":"4740_CR23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00534-010-0305-1","volume":"18","author":"S Terai","year":"2011","unstructured":"Terai S, Sakaida I. Autologous bone marrow cell infusion therapy for liver cirrhosis patients[J]. J Hepatobiliary Pancreat Sci. 2011;18(1):23\u20135.","journal-title":"J Hepatobiliary Pancreat Sci"},{"issue":"1","key":"4740_CR24","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1097\/MEG.0b013e32832eb69a","volume":"22","author":"AC Lyra","year":"2010","unstructured":"Lyra AC, Soares MBP, Da Silva LF, M, et al. Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study[J]. Eur J Gastroenterol Hepatol. 2010;22(1):33\u201342.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"4740_CR25","doi-asserted-by":"crossref","unstructured":"Zhang W, Teng M, Liu B et al. Repeated autologous bone marrow transfusion through portal vein for treating decompensated liver cirrhosis after Splenectomy[J]. Gastroenterol Res Pract. 2018;2018:4136082.","DOI":"10.1155\/2018\/4136082"},{"issue":"42","key":"4740_CR26","doi-asserted-by":"publisher","first-page":"5297","DOI":"10.3748\/wjg.v16.i42.5297","volume":"16","author":"H Salama","year":"2010","unstructured":"Salama H, Zekri AN, Bahnassy AA, et al. Autologous CD34\u2009+\u2009and CD133\u2009+\u2009stem cells transplantation in patients with end stage liver disease[J]. World J Gastroenterol. 2010;16(42):5297\u2013305.","journal-title":"World J Gastroenterol"},{"issue":"6","key":"4740_CR27","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.cgh.2018.10.034","volume":"17","author":"C Guo","year":"2019","unstructured":"Guo C, Guo G, Zhou X, et al. Long-term outcomes of autologous peripheral blood stem cell transplantation in patients with Cirrhosis[J]. Clin Gastroenterol Hepatol. 2019;17(6):1175\u201382.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"4740_CR28","doi-asserted-by":"crossref","unstructured":"Zhong Y, Tang Z, Xu R et al. Effect of transplantation route on stem cell migration to fibrotic liver of rats via cellular magnetic resonance imaging[J]. Cytotherapy. 2013;15(10):1266\u201374.","DOI":"10.1016\/j.jcyt.2013.05.023"},{"key":"4740_CR29","doi-asserted-by":"crossref","unstructured":"Li D, He X, Zhang S et al. Bone marrow-derived mesenchymal stem cells promote hepatic regeneration after partial hepatectomy in rats[J]. Pathobiology. 2013;80(5):228\u201334.","DOI":"10.1159\/000346796"},{"key":"4740_CR30","doi-asserted-by":"crossref","unstructured":"Hu C, Zhao L, Duan J et al. Strategies to improve the efficiency of mesenchymal stem cell transplantation for reversal of liver fibrosis[J]. J Cell Mol Med. 2019;23(3):1657\u201370.","DOI":"10.1111\/jcmm.14115"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-025-04740-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-025-04740-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-025-04740-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T10:35:21Z","timestamp":1762338921000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-025-04740-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,5]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4740"],"URL":"https:\/\/doi.org\/10.1186\/s13287-025-04740-5","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,5]]},"assertion":[{"value":"4 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study\n                      Therapeutic application of EUS-guided intraportal autologous bone marrow transplantation for decompensated liver cirrhosis\n                      was approved by the Medical Ethical Committee of the Third Xiangya Hospital of Central South University (NO.2018-S403; date: December 26, 2018) and registered in the Chinese Clinical Trial Registry (NO. ChiCTR2000035269; date: August 06,2020,\n                      \n                      ). All patients or their representatives signed an informed consent form to participate in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"612"}}