{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:56:06Z","timestamp":1790283366383,"version":"4.1.0"},"reference-count":155,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Taighde \u00c9ireann - Research Ireland\u2019s National Challenge Fund","award":["22\/NCF\/DR\/11293G"],"award-info":[{"award-number":["22\/NCF\/DR\/11293G"]}]},{"name":"C\u00daRAM, Research Ireland Centre for medical devices","award":["SFI\/13\/RC\/2073_P2"],"award-info":[{"award-number":["SFI\/13\/RC\/2073_P2"]}]},{"name":"AMBER, Research Ireland Centre for materials research","award":["SFI\/12\/RC\/2278_P2"],"award-info":[{"award-number":["SFI\/12\/RC\/2278_P2"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-025-04745-0","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T09:49:35Z","timestamp":1762249775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Engineering hypoimmune stem cell-derived beta cells"],"prefix":"10.1186","volume":"16","author":[{"given":"Benedikt J. M.","family":"Licht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry P.","family":"Duffy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth E.","family":"Levey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"4745_CR1","unstructured":"World Health Organization. others. WHO Global report on diabetes. 2016."},{"issue":"1","key":"4745_CR2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.cmet.2019.11.017","volume":"31","author":"JT Warshauer","year":"2020","unstructured":"Warshauer JT, Bluestone JA, Anderson MS. New frontiers in the treatment of type 1 diabetes. Cell Metab. 2020;31(1):46\u201361.","journal-title":"Cell Metab"},{"issue":"3","key":"4745_CR3","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/S2213-8587(19)30412-7","volume":"8","author":"JM Norris","year":"2020","unstructured":"Norris JM, Johnson RK, Stene LC. Type 1 diabetes\u2014early life origins and changing epidemiology. Lancet Diabetes Endocrinol. 2020;8(3):226\u201338.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"12","key":"4745_CR4","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1007\/s00125-021-05571-8","volume":"64","author":"A Green","year":"2021","unstructured":"Green A, Hede SM, Patterson CC, Wild SH, Imperatore G, Roglic G, et al. Type 1 diabetes in 2017: global estimates of incident and prevalent cases in children and adults. Diabetologia. 2021;64(12):2741\u201350.","journal-title":"Diabetologia"},{"issue":"2","key":"4745_CR5","doi-asserted-by":"publisher","first-page":"98","DOI":"10.34172\/hpp.2020.18","volume":"10","author":"M Mobasseri","year":"2020","unstructured":"Mobasseri M, Shirmohammadi M, Amiri T, Vahed N, Hosseini Fard H, Ghojazadeh M. Prevalence and incidence of type 1 diabetes in the world: a systematic review and meta-analysis. Health Promot Perspect. 2020;10(2):98\u2013115.","journal-title":"Health Promot Perspect"},{"issue":"10","key":"4745_CR6","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1111\/j.1600-6143.2008.02353.x","volume":"8","author":"P Fiorina","year":"2008","unstructured":"Fiorina P, Shapiro AMJ, Ricordi C, Secchi A. The clinical impact of islet transplantation. Am J Transplant. 2008;8(10):1990\u20137.","journal-title":"Am J Transplant"},{"issue":"12","key":"4745_CR7","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/s41574-021-00542-w","volume":"17","author":"C Mathieu","year":"2021","unstructured":"Mathieu C, Martens PJ, Vangoitsenhoven R. One hundred years of insulin therapy. Nat Rev Endocrinol. 2021;17(12):715\u201325.","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"4745_CR8","doi-asserted-by":"publisher","first-page":"E109","DOI":"10.1152\/ajpendo.00310.2021","volume":"322","author":"S Walker","year":"2022","unstructured":"Walker S, Appari M, Forbes S. Considerations and challenges of islet transplantation and future therapies on the horizon. Am J Physiology-Endocrinology Metabolism. 2022;322(2):E109\u201317.","journal-title":"Am J Physiology-Endocrinology Metabolism"},{"key":"4745_CR9","doi-asserted-by":"publisher","unstructured":"Reichman TW, Markmann JF, Odorico J, Witkowski P, Fung JJ, Wijkstrom M, et al. Stem cell\u2013derived, fully differentiated islets for type 1 diabetes. N Engl J Med. 2025. https:\/\/doi.org\/10.1056\/NEJMoa2506549.","DOI":"10.1056\/NEJMoa2506549"},{"issue":"4","key":"4745_CR10","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1056\/NEJM200007273430401","volume":"343","author":"AMJ Shapiro","year":"2000","unstructured":"Shapiro AMJ, Lakey JRT, Ryan EA, Korbutt GS, Toth E, Warnock GL, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a Glucocorticoid-Free immunosuppressive regimen. N Engl J Med. 2000;343(4):230\u20138.","journal-title":"N Engl J Med"},{"key":"4745_CR11","doi-asserted-by":"crossref","unstructured":"Siehler J, Bl\u00f6chinger AK, Meier M, Lickert H. Engineering islets from stem cells for advanced therapies of diabetes. Nat Rev Drug Discov. 2021;20(12):920\u201340. https:\/\/www.nature.com\/articles\/s41573-021-00262-w. Accessed 13 Sep 2024.","DOI":"10.1038\/s41573-021-00262-w"},{"key":"4745_CR12","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.addr.2018.04.018","volume":"139","author":"M Farina","year":"2019","unstructured":"Farina M, Alexander JF, Thekkedath U, Ferrari M, Grattoni A. Cell encapsulation: overcoming barriers in cell transplantation in diabetes and beyond. Adv Drug Deliv Rev. 2019;139:92\u2013115.","journal-title":"Adv Drug Deliv Rev"},{"issue":"3","key":"4745_CR13","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1007\/s00125-013-3109-4","volume":"57","author":"DJ Borg","year":"2014","unstructured":"Borg DJ, Weigelt M, Wilhelm C, Gerlach M, Bickle M, Speier S, et al. Mesenchymal stromal cells improve transplanted islet survival and islet function in a syngeneic mouse model. Diabetologia. 2014;57(3):522\u201331.","journal-title":"Diabetologia"},{"issue":"5","key":"4745_CR14","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1007\/s11892-012-0305-4","volume":"12","author":"NE Davis","year":"2012","unstructured":"Davis NE, Hamilton D, Fontaine MJ. Harnessing the Immunomodulatory and tissue repair properties of mesenchymal stem cells to restore \u03b2 cell function. Curr Diab Rep. 2012;12(5):612\u201322.","journal-title":"Curr Diab Rep"},{"issue":"3","key":"4745_CR15","doi-asserted-by":"publisher","first-page":"e90387","DOI":"10.1371\/journal.pone.0090387","volume":"9","author":"F Xiao","year":"2014","unstructured":"Xiao F, Ma L, Zhao M, Huang G, Mirenda V, Dorling A, et al. Ex vivo expanded human regulatory T cells delay islet allograft rejection via inhibiting islet-Derived monocyte chemoattractant Protein-1 production in CD34\u2009+\u2009Stem cells-Reconstituted NOD-scid IL2r\u03b3null mice. PLoS ONE. 2014;9(3):e90387.","journal-title":"PLoS ONE"},{"issue":"5","key":"4745_CR16","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1097\/TP.0000000000000579","volume":"99","author":"N Takemoto","year":"2015","unstructured":"Takemoto N, Konagaya S, Kuwabara R, Iwata H. Coaggregates of regulatory T cells and islet cells allow Long-term graft survival in liver without immunosuppression. Transplantation. 2015;99(5):942\u20137.","journal-title":"Transplantation"},{"key":"4745_CR17","doi-asserted-by":"crossref","unstructured":"Muller YD, Ferreira LMR, Ronin E, Ho P, Nguyen V, Faleo G, et al. Precision engineering of an Anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance. Front Immunol. 2021;12.","DOI":"10.3389\/fimmu.2021.686439"},{"issue":"6","key":"4745_CR18","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1016\/j.transproceed.2014.05.074","volume":"46","author":"E Fabryova","year":"2014","unstructured":"Fabryova E, Jirak D, Girman P, Zacharovova K, Galisova A, Saudek F, et al. Effect of mesenchymal stem cells on the vascularization of the artificial site for islet transplantation in rats. Transpl Proc. 2014;46(6):1963\u20136.","journal-title":"Transpl Proc"},{"issue":"5","key":"4745_CR19","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1097\/TP.0b013e3181c7dc99","volume":"89","author":"KS Park","year":"2010","unstructured":"Park KS, Kim YS, Kim JH, Choi B, Kim SH, Tan AHK, et al. Trophic molecules derived from human mesenchymal stem cells enhance Survival, Function, and angiogenesis of isolated Islets after transplantation. Transplantation. 2010;89(5):509\u201317.","journal-title":"Transplantation"},{"key":"4745_CR20","doi-asserted-by":"crossref","unstructured":"Saito R, Inagaki A, Nakamura Y, Imura T, Kanai N, Mitsugashira H, et al. A gelatin hydrogel nonwoven fabric combined with adipose Tissue\u2013Derived stem cells enhances subcutaneous islet engraftment. Cell Transpl. 2024;33.","DOI":"10.1177\/09636897241251621"},{"issue":"2","key":"4745_CR21","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.ymeth.2008.03.006","volume":"45","author":"B Bunnell","year":"2008","unstructured":"Bunnell B, Flaat M, Gagliardi C, Patel B, Ripoll C. Adipose-derived stem cells: Isolation, expansion and differentiation. Methods. 2008;45(2):115\u201320.","journal-title":"Methods"},{"issue":"13","key":"4745_CR22","doi-asserted-by":"publisher","first-page":"4057","DOI":"10.1182\/blood-2005-03-1004","volume":"106","author":"N Eliopoulos","year":"2005","unstructured":"Eliopoulos N, Stagg J, Lejeune L, Pommey S, Galipeau J. Allogeneic marrow stromal cells are immune rejected by MHC class I\u2013 and class II\u2013mismatched recipient mice. Blood. 2005;106(13):4057\u201365.","journal-title":"Blood"},{"issue":"10","key":"4745_CR23","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1016\/j.exphem.2008.04.022","volume":"36","author":"TB Prigozhina","year":"2008","unstructured":"Prigozhina TB, Khitrin S, Elkin G, Eizik O, Morecki S, Slavin S. Mesenchymal stromal cells lose their immunosuppressive potential after allotransplantation. Exp Hematol. 2008;36(10):1370\u20136.","journal-title":"Exp Hematol"},{"issue":"6","key":"4745_CR24","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1182\/blood-2005-11-011650","volume":"108","author":"AJ Nauta","year":"2006","unstructured":"Nauta AJ, Westerhuis G, Kruisselbrink AB, Lurvink EGA, Willemze R, Fibbe WE. Donor-derived mesenchymal stem cells are Immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting. Blood. 2006;108(6):2114\u201320.","journal-title":"Blood"},{"key":"4745_CR25","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jcis.2022.12.123","volume":"636","author":"M Neumann","year":"2023","unstructured":"Neumann M, Arnould T, Su BL. Encapsulation of stem-cell derived \u03b2-cells: A promising approach for the treatment for type 1 diabetes mellitus. J Colloid Interface Sci. 2023;636:90\u2013102.","journal-title":"J Colloid Interface Sci"},{"key":"4745_CR26","doi-asserted-by":"publisher","unstructured":"Korsgren O. Islet encapsulation: physiological possibilities and limitations. Diabetes. 2017;66(7):1748\u201354. https:\/\/doi.org\/10.2337\/db17-0065.","DOI":"10.2337\/db17-0065"},{"issue":"17","key":"4745_CR27","doi-asserted-by":"publisher","first-page":"3663","DOI":"10.1016\/j.biomaterials.2003.10.062","volume":"25","author":"JY Jang","year":"2004","unstructured":"Jang JY, Lee DY, Park SJ, Byun Y. Immune reactions of lymphocytes and macrophages against PEG-grafted pancreatic Islets. Biomaterials. 2004;25(17):3663\u20139.","journal-title":"Biomaterials"},{"issue":"12","key":"4745_CR28","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1097\/00007890-199606270-00002","volume":"61","author":"J Brauker","year":"1996","unstructured":"Brauker J, Martinson LA, Young SK, Johnson RC. Local inflammatory response around diffusion chambers containing xenografts: nonspecific destruction of tissues and decreased local vascularization. Transplantation. 1996;61(12):1671\u20137.","journal-title":"Transplantation"},{"key":"4745_CR29","doi-asserted-by":"publisher","unstructured":"Liu Q, Wang X, Chiu A, Liu W, Fuchs S, Wang B, et al. A zwitterionic polyurethane nanoporous device with low foreign-body response for islet encapsulation. Adv Mater. 2021;33(39):2102852. https:\/\/doi.org\/10.1002\/adma.202102852.","DOI":"10.1002\/adma.202102852"},{"issue":"4","key":"4745_CR30","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.4049\/jimmunol.0900679","volume":"183","author":"SJ Shieh","year":"2009","unstructured":"Shieh SJ, Chou FC, Yu PN, Lin WC, Chang DM, Roffler SR, et al. Transgenic expression of Single-Chain Anti-CTLA-4 Fv on \u03b2 cells protects Nonobese diabetic mice from autoimmune diabetes. J Immunol. 2009;183(4):2277\u201385.","journal-title":"J Immunol"},{"key":"4745_CR31","unstructured":"Sana Biotechnology I. Sana biotechnology announces positive six-month clinical results from type 1 diabetes study of islet cell transplantation without immunosuppression. 2025. https:\/\/ir.sana.com\/news-releases\/news-release-details\/sana-biotechnology-announces-positive-six-month-clinical-results\/."},{"issue":"3","key":"4745_CR32","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/s41587-023-01784-x","volume":"42","author":"X Hu","year":"2024","unstructured":"Hu X, White K, Olroyd AG, DeJesus R, Dominguez AA, Dowdle WE, et al. Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques. Nat Biotechnol. 2024;42(3):413\u201323.","journal-title":"Nat Biotechnol"},{"issue":"7","key":"4745_CR33","doi-asserted-by":"publisher","first-page":"109538","DOI":"10.1016\/j.celrep.2021.109538","volume":"36","author":"AV Parent","year":"2021","unstructured":"Parent AV, Faleo G, Chavez J, Saxton M, Berrios DI, Kerper NR, et al. Selective deletion of human leukocyte antigens protects stem cell-derived Islets from immune rejection. Cell Rep. 2021;36(7):109538.","journal-title":"Cell Rep"},{"issue":"13","key":"4745_CR34","doi-asserted-by":"publisher","first-page":"111423","DOI":"10.1016\/j.celrep.2022.111423","volume":"40","author":"R Chimienti","year":"2022","unstructured":"Chimienti R, Baccega T, Torchio S, Manenti F, Pellegrini S, Cospito A, et al. Engineering of immune checkpoints B7-H3 and CD155 enhances immune compatibility of MHC-I\u2013\/\u2013 iPSCs for \u03b2 cell replacement. Cell Rep. 2022;40(13):111423.","journal-title":"Cell Rep"},{"issue":"7830","key":"4745_CR35","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/s41586-020-2631-z","volume":"586","author":"E Yoshihara","year":"2020","unstructured":"Yoshihara E, O\u2019Connor C, Gasser E, Wei Z, Oh TG, Tseng TW, et al. Immune-evasive human islet-like organoids ameliorate diabetes. Nature. 2020;586(7830):606\u201311.","journal-title":"Nature"},{"issue":"1","key":"4745_CR36","doi-asserted-by":"publisher","first-page":"100879","DOI":"10.1016\/j.xcrm.2022.100879","volume":"4","author":"D Gerace","year":"2023","unstructured":"Gerace D, Zhou Q, Kenty JHR, Veres A, Sintov E, Wang X, et al. Engineering human stem cell-derived Islets to evade immune rejection and promote localized immune tolerance. Cell Rep Med. 2023;4(1):100879.","journal-title":"Cell Rep Med"},{"issue":"9","key":"4745_CR37","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1016\/j.stemcr.2022.08.002","volume":"17","author":"E Sintov","year":"2022","unstructured":"Sintov E, Nikolskiy I, Barrera V, Hyoje-Ryu Kenty J, Atkin AS, Gerace D, et al. Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived Islets. Stem Cell Rep. 2022;17(9):1976\u201390.","journal-title":"Stem Cell Rep"},{"issue":"4","key":"4745_CR38","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.stemcr.2022.01.018","volume":"17","author":"NC Leite","year":"2022","unstructured":"Leite NC, Pelayo GC, Melton DA. Genetic manipulation of stress pathways can protect stem-cell-derived Islets from apoptosis in vitro. Stem Cell Rep. 2022;17(4):766\u201374.","journal-title":"Stem Cell Rep"},{"issue":"44","key":"4745_CR39","doi-asserted-by":"publisher","first-page":"50549","DOI":"10.1021\/acsami.2c12939","volume":"15","author":"F Li","year":"2023","unstructured":"Li F, Crumley K, Bealer E, King JL, Saito E, Grimany-Nuno O, et al. Fas Ligand-Modified scaffolds protect stem cell derived \u03b2-Cells by modulating immune cell numbers and polarization. ACS Appl Mater Interfaces. 2023;15(44):50549\u201359.","journal-title":"ACS Appl Mater Interfaces"},{"key":"4745_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/451035","volume":"2014","author":"MA Kanak","year":"2014","unstructured":"Kanak MA, Takita M, Kunnathodi F, Lawrence MC, Levy MF, Naziruddin B. Inflammatory response in islet transplantation. Int J Endocrinol. 2014;2014:1\u201313.","journal-title":"Int J Endocrinol"},{"issue":"4","key":"4745_CR41","doi-asserted-by":"publisher","first-page":"104139","DOI":"10.1016\/j.lpm.2022.104139","volume":"51","author":"T Berney","year":"2022","unstructured":"Berney T, Wassmer CH, Lebreton F, Bellofatto K, Fonseca LM, Bignard J, et al. From islet of Langerhans transplantation to the bioartificial pancreas. Presse Med. 2022;51(4):104139.","journal-title":"Presse Med"},{"issue":"6","key":"4745_CR42","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.2337\/diabetes.54.6.1755","volume":"54","author":"H Johansson","year":"2005","unstructured":"Johansson H, Lukinius A, Moberg L, Lundgren T, Berne C, Foss A, et al. Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation. Diabetes. 2005;54(6):1755\u201362.","journal-title":"Diabetes"},{"issue":"5","key":"4745_CR43","doi-asserted-by":"publisher","first-page":"796","DOI":"10.3390\/cells12050796","volume":"12","author":"A Kale","year":"2023","unstructured":"Kale A, Rogers NM. No time to Die\u2014How Islets Meet their demise in transplantation. Cells. 2023;12(5):796.","journal-title":"Cells"},{"key":"4745_CR44","first-page":"e2739","volume":"7","author":"M Kanak","year":"2019","unstructured":"Kanak M, Saravanan P, Levy M. Inflammatory response and its impact on outcome of islet transplantation. CellR4. 2019;7:e2739.","journal-title":"CellR4"},{"issue":"5","key":"4745_CR45","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1007\/s11892-010-0130-6","volume":"10","author":"A Rajab","year":"2010","unstructured":"Rajab A. Islet transplantation: alternative sites. Curr Diab Rep. 2010;10(5):332\u20137.","journal-title":"Curr Diab Rep"},{"issue":"11","key":"4745_CR46","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.2337\/diabetes.50.11.2464","volume":"50","author":"E Bosi","year":"2001","unstructured":"Bosi E, Braghi S, Maffi P, Scirpoli M, Bertuzzi F, Pozza G, et al. Autoantibody response to islet transplantation in type 1 diabetes. Diabetes. 2001;50(11):2464\u201371.","journal-title":"Diabetes"},{"issue":"6","key":"4745_CR47","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1038\/mt.2013.59","volume":"21","author":"L Riolobos","year":"2013","unstructured":"Riolobos L, Hirata RK, Turtle CJ, Wang PR, Gornalusse GG, Zavajlevski M, et al. HLA engineering of human pluripotent stem cells. Mol Ther. 2013;21(6):1232\u201341.","journal-title":"Mol Ther"},{"issue":"8","key":"4745_CR48","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1182\/blood-2013-03-478255","volume":"122","author":"H Torikai","year":"2013","unstructured":"Torikai H, Reik A, Soldner F, Warren EH, Yuen C, Zhou Y, et al. Toward eliminating HLA class I expression to generate universal cells from allogeneic donors. Blood. 2013;122(8):1341\u20139.","journal-title":"Blood"},{"issue":"8","key":"4745_CR49","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1080\/09168451.2016.1165601","volume":"80","author":"D Cui","year":"2016","unstructured":"Cui D, Wang J, Zeng Y, Rao L, Chen H, Li W, et al. Generating hESCs with reduced immunogenicity by disrupting TAP1 or TAPBP. Biosci Biotechnol Biochem. 2016;80(8):1484\u201391.","journal-title":"Biosci Biotechnol Biochem"},{"key":"4745_CR50","doi-asserted-by":"crossref","unstructured":"Mattapally S, Pawlik KM, Fast VG, Zumaquero E, Lund FE, Randall TD, et al. Human leukocyte antigen class I and II knockout human induced pluripotent stem cell\u2013derived cells: universal donor for cell therapy. J Am Heart Assoc. 2018;7(23).","DOI":"10.1161\/JAHA.118.010239"},{"issue":"7","key":"4745_CR51","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0167-5699(90)90097-S","volume":"11","author":"HG Ljunggren","year":"1990","unstructured":"Ljunggren HG, K\u00e4rre K. In search of the \u2018missing self\u2019: MHC molecules and NK cell recognition. Immunol Today. 1990;11(7):237\u201344.","journal-title":"Immunol Today"},{"issue":"2","key":"4745_CR52","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/sj.emboj.7600019","volume":"23","author":"L Moretta","year":"2004","unstructured":"Moretta L, Moretta A. Unravelling natural killer cell function: triggering and inhibitory human NK receptors. EMBO J. 2004;23(2):255\u20139.","journal-title":"EMBO J"},{"issue":"1","key":"4745_CR53","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1182\/blood-2008-10-184549","volume":"114","author":"S Andersson","year":"2009","unstructured":"Andersson S, Fauriat C, Malmberg JA, Ljunggren HG, Malmberg KJ. KIR acquisition probabilities are independent of self-HLA class I ligands and increase with cellular KIR expression. Blood. 2009;114(1):95\u2013104.","journal-title":"Blood"},{"issue":"208","key":"4745_CR54","doi-asserted-by":"publisher","first-page":"208ra145","DOI":"10.1126\/scitranslmed.3006702","volume":"5","author":"A Horowitz","year":"2013","unstructured":"Horowitz A, Strauss-Albee DM, Leipold M, Kubo J, Nemat-Gorgani N, Dogan OC, et al. Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry. Sci Transl Med. 2013;5(208):208ra145.","journal-title":"Sci Transl Med"},{"issue":"8","key":"4745_CR55","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1038\/nbt.3860","volume":"35","author":"GG Gornalusse","year":"2017","unstructured":"Gornalusse GG, Hirata RK, Funk SE, Riolobos L, Lopes VS, Manske G, et al. HLA-E-expressing pluripotent stem cells escape allogeneic responses and Lysis by NK cells. Nat Biotechnol. 2017;35(8):765\u201372.","journal-title":"Nat Biotechnol"},{"issue":"3","key":"4745_CR56","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/s41587-019-0016-3","volume":"37","author":"T Deuse","year":"2019","unstructured":"Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, et al. Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients. Nat Biotechnol. 2019;37(3):252\u20138.","journal-title":"Nat Biotechnol"},{"issue":"4","key":"4745_CR57","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.stem.2019.02.005","volume":"24","author":"H Xu","year":"2019","unstructured":"Xu H, Wang B, Ono M, Kagita A, Fujii K, Sasakawa N, et al. Targeted disruption of HLA genes via CRISPR-Cas9 generates iPSCs with enhanced immune compatibility. Cell Stem Cell. 2019;24(4):566\u2013e5787.","journal-title":"Cell Stem Cell"},{"key":"4745_CR58","doi-asserted-by":"crossref","unstructured":"Han X, Wang M, Duan S, Franco PJ, Kenty JHR, Hedrick P, et al. Generation of hypoimmunogenic human pluripotent stem cells. Proc Natl Acad Sci. 2019;116(21):10441\u20136.","DOI":"10.1073\/pnas.1902566116"},{"issue":"3","key":"4745_CR59","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.stem.2024.02.001","volume":"31","author":"X Hu","year":"2024","unstructured":"Hu X, White K, Young C, Olroyd AG, Kievit P, Connolly AJ, et al. Hypoimmune Islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate. Cell Stem Cell. 2024;31(3):334\u2013e3405.","journal-title":"Cell Stem Cell"},{"key":"4745_CR60","doi-asserted-by":"crossref","unstructured":"Hu X, Gattis C, Olroyd AG, Friera AM, White K, Young C, et al. Human hypoimmune primary pancreatic Islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice. Sci Transl Med. 2023;15(691).","DOI":"10.1126\/scitranslmed.adg5794"},{"key":"4745_CR61","doi-asserted-by":"publisher","unstructured":"Carlsson PO, Hu X, Scholz H, Ingvast S, Lundgren T, Scholz T, et al. Survival of transplanted allogeneic beta cells with no immunosuppression. N Engl J Med. 2025. https:\/\/doi.org\/10.1056\/NEJMoa2503822.","DOI":"10.1056\/NEJMoa2503822"},{"issue":"6","key":"4745_CR62","doi-asserted-by":"publisher","first-page":"3408","DOI":"10.4049\/jimmunol.174.6.3408","volume":"174","author":"SE Sandner","year":"2005","unstructured":"Sandner SE, Clarkson MR, Salama AD, Sanchez-Fueyo A, Domenig C, Habicht A, et al. Role of the programmed Death-1 pathway in regulation of alloimmune responses in vivo. J Immunol. 2005;174(6):3408\u201315.","journal-title":"J Immunol"},{"issue":"10","key":"4745_CR63","doi-asserted-by":"publisher","first-page":"2840","DOI":"10.4049\/jimmunol.2000055","volume":"204","author":"L Batra","year":"2020","unstructured":"Batra L, Shrestha P, Zhao H, Woodward KB, Togay A, Tan M, et al. Localized Immunomodulation with PD-L1 results in sustained survival and function of allogeneic Islets without chronic immunosuppression. J Immunol. 2020;204(10):2840\u201351.","journal-title":"J Immunol"},{"issue":"4","key":"4745_CR64","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.cmet.2016.03.005","volume":"23","author":"E Yoshihara","year":"2016","unstructured":"Yoshihara E, Wei Z, Lin CS, Fang S, Ahmadian M, Kida Y, et al. ERR\u03b3 is required for the metabolic maturation of therapeutically functional Glucose-Responsive \u03b2 cells. Cell Metab. 2016;23(4):622\u201334.","journal-title":"Cell Metab"},{"issue":"7612","key":"4745_CR65","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/nature18624","volume":"535","author":"E Bader","year":"2016","unstructured":"Bader E, Migliorini A, Gegg M, Moruzzi N, Gerdes J, Roscioni SS, et al. Identification of proliferative and mature \u03b2-cells in the Islets of Langerhans. Nature. 2016;535(7612):430\u20134.","journal-title":"Nature"},{"key":"4745_CR66","doi-asserted-by":"crossref","unstructured":"Castro-Gutierrez R, Alkanani A, Mathews CE, Michels A, Russ HA. Protecting stem cell derived pancreatic beta-like cells from diabetogenic T cell recognition. Front Endocrinol. 2021;12.","DOI":"10.3389\/fendo.2021.707881"},{"issue":"17\u201318","key":"4745_CR67","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1016\/j.cca.2012.02.009","volume":"413","author":"P Romagnani","year":"2012","unstructured":"Romagnani P, Crescioli C. CXCL10: A candidate biomarker in transplantation. Clin Chim Acta. 2012;413(17\u201318):1364\u201373.","journal-title":"Clin Chim Acta"},{"issue":"5\u20136","key":"4745_CR68","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s00335-019-09796-2","volume":"30","author":"LD Shultz","year":"2019","unstructured":"Shultz LD, Keck J, Burzenski L, Jangalwe S, Vaidya S, Greiner DL, et al. Humanized mouse models of immunological diseases and precision medicine. Mamm Genome. 2019;30(5\u20136):123\u201342.","journal-title":"Mamm Genome"},{"issue":"4","key":"4745_CR69","doi-asserted-by":"publisher","first-page":"107","DOI":"10.5500\/wjt.v13.i4.107","volume":"13","author":"P Kabakchieva","year":"2023","unstructured":"Kabakchieva P, Assyov Y, Gerasoudis S, Vasilev G, Peshevska-Sekulovska M, Sekulovski M, et al. Islet transplantation-immunological challenges and current perspectives. World J Transpl. 2023;13(4):107\u201321.","journal-title":"World J Transpl"},{"issue":"7","key":"4745_CR70","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S2213-8587(22)00114-0","volume":"10","author":"BA Marfil-Garza","year":"2022","unstructured":"Marfil-Garza BA, Imes S, Verhoeff K, Hefler J, Lam A, Dajani K, et al. Pancreatic islet transplantation in type 1 diabetes: 20-year experience from a single-centre cohort in Canada. Lancet Diabetes Endocrinol. 2022;10(7):519\u201332.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"2","key":"4745_CR71","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1677\/joe.0.1630181","volume":"163","author":"R Wang","year":"1999","unstructured":"Wang R, Rosenberg L. Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship. J Endocrinol. 1999;163(2):181\u201390.","journal-title":"J Endocrinol"},{"issue":"6","key":"4745_CR72","doi-asserted-by":"publisher","first-page":"e322","DOI":"10.1038\/cddis.2012.66","volume":"3","author":"X Zheng","year":"2012","unstructured":"Zheng X, Zheng X, Wang X, Ma Z, Gupta Sunkari V, Botusan I, et al. Acute hypoxia induces apoptosis of pancreatic \u03b2-cell by activation of the unfolded protein response and upregulation of CHOP. Cell Death Dis. 2012;3(6):e322\u2013322.","journal-title":"Cell Death Dis"},{"issue":"s3","key":"4745_CR73","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/j.1463-1326.2012.01657.x","volume":"14","author":"J Montane","year":"2012","unstructured":"Montane J, Klimek-Abercrombie A, Potter KJ, Westwell\u2010Roper C, Bruce Verchere C. Metabolic stress, IAPP and islet amyloid. Diabetes Obes Metab. 2012;14(s3):68\u201377.","journal-title":"Diabetes Obes Metab"},{"key":"4745_CR74","doi-asserted-by":"crossref","unstructured":"Fonseca SG, Gromada J, Urano F. Endoplasmic reticulum stress and pancreatic \u03b2-cell death. Trends Endocrinol Metabol. 2011.","DOI":"10.1016\/j.tem.2011.02.008"},{"issue":"6550","key":"4745_CR75","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/377630a0","volume":"377","author":"D Bellgrau","year":"1995","unstructured":"Bellgrau D, Gold D, Selawry H, Moore J, Franzusoff A, Duke RC. A role for CD95 ligand in preventing graft rejection. Nature. 1995;377(6550):630\u20132.","journal-title":"Nature"},{"issue":"5239","key":"4745_CR76","first-page":"1189","volume":"270","author":"TS Griffith","year":"1995","unstructured":"Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA. Fas Ligand-Induced apoptosis as a mechanism of immune privilege. Sci (1979). 1995;270(5239):1189\u201392.","journal-title":"Sci (1979)"},{"issue":"6","key":"4745_CR77","doi-asserted-by":"publisher","first-page":"189004","DOI":"10.1016\/j.bbcan.2023.189004","volume":"1878","author":"L Haymour","year":"2023","unstructured":"Haymour L, Jean M, Smulski C, Legembre P. CD95 (Fas) and CD95L (FasL)-mediated non-canonical signaling pathways. Biochim Et Biophys Acta (BBA) - Reviews Cancer. 2023;1878(6):189004.","journal-title":"Biochim Et Biophys Acta (BBA) - Reviews Cancer"},{"issue":"5","key":"4745_CR78","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1111\/ajt.15747","volume":"20","author":"KB Woodward","year":"2020","unstructured":"Woodward KB, Zhao H, Shrestha P, Batra L, Tan M, Grimany-Nuno O, et al. Pancreatic Islets engineered with a FasL protein induce systemic tolerance at the induction phase that evolves into long-term graft-localized immune privilege. Am J Transplant. 2020;20(5):1285\u201395.","journal-title":"Am J Transplant"},{"issue":"6","key":"4745_CR79","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/S1074-7613(02)00482-X","volume":"17","author":"ES Yolcu","year":"2002","unstructured":"Yolcu ES, Askenasy N, Singh NP, Cherradi SEL, Shirwan H. Cell membrane modification for rapid display of proteins as a novel means of immunomodulation: FasL-decorated cells prevent islet graft rejection. Immunity. 2002;17(6):795\u2013808.","journal-title":"Immunity"},{"key":"4745_CR80","doi-asserted-by":"crossref","unstructured":"Lei J, Coronel MM, Yolcu ES, Deng H, Grimany-Nuno O, Hunckler MD, et al. FasL microgels induce immune acceptance of isllografts in nonhuman primates. Sci Adv. 2022;8(19).","DOI":"10.1126\/sciadv.abm9881"},{"issue":"8","key":"4745_CR81","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/s41563-018-0099-0","volume":"17","author":"DM Headen","year":"2018","unstructured":"Headen DM, Woodward KB, Coronel MM, Shrestha P, Weaver JD, Zhao H, et al. Local Immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance. Nat Mater. 2018;17(8):732\u20139.","journal-title":"Nat Mater"},{"issue":"7","key":"4745_CR82","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/nm0797-738","volume":"3","author":"SM Kang","year":"1997","unstructured":"Kang SM, Schneider DB, Lin Z, Hanahan D, Dichek DA, Stock PG, et al. Fas ligand expression in Islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction. Nat Med. 1997;3(7):738\u201343.","journal-title":"Nat Med"},{"issue":"6","key":"4745_CR83","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.4049\/jimmunol.162.6.3601","volume":"162","author":"L Ottonello","year":"1999","unstructured":"Ottonello L, Tortolina G, Amelotti M, Dallegri F. Soluble Fas ligand is chemotactic for human neutrophilic polymorphonuclear leukocytes. J Immunol. 1999;162(6):3601\u20136.","journal-title":"J Immunol"},{"key":"4745_CR84","doi-asserted-by":"publisher","unstructured":"Ahlqvist E, Prasad RB, Groop L. Subtypes of type 2 diabetes determined from clinical parameters. Diabetes. 2020;69(10):2086\u201393. https:\/\/doi.org\/10.2337\/dbi20-0001.","DOI":"10.2337\/dbi20-0001"},{"key":"4745_CR85","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.diabres.2018.05.014","volume":"141","author":"N Safai","year":"2018","unstructured":"Safai N, Ali A, Rossing P, Ridderstr\u00e5le M. Stratification of type 2 diabetes based on routine clinical markers. Diabetes Res Clin Pract. 2018;141:275\u201383.","journal-title":"Diabetes Res Clin Pract"},{"key":"4745_CR86","doi-asserted-by":"publisher","unstructured":"Verhoeff K, Marfil-Garza BA, Czarnecka Z, Cuesta-Gomez N, Jasra IT, Dadheech N, et al. Stem cell\u2013derived islet transplantation in patients with type 2 diabetes: can diabetes subtypes guide implementation? J Clin Endocrinol Metab. 2023;108(11):2772\u20138. https:\/\/doi.org\/10.1210\/clinem\/dgad257.","DOI":"10.1210\/clinem\/dgad257"},{"key":"4745_CR87","unstructured":"Cousminer DL, Ahlqvist E, Mishra R, Andersen MK, Chesi A, Hawa MI, et al. First genome-wide association study of latent autoimmune diabetes in adults reveals novel insights linking immune and metabolic diabetes. Diabetes Care. 2018;41(11):2396\u2013403. https:\/\/pubmed.ncbi.nlm.nih.gov\/30254083\/. Accessed 5 Sep 2025."},{"key":"4745_CR88","doi-asserted-by":"crossref","unstructured":"Wu J, Li T, Guo M, Ji J, Meng X, Fu, T et al. Treating a type 2 diabetic patient with impaired pancreatic islet function by personalized endoderm stem cell-derived islet tissue. Cell Discov. 2024. 2024;10(1):1\u20135. https:\/\/www.nature.com\/articles\/s41421-024-00662-3. Accessed 11 Sep 2025.","DOI":"10.1038\/s41421-024-00662-3"},{"issue":"4","key":"4745_CR89","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.jamcollsurg.2014.12.020","volume":"220","author":"RJ Stratta","year":"2015","unstructured":"Stratta RJ, Rogers J, Farney AC, Orlando G, El-Hennawy H, Gautreaux MD, et al. Pancreas transplantation in C-Peptide positive patients: does type of diabetes really matter? J Am Coll Surg. 2015;220(4):716\u201327.","journal-title":"J Am Coll Surg"},{"key":"4745_CR90","doi-asserted-by":"crossref","unstructured":"Shin S, Jung CH, Choi JY, Kwon HW, Jung JH, Kim YH, et al. Long-term metabolic outcomes of functioning pancreas transplants in type 2 diabetic recipients. transplantation. 2017;101(6):1254\u201360. https:\/\/journals.lww.com\/transplantjournal\/fulltext\/2017\/06000\/long_term_metabolic_outcomes_of_functioning.20.aspx. Accessed 5 Sep 2025.","DOI":"10.1097\/TP.0000000000001269"},{"key":"4745_CR91","doi-asserted-by":"publisher","unstructured":"Zhang X, Li X, Yang Z, Tao K, Wang Q, Dai B, et al. A review of pig liver xenotransplantation: current problems and recent progress. Xenotransplantation. 2019;26(3):e12497. https:\/\/doi.org\/10.1111\/xen.12497.","DOI":"10.1111\/xen.12497"},{"key":"4745_CR92","doi-asserted-by":"crossref","unstructured":"Cooper DKC, Dou KF, Tao KS, Yang ZX, Tector AJ, Ekser B. Pig liver xenotransplantation: a review of progress toward the clinic. Transplantation. 2016;100(10):2039\u201347. https:\/\/journals.lww.com\/transplantjournal\/fulltext\/2016\/10000\/pig_liver_xenotransplantation__a_review_of.9.aspx. Accessed 9 Sep 2025.","DOI":"10.1097\/TP.0000000000001319"},{"key":"4745_CR93","doi-asserted-by":"publisher","unstructured":"Griffith BP, Goerlich CE, Singh AK, Rothblatt M, Lau CL, Shah A, et al. Genetically modified porcine-to-human cardiac xenotransplantation. New Engl J Med. 2022;387(1):35\u201344. https:\/\/doi.org\/10.1056\/NEJMoa2201422.","DOI":"10.1056\/NEJMoa2201422"},{"key":"4745_CR94","doi-asserted-by":"crossref","unstructured":"Cross-Najafi AA, Lopez K, Isidan A, Park Y, Zhang W, Li P, et al. Current barriers to clinical liver xenotransplantation. Front Immunol. 2022;13:827535. https:\/\/www.frontiersin.org\/. Accessed 9 Sep 2025.","DOI":"10.3389\/fimmu.2022.827535"},{"key":"4745_CR95","doi-asserted-by":"crossref","unstructured":"Sonnenberg GE, Berger M. Human insulin - therapeutic progress? Dtsch Med Wochenschr. 1983;108(24):927\u20139. https:\/\/pubmed.ncbi.nlm.nih.gov\/6343053\/. Accessed 8 Sep 2025.","DOI":"10.1055\/s-2008-1069669"},{"key":"4745_CR96","doi-asserted-by":"publisher","unstructured":"Vanderschelden R, Sathialingam M, Alexander M, Lakey JRT. Cost and scalability analysis of porcine islet isolation for islet transplantation: comparison of juvenile, neonatal and adult pigs. Cell Transplant. 2019;28(7):967\u201372. https:\/\/doi.org\/10.1177\/0963689719847460.","DOI":"10.1177\/0963689719847460"},{"key":"4745_CR97","doi-asserted-by":"publisher","first-page":"1366530","DOI":"10.3389\/fimmu.2024.1366530","volume":"15","author":"DKC Cooper","year":"2024","unstructured":"Cooper DKC, Mou L, Bottino R. A brief review of the current status of pig islet xenotransplantation. Front Immunol. 2024;15:1366530.","journal-title":"Front Immunol"},{"key":"4745_CR98","doi-asserted-by":"publisher","unstructured":"Salama BF, Seeberger KL, Korbutt GS. Fibrin supports subcutaneous neonatal porcine islet transplantation without the need for pre-vascularization. Xenotransplantation. 2020;27(4):e12575. https:\/\/doi.org\/10.1111\/xen.12575.","DOI":"10.1111\/xen.12575"},{"key":"4745_CR99","doi-asserted-by":"crossref","unstructured":"Ekser B, Bottino R, Cooper DKC. Clinical islet xenotransplantation: a step forward. EBioMedicine. 2016;12:22\u20133. https:\/\/www.thelancet.com\/action\/showFullText?pii=S2352396416304443. Accessed 1 Oct 2016.","DOI":"10.1016\/j.ebiom.2016.09.023"},{"key":"4745_CR100","doi-asserted-by":"crossref","unstructured":"Matsumoto S, Abalovich A, Wechsler C, Wynyard S, Elliott RB. Clinical benefit of islet xenotransplantation for the treatment of type 1 diabetes. EBioMedicine. 2016;12:255\u201362. https:\/\/www.thelancet.com\/action\/showFullText?pii=S2352396416303899. Accessed 8 Sep 2025.","DOI":"10.1016\/j.ebiom.2016.08.034"},{"key":"4745_CR101","doi-asserted-by":"crossref","unstructured":"Caplan A, Parent B. Ethics and the emerging use of pig organs for xenotransplantation. J Heart Lung Transplant. 2022;41(9):1204\u20136. https:\/\/www.jhltonline.org\/action\/showFullText?pii=S105324982201988X. Accessed 9 Sep 2025.","DOI":"10.1016\/j.healun.2022.06.008"},{"issue":"2","key":"4745_CR102","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1177\/02676591221140767","volume":"39","author":"AJ George","year":"2024","unstructured":"George AJ. Ethics, virtues and xenotransplantation. Perfusion. 2024;39(2):334\u201343.","journal-title":"Perfusion"},{"key":"4745_CR103","doi-asserted-by":"crossref","unstructured":"Tahbaz M, Yoshihara E. Immune protection of stem cell-Derived islet cell therapy for treating diabetes. Front Endocrinol. 2021;12.","DOI":"10.3389\/fendo.2021.716625"},{"key":"4745_CR104","doi-asserted-by":"publisher","first-page":"100321","DOI":"10.1016\/j.coemr.2022.100321","volume":"23","author":"PS Misra","year":"2022","unstructured":"Misra PS, Nostro MC. Designing next-generation islet-like cells from human pluripotent stem cells: advances in overcoming allorejection and recurrent type 1 diabetes. Curr Opin Endocr Metab Res. 2022;23:100321.","journal-title":"Curr Opin Endocr Metab Res"},{"key":"4745_CR105","doi-asserted-by":"crossref","unstructured":"Ho BX, Teo AKK, Ng NHJ. Innovations in bio-engineering and cell-based approaches to address immunological challenges in islet transplantation. Front Immunol. 2024;15.","DOI":"10.3389\/fimmu.2024.1375177"},{"issue":"10","key":"4745_CR106","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.5966\/sctm.2015-0049","volume":"4","author":"D Wang","year":"2015","unstructured":"Wang D, Quan Y, Yan Q, Morales JE, Wetsel RA. Targeted disruption of the \u03b22-Microglobulin gene minimizes the immunogenicity of human embryonic stem cells. Stem Cells Transl Med. 2015;4(10):1234\u201345.","journal-title":"Stem Cells Transl Med"},{"key":"4745_CR107","doi-asserted-by":"crossref","unstructured":"Harding J, Vintersten-Nagy K, Shutova M, Yang H, Tang JK, Massumi M, et al. Induction of long-term allogeneic cell acceptance and formation of immune privileged tissue in immunocompetent hosts. bioRxiv. 2019. https:\/\/www.biorxiv.org\/content\/early\/2019\/07\/30\/716571.","DOI":"10.1101\/716571"},{"issue":"3","key":"4745_CR108","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1002\/bit.27641","volume":"118","author":"K Enck","year":"2021","unstructured":"Enck K, Tamburrini R, Deborah C, Gazia C, Jost A, Khalil F, et al. Effect of alginate matrix engineered to mimic the pancreatic microenvironment on encapsulated islet function. Biotechnol Bioeng. 2021;118(3):1177\u201385.","journal-title":"Biotechnol Bioeng"},{"issue":"1","key":"4745_CR109","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/jbm.a.36798","volume":"108","author":"C Chu","year":"2020","unstructured":"Chu C, Liu L, Rung S, Wang Y, Ma Y, Hu C, et al. Modulation of foreign body reaction and macrophage phenotypes concerning microenvironment. J Biomed Mater Res A. 2020;108(1):127\u201335.","journal-title":"J Biomed Mater Res A"},{"key":"4745_CR110","doi-asserted-by":"crossref","unstructured":"Capuani S, Malgir G, Chua CYX, Grattoni A. Advanced strategies to thwart foreign body response to implantable devices. Bioeng Transl Med. 2022;7(3).","DOI":"10.1002\/btm2.10300"},{"issue":"9","key":"4745_CR111","doi-asserted-by":"publisher","first-page":"5671","DOI":"10.3390\/ma8095269","volume":"8","author":"Z Sheikh","year":"2015","unstructured":"Sheikh Z, Brooks P, Barzilay O, Fine N, Glogauer M, Macrophages. Foreign body giant cells and their response to implantable biomaterials. Materials. 2015;8(9):5671\u2013701.","journal-title":"Materials"},{"key":"4745_CR112","doi-asserted-by":"crossref","unstructured":"Wu S, Wang L, Fang Y, Huang H, You X, Wu J. Advances in encapsulation and delivery strategies for islet transplantation. Adv Healthc Mater. 2021;10(20).","DOI":"10.1002\/adhm.202100965"},{"key":"4745_CR113","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.addr.2020.06.008","volume":"167","author":"NG Welch","year":"2020","unstructured":"Welch NG, Winkler DA, Thissen H. Antifibrotic strategies for medical devices. Adv Drug Deliv Rev. 2020;167:109\u201320.","journal-title":"Adv Drug Deliv Rev"},{"issue":"6","key":"4745_CR114","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/nmat4290","volume":"14","author":"O Veiseh","year":"2015","unstructured":"Veiseh O, Doloff JC, Ma M, Vegas AJ, Tam HH, Bader AR, et al. Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates. Nat Mater. 2015;14(6):643\u201351.","journal-title":"Nat Mater"},{"issue":"23","key":"4745_CR115","doi-asserted-by":"publisher","first-page":"5283","DOI":"10.1016\/j.polymer.2010.08.022","volume":"51","author":"S Chen","year":"2010","unstructured":"Chen S, Li L, Zhao C, Zheng J. Surface hydration: principles and applications toward low-fouling\/nonfouling biomaterials. Polym (Guildf). 2010;51(23):5283\u201393.","journal-title":"Polym (Guildf)"},{"key":"4745_CR116","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1126\/scirobotics.aax7043","volume":"4","author":"EB Dolan","year":"2019","unstructured":"Dolan EB, Varela CE, Mendez K, Whyte W, Levey RE, Robinson ST, et al. An actuatable soft reservoir modulates host foreign body response. Sci Robot. 2019;4:33.","journal-title":"Sci Robot"},{"issue":"11","key":"4745_CR117","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.1039\/D4BM00107A","volume":"12","author":"L Trask","year":"2024","unstructured":"Trask L, Ward NA, Tarpey R, Beatty R, Wallace E, O\u2019Dwyer J, et al. Exploring therapy transport from implantable medical devices using experimentally informed computational methods. Biomater Sci. 2024;12(11):2899\u2013913.","journal-title":"Biomater Sci"},{"key":"4745_CR118","doi-asserted-by":"crossref","unstructured":"Cuesta-Gomez N, Verhoeff K, Dadheech N, Dang T, Jasra IT, de Leon MB, et al. Suspension culture improves iPSC expansion and pluripotency phenotype. Stem Cell Res Ther. 2023;14(1). https:\/\/pubmed.ncbi.nlm.nih.gov\/37280707\/. Accessed 1 Dec 2023.","DOI":"10.1186\/s13287-023-03382-9"},{"key":"4745_CR119","doi-asserted-by":"crossref","unstructured":"Verhoeff K, Cuesta-Gomez N, Maghera J, Dadheech N, Pawlick R, Smith N, et al. Scalable bioreactor-based suspension approach to generate stem cell-derived islets from healthy donor-derived iPSCs. Transplantation. 2025;109(1):e22\u201335. https:\/\/journals.lww.com\/transplantjournal\/fulltext\/2025\/01000\/scalable_bioreactor_based_suspension_approach_to.25.aspx. Accessed 11 Sep 2025.","DOI":"10.1097\/TP.0000000000005108"},{"key":"4745_CR120","doi-asserted-by":"crossref","unstructured":"Dadheech N, Berm\u00fadez de Le\u00f3n M, Czarnecka Z, Cuesta-Gomez N, Jasra IT, Pawlick R et al. Scale up manufacturing approach for production of human induced pluripotent stem cell-derived islets using Vertical Wheel\u00ae bioreactors. Npj Regen Med. 2025;10(1):1\u201323. https:\/\/www.nature.com\/articles\/s41536-025-00409-y. Accessed 11 Sep 2025.","DOI":"10.1038\/s41536-025-00409-y"},{"key":"4745_CR121","doi-asserted-by":"publisher","unstructured":"De Kanter AFJ, Jongsma KR, Verhaar MC, Bredenoord AL. The ethical implications of tissue engineering for regenerative purposes: a systematic review. Tissue Eng Part B Rev. 2023;29(2):167\u201387. https:\/\/doi.org\/10.1089\/ten.teb.2022.0033.","DOI":"10.1089\/ten.teb.2022.0033"},{"key":"4745_CR122","doi-asserted-by":"publisher","first-page":"11705","DOI":"10.3389\/ti.2023.11705","volume":"36","author":"D de Jongh","year":"2023","unstructured":"de Jongh D, Thom RL, Cronin AJ, Bunnik EM, Massey EK. Clinical translation of Bio-Artificial pancreas therapies: Ethical, legal and psychosocial interdisciplinary considerations and key recommendations. Transpl Int. 2023;36:11705.","journal-title":"Transpl Int"},{"key":"4745_CR123","unstructured":"The European Parliament and the Council of the European Union. Directive 2004\/23\/EC of the European Parliament and of the Council of 31 March 2004 on setting standards of quality and safety for the donation, procurement, testing, processing, preservation, storage and distribution of human tissues and cells. 2003. pp. 48\u20139. https:\/\/eur-lex.europa.eu\/LexUriServ\/LexUriServ.do?uri=OJ:L:2004:102:0048:0058:en:PDF. Accessed 11 Sep 2025."},{"key":"4745_CR124","doi-asserted-by":"crossref","unstructured":"Lin X, Xu Y, Pan X, Xu J, Ding Y, Sun X, et al. Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Sci Rep. 2020;10(1):1\u201311. https:\/\/www.nature.com\/articles\/s41598-020-71908-9. Accessed 11 Sep 2025.","DOI":"10.1038\/s41598-020-71908-9"},{"key":"4745_CR125","doi-asserted-by":"crossref","unstructured":"de Jongh D, Massey EK, Cronin AJ, Schermer MHN, Bunnik EM. Early-phase clinical trials of bio-artificial organ technology: a systematic review of ethical issues. Transplant Int. 2022;35:10751. https:\/\/vanguard-project.eu\/. Accessed 11 Sep 2022.","DOI":"10.3389\/ti.2022.10751"},{"issue":"1","key":"4745_CR126","doi-asserted-by":"publisher","first-page":"11463","DOI":"10.1038\/ncomms11463","volume":"7","author":"JR Millman","year":"2016","unstructured":"Millman JR, Xie C, Van Dervort A, G\u00fcrtler M, Pagliuca FW, Melton DA. Generation of stem cell-derived \u03b2-cells from patients with type 1 diabetes. Nat Commun. 2016;7(1):11463.","journal-title":"Nat Commun"},{"issue":"9","key":"4745_CR127","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1038\/s42255-020-0254-1","volume":"2","author":"EP Cai","year":"2020","unstructured":"Cai EP, Ishikawa Y, Zhang W, Leite NC, Li J, Hou S, et al. Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes. Nat Metab. 2020;2(9):934\u201345.","journal-title":"Nat Metab"},{"issue":"5","key":"4745_CR128","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/j.cell.2018.04.013","volume":"173","author":"Z Wei","year":"2018","unstructured":"Wei Z, Yoshihara E, He N, Hah N, Fan W, Pinto AFM, et al. Vitamin D switches BAF complexes to protect \u03b2 cells. Cell. 2018;173(5):1135\u2013e114915.","journal-title":"Cell"},{"key":"4745_CR129","doi-asserted-by":"crossref","unstructured":"Filatov E, Sasaki S, Haque M, Kar S, Fung VCW, Mojibian M, et al. CCL22-expressing stem cell\u2013derived islet grafts recruit regulatory T cells in mice. Transplantation. 2025.","DOI":"10.1097\/TP.0000000000005463"},{"issue":"11","key":"4745_CR130","doi-asserted-by":"publisher","first-page":"114994","DOI":"10.1016\/j.celrep.2024.114994","volume":"43","author":"JM Barra","year":"2024","unstructured":"Barra JM, Robino RA, Castro-Gutierrez R, Proia J, Russ HA, Ferreira LMR. Combinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cells. Cell Rep. 2024;43(11):114994.","journal-title":"Cell Rep"},{"issue":"20","key":"4745_CR131","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1056\/NEJMoa035075","volume":"349","author":"JM Kremer","year":"2003","unstructured":"Kremer JM, Westhovens R, Leon M, Di Giorgio E, Alten R, Steinfeld S, et al. Treatment of rheumatoid arthritis by selective Inhibition of T-Cell activation with fusion protein CTLA4Ig. N Engl J Med. 2003;349(20):1907\u201315.","journal-title":"N Engl J Med"},{"key":"4745_CR132","doi-asserted-by":"crossref","unstructured":"Lenschow DJ, Zeng Y, Thistlethwaite JR, Montag A, Brady W, Gibson MG, et al. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg. Science (1979). 1992;257(5071):789\u201392.","DOI":"10.1126\/science.1323143"},{"issue":"3","key":"4745_CR133","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/j.1600-6143.2005.00749.x","volume":"5","author":"CP Larsen","year":"2005","unstructured":"Larsen CP, Pearson TC, Adams AB, Tso P, Shirasugi N, Strobertb E, et al. Rational development of LEA29Y (belatacept), a High-Affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am J Transplant. 2005;5(3):443\u201353.","journal-title":"Am J Transplant"},{"issue":"6","key":"4745_CR134","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.2337\/db11-1325","volume":"61","author":"N Klymiuk","year":"2012","unstructured":"Klymiuk N, van Buerck L, B\u00e4hr A, Offers M, Kessler B, Wuensch A, et al. Xenografted islet cell clusters from INSLEA29Y Transgenic pigs rescue diabetes and prevent immune rejection in humanized mice. Diabetes. 2012;61(6):1527\u201332.","journal-title":"Diabetes"},{"issue":"1","key":"4745_CR135","first-page":"36","volume":"32","author":"ZH Mo","year":"2007","unstructured":"Mo ZH, Wang W, Liu T, Zeng QH, Wu XB, Xie YH. Expression of hCTLA4-Ig mediated by adeno-associated virus in Porcine Islets and their biological activity. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007;32(1):36\u201340.","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"4745_CR136","doi-asserted-by":"crossref","unstructured":"Kimura F, Gotoh M, Tanaka T, Luo Z, Miyazaki J, Monden M, et al. Effects of locally expressed CTLA4-Ig in a pancreatic beta cell line on the accelerated graft rejection response induced by DST. Transplant Proc. 2001;33(1\u20132):552.","DOI":"10.1016\/S0041-1345(00)02138-2"},{"issue":"4","key":"4745_CR137","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1111\/j.1600-6143.2011.03929.x","volume":"12","author":"LV Riella","year":"2012","unstructured":"Riella LV, Liu T, Yang J, Chock S, Shimizu T, Mfarrej B, et al. Deleterious effect of CTLA4-Ig on a Treg-Dependent transplant model. Am J Transplant. 2012;12(4):846\u201355.","journal-title":"Am J Transplant"},{"issue":"10","key":"4745_CR138","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1111\/j.1600-6143.2008.02377.x","volume":"8","author":"JA Bluestone","year":"2008","unstructured":"Bluestone JA, Liu W, Yabu JM, Laszik ZG, Putnam A, Belingheri M, et al. The effect of costimulatory and Interleukin 2 receptor Blockade on regulatory T cells in renal transplantation. Am J Transplant. 2008;8(10):2086\u201396.","journal-title":"Am J Transplant"},{"issue":"6","key":"4745_CR139","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/S1074-7613(03)00152-3","volume":"18","author":"GL Sica","year":"2003","unstructured":"Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, et al. B7-H4, a molecule of the B7 Family, negatively regulates T cell immunity. Immunity. 2003;18(6):849\u201361.","journal-title":"Immunity"},{"issue":"1","key":"4745_CR140","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1097\/TP.0b013e318277229d","volume":"95","author":"X Wang","year":"2013","unstructured":"Wang X, Hao J, Metzger DL, Mui A, Lee IF, Akhoundsadegh N, et al. Endogenous expression of B7-H4 improves long-term murine islet allograft survival. Transplantation. 2013;95(1):94\u20139.","journal-title":"Transplantation"},{"issue":"3","key":"4745_CR141","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.trim.2009.03.007","volume":"21","author":"CL Yuan","year":"2009","unstructured":"Yuan CL, Xu JF, Tong J, Yang H, He FR, Gong Q, et al. B7-H4 transfection prolongs beta-cell graft survival. Transpl Immunol. 2009;21(3):143\u20139.","journal-title":"Transpl Immunol"},{"issue":"23","key":"4745_CR142","doi-asserted-by":"publisher","first-page":"6388","DOI":"10.1016\/S0021-9258(18)63477-5","volume":"244","author":"R Tenhunen","year":"1969","unstructured":"Tenhunen R, Marver HS, Schmid R. Microsomal Heme oxygenase: characterization of the enzyme. J Biol Chem. 1969;244(23):6388\u201394.","journal-title":"J Biol Chem"},{"issue":"1","key":"4745_CR143","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1146\/annurev.pharmtox.37.1.517","volume":"37","author":"MD Maines","year":"1997","unstructured":"Maines MD. The Heme Oxygenase system: regulator of second messenger gases. Annu Rev Pharmacol Toxicol. 1997;37(1):517\u201354.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"17","key":"4745_CR144","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","volume":"73","author":"A Loboda","year":"2016","unstructured":"Loboda A, Damulewicz M, Pyza E, Jozkowicz A, Dulak J. Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cell Mol Life Sci. 2016;73(17):3221\u201347.","journal-title":"Cell Mol Life Sci"},{"key":"4745_CR145","doi-asserted-by":"crossref","unstructured":"Li YX, Li G, Dong WP, Lu DR, Tan JM. Protection of human islets from induction of apoptosis and improved islet function with HO-1 gene transduction. Chin Med J (Engl). 2006;119(19):1639\u201345.","DOI":"10.1097\/00029330-200610010-00008"},{"issue":"11","key":"4745_CR146","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1007\/s00125-010-1858-x","volume":"53","author":"SH Huang","year":"2010","unstructured":"Huang SH, Chu CH, Yu JC, Chuang WC, Lin GJ, Chen PL, et al. Transgenic expression of haem oxygenase-1 in pancreatic beta cells protects non-obese mice used as a model of diabetes from autoimmune destruction and prolongs graft survival following islet transplantation. Diabetologia. 2010;53(11):2389\u2013400.","journal-title":"Diabetologia"},{"issue":"2\u20133","key":"4745_CR147","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3727\/000000005783983160","volume":"14","author":"A Pileggi","year":"2005","unstructured":"Pileggi A, Molano RD, Berney T, Ichii H, Jose SS, Zahr E, et al. Prolonged allogeneic islet graft survival by protoporphyrins. Cell Transpl. 2005;14(2\u20133):85\u201396.","journal-title":"Cell Transpl"},{"issue":"40","key":"4745_CR148","doi-asserted-by":"publisher","first-page":"33720","DOI":"10.1074\/jbc.M112.385542","volume":"287","author":"C Cai","year":"2012","unstructured":"Cai C, Teng L, Vu D, He JQ, Guo Y, Li Q, et al. The Heme Oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular Signal-regulated kinase (ERK)\/NRF2 signaling pathway and cytokine release. J Biol Chem. 2012;287(40):33720\u201332.","journal-title":"J Biol Chem"},{"issue":"Supplement 1","key":"4745_CR149","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1182\/blood-2022-163086","volume":"140","author":"Q Hammer","year":"2022","unstructured":"Hammer Q, Perica K, Mbofung RM, van Ooijen H, Varady E, Jelcic M, et al. Combined genetic ablation of CD54 and CD58 in CAR engineered cytotoxic lymphocytes effectively averts allogeneic immune cell rejection. Blood. 2022;140(Supplement 1):1165\u20136.","journal-title":"Blood"},{"key":"4745_CR150","doi-asserted-by":"publisher","unstructured":"Arai K, Sunamura M, Wada Y, Takahashi M, Kobari M, Kato K, et al. Preventing effect of anti-ICAM-1 and anti-LFA-1 monoclonal antibodies on murine isllograft rejection. Int J Pancreatol. 1999;26(1):23\u201331.  https:\/\/doi.org\/10.1385\/IJGC:26:1:23","DOI":"10.1385\/IJGC:26:1:23"},{"issue":"5","key":"4745_CR151","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/s41587-022-01540-7","volume":"41","author":"A Gravina","year":"2023","unstructured":"Gravina A, Tediashvili G, Rajalingam R, Quandt Z, Deisenroth C, Schrepfer S, et al. Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression. Nat Biotechnol. 2023;41(5):717\u201327.","journal-title":"Nat Biotechnol"},{"issue":"12","key":"4745_CR152","doi-asserted-by":"publisher","first-page":"3398","DOI":"10.1016\/j.ymthe.2021.06.022","volume":"29","author":"L Peraro","year":"2021","unstructured":"Peraro L, Bourne CM, Dacek MM, Akalin E, Park JH, Smith EL, et al. Incorporation of bacterial Immunoevasins to protect cell therapies from host antibody-mediated immune rejection. Mol Ther. 2021;29(12):3398\u2013409.","journal-title":"Mol Ther"},{"issue":"2\u20133","key":"4745_CR153","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.trim.2011.11.003","volume":"26","author":"O Thaunat","year":"2012","unstructured":"Thaunat O. Humoral immunity in chronic allograft rejection: puzzle pieces come together. Transpl Immunol. 2012;26(2\u20133):101\u20136.","journal-title":"Transpl Immunol"},{"issue":"1","key":"4745_CR154","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1046\/j.1600-065X.2003.00085.x","volume":"196","author":"AMJ Shapiro","year":"2003","unstructured":"Shapiro AMJ, Nanji SA, Lakey JRT. Clinical islet transplant: current and future directions towards tolerance. Immunol Rev. 2003;196(1):219\u201336.","journal-title":"Immunol Rev"},{"key":"4745_CR155","doi-asserted-by":"crossref","unstructured":"Podojil JR, Miller SD. Potential targeting of B7-H4 for the treatment of cancer. Immunol Rev. 2017;276(1):40. https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5630270\/. Accessed 13 Sep 2025.","DOI":"10.1111\/imr.12530"}],"container-title":["Stem Cell Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-025-04745-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-025-04745-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-025-04745-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T21:03:05Z","timestamp":1762290185000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-025-04745-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":155,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4745"],"URL":"https:\/\/doi.org\/10.1186\/s13287-025-04745-0","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"28 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"610"}}