{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:15:45Z","timestamp":1793229345811,"version":"4.5.0"},"reference-count":250,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160358"],"award-info":[{"award-number":["82160358"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gansu Provincial Health Industry Research Program","award":["GSWSKY2023-24"],"award-info":[{"award-number":["GSWSKY2023-24"]}]},{"name":"Gansu Provincial Youth Science and Technology Foundation","award":["20JR10RA710"],"award-info":[{"award-number":["20JR10RA710"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-025-04752-1","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T12:26:24Z","timestamp":1762345584000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mesenchymal stem cells in sepsis-induced organ dysfunction: mechanisms and therapeutic potential"],"prefix":"10.1186","volume":"16","author":[{"given":"Tingyu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiapan","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3986-2758","authenticated-orcid":false,"given":"Zhimin","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"issue":"8","key":"4752_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801\u201310.","journal-title":"JAMA"},{"issue":"3","key":"4752_CR2","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","volume":"43","author":"A Rhodes","year":"2017","unstructured":"Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med. 2017;43(3):304\u201377.","journal-title":"Intensive Care Med"},{"issue":"Suppl 1","key":"4752_CR3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s00134-019-05878-6","volume":"46","author":"SL Weiss","year":"2020","unstructured":"Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, et al. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Med. 2020;46(Suppl 1):10\u201367.","journal-title":"Intensive Care Med"},{"issue":"10219","key":"4752_CR4","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","volume":"395","author":"KE Rudd","year":"2020","unstructured":"Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer S, et al. Global, regional, and National sepsis incidence and mortality, 1990\u20132017: analysis for the global burden of disease study. Lancet. 2020;395(10219):200\u201311.","journal-title":"Lancet"},{"issue":"13","key":"4752_CR5","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1001\/jama.2014.2637","volume":"311","author":"KM Kaukonen","year":"2014","unstructured":"Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and new Zealand, 2000\u20132012. JAMA. 2014;311(13):1308\u201316.","journal-title":"JAMA"},{"issue":"7","key":"4752_CR6","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/s41577-021-00643-7","volume":"22","author":"T Manabe","year":"2022","unstructured":"Manabe T, Heneka MT. Cerebral dysfunctions caused by sepsis during ageing. Nat Rev Immunol. 2022;22(7):444\u201358.","journal-title":"Nat Rev Immunol"},{"issue":"13","key":"4752_CR7","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1001\/jama.2019.11825","volume":"322","author":"AA Fowler","year":"2019","unstructured":"Fowler AA 3rd, Truwit JD, Hite RD, Morris PE, DeWilde C, Priday A, Fisher B, Thacker LR 2nd, Natarajan R, Brophy DF, et al. Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial. JAMA. 2019;322(13):1261\u201370.","journal-title":"JAMA"},{"key":"4752_CR8","first-page":"30","volume":"3","author":"X Lv","year":"2016","unstructured":"Lv X, Wang H. Pathophysiology of sepsis-induced myocardial dysfunction. Mil Med Res. 2016;3:30.","journal-title":"Mil Med Res"},{"issue":"6","key":"4752_CR9","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41581-023-00683-3","volume":"19","author":"A Zarbock","year":"2023","unstructured":"Zarbock A, Nadim MK, Pickkers P, Gomez H, Bell S, Joannidis M, Kashani K, Koyner JL, Pannu N, Meersch M, et al. Sepsis-associated acute kidney injury: consensus report of the 28th acute disease quality initiative workgroup. Nat Rev Nephrol. 2023;19(6):401\u201317.","journal-title":"Nat Rev Nephrol"},{"issue":"7","key":"4752_CR10","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41581-018-0005-7","volume":"14","author":"C Lelubre","year":"2018","unstructured":"Lelubre C, Vincent JL. Mechanisms and treatment of organ failure in sepsis. Nat Rev Nephrol. 2018;14(7):417\u201327.","journal-title":"Nat Rev Nephrol"},{"key":"4752_CR11","doi-asserted-by":"publisher","first-page":"1575554","DOI":"10.3389\/fimmu.2025.1575554","volume":"16","author":"X Xu","year":"2025","unstructured":"Xu X, Yang T, An J, Li B, Dou Z. Liver injury in sepsis: manifestations, mechanisms and emerging therapeutic strategies. Front Immunol. 2025;16:1575554.","journal-title":"Front Immunol"},{"issue":"4","key":"4752_CR12","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.molmed.2013.08.004","volume":"20","author":"R Mittal","year":"2014","unstructured":"Mittal R, Coopersmith CM. Redefining the gut as the motor of critical illness. Trends Mol Med. 2014;20(4):214\u201323.","journal-title":"Trends Mol Med"},{"issue":"1","key":"4752_CR13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nrneph.2016.171","volume":"13","author":"TJ Graetz","year":"2017","unstructured":"Graetz TJ, Hotchkiss RS. Sepsis: preventing organ failure in sepsis - the search continues. Nat Rev Nephrol. 2017;13(1):5\u20136.","journal-title":"Nat Rev Nephrol"},{"key":"4752_CR14","doi-asserted-by":"publisher","first-page":"i1585","DOI":"10.1136\/bmj.i1585","volume":"353","author":"JE Gotts","year":"2016","unstructured":"Gotts JE, Matthay MA. Sepsis: pathophysiology and clinical management. BMJ. 2016;353:i1585.","journal-title":"BMJ"},{"key":"4752_CR15","doi-asserted-by":"publisher","first-page":"104318","DOI":"10.1016\/j.ebiom.2022.104318","volume":"86","author":"JL Vincent","year":"2022","unstructured":"Vincent JL. Current sepsis therapeutics. EBioMedicine. 2022;86:104318.","journal-title":"EBioMedicine"},{"key":"4752_CR16","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.semcancer.2019.06.003","volume":"60","author":"M Timaner","year":"2020","unstructured":"Timaner M, Tsai KK, Shaked Y. The multifaceted role of mesenchymal stem cells in cancer. Semin Cancer Biol. 2020;60:225\u201337.","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"4752_CR17","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s12016-025-09030-9","volume":"68","author":"L Li","year":"2025","unstructured":"Li L, He Y, Zhao J, Yin H, Feng X, Fan X, Wu W, Lu Q. Mesenchymal stromal Cell-Based therapy: A promising approach for autoimmune diseases. Clin Rev Allergy Immunol. 2025;68(1):21.","journal-title":"Clin Rev Allergy Immunol"},{"issue":"4","key":"4752_CR18","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1093\/stcltm\/szae003","volume":"13","author":"C Hum","year":"2024","unstructured":"Hum C, Tahir U, Mei SHJ, Champagne J, Fergusson DA, Lalu M, Stewart DJ, Walley K, Marshall J, Dos Santos CC, et al. Efficacy and safety of umbilical Cord-Derived mesenchymal stromal cell therapy in preclinical models of sepsis: A systematic review and Meta-analysis. Stem Cells Transl Med. 2024;13(4):346\u201361.","journal-title":"Stem Cells Transl Med"},{"key":"4752_CR19","doi-asserted-by":"publisher","unstructured":"Dos Santos CC, Amatullah H, Vaswani CM, Maron-Gutierrez T, Kim M, Mei SHJ, Szaszi K, Monteiro APT, Varkouhi AK, Herreroz R et al. Mesenchymal stromal (stem) cell therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury. Eur Respir J 2022, 59(1).https:\/\/doi.org\/10.1183\/13993003.04216-2020","DOI":"10.1183\/13993003.04216-2020"},{"key":"4752_CR20","doi-asserted-by":"crossref","unstructured":"Wang D, Xu L, Liu Y, Wang C, Qi S, Li Z, Bai X, Liao Y, Wang Y. Role of mesenchymal stem cells in sepsis and their therapeutic potential in sepsis\u2013associated myopathy (Review). Int J Mol Med 2024, 54(5):92.","DOI":"10.3892\/ijmm.2024.5416"},{"issue":"3","key":"4752_CR21","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/s41401-021-00676-7","volume":"43","author":"C Deng","year":"2022","unstructured":"Deng C, Zhao L, Yang Z, Shang JJ, Wang CY, Shen MZ, Jiang S, Li T, Di WC, Chen Y, et al. Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury. Acta Pharmacol Sin. 2022;43(3):520\u20138.","journal-title":"Acta Pharmacol Sin"},{"key":"4752_CR22","doi-asserted-by":"crossref","unstructured":"Srdi\u0107 T, \u0110ura\u0161evi\u0107 S, Laki\u0107 I, Ru\u017ei\u010di\u0107 A, Vujovi\u0107 P, Jev\u0111ovi\u0107 T, Daki\u0107 T, \u0110or\u0111evi\u0107 J, Tosti T, Glumac S et al. From molecular mechanisms to clinical therapy: Understanding Sepsis-Induced multiple organ dysfunction. Int J Mol Sci 2024, 25(14):7770.","DOI":"10.3390\/ijms25147770"},{"issue":"2","key":"4752_CR23","doi-asserted-by":"publisher","first-page":"65","DOI":"10.4266\/acc.2018.00157","volume":"33","author":"H Nagar","year":"2018","unstructured":"Nagar H, Piao S, Kim CS. Role of mitochondrial oxidative stress in sepsis. Acute Crit Care. 2018;33(2):65\u201372.","journal-title":"Acute Crit Care"},{"key":"4752_CR24","doi-asserted-by":"crossref","unstructured":"Zuo L, Prather ER, Stetskiv M, Garrison DE, Meade JR, Peace TI, Zhou T. Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments. Int J Mol Sci 2019, 20(18):4472.","DOI":"10.3390\/ijms20184472"},{"issue":"10","key":"4752_CR25","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1007\/s00134-024-07586-2","volume":"50","author":"M Girardis","year":"2024","unstructured":"Girardis M, David S, Ferrer R, Helms J, Juffermans NP, Martin-Loeches I, Povoa P, Russell L, Shankar-Hari M, Iba T, et al. Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis. Intensive Care Med. 2024;50(10):1580\u201392.","journal-title":"Intensive Care Med"},{"key":"4752_CR26","doi-asserted-by":"publisher","first-page":"837180","DOI":"10.3389\/fimmu.2022.837180","volume":"13","author":"GF Alves","year":"2022","unstructured":"Alves GF, Aimaretti E, Einaudi G, Mastrocola R, de Oliveira JG, Collotta D, Porchietto E, Aragno M, Cifani C, Sordi R, et al. Pharmacological Inhibition of FAK-Pyk2 pathway protects against organ damage and prolongs the survival of septic mice. Front Immunol. 2022;13:837180.","journal-title":"Front Immunol"},{"key":"4752_CR27","doi-asserted-by":"publisher","first-page":"664896","DOI":"10.3389\/fcell.2021.664896","volume":"9","author":"CL Zhu","year":"2021","unstructured":"Zhu CL, Yao RQ, Li LX, Li P, Xie J, Wang JF, Deng XM. Mechanism of mitophagy and its role in sepsis induced organ dysfunction: A review. Front Cell Dev Biol. 2021;9:664896.","journal-title":"Front Cell Dev Biol"},{"key":"4752_CR28","doi-asserted-by":"publisher","first-page":"1577105","DOI":"10.3389\/fimmu.2025.1577105","volume":"16","author":"X Gao","year":"2025","unstructured":"Gao X, Cai S, Li X, Wu G. Sepsis-induced immunosuppression: mechanisms, biomarkers and immunotherapy. Front Immunol. 2025;16:1577105.","journal-title":"Front Immunol"},{"issue":"1","key":"4752_CR29","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s13613-024-01377-0","volume":"14","author":"A Borges","year":"2024","unstructured":"Borges A, Bento L. Organ crosstalk and dysfunction in sepsis. Ann Intensive Care. 2024;14(1):147.","journal-title":"Ann Intensive Care"},{"issue":"2","key":"4752_CR30","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1097\/MOP.0000000000001207","volume":"35","author":"N Fleiss","year":"2023","unstructured":"Fleiss N, Polin RA. Sequential organ failure assessment scores to predict outcomes: from adults to neonates. Curr Opin Pediatr. 2023;35(2):218\u201322.","journal-title":"Curr Opin Pediatr"},{"issue":"2","key":"4752_CR31","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S0749-0704(05)70111-1","volume":"16","author":"AM Fein","year":"2000","unstructured":"Fein AM, Calalang-Colucci MG. Acute lung injury and acute respiratory distress syndrome in sepsis and septic shock. Crit Care Clin. 2000;16(2):289\u2013317.","journal-title":"Crit Care Clin"},{"key":"4752_CR32","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.3389\/fimmu.2020.01722","volume":"11","author":"V Kumar","year":"2020","unstructured":"Kumar V. Pulmonary innate immune response determines the outcome of inflammation during pneumonia and Sepsis-Associated acute lung injury. Front Immunol. 2020;11:1722.","journal-title":"Front Immunol"},{"key":"4752_CR33","doi-asserted-by":"crossref","unstructured":"Xu Y, Xin J, Sun Y, Wang X, Sun L, Zhao F, Niu C, Liu S. Mechanisms of Sepsis-Induced acute lung injury and advancements of natural small molecules in its treatment. Pharmaceuticals (Basel) 2024, 17(4):472.","DOI":"10.3390\/ph17040472"},{"issue":"6","key":"4752_CR34","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1631\/jzus.B2101075","volume":"23","author":"J Lu","year":"2022","unstructured":"Lu J, Liu J, Li A. Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis. J Zhejiang Univ Sci B. 2022;23(6):437\u201350.","journal-title":"J Zhejiang Univ Sci B"},{"issue":"5","key":"4752_CR35","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.kint.2019.05.026","volume":"96","author":"S Peerapornratana","year":"2019","unstructured":"Peerapornratana S, Manrique-Caballero CL, G\u00f3mez H, Kellum JA. Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int. 2019;96(5):1083\u201399.","journal-title":"Kidney Int"},{"issue":"6","key":"4752_CR36","first-page":"546","volume":"22","author":"H G\u00f3mez","year":"2016","unstructured":"G\u00f3mez H, Kellum JA. Sepsis-induced acute kidney injury. Curr Opin Crit Care. 2016;22(6):546\u201353.","journal-title":"Curr Opin Crit Care"},{"key":"4752_CR37","doi-asserted-by":"crossref","unstructured":"Kei CY, Singh K, Dautov RF, Nguyen TH, Chirkov YY, Horowitz JD. Coronary microvascular dysfunction: evolving Understanding of Pathophysiology, clinical Implications, and potential therapeutics. Int J Mol Sci 2023, 24(14):11287.","DOI":"10.3390\/ijms241411287"},{"issue":"1","key":"4752_CR38","doi-asserted-by":"publisher","first-page":"18323","DOI":"10.1038\/s41598-024-69202-z","volume":"14","author":"D Medica","year":"2024","unstructured":"Medica D, Quercia AD, Marengo M, Fanelli V, Castellano G, Fabbrini P, Migliori M, Merlotti G, Camussi G, Joannes-Boyau O, et al. High-volume hemofiltration does not protect human kidney endothelial and tubular epithelial cells from septic plasma-induced injury. Sci Rep. 2024;14(1):18323.","journal-title":"Sci Rep"},{"issue":"1","key":"4752_CR39","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/2110-5820-1-27","volume":"1","author":"D De Backer","year":"2011","unstructured":"De Backer D, Donadello K, Taccone FS, Ospina-Tascon G, Salgado D, Vincent JL. Microcirculatory alterations: potential mechanisms and implications for therapy. Ann Intensive Care. 2011;1(1):27.","journal-title":"Ann Intensive Care"},{"issue":"1","key":"4752_CR40","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13613-020-00651-1","volume":"10","author":"GA Ospina-Tasc\u00f3n","year":"2020","unstructured":"Ospina-Tasc\u00f3n GA, Bautista DF, Madri\u00f1\u00e1n HJ, Valencia JD, Berm\u00fadez WF, Qui\u00f1ones E, Calder\u00f3n-Tapia LE, Hernandez G, Bruhn A, De Backer D. Microcirculatory dysfunction and dead-space ventilation in early ARDS: a hypothesis-generating observational study. Ann Intensive Care. 2020;10(1):35.","journal-title":"Ann Intensive Care"},{"issue":"1","key":"4752_CR41","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.kint.2016.07.032","volume":"91","author":"EH Post","year":"2017","unstructured":"Post EH, Kellum JA, Bellomo R, Vincent JL. Renal perfusion in sepsis: from macro- to microcirculation. Kidney Int. 2017;91(1):45\u201360.","journal-title":"Kidney Int"},{"issue":"1","key":"4752_CR42","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/SHK.0b013e3182169d5a","volume":"36","author":"A Dyson","year":"2011","unstructured":"Dyson A, Bezemer R, Legrand M, Balestra G, Singer M, Ince C. Microvascular and interstitial oxygen tension in the renal cortex and medulla studied in a 4-h rat model of LPS-induced endotoxemia. Shock. 2011;36(1):83\u20139.","journal-title":"Shock"},{"issue":"6","key":"4752_CR43","first-page":"507","volume":"72","author":"E Almac","year":"2006","unstructured":"Almac E, Siegemund M, Demirci C, Ince C. Microcirculatory recruitment maneuvers correct tissue CO2 abnormalities in sepsis. Minerva Anestesiol. 2006;72(6):507\u201319.","journal-title":"Minerva Anestesiol"},{"issue":"1","key":"4752_CR44","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/cc13709","volume":"18","author":"R Rajendram","year":"2014","unstructured":"Rajendram R, Prowle JR. Venous congestion: are we adding insult to kidney injury in sepsis? Crit Care. 2014;18(1):104.","journal-title":"Crit Care"},{"key":"4752_CR45","doi-asserted-by":"publisher","first-page":"1329644","DOI":"10.3389\/fphys.2024.1329644","volume":"15","author":"T Wang","year":"2024","unstructured":"Wang T, Huang Y, Zhang X, Zhang Y, Zhang X. Advances in metabolic reprogramming of renal tubular epithelial cells in sepsis-associated acute kidney injury. Front Physiol. 2024;15:1329644.","journal-title":"Front Physiol"},{"issue":"2","key":"4752_CR46","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ccc.2020.11.010","volume":"37","author":"CL Manrique-Caballero","year":"2021","unstructured":"Manrique-Caballero CL, Del Rio-Pertuz G, Gomez H. Sepsis-Associated acute kidney injury. Crit Care Clin. 2021;37(2):279\u2013301.","journal-title":"Crit Care Clin"},{"key":"4752_CR47","doi-asserted-by":"publisher","first-page":"118648","DOI":"10.1016\/j.jep.2024.118648","volume":"335","author":"G Shu","year":"2024","unstructured":"Shu G, Wang C, Song A, Zheng Z, Zheng S, Song Y, Wang X, Yu H, Yin S, Deng X. Water extract of earthworms mitigates kidney injury triggered by oxidative stress via activating intrarenal Sirt1\/Nrf2 cascade and ameliorating mitochondrial damage. J Ethnopharmacol. 2024;335:118648.","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"4752_CR48","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s10238-024-01545-3","volume":"25","author":"LR Van Nynatten","year":"2025","unstructured":"Van Nynatten LR, Patel MA, Daley M, Miller MR, Cepinskas G, Slessarev M, Russell JA, Fraser DD. Putative biomarkers of hepatic dysfunction in critically ill sepsis patients. Clin Exp Med. 2025;25(1):28.","journal-title":"Clin Exp Med"},{"issue":"1","key":"4752_CR49","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nrgastro.2016.168","volume":"14","author":"P Strnad","year":"2017","unstructured":"Strnad P, Tacke F, Koch A, Trautwein C. Liver - guardian, modifier and target of sepsis. Nat Rev Gastroenterol Hepatol. 2017;14(1):55\u201366.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"2","key":"4752_CR50","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1152\/physrev.00004.2023","volume":"105","author":"V Ronca","year":"2025","unstructured":"Ronca V, Gerussi A, Collins P, Parente A, Oo YH, Invernizzi P. The liver as a central hub of the immune system: pathophysiological implications. Physiol Rev. 2025;105(2):493\u2013539.","journal-title":"Physiol Rev"},{"key":"4752_CR51","doi-asserted-by":"crossref","unstructured":"Eyenga P, Rey B, Eyenga L, Sheu SS. Regulation of oxidative phosphorylation of liver mitochondria in sepsis. Cells 2022, 11(10):1598.","DOI":"10.3390\/cells11101598"},{"issue":"3","key":"4752_CR52","doi-asserted-by":"publisher","first-page":"49","DOI":"10.4103\/jtccm.jtccm_27_20","volume":"2","author":"K Kang","year":"2020","unstructured":"Kang K, Li N-N, Gao Y, Du X, Zhang X-Y, Zhao M-Y, Yu K-J. Research progress on Sepsis-Related liver injury. J Translational Crit Care Med. 2020;2(3):49\u201353.","journal-title":"J Translational Crit Care Med"},{"key":"4752_CR53","unstructured":"Liu H, Yoon KT, Lee SS. Hypoxic Hepatitis. In: Vascular Disorders of the Liver: VALDIG\u2019s Guide to Management and Causes. Edited by Valla D, Garcia-Pagan JC, De Gottardi A, Rautou P-E. Cham: Springer International Publishing; 2022: 177\u2013188."},{"issue":"1","key":"4752_CR54","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s13054-022-04163-1","volume":"26","author":"R Perez","year":"2022","unstructured":"Perez R, de Garibay A, Kortgen A, Leonhardt J, Zipprich A, Bauer M. Critical care hepatology: definitions, incidence, prognosis and role of liver failure in critically ill patients. Crit Care. 2022;26(1):289.","journal-title":"Crit Care"},{"issue":"7","key":"4752_CR55","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s00063-020-00707-x","volume":"115","author":"P Kasper","year":"2020","unstructured":"Kasper P, Tacke F, Steffen HM, Michels G. [Hepatic dysfunction in sepsis]. Med Klin Intensivmed Notfmed. 2020;115(7):609\u201319.","journal-title":"Med Klin Intensivmed Notfmed"},{"issue":"5","key":"4752_CR56","doi-asserted-by":"publisher","first-page":"G831","DOI":"10.1152\/ajpgi.00307.2004","volume":"289","author":"A Geier","year":"2005","unstructured":"Geier A, Dietrich CG, Voigt S, Ananthanarayanan M, Lammert F, Schmitz A, Trauner M, Wasmuth HE, Boraschi D, Balasubramaniyan N, et al. Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver. Am J Physiol Gastrointest Liver Physiol. 2005;289(5):G831\u2013841.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"2","key":"4752_CR57","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1055\/s-0030-1253227","volume":"30","author":"A Kosters","year":"2010","unstructured":"Kosters A, Karpen SJ. The role of inflammation in cholestasis: clinical and basic aspects. Semin Liver Dis. 2010;30(2):186\u201394.","journal-title":"Semin Liver Dis"},{"issue":"1","key":"4752_CR58","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2741\/E598","volume":"5","author":"HK Bhogal","year":"2013","unstructured":"Bhogal HK, Sanyal AJ. The molecular pathogenesis of cholestasis in sepsis. Front Biosci (Elite Ed). 2013;5(1):87\u201396.","journal-title":"Front Biosci (Elite Ed)"},{"issue":"6","key":"4752_CR59","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/j.jhep.2015.08.001","volume":"63","author":"HX Liu","year":"2015","unstructured":"Liu HX, Keane R, Sheng L, Wan YJ. Implications of microbiota and bile acid in liver injury and regeneration. J Hepatol. 2015;63(6):1502\u201310.","journal-title":"J Hepatol"},{"issue":"1","key":"4752_CR60","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1159\/000324141","volume":"29","author":"M Trauner","year":"2011","unstructured":"Trauner M, Baghdasaryan A, Claudel T, Fickert P, Halilbasic E, Moustafa T, Zollner G. Targeting nuclear bile acid receptors for liver disease. Dig Dis. 2011;29(1):98\u2013102.","journal-title":"Dig Dis"},{"issue":"8","key":"4752_CR61","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1055\/a-0958-2843","volume":"57","author":"F Hentschel","year":"2019","unstructured":"Hentschel F, Bornscheuer T, L\u00fcth S. [Secondary cholangitis of the critically ill]. Z Gastroenterol. 2019;57(8):977\u201382.","journal-title":"Z Gastroenterol"},{"issue":"12","key":"4752_CR62","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1002\/lt.25882","volume":"26","author":"O Tyc","year":"2020","unstructured":"Tyc O, Jansen C, Schierwagen R, Uschner FE, Israelsen M, Klein S, Ortiz C, Strassburg CP, Zeuzem S, Gu W, et al. Variation in bile Microbiome by the etiology of cholestatic liver disease. Liver Transpl. 2020;26(12):1652\u20137.","journal-title":"Liver Transpl"},{"issue":"4","key":"4752_CR63","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.jcmgh.2024.01.005","volume":"17","author":"L Ceci","year":"2024","unstructured":"Ceci L, Gaudio E, Kennedy L. Cellular interactions and crosstalk facilitating biliary fibrosis in cholestasis. Cell Mol Gastroenterol Hepatol. 2024;17(4):553\u201365.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"8","key":"4752_CR64","doi-asserted-by":"publisher","first-page":"3478","DOI":"10.7150\/ijbs.111288","volume":"21","author":"W Yang","year":"2025","unstructured":"Yang W, Cao Y, Li J, Zhang X, Liu X, Tian Y, Shan L, Yang Y. Pathogenesis and treatment strategies of sepsis-induced myocardial injury: modern and traditional medical perspectives. Int J Biol Sci. 2025;21(8):3478\u2013504.","journal-title":"Int J Biol Sci"},{"issue":"1","key":"4752_CR65","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/s42255-022-00715-5","volume":"5","author":"K Zhang","year":"2023","unstructured":"Zhang K, Wang Y, Chen S, Mao J, Jin Y, Ye H, Zhang Y, Liu X, Gong C, Cheng X, et al. TREM2(hi) resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis. Nat Metab. 2023;5(1):129\u201346.","journal-title":"Nat Metab"},{"issue":"4","key":"4752_CR66","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1164\/rccm.200206-518OC","volume":"167","author":"HB Suliman","year":"2003","unstructured":"Suliman HB, Carraway MS, Piantadosi CA. Postlipopolysaccharide oxidative damage of mitochondrial DNA. Am J Respir Crit Care Med. 2003;167(4):570\u20139.","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"4752_CR67","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/SHK.0b013e3182391831","volume":"37","author":"C Xu","year":"2012","unstructured":"Xu C, Yi C, Wang H, Bruce IC, Xia Q. Mitochondrial nitric oxide synthase participates in septic shock myocardial depression by nitric oxide overproduction and mitochondrial permeability transition pore opening. Shock. 2012;37(1):110\u20135.","journal-title":"Shock"},{"issue":"6","key":"4752_CR68","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1164\/rccm.201003-0326OC","volume":"182","author":"JE Carr\u00e9","year":"2010","unstructured":"Carr\u00e9 JE, Orban J-C, Re L, Felsmann K, Iffert W, Bauer M, Suliman HB, Piantadosi CA, Mayhew TM, Breen P. Survival in critical illness is associated with early activation of mitochondrial biogenesis. Am J Respir Crit Care Med. 2010;182(6):745\u201351.","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"4752_CR69","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1007\/s00134-005-2719-9","volume":"31","author":"E Chinga-Alayo","year":"2005","unstructured":"Chinga-Alayo E, Villena J, Evans AT, Zimic M. Thyroid hormone levels improve the prediction of mortality among patients admitted to the intensive care unit. Intensive Care Med. 2005;31(10):1356\u201361.","journal-title":"Intensive Care Med"},{"issue":"1","key":"4752_CR70","doi-asserted-by":"publisher","first-page":"R11","DOI":"10.1186\/cc11151","volume":"16","author":"F Wang","year":"2012","unstructured":"Wang F, Pan W, Wang H, Wang S, Pan S, Ge J. Relationship between thyroid function and ICU mortality: a prospective observation study. Crit Care. 2012;16(1):R11.","journal-title":"Crit Care"},{"issue":"5","key":"4752_CR71","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1210\/er.2011-0007","volume":"32","author":"A Boelen","year":"2011","unstructured":"Boelen A, Kwakkel J, Fliers E. Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection. Endocr Rev. 2011;32(5):670\u201393.","journal-title":"Endocr Rev"},{"issue":"13","key":"4752_CR72","doi-asserted-by":"publisher","first-page":"7631","DOI":"10.1073\/pnas.95.13.7631","volume":"95","author":"E Clementi","year":"1998","unstructured":"Clementi E, Brown GC, Feelisch M, Moncada S. Persistent Inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc Natl Acad Sci. 1998;95(13):7631\u20136.","journal-title":"Proc Natl Acad Sci"},{"issue":"7","key":"4752_CR73","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/S0891-5849(96)00240-7","volume":"21","author":"JP Bolanos","year":"1996","unstructured":"Bolanos JP, Heales SJ, Peuchen S, Barker JE, Land JM, Clark JB. Nitric oxide-mediated mitochondrial damage: a potential neuroprotective role for glutathione. Free Radic Biol Med. 1996;21(7):995\u20131001.","journal-title":"Free Radic Biol Med"},{"issue":"2\u20133","key":"4752_CR74","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0014-5793(94)01290-3","volume":"356","author":"GC Brown","year":"1994","unstructured":"Brown GC, Cooper CE. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett. 1994;356(2\u20133):295\u20138.","journal-title":"FEBS Lett"},{"key":"4752_CR75","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.yjmcc.2024.08.003","volume":"195","author":"D Fan","year":"2024","unstructured":"Fan D, Wu R. Mechanisms of the septic heart: from inflammatory response to myocardial edema. J Mol Cell Cardiol. 2024;195:73\u201382.","journal-title":"J Mol Cell Cardiol"},{"issue":"11","key":"4752_CR76","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1161\/CIRCULATIONAHA.121.057666","volume":"145","author":"RH Stewart","year":"2022","unstructured":"Stewart RH, Cox CS Jr, Allen SJ, Laine GA. Myocardial edema provides a link between pulmonary arterial hypertension and pericardial effusion. Circulation. 2022;145(11):793\u20135.","journal-title":"Circulation"},{"issue":"2","key":"4752_CR77","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1002\/ehf2.13775","volume":"9","author":"F Vasques-N\u00f3voa","year":"2022","unstructured":"Vasques-N\u00f3voa F, Ang\u00e9lico\u2010Gon\u00e7alves A, Alvarenga JM, Nobrega J, Cerqueira RJ, Mancio J, Leite\u2010Moreira AF, Roncon\u2010Albuquerque R Jr. Myocardial oedema: pathophysiological basis and implications for the failing heart. ESC Heart Fail. 2022;9(2):958\u201376.","journal-title":"ESC Heart Fail"},{"key":"4752_CR78","doi-asserted-by":"crossref","unstructured":"Carbone F, Liberale L, Preda A, Schindler TH, Montecucco F. Septic cardiomyopathy: from pathophysiology to the clinical setting. Cells 2022, 11(18):2833.","DOI":"10.3390\/cells11182833"},{"issue":"4","key":"4752_CR79","first-page":"629","volume":"92","author":"C Caraballo","year":"2019","unstructured":"Caraballo C, Jaimes F. Organ dysfunction in sepsis: an ominous trajectory from infection to death. Yale J Biol Med. 2019;92(4):629\u201340.","journal-title":"Yale J Biol Med"},{"key":"4752_CR80","doi-asserted-by":"crossref","unstructured":"Pan S, Lv Z, Wang R, Shu H, Yuan S, Yu Y, Shang Y. Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment. Oxid Med Cell Longev 2022, 2022:1328729.","DOI":"10.1155\/2022\/1328729"},{"issue":"1","key":"4752_CR81","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1186\/s13054-020-03101-3","volume":"24","author":"K Erikson","year":"2020","unstructured":"Erikson K, Tuominen H, Vakkala M, Liisanantti JH, Karttunen T, Syrj\u00e4l\u00e4 H, Ala-Kokko TI. Brain tight junction protein expression in sepsis in an autopsy series. Crit Care. 2020;24(1):385.","journal-title":"Crit Care"},{"issue":"5","key":"4752_CR82","doi-asserted-by":"publisher","first-page":"e13722","DOI":"10.1111\/jfbc.13722","volume":"45","author":"HC Zhou","year":"2021","unstructured":"Zhou HC, Guo CA, Yu WW, Yan XY, Long JP, Liu ZC, Liang XQ, Liu HB. Zizyphus Jujuba cv. Muzao polysaccharides enhance intestinal barrier function and improve the survival of septic mice. J Food Biochem. 2021;45(5):e13722.","journal-title":"J Food Biochem"},{"key":"4752_CR83","doi-asserted-by":"crossref","unstructured":"Wang K, Sun M, Juan Z, Zhang J, Sun Y, Wang G, Wang C, Li Y, Kong W, Fan L et al. The Improvement of Sepsis-Associated Encephalopathy by P2X7R Inhibitor through Inhibiting the Omi\/HtrA2 Apoptotic Signaling Pathway. Behav Neurol : 2022, 2022:3777351.","DOI":"10.1155\/2022\/3777351"},{"issue":"6","key":"4752_CR84","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/cr.2015.61","volume":"25","author":"H Wang","year":"2015","unstructured":"Wang H, Hong LJ, Huang JY, Jiang Q, Tao RR, Tan C, Lu NN, Wang CK, Ahmed MM, Lu YM, et al. P2RX7 sensitizes Mac-1\/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy. Cell Res. 2015;25(6):674\u201390.","journal-title":"Cell Res"},{"issue":"2","key":"4752_CR85","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s12640-020-00270-5","volume":"39","author":"M Gu","year":"2021","unstructured":"Gu M, Mei XL, Zhao YN. Sepsis and cerebral dysfunction: BBB Damage, Neuroinflammation, oxidative Stress, apoptosis and autophagy as key mediators and the potential therapeutic approaches. Neurotox Res. 2021;39(2):489\u2013503.","journal-title":"Neurotox Res"},{"issue":"8","key":"4752_CR86","doi-asserted-by":"publisher","first-page":"5244","DOI":"10.4049\/jimmunol.0901309","volume":"183","author":"H Zhou","year":"2009","unstructured":"Zhou H, Andonegui G, Wong CH, Kubes P. Role of endothelial TLR4 for neutrophil recruitment into central nervous system microvessels in systemic inflammation. J Immunol. 2009;183(8):5244\u201350.","journal-title":"J Immunol"},{"key":"4752_CR87","doi-asserted-by":"crossref","unstructured":"Hu J, Xie S, Zhang H, Wang X, Meng B, Zhang L. Microglial activation: key players in Sepsis-Associated encephalopathy. Brain Sci 2023, 13(10):1453.","DOI":"10.3390\/brainsci13101453"},{"issue":"1","key":"4752_CR88","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12974-020-1701-3","volume":"17","author":"C Ren","year":"2020","unstructured":"Ren C, Yao RQ, Zhang H, Feng YW, Yao YM. Sepsis-associated encephalopathy: a vicious cycle of immunosuppression. J Neuroinflammation. 2020;17(1):14.","journal-title":"J Neuroinflammation"},{"key":"4752_CR89","doi-asserted-by":"publisher","first-page":"929316","DOI":"10.3389\/fimmu.2022.929316","volume":"13","author":"X Yan","year":"2022","unstructured":"Yan X, Yang K, Xiao Q, Hou R, Pan X, Zhu X. Central role of microglia in sepsis-associated encephalopathy: from mechanism to therapy. Front Immunol. 2022;13:929316.","journal-title":"Front Immunol"},{"issue":"3","key":"4752_CR90","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.it.2007.01.005","volume":"28","author":"C Farina","year":"2007","unstructured":"Farina C, Aloisi F, Meinl E. Astrocytes are active players in cerebral innate immunity. Trends Immunol. 2007;28(3):138\u201345.","journal-title":"Trends Immunol"},{"issue":"7883","key":"4752_CR91","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41586-021-03960-y","volume":"599","author":"KA Guttenplan","year":"2021","unstructured":"Guttenplan KA, Weigel MK, Prakash P, Wijewardhane PR, Hasel P, Rufen-Blanchette U, M\u00fcnch AE, Blum JA, Fine J, Neal MC, et al. Neurotoxic reactive astrocytes induce cell death via saturated lipids. Nature. 2021;599(7883):102\u20137.","journal-title":"Nature"},{"key":"4752_CR92","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.jcrc.2016.11.006","volume":"38","author":"A Al Tayar","year":"2017","unstructured":"Al Tayar A, Abouelela A, Mohiuddeen K. Can the cerebral regional oxygen saturation be a perfusion parameter in shock? J Crit Care. 2017;38:164\u20137.","journal-title":"J Crit Care"},{"key":"4752_CR93","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1742-2094-5-38","volume":"5","author":"A Semmler","year":"2008","unstructured":"Semmler A, Hermann S, Mormann F, Weberpals M, Paxian SA, Okulla T, Sch\u00e4fers M, Kummer MP, Klockgether T, Heneka MT. Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism. J Neuroinflammation. 2008;5:38.","journal-title":"J Neuroinflammation"},{"issue":"5","key":"4752_CR94","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/cc9254","volume":"14","author":"T Sharshar","year":"2010","unstructured":"Sharshar T, Polito A, Checinski A, Stevens RD. Septic-associated encephalopathy\u2013everything starts at a microlevel. Crit Care. 2010;14(5):199.","journal-title":"Crit Care"},{"issue":"2","key":"4752_CR95","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s12015-023-10658-3","volume":"20","author":"N Jiang","year":"2024","unstructured":"Jiang N, Tian X, Wang Q, Hao J, Jiang J, Wang H. Regulation mechanisms and maintenance strategies of stemness in mesenchymal stem cells. Stem Cell Rev Rep. 2024;20(2):455\u201383.","journal-title":"Stem Cell Rev Rep"},{"issue":"1","key":"4752_CR96","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13008-025-00146-0","volume":"20","author":"S Abolhasani","year":"2025","unstructured":"Abolhasani S, Ahmadi Y, Rostami Y, Fattahi D. The role of MicroRNAs in mesenchymal stem cell differentiation into vascular smooth muscle cells. Cell Div. 2025;20(1):6.","journal-title":"Cell Div"},{"issue":"1","key":"4752_CR97","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s10020-024-00967-9","volume":"30","author":"Q Xu","year":"2024","unstructured":"Xu Q, Hou W, Zhao B, Fan P, Wang S, Wang L, Gao J. Mesenchymal stem cells lineage and their role in disease development. Mol Med. 2024;30(1):207.","journal-title":"Mol Med"},{"issue":"9","key":"4752_CR98","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1002\/term.2914","volume":"13","author":"C Brown","year":"2019","unstructured":"Brown C, McKee C, Bakshi S, Walker K, Hakman E, Halassy S, Svinarich D, Dodds R, Govind CK, Chaudhry GR. Mesenchymal stem cells: cell therapy and regeneration potential. J Tissue Eng Regen Med. 2019;13(9):1738\u201355.","journal-title":"J Tissue Eng Regen Med"},{"key":"4752_CR99","doi-asserted-by":"publisher","first-page":"118363","DOI":"10.1016\/j.lfs.2020.118363","volume":"261","author":"MG Zubir\u00eda","year":"2020","unstructured":"Zubir\u00eda MG, Giordano AP, Gambaro SE, Alzamendi A, Frontini-L\u00f3pez YR, Moreno G, Spinedi E, Giovambattista A. Dexamethasone primes adipocyte precursor cells for differentiation by enhancing adipogenic competency. Life Sci. 2020;261:118363.","journal-title":"Life Sci"},{"issue":"1","key":"4752_CR100","first-page":"123","volume":"22","author":"Y Li","year":"2022","unstructured":"Li Y, Fu G, Gong Y, Li B, Li W, Liu D, Yang X. BMP-2 promotes osteogenic differentiation of mesenchymal stem cells by enhancing mitochondrial activity. J Musculoskelet Neuronal Interact. 2022;22(1):123\u201331.","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"4752_CR101","doi-asserted-by":"publisher","first-page":"115201","DOI":"10.1016\/j.biopha.2023.115201","volume":"165","author":"K Li","year":"2023","unstructured":"Li K, Zhu Z, Sun X, Zhao L, Liu Z, Xing J. Harnessing the therapeutic potential of mesenchymal stem cell-derived exosomes in cardiac arrest: current advances and future perspectives. Biomed Pharmacother. 2023;165:115201.","journal-title":"Biomed Pharmacother"},{"key":"4752_CR102","doi-asserted-by":"publisher","first-page":"963689724124494","DOI":"10.1177\/09636897241244943","volume":"33","author":"M Wu","year":"2024","unstructured":"Wu M, Mi J, Qu GX, Zhang S, Jian Y, Gao C, Cai Q, Liu J, Jiang J, Huang H. Role of Hedgehog signaling pathways in multipotent mesenchymal stem cells differentiation. Cell Transpl. 2024;33:9636897241244943.","journal-title":"Cell Transpl"},{"issue":"7","key":"4752_CR103","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41580-021-00357-7","volume":"22","author":"A Rauch","year":"2021","unstructured":"Rauch A, Mandrup S. Transcriptional networks controlling stromal cell differentiation. Nat Rev Mol Cell Biol. 2021;22(7):465\u201382.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"4752_CR104","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/s12276-022-00749-5","volume":"54","author":"Z Xie","year":"2022","unstructured":"Xie Z, Yu W, Ye G, Li J, Zheng G, Liu W, Lin J, Su Z, Che Y, Ye F, et al. Single-cell RNA sequencing analysis of human bone-marrow-derived mesenchymal stem cells and functional subpopulation identification. Exp Mol Med. 2022;54(4):483\u201392.","journal-title":"Exp Mol Med"},{"issue":"9","key":"4752_CR105","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.tips.2020.06.009","volume":"41","author":"N Song","year":"2020","unstructured":"Song N, Scholtemeijer M, Shah K. Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential. Trends Pharmacol Sci. 2020;41(9):653\u201364.","journal-title":"Trends Pharmacol Sci"},{"issue":"1","key":"4752_CR106","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/s12964-023-01191-4","volume":"21","author":"L Yan","year":"2023","unstructured":"Yan L, Li J, Zhang C. The role of MSCs and CAR-MSCs in cellular immunotherapy. Cell Commun Signal. 2023;21(1):187.","journal-title":"Cell Commun Signal"},{"issue":"11","key":"4752_CR107","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1016\/j.stem.2022.10.001","volume":"29","author":"Y Wang","year":"2022","unstructured":"Wang Y, Fang J, Liu B, Shao C, Shi Y. Reciprocal regulation of mesenchymal stem cells and immune responses. Cell Stem Cell. 2022;29(11):1515\u201330.","journal-title":"Cell Stem Cell"},{"key":"4752_CR108","doi-asserted-by":"crossref","unstructured":"Huang Y, Wu Q, Tam PKH. Immunomodulatory mechanisms of mesenchymal stem cells and their potential clinical applications. Int J Mol Sci 2022, 23(17):10023.","DOI":"10.3390\/ijms231710023"},{"issue":"3","key":"4752_CR109","doi-asserted-by":"publisher","first-page":"103560","DOI":"10.4252\/wjsc.v17.i3.103560","volume":"17","author":"YF Yi","year":"2025","unstructured":"Yi YF, Fan ZQ, Liu C, Ding YT, Chen Y, Wen J, Jian XH, Li YF. Immunomodulatory effects and clinical application of exosomes derived from mesenchymal stem cells. World J Stem Cells. 2025;17(3):103560.","journal-title":"World J Stem Cells"},{"issue":"8","key":"4752_CR110","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41581-018-0023-5","volume":"14","author":"Y Shi","year":"2018","unstructured":"Shi Y, Wang Y, Li Q, Liu K, Hou J, Shao C, Wang Y. Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases. Nat Rev Nephrol. 2018;14(8):493\u2013507.","journal-title":"Nat Rev Nephrol"},{"issue":"12","key":"4752_CR111","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1093\/stcltm\/szae045","volume":"13","author":"U Sajjad","year":"2024","unstructured":"Sajjad U, Ahmed M, Iqbal MZ, Riaz M, Mustafa M, Biedermann T, Klar AS. Exploring mesenchymal stem cells homing mechanisms and improvement strategies. Stem Cells Transl Med. 2024;13(12):1161\u201377.","journal-title":"Stem Cells Transl Med"},{"issue":"1","key":"4752_CR112","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s13287-022-02858-4","volume":"13","author":"M Yuan","year":"2022","unstructured":"Yuan M, Hu X, Yao L, Jiang Y, Li L. Mesenchymal stem cell homing to improve therapeutic efficacy in liver disease. Stem Cell Res Ther. 2022;13(1):179.","journal-title":"Stem Cell Res Ther"},{"issue":"6","key":"4752_CR113","doi-asserted-by":"publisher","first-page":"619","DOI":"10.4252\/wjsc.v13.i6.619","volume":"13","author":"R Szydlak","year":"2021","unstructured":"Szydlak R. Biological, chemical and mechanical factors regulating migration and homing of mesenchymal stem cells. World J Stem Cells. 2021;13(6):619\u201331.","journal-title":"World J Stem Cells"},{"issue":"4","key":"4752_CR114","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/leu.2010.310","volume":"25","author":"R Meisel","year":"2011","unstructured":"Meisel R, Brockers S, Heseler K, Degistirici O, B\u00fclle H, Woite C, Stuhlsatz S, Schwippert W, J\u00e4ger M, Sorg R, et al. Human but not murine multipotent mesenchymal stromal cells exhibit broad-spectrum antimicrobial effector function mediated by indoleamine 2,3-dioxygenase. Leukemia. 2011;25(4):648\u201354.","journal-title":"Leukemia"},{"issue":"7","key":"4752_CR115","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1136\/thoraxjnl-2015-206813","volume":"70","author":"J Devaney","year":"2015","unstructured":"Devaney J, Horie S, Masterson C, Elliman S, Barry F, O\u2019Brien T, Curley GF, O\u2019Toole D, Laffey JG. Human mesenchymal stromal cells decrease the severity of acute lung injury induced by E. coli in the rat. Thorax. 2015;70(7):625\u201335.","journal-title":"Thorax"},{"issue":"7","key":"4752_CR116","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1164\/rccm.201206-0990OC","volume":"187","author":"JW Lee","year":"2013","unstructured":"Lee JW, Krasnodembskaya A, McKenna DH, Song Y, Abbott J, Matthay MA. Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria. Am J Respir Crit Care Med. 2013;187(7):751\u201360.","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"4752_CR117","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1002\/stem.544","volume":"28","author":"A Krasnodembskaya","year":"2010","unstructured":"Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA. Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells. 2010;28(12):2229\u201338.","journal-title":"Stem Cells"},{"key":"4752_CR118","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s12931-015-0288-1","volume":"16","author":"H Hackstein","year":"2015","unstructured":"Hackstein H, Lippitsch A, Krug P, Schevtschenko I, Kranz S, Hecker M, Dietert K, Gruber AD, Bein G, Brendel C, et al. Prospectively defined murine mesenchymal stem cells inhibit Klebsiella pneumoniae-induced acute lung injury and improve pneumonia survival. Respir Res. 2015;16:123.","journal-title":"Respir Res"},{"issue":"7","key":"4752_CR119","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1002\/stem.2353","volume":"34","author":"JS Kim","year":"2016","unstructured":"Kim JS, Cha SH, Kim WS, Han SJ, Cha SB, Kim HM, Kwon KW, Kim SJ, Choi HH, Lee J, et al. A novel therapeutic approach using mesenchymal stem cells to protect against Mycobacterium abscessus. Stem Cells. 2016;34(7):1957\u201370.","journal-title":"Stem Cells"},{"issue":"13","key":"4752_CR120","doi-asserted-by":"publisher","first-page":"3621","DOI":"10.1073\/pnas.1601911113","volume":"113","author":"MC Chan","year":"2016","unstructured":"Chan MC, Kuok DI, Leung CY, Hui KP, Valkenburg SA, Lau EH, Nicholls JM, Fang X, Guan Y, Lee JW, et al. Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo. Proc Natl Acad Sci U S A. 2016;113(13):3621\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"4752_CR121","doi-asserted-by":"publisher","first-page":"2744","DOI":"10.1634\/stemcells.2006-0189","volume":"24","author":"H Hwa Cho","year":"2006","unstructured":"Hwa Cho H, Bae YC, Jung JS. Role of toll-like receptors on human adipose-derived stromal cells. Stem Cells. 2006;24(12):2744\u201352.","journal-title":"Stem Cells"},{"issue":"10","key":"4752_CR122","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s11274-023-03725-x","volume":"39","author":"M Bicer","year":"2023","unstructured":"Bicer M, Fidan O. Can mesenchymal stem\/stromal cells and their secretomes combat bacterial persisters? World J Microbiol Biotechnol. 2023;39(10):276.","journal-title":"World J Microbiol Biotechnol"},{"issue":"1","key":"4752_CR123","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/s13287-020-01807-3","volume":"11","author":"H Yagi","year":"2020","unstructured":"Yagi H, Chen AF, Hirsch D, Rothenberg AC, Tan J, Alexander PG, Tuan RS. Antimicrobial activity of mesenchymal stem cells against Staphylococcus aureus. Stem Cell Res Ther. 2020;11(1):293.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"4752_CR124","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13287-025-04158-z","volume":"16","author":"A Hoseinzadeh","year":"2025","unstructured":"Hoseinzadeh A, Esmaeili SA, Sahebi R, Melak AM, Mahmoudi M, Hasannia M, Baharlou R. Fate and long-lasting therapeutic effects of mesenchymal stromal\/stem-like cells: mechanistic insights. Stem Cell Res Ther. 2025;16(1):33.","journal-title":"Stem Cell Res Ther"},{"issue":"2","key":"4752_CR125","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s12015-020-10040-7","volume":"17","author":"X Qian","year":"2021","unstructured":"Qian X, An N, Ren Y, Yang C, Zhang X, Li L. Immunosuppressive effects of mesenchymal stem Cells-derived exosomes. Stem Cell Rev Rep. 2021;17(2):411\u201327.","journal-title":"Stem Cell Rev Rep"},{"issue":"9","key":"4752_CR126","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1002\/sctm.19-0446","volume":"9","author":"R Stavely","year":"2020","unstructured":"Stavely R, Nurgali K. The emerging antioxidant paradigm of mesenchymal stem cell therapy. Stem Cells Transl Med. 2020;9(9):985\u20131006.","journal-title":"Stem Cells Transl Med"},{"issue":"11","key":"4752_CR127","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1089\/ars.2016.6748","volume":"26","author":"D Klein","year":"2017","unstructured":"Klein D, Steens J, Wiesemann A, Schulz F, Kaschani F, R\u00f6ck K, Yamaguchi M, Wirsd\u00f6rfer F, Kaiser M, Fischer JW, et al. Mesenchymal stem cell therapy protects lungs from Radiation-Induced endothelial cell loss by restoring superoxide dismutase 1 expression. Antioxid Redox Signal. 2017;26(11):563\u201382.","journal-title":"Antioxid Redox Signal"},{"key":"4752_CR128","doi-asserted-by":"publisher","first-page":"727272","DOI":"10.3389\/fendo.2021.727272","volume":"12","author":"C Xia","year":"2021","unstructured":"Xia C, Dai Z, Jin Y, Chen P. Emerging antioxidant paradigm of mesenchymal stem Cell-Derived exosome therapy. Front Endocrinol (Lausanne). 2021;12:727272.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"7","key":"4752_CR129","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1038\/cdd.2017.51","volume":"24","author":"M Mahrouf-Yorgov","year":"2017","unstructured":"Mahrouf-Yorgov M, Augeul L, Da Silva CC, Jourdan M, Rigolet M, Manin S, Ferrera R, Ovize M, Henry A, Guguin A, et al. Mesenchymal stem cells sense mitochondria released from damaged cells as danger signals to activate their rescue properties. Cell Death Differ. 2017;24(7):1224\u201338.","journal-title":"Cell Death Differ"},{"key":"4752_CR130","doi-asserted-by":"publisher","first-page":"653322","DOI":"10.3389\/fcell.2021.653322","volume":"9","author":"MO Gomzikova","year":"2021","unstructured":"Gomzikova MO, James V, Rizvanov AA. Mitochondria donation by mesenchymal stem cells: current Understanding and mitochondria transplantation strategies. Front Cell Dev Biol. 2021;9:653322.","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"4752_CR131","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1186\/s12967-024-05047-4","volume":"22","author":"R Iorio","year":"2024","unstructured":"Iorio R, Petricca S, Mattei V, Delle Monache S. Horizontal mitochondrial transfer as a novel bioenergetic tool for mesenchymal stromal\/stem cells: molecular mechanisms and therapeutic potential in a variety of diseases. J Transl Med. 2024;22(1):491.","journal-title":"J Transl Med"},{"issue":"18","key":"4752_CR132","doi-asserted-by":"publisher","first-page":"2497","DOI":"10.1089\/scd.2013.0136","volume":"22","author":"J DeSantiago","year":"2013","unstructured":"DeSantiago J, Bare DJ, Banach K. Ischemia\/Reperfusion injury protection by mesenchymal stem cell derived antioxidant capacity. Stem Cells Dev. 2013;22(18):2497\u2013507.","journal-title":"Stem Cells Dev"},{"key":"4752_CR133","doi-asserted-by":"publisher","first-page":"114863","DOI":"10.1016\/j.bcp.2021.114863","volume":"195","author":"W Yang","year":"2022","unstructured":"Yang W, Tao K, Zhang P, Chen X, Sun X, Li R. Maresin 1 protects against lipopolysaccharide\/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response. Biochem Pharmacol. 2022;195:114863.","journal-title":"Biochem Pharmacol"},{"issue":"9","key":"4752_CR134","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1038\/s41418-020-0536-x","volume":"27","author":"J Liu","year":"2020","unstructured":"Liu J, Du S, Kong Q, Zhang X, Jiang S, Cao X, Li Y, Li C, Chen H, Ding Z, et al. HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1\u03b1-dependent acyloxyacyl hydrolase expression. Cell Death Differ. 2020;27(9):2651\u201367.","journal-title":"Cell Death Differ"},{"issue":"1","key":"4752_CR135","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13287-019-1158-4","volume":"10","author":"A Naji","year":"2019","unstructured":"Naji A, Favier B, Deschaseaux F, Rouas-Freiss N, Eitoku M, Suganuma N. Mesenchymal stem\/stromal cell function in modulating cell death. Stem Cell Res Ther. 2019;10(1):56.","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"4752_CR136","doi-asserted-by":"publisher","first-page":"E194","DOI":"10.1111\/hepr.12969","volume":"48","author":"J Wang","year":"2018","unstructured":"Wang J, Ren H, Yuan X, Ma H, Shi X, Ding Y. Interleukin-10 secreted by mesenchymal stem cells attenuates acute liver failure through inhibiting pyroptosis. Hepatol Res. 2018;48(3):E194\u2013202.","journal-title":"Hepatol Res"},{"issue":"1","key":"4752_CR137","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13287-025-04169-w","volume":"16","author":"Y Tian","year":"2025","unstructured":"Tian Y, Jin M, Ye N, Gao Z, Jiang Y, Yan S. Mesenchymal stem cells-derived exosomes attenuate mouse non-heart-beating liver transplantation through Mir-17-5p-regulated Kupffer cell pyroptosis. Stem Cell Res Ther. 2025;16(1):57.","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"4752_CR138","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s00011-022-01653-4","volume":"72","author":"Z Xie","year":"2023","unstructured":"Xie Z, Tang J, Chen Z, Wei L, Chen J, Liu Q. Human bone marrow mesenchymal stem cell-derived extracellular vesicles reduce inflammation and pyroptosis in acute kidney injury via miR-223-3p\/HDAC2\/SNRK. Inflamm Res. 2023;72(3):553\u201376.","journal-title":"Inflamm Res"},{"issue":"21","key":"4752_CR139","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.1242\/jcs.200667","volume":"130","author":"TM Ribeiro-Rodrigues","year":"2017","unstructured":"Ribeiro-Rodrigues TM, Martins-Marques T, Morel S, Kwak BR, Gir\u00e3o H. Role of connexin 43 in different forms of intercellular communication - gap junctions, extracellular vesicles and tunnelling nanotubes. J Cell Sci. 2017;130(21):3619\u201330.","journal-title":"J Cell Sci"},{"issue":"1","key":"4752_CR140","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13287-025-04193-w","volume":"16","author":"P Hassanpour","year":"2025","unstructured":"Hassanpour P, Sadeghsoltani F, Saghebasl S, Boroumand S, Khanicheragh P, Tafti SHA, Rahbarghazi R, Rahmati M. Mitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart disease. Stem Cell Res Ther. 2025;16(1):54.","journal-title":"Stem Cell Res Ther"},{"issue":"5","key":"4752_CR141","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/ni.2017","volume":"12","author":"A Schajnovitz","year":"2011","unstructured":"Schajnovitz A, Itkin T, D\u2019Uva G, Kalinkovich A, Golan K, Ludin A, Cohen D, Shulman Z, Avigdor A, Nagler A, et al. CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions. Nat Immunol. 2011;12(5):391\u20138.","journal-title":"Nat Immunol"},{"issue":"4","key":"4752_CR142","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/s12276-024-01201-6","volume":"56","author":"HI Kim","year":"2024","unstructured":"Kim HI, Park J, Zhu Y, Wang X, Han Y, Zhang D. Recent advances in extracellular vesicles for therapeutic cargo delivery. Exp Mol Med. 2024;56(4):836\u201349.","journal-title":"Exp Mol Med"},{"key":"4752_CR143","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.2147\/IJN.S404925","volume":"18","author":"X Lu","year":"2023","unstructured":"Lu X, Guo H, Wei X, Lu D, Shu W, Song Y, Qiu N, Xu X. Current status and prospect of delivery vehicle based on mesenchymal stem Cell-Derived exosomes in liver diseases. Int J Nanomed. 2023;18:2873\u201390.","journal-title":"Int J Nanomed"},{"key":"4752_CR144","doi-asserted-by":"crossref","unstructured":"Hade MD, Suire CN, Suo Z. Mesenchymal stem Cell-Derived exosomes: applications in regenerative medicine. Volume 10. Cells; 2021. 8.","DOI":"10.3390\/cells10081959"},{"key":"4752_CR145","doi-asserted-by":"publisher","first-page":"833878","DOI":"10.3389\/fimmu.2022.833878","volume":"13","author":"R Wu","year":"2022","unstructured":"Wu R, Fan X, Wang Y, Shen M, Zheng Y, Zhao S, Yang L. Mesenchymal stem Cell-Derived extracellular vesicles in liver immunity and therapy. Front Immunol. 2022;13:833878.","journal-title":"Front Immunol"},{"issue":"8","key":"4752_CR146","doi-asserted-by":"publisher","first-page":"814","DOI":"10.4252\/wjsc.v12.i8.814","volume":"12","author":"ZJ Ma","year":"2020","unstructured":"Ma ZJ, Yang JJ, Lu YB, Liu ZY, Wang XX. Mesenchymal stem cell-derived exosomes: toward cell-free therapeutic strategies in regenerative medicine. World J Stem Cells. 2020;12(8):814\u201340.","journal-title":"World J Stem Cells"},{"key":"4752_CR147","doi-asserted-by":"publisher","first-page":"816656","DOI":"10.3389\/fmed.2022.816656","volume":"9","author":"Q Cao","year":"2022","unstructured":"Cao Q, Huang C, Chen XM, Pollock CA. Mesenchymal stem Cell-Derived exosomes: toward Cell-Free therapeutic strategies in chronic kidney disease. Front Med (Lausanne). 2022;9:816656.","journal-title":"Front Med (Lausanne)"},{"key":"4752_CR148","doi-asserted-by":"publisher","first-page":"108634","DOI":"10.1016\/j.intimp.2022.108634","volume":"106","author":"H Huldani","year":"2022","unstructured":"Huldani H, Abdalkareem Jasim S, Olegovich Bokov D, Abdelbasset WK, Nader Shalaby M, Thangavelu L, Margiana R, Qasim MT. Application of extracellular vesicles derived from mesenchymal stem cells as potential therapeutic tools in autoimmune and rheumatic diseases. Int Immunopharmacol. 2022;106:108634.","journal-title":"Int Immunopharmacol"},{"key":"4752_CR149","doi-asserted-by":"crossref","unstructured":"Chen S, Sun F, Qian H, Xu W, Jiang J. Preconditioning and Engineering Strategies for Improving the Efficacy of Mesenchymal Stem Cell-Derived Exosomes in Cell-Free Therapy. Stem Cells Int 2022, 2022:1779346.","DOI":"10.1155\/2022\/1779346"},{"key":"4752_CR150","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jconrel.2019.02.032","volume":"299","author":"F Hosseini Shamili","year":"2019","unstructured":"Hosseini Shamili F, Alibolandi M, Rafatpanah H, Abnous K, Mahmoudi M, Kalantari M, Taghdisi SM, Ramezani M. Immunomodulatory properties of MSC-derived exosomes armed with high affinity aptamer toward Mylein as a platform for reducing multiple sclerosis clinical score. J Control Release. 2019;299:149\u201364.","journal-title":"J Control Release"},{"issue":"2","key":"4752_CR151","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.intimp.2012.12.008","volume":"15","author":"Y Zhao","year":"2013","unstructured":"Zhao Y, Yang C, Wang H, Li H, Du J, Gu W, Jiang J. Therapeutic effects of bone marrow-derived mesenchymal stem cells on pulmonary impact injury complicated with endotoxemia in rats. Int Immunopharmacol. 2013;15(2):246\u201353.","journal-title":"Int Immunopharmacol"},{"issue":"28","key":"4752_CR152","doi-asserted-by":"publisher","first-page":"45626","DOI":"10.18632\/oncotarget.17320","volume":"8","author":"FY Lee","year":"2017","unstructured":"Lee FY, Chen KH, Wallace CG, Sung PH, Sheu JJ, Chung SY, Chen YL, Lu HI, Ko SF, Sun CK, et al. Xenogeneic human umbilical cord-derived mesenchymal stem cells reduce mortality in rats with acute respiratory distress syndrome complicated by sepsis. Oncotarget. 2017;8(28):45626\u201342.","journal-title":"Oncotarget"},{"issue":"3","key":"4752_CR153","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.jcyt.2018.01.003","volume":"20","author":"T Asami","year":"2018","unstructured":"Asami T, Ishii M, Namkoong H, Yagi K, Tasaka S, Asakura T, Suzuki S, Kamo T, Okamori S, Kamata H, et al. Anti-inflammatory roles of mesenchymal stromal cells during acute Streptococcus pneumoniae pulmonary infection in mice. Cytotherapy. 2018;20(3):302\u201313.","journal-title":"Cytotherapy"},{"issue":"5","key":"4752_CR154","first-page":"439","volume":"6","author":"HH Chen","year":"2014","unstructured":"Chen HH, Chang CL, Lin KC, Sung PH, Chai HT, Zhen YY, Chen YC, Wu YC, Leu S, Tsai TH, et al. Melatonin augments apoptotic adipose-derived mesenchymal stem cell treatment against sepsis-induced acute lung injury. Am J Transl Res. 2014;6(5):439\u201358.","journal-title":"Am J Transl Res"},{"issue":"1","key":"4752_CR155","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41420-021-00785-6","volume":"8","author":"X Wang","year":"2022","unstructured":"Wang X, Liu D, Zhang X, Yang L, Xia Z, Zhang Q. Exosomes from adipose-derived mesenchymal stem cells alleviate sepsis-induced lung injury in mice by inhibiting the secretion of IL-27 in macrophages. Cell Death Discov. 2022;8(1):18.","journal-title":"Cell Death Discov"},{"issue":"2","key":"4752_CR156","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1097\/SHK.0000000000000080","volume":"41","author":"CJ Luo","year":"2014","unstructured":"Luo CJ, Zhang FJ, Zhang L, Geng YQ, Li QG, Hong Q, Fu B, Zhu F, Cui SY, Feng Z, et al. Mesenchymal stem cells ameliorate sepsis-associated acute kidney injury in mice. Shock. 2014;41(2):123\u20139.","journal-title":"Shock"},{"issue":"8","key":"4752_CR157","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.5966\/sctm.2015-0138","volume":"5","author":"JM C\u00f3ndor","year":"2016","unstructured":"C\u00f3ndor JM, Rodrigues CE, Sousa Moreira R, Canale D, Volpini RA, Shimizu MH, Camara NO, Noronha Ide L, Andrade L. Treatment with human wharton\u2019s Jelly-Derived mesenchymal stem cells attenuates Sepsis-Induced kidney Injury, liver Injury, and endothelial dysfunction. Stem Cells Transl Med. 2016;5(8):1048\u201357.","journal-title":"Stem Cells Transl Med"},{"issue":"10","key":"4752_CR158","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1681\/ASN.2014070710","volume":"26","author":"F Collino","year":"2015","unstructured":"Collino F, Bruno S, Incarnato D, Dettori D, Neri F, Provero P, Pomatto M, Oliviero S, Tetta C, Quesenberry PJ, et al. AKI recovery induced by mesenchymal stromal Cell-Derived extracellular vesicles carrying MicroRNAs. J Am Soc Nephrol. 2015;26(10):2349\u201360.","journal-title":"J Am Soc Nephrol"},{"key":"4752_CR159","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ijcard.2016.04.061","volume":"216","author":"KC Lin","year":"2016","unstructured":"Lin KC, Yip HK, Shao PL, Wu SC, Chen KH, Chen YT, Yang CC, Sun CK, Kao GS, Chen SY, et al. Combination of adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes for protecting kidney from acute ischemia-reperfusion injury. Int J Cardiol. 2016;216:173\u201385.","journal-title":"Int J Cardiol"},{"issue":"6","key":"4752_CR160","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3727\/096368910X508942","volume":"19","author":"H Yagi","year":"2010","unstructured":"Yagi H, Soto-Gutierrez A, Kitagawa Y, Tilles AW, Tompkins RG, Yarmush ML. Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn. Cell Transpl. 2010;19(6):823\u201330.","journal-title":"Cell Transpl"},{"key":"4752_CR161","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.imlet.2016.09.009","volume":"179","author":"CM Miao","year":"2016","unstructured":"Miao CM, Jiang XW, He K, Li PZ, Liu ZJ, Cao D, Ou ZB, Gong JP, Liu CA, Cheng Y. Bone marrow stromal cells attenuate LPS-induced mouse acute liver injury via the prostaglandin E 2-dependent repression of the NLRP3 inflammasome in Kupffer cells. Immunol Lett. 2016;179:102\u201313.","journal-title":"Immunol Lett"},{"issue":"6","key":"4752_CR162","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1097\/SHK.0000000000000546","volume":"45","author":"KH Wu","year":"2016","unstructured":"Wu KH, Wu HP, Chao WR, Lo WY, Tseng PC, Lee CJ, Peng CT, Lee MS, Chao YH. Time-Series expression of Toll-Like receptor 4 signaling in septic mice treated with mesenchymal stem cells. Shock. 2016;45(6):634\u201340.","journal-title":"Shock"},{"issue":"1","key":"4752_CR163","doi-asserted-by":"publisher","first-page":"111465","DOI":"10.1016\/j.yexcr.2019.06.010","volume":"383","author":"H Liang","year":"2019","unstructured":"Liang H, Ding X, Yu Y, Zhang H, Wang L, Kan Q, Ma S, Guan F, Sun T. Adipose-derived mesenchymal stem cells ameliorate acute liver injury in rat model of CLP induced-sepsis via sTNFR1. Exp Cell Res. 2019;383(1):111465.","journal-title":"Exp Cell Res"},{"key":"4752_CR164","doi-asserted-by":"publisher","first-page":"1397722","DOI":"10.3389\/fimmu.2024.1397722","volume":"15","author":"T Zheng","year":"2024","unstructured":"Zheng T, Li S, Zhang T, Fu W, Liu S, He Y, Wang X, Ma T. Exosome-shuttled miR-150-5p from LPS-preconditioned mesenchymal stem cells down-regulate PI3K\/Akt\/mTOR pathway via Irs1 to enhance M2 macrophage polarization and confer protection against sepsis. Front Immunol. 2024;15:1397722.","journal-title":"Front Immunol"},{"key":"4752_CR165","doi-asserted-by":"publisher","first-page":"111575","DOI":"10.1016\/j.intimp.2024.111575","volume":"128","author":"L Pei","year":"2024","unstructured":"Pei L, Li R, Wang X, Xu D, Gong F, Chen W, Zheng X, Liu W, Zhao S, Wang Q, et al. MSCs-derived extracellular vesicles alleviate sepsis-associated liver dysfunction by inhibiting macrophage glycolysis-mediated inflammatory response. Int Immunopharmacol. 2024;128:111575.","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"4752_CR166","doi-asserted-by":"publisher","first-page":"5317","DOI":"10.3892\/mmr.2016.5151","volume":"13","author":"Y Wu","year":"2016","unstructured":"Wu Y, Zhou J, Bi L, Huang M, Han Y, Zhang Q, Zhu D, Zhou S. Effects of bone marrow mesenchymal stem cells on the cardiac function and immune system of mice with endotoxemia. Mol Med Rep. 2016;13(6):5317\u201325.","journal-title":"Mol Med Rep"},{"key":"4752_CR167","doi-asserted-by":"publisher","first-page":"13721","DOI":"10.1038\/srep13721","volume":"5","author":"X Wang","year":"2015","unstructured":"Wang X, Gu H, Qin D, Yang L, Huang W, Essandoh K, Wang Y, Caldwell CC, Peng T, Zingarelli B, et al. Exosomal miR-223 contributes to mesenchymal stem Cell-Elicited cardioprotection in polymicrobial sepsis. Sci Rep. 2015;5:13721.","journal-title":"Sci Rep"},{"issue":"1","key":"4752_CR168","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s13287-017-0531-4","volume":"8","author":"E Redondo-Castro","year":"2017","unstructured":"Redondo-Castro E, Cunningham C, Miller J, Martuscelli L, Aoulad-Ali S, Rothwell NJ, Kielty CM, Allan SM, Pinteaux E. Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro. Stem Cell Res Ther. 2017;8(1):79.","journal-title":"Stem Cell Res Ther"},{"key":"4752_CR169","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.nbd.2013.06.001","volume":"58","author":"SW Yoo","year":"2013","unstructured":"Yoo SW, Chang DY, Lee HS, Kim GH, Park JS, Ryu BY, Joe EH, Lee YD, Kim SS, Suh-Kim H. Immune following suppression mesenchymal stem cell transplantation in the ischemic brain is mediated by TGF-\u03b2. Neurobiol Dis. 2013;58:249\u201357.","journal-title":"Neurobiol Dis"},{"issue":"10","key":"4752_CR170","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1016\/j.jcyt.2014.05.007","volume":"16","author":"P Huang","year":"2014","unstructured":"Huang P, Gebhart N, Richelson E, Brott TG, Meschia JF, Zubair AC. Mechanism of mesenchymal stem cell-induced neuron recovery and anti-inflammation. Cytotherapy. 2014;16(10):1336\u201344.","journal-title":"Cytotherapy"},{"key":"4752_CR171","doi-asserted-by":"publisher","first-page":"114900","DOI":"10.1016\/j.expneurol.2024.114900","volume":"380","author":"Y Zhan","year":"2024","unstructured":"Zhan Y, Zhang L, Sun J, Yao H, Chen J, Tian M. ADSC-derived exosomes provide neuroprotection in sepsis-associated encephalopathy by regulating hippocampal pyroptosis. Exp Neurol. 2024;380:114900.","journal-title":"Exp Neurol"},{"issue":"2","key":"4752_CR172","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1002\/stem.2551","volume":"35","author":"MA Matthay","year":"2017","unstructured":"Matthay MA, Pati S, Lee JW. Concise review: mesenchymal stem (Stromal) cells: biology and preclinical evidence for therapeutic potential for organ dysfunction following trauma or sepsis. Stem Cells. 2017;35(2):316\u201324.","journal-title":"Stem Cells"},{"issue":"3","key":"4752_CR173","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00418-018-1731-4","volume":"151","author":"SA Selim","year":"2019","unstructured":"Selim SA, El-Baset SAA, Kattaia AAA, Askar EM, Elkader EA. Bone marrow-derived mesenchymal stem cells ameliorate liver injury in a rat model of sepsis by activating Nrf2 signaling. Histochem Cell Biol. 2019;151(3):249\u201362.","journal-title":"Histochem Cell Biol"},{"key":"4752_CR174","doi-asserted-by":"crossref","unstructured":"Tang Y, Ding F, Wu C, Liu B. hucMSC Conditioned Medium Ameliorate Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Oxidative Stress and Inflammation via Nrf2\/NF-\u03baB Signaling Pathway. Anal Cell Pathol (Amst) 2021, 2021:6653681.","DOI":"10.1155\/2021\/6653681"},{"key":"4752_CR175","doi-asserted-by":"crossref","unstructured":"Zhang L, Wang Z, Sun X, Rong W, Deng W, Yu J, Xu X, Yu Q. Nasal mucosa-derived mesenchymal stem cells prolonged the survival of septic rats by protecting macrophages from pyroptosis. Cell Immunol 2024, 401:104840.","DOI":"10.1016\/j.cellimm.2024.104840"},{"key":"4752_CR176","doi-asserted-by":"publisher","first-page":"156173","DOI":"10.1016\/j.phymed.2024.156173","volume":"135","author":"Q Yu","year":"2024","unstructured":"Yu Q, Zhang L, Wang Z, Wang Q, Sun X, Deng W, Cao X, Yu J, Xu X. Anti-inflammatory oligosaccharide licensed mesenchymal stem cells allow prolonged survival of septic rats via the promotion of glutathione synthesis. Phytomedicine. 2024;135:156173.","journal-title":"Phytomedicine"},{"issue":"1","key":"4752_CR177","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/jpi.12140","volume":"57","author":"HH Chen","year":"2014","unstructured":"Chen HH, Lin KC, Wallace CG, Chen YT, Yang CC, Leu S, Chen YC, Sun CK, Tsai TH, Chen YL, et al. Additional benefit of combined therapy with melatonin and apoptotic adipose-derived mesenchymal stem cell against sepsis-induced kidney injury. J Pineal Res. 2014;57(1):16\u201332.","journal-title":"J Pineal Res"},{"issue":"2","key":"4752_CR178","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.ymthe.2016.11.019","volume":"25","author":"Y Yan","year":"2017","unstructured":"Yan Y, Jiang W, Tan Y, Zou S, Zhang H, Mao F, Gong A, Qian H, Xu W. HucMSC Exosome-Derived GPX1 is required for the recovery of hepatic oxidant injury. Mol Ther. 2017;25(2):465\u201379.","journal-title":"Mol Ther"},{"key":"4752_CR179","doi-asserted-by":"publisher","first-page":"1157793","DOI":"10.3389\/fimmu.2023.1157793","volume":"14","author":"J Cai","year":"2023","unstructured":"Cai J, Tang D, Hao X, Liu E, Li W, Shi J. Mesenchymal stem cell-derived exosome alleviates sepsis- associated acute liver injury by suppressing MALAT1 through microRNA-26a-5p: an innovative Immunopharmacological intervention and therapeutic approach for sepsis. Front Immunol. 2023;14:1157793.","journal-title":"Front Immunol"},{"key":"4752_CR180","doi-asserted-by":"crossref","unstructured":"Xiang B, Chen L, Wang X, Zhao Y, Wang Y, Xiang C. Transplantation of menstrual Blood-Derived mesenchymal stem cells promotes the repair of LPS-Induced acute lung injury. Int J Mol Sci 2017, 18(4):689.","DOI":"10.3390\/ijms18040689"},{"issue":"2","key":"4752_CR181","doi-asserted-by":"publisher","first-page":"e132","DOI":"10.1097\/CCM.0000000000002833","volume":"46","author":"JD Silva","year":"2018","unstructured":"Silva JD, Lopes-Pacheco M, Paz AHR, Cruz FF, Melo EB, de Oliveira MV, Xisto DG, Capelozzi VL, Morales MM, Pelosi P, et al. Mesenchymal stem cells from bone Marrow, adipose tissue, and lung tissue differentially mitigate lung and distal organ damage in experimental acute respiratory distress syndrome. Crit Care Med. 2018;46(2):e132\u201340.","journal-title":"Crit Care Med"},{"issue":"2","key":"4752_CR182","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1002\/cbin.10359","volume":"39","author":"B Li","year":"2015","unstructured":"Li B, Zhang H, Zeng M, He W, Li M, Huang X, Deng DY, Wu J. Bone marrow mesenchymal stem cells protect alveolar macrophages from lipopolysaccharide-induced apoptosis partially by inhibiting the Wnt\/\u03b2-catenin pathway. Cell Biol Int. 2015;39(2):192\u2013200.","journal-title":"Cell Biol Int"},{"key":"4752_CR183","doi-asserted-by":"publisher","first-page":"102655","DOI":"10.1016\/j.redox.2023.102655","volume":"62","author":"K Shen","year":"2023","unstructured":"Shen K, Wang X, Wang Y, Jia Y, Zhang Y, Wang K, Luo L, Cai W, Li J, Li S, et al. miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1\/Nrf2\/GPX4 in sepsis lung injury. Redox Biol. 2023;62:102655.","journal-title":"Redox Biol"},{"key":"4752_CR184","doi-asserted-by":"publisher","first-page":"7095","DOI":"10.2147\/IJN.S441133","volume":"18","author":"Y Tao","year":"2023","unstructured":"Tao Y, Xu X, Yang B, Zhao H, Li Y. Mitigation of Sepsis-Induced acute lung injury by BMSC-Derived Exosomal miR-125b-5p through STAT3-Mediated suppression of macrophage pyroptosis. Int J Nanomed. 2023;18:7095\u2013113.","journal-title":"Int J Nanomed"},{"issue":"4","key":"4752_CR185","doi-asserted-by":"publisher","first-page":"9060","DOI":"10.1080\/21655979.2022.2052652","volume":"13","author":"X He","year":"2022","unstructured":"He X, Li C, Yin H, Tan X, Yi J, Tian S, Wang Y, Liu J. Mesenchymal stem cells inhibited the apoptosis of alveolar epithelial cells caused by ARDS through CXCL12\/CXCR4 axis. Bioengineered. 2022;13(4):9060\u201370.","journal-title":"Bioengineered"},{"key":"4752_CR186","doi-asserted-by":"publisher","first-page":"7745","DOI":"10.2147\/IJN.S417627","volume":"18","author":"C Jin","year":"2023","unstructured":"Jin C, Cao Y, Li Y. Bone mesenchymal stem cells origin exosomes are effective against Sepsis-Induced acute kidney injury in rat model. Int J Nanomed. 2023;18:7745\u201358.","journal-title":"Int J Nanomed"},{"key":"4752_CR187","doi-asserted-by":"publisher","first-page":"117719","DOI":"10.1016\/j.lfs.2020.117719","volume":"255","author":"F Gao","year":"2020","unstructured":"Gao F, Zuo B, Wang Y, Li S, Yang J, Sun D. Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway. Life Sci. 2020;255:117719.","journal-title":"Life Sci"},{"key":"4752_CR188","doi-asserted-by":"publisher","first-page":"639165","DOI":"10.3389\/fendo.2021.639165","volume":"12","author":"J Guo","year":"2021","unstructured":"Guo J, Wang R, Liu D. Bone Marrow-Derived mesenchymal stem cells ameliorate Sepsis-Induced acute kidney injury by promoting mitophagy of renal tubular epithelial cells via the SIRT1\/Parkin axis. Front Endocrinol (Lausanne). 2021;12:639165.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"4752_CR189","doi-asserted-by":"publisher","first-page":"361","DOI":"10.2174\/1574888X17666220407103441","volume":"17","author":"Y Yin","year":"2022","unstructured":"Yin Y, Tang L, Liu K, Ding X, Wang D, Chen L. Attenuation of Lipopolysaccharide-induced liver injury by bone marrow mesenchymal stem cells via inhibiting the NLRP3 inflammasome and hepatocyte pyroptosis. Curr Stem Cell Res Ther. 2022;17(4):361\u20139.","journal-title":"Curr Stem Cell Res Ther"},{"key":"4752_CR190","doi-asserted-by":"publisher","first-page":"2887","DOI":"10.2147\/DDDT.S220190","volume":"13","author":"S Zhao","year":"2019","unstructured":"Zhao S, Liu Y, Pu Z. Bone marrow mesenchymal stem cell-derived exosomes attenuate D-GaIN\/LPS-induced hepatocyte apoptosis by activating autophagy in vitro. Drug Des Devel Ther. 2019;13:2887\u201397.","journal-title":"Drug Des Devel Ther"},{"key":"4752_CR191","doi-asserted-by":"publisher","first-page":"109931","DOI":"10.1016\/j.intimp.2023.109931","volume":"117","author":"J Liu","year":"2023","unstructured":"Liu J, Tang M, Li Q, Li Q, Dai Y, Zhou H. ATG2B upregulated in LPS-stimulated BMSCs-derived exosomes attenuates septic liver injury by inhibiting macrophage STING signaling. Int Immunopharmacol. 2023;117:109931.","journal-title":"Int Immunopharmacol"},{"key":"4752_CR192","doi-asserted-by":"crossref","unstructured":"Liu C, Xue J, Xu B, Zhang A, Qin L, Liu J, Yang Y. Exosomes Derived from miR-146a-5p-Enriched Mesenchymal Stem Cells Protect the Cardiomyocytes and Myocardial Tissues in the Polymicrobial Sepsis through Regulating MYBL1. Stem Cells Int 2021, 2021:1530445.","DOI":"10.1155\/2021\/1530445"},{"key":"4752_CR193","doi-asserted-by":"publisher","first-page":"108910","DOI":"10.1016\/j.intimp.2022.108910","volume":"110","author":"L Pan","year":"2022","unstructured":"Pan L, Yan B, Zhang J, Zhao P, Jing Y, Yu J, Hui J, Lu Q. Mesenchymal stem cells-derived extracellular vesicles-shuttled microRNA-223-3p suppress lipopolysaccharide-induced cardiac inflammation, pyroptosis, and dysfunction. Int Immunopharmacol. 2022;110:108910.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"4752_CR194","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/s42003-024-06236-z","volume":"7","author":"Y Ma","year":"2024","unstructured":"Ma Y, She X, Liu Y, Qin X. MSC-derived Exosomal miR-140-3p improves cognitive dysfunction in sepsis-associated encephalopathy by HMGB1 and S-lactoylglutathione metabolism. Commun Biol. 2024;7(1):562.","journal-title":"Commun Biol"},{"issue":"1","key":"4752_CR195","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41419-025-07439-w","volume":"16","author":"LL Xue","year":"2025","unstructured":"Xue LL, Cheng J, Du RL, Luo BY, Chen L, Xiao QX, Zhou HS, She HQ, Wang SF, Chen TB, et al. Bone marrow mesenchymal stem cells alleviate neurological dysfunction by reducing autophagy damage via downregulation of SYNPO2 in neonatal hypoxic-ischemic encephalopathy rats. Cell Death Dis. 2025;16(1):131.","journal-title":"Cell Death Dis"},{"issue":"5","key":"4752_CR196","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1007\/s11010-023-04785-1","volume":"479","author":"Y Wang","year":"2024","unstructured":"Wang Y, Dong H, Dong T, Zhao L, Fan W, Zhang Y, Yao W. Treatment of cytokine release syndrome-induced vascular endothelial injury using mesenchymal stem cells. Mol Cell Biochem. 2024;479(5):1149\u201364.","journal-title":"Mol Cell Biochem"},{"issue":"3","key":"4752_CR197","doi-asserted-by":"publisher","first-page":"e0193178","DOI":"10.1371\/journal.pone.0193178","volume":"13","author":"RL Kadle","year":"2018","unstructured":"Kadle RL, Abdou SA, Villarreal-Ponce AP, Soares MA, Sultan DL, David JA, Massie J, Rifkin WJ, Rabbani P, Ceradini DJ. Microenvironmental cues enhance mesenchymal stem cell-mediated Immunomodulation and regulatory T-cell expansion. PLoS ONE. 2018;13(3):e0193178.","journal-title":"PLoS ONE"},{"issue":"1","key":"4752_CR198","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13287-020-02118-3","volume":"12","author":"S Zhang","year":"2021","unstructured":"Zhang S, Fang J, Liu Z, Hou P, Cao L, Zhang Y, Liu R, Li Y, Shang Q, Chen Y, et al. Inflammatory cytokines-stimulated human muscle stem cells ameliorate ulcerative colitis via the IDO-TSG6 axis. Stem Cell Res Ther. 2021;12(1):50.","journal-title":"Stem Cell Res Ther"},{"issue":"23\u201324","key":"4752_CR199","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1089\/ten.tea.2020.0170","volume":"26","author":"MH Ding","year":"2020","unstructured":"Ding MH, Lozoya EG, Rico RN, Chew SA. The role of Angiogenesis-Inducing MicroRNAs in vascular tissue engineering. Tissue Eng Part A. 2020;26(23\u201324):1283\u2013302.","journal-title":"Tissue Eng Part A"},{"key":"4752_CR200","doi-asserted-by":"crossref","unstructured":"Rautiainen S, Laaksonen T, Koivuniemi R. Angiogenic effects and crosstalk of Adipose-Derived mesenchymal Stem\/Stromal cells and their extracellular vesicles with endothelial cells. Int J Mol Sci 2021, 22(19):10890.","DOI":"10.3390\/ijms221910890"},{"issue":"3","key":"4752_CR201","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1111\/j.1600-6143.2011.03870.x","volume":"12","author":"T Ma","year":"2012","unstructured":"Ma T, Liu H, Chen W, Xia X, Bai X, Liang L, Zhang Y, Liang T. Implanted adipose-derived stem cells attenuate small-for-size liver graft injury by secretion of VEGF in rats. Am J Transpl. 2012;12(3):620\u20139.","journal-title":"Am J Transpl"},{"issue":"1","key":"4752_CR202","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s13287-016-0320-5","volume":"7","author":"S Hu","year":"2016","unstructured":"Hu S, Li J, Xu X, Liu A, He H, Xu J, Chen Q, Liu S, Liu L, Qiu H, et al. The hepatocyte growth factor-expressing character is required for mesenchymal stem cells to protect the lung injured by lipopolysaccharide in vivo. Stem Cell Res Ther. 2016;7(1):66.","journal-title":"Stem Cell Res Ther"},{"key":"4752_CR203","doi-asserted-by":"crossref","unstructured":"Meng SS, Guo FM, Huang LL, Huang YZ, Xie JF, Yang CS, Qiu HB, Yang Y. mTORC2 Activation Mediated by Mesenchymal Stem Cell-Secreted Hepatocyte Growth Factors for the Recovery of Lipopolysaccharide-Induced Vascular Endothelial Barrier. Stem Cells Int 2021, 2021:9981589.","DOI":"10.1155\/2021\/9981589"},{"issue":"1","key":"4752_CR204","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/s12964-023-01229-7","volume":"21","author":"Z Li","year":"2023","unstructured":"Li Z, Xu Y, Lu S, Gao Y, Deng Y. Bone mesenchymal stem cell extracellular vesicles delivered MiR let-7-5p alleviate endothelial glycocalyx degradation and leakage via targeting ABL2. Cell Commun Signal. 2023;21(1):205.","journal-title":"Cell Commun Signal"},{"issue":"8","key":"4752_CR205","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/s41419-020-02857-4","volume":"11","author":"X Wei","year":"2020","unstructured":"Wei X, Yi X, Lv H, Sui X, Lu P, Li L, An Y, Yang Y, Yi H, Chen G. MicroRNA-377-3p released by mesenchymal stem cell exosomes ameliorates lipopolysaccharide-induced acute lung injury by targeting RPTOR to induce autophagy. Cell Death Dis. 2020;11(8):657.","journal-title":"Cell Death Dis"},{"issue":"9","key":"4752_CR206","doi-asserted-by":"publisher","first-page":"e25171","DOI":"10.1371\/journal.pone.0025171","volume":"6","author":"S Pati","year":"2011","unstructured":"Pati S, Gerber MH, Menge TD, Wataha KA, Zhao Y, Baumgartner JA, Zhao J, Letourneau PA, Huby MP, Baer LA, et al. Bone marrow derived mesenchymal stem cells inhibit inflammation and preserve vascular endothelial integrity in the lungs after hemorrhagic shock. PLoS ONE. 2011;6(9):e25171.","journal-title":"PLoS ONE"},{"issue":"1","key":"4752_CR207","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/s12951-023-02038-3","volume":"21","author":"J Chen","year":"2023","unstructured":"Chen J, Ma S, Luo B, Hao H, Li Y, Yang H, Zhu F, Zhang P, Niu R, Pan P. Human umbilical cord mesenchymal stromal cell small extracellular vesicle transfer of microRNA-223-3p to lung epithelial cells attenuates inflammation in acute lung injury in mice. J Nanobiotechnol. 2023;21(1):295.","journal-title":"J Nanobiotechnol"},{"key":"4752_CR208","doi-asserted-by":"crossref","unstructured":"Ishii M, Tsuchiya T, Doi R, Morofuji Y, Fujimoto T, Muto H, Suematsu T, Mori R, Matsumoto K, Miyazaki T et al. Increased in vitro intercellular barrier function of lung epithelial cells using Adipose-Derived mesenchymal Stem\/Stromal cells. Pharmaceutics 2021, 13(8):1264.","DOI":"10.3390\/pharmaceutics13081264"},{"issue":"6","key":"4752_CR209","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.jcyt.2023.02.002","volume":"25","author":"R Niu","year":"2023","unstructured":"Niu R, Pan P, Li C, Luo B, Ma H, Hao H, Zhao Z, Yang H, Ma S, Zhu F, et al. Bone mesenchymal stromal cell-derived small extracellular vesicles inhibit inflammation and ameliorate sepsis via delivery of microRNA-21a-5p. Cytotherapy. 2023;25(6):625\u201339.","journal-title":"Cytotherapy"},{"issue":"3","key":"4752_CR210","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1097\/SHK.0000000000002191","volume":"60","author":"DR Ramos Maia","year":"2023","unstructured":"Ramos Maia DR, Otsuki DA, Rodrigues CE, Zboril S, Sanches TR, Neto AND, Andrade L, Auler JOC Jr. TREATMENT WITH HUMAN UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS IN A PIG MODEL OF SEPSIS-INDUCED ACUTE KIDNEY INJURY: EFFECTS ON MICROVASCULAR ENDOTHELIAL CELLS AND TUBULAR CELLS IN THE KIDNEY. Shock. 2023;60(3):469\u201377.","journal-title":"Shock"},{"issue":"5","key":"4752_CR211","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1093\/stcltm\/szac016","volume":"11","author":"J Yi","year":"2022","unstructured":"Yi J, Zhang J, Zhang Q, Chen X, Qi R, Liang R, Wang Y, Wang F, Zhong Y, Zhang X, et al. Chemical-Empowered human Adipose-Derived stem cells with lower immunogenicity and enhanced Pro-angiogenic ability promote fast tissue regeneration. Stem Cells Transl Med. 2022;11(5):552\u201365.","journal-title":"Stem Cells Transl Med"},{"issue":"42","key":"4752_CR212","doi-asserted-by":"publisher","first-page":"4486","DOI":"10.2174\/1381612825666191116125525","volume":"25","author":"EJ Park","year":"2019","unstructured":"Park EJ, Appiah MG, Myint PK, Gaowa A, Kawamoto E, Shimaoka M. Exosomes in sepsis and inflammatory tissue injury. Curr Pharm Des. 2019;25(42):4486\u201395.","journal-title":"Curr Pharm Des"},{"issue":"1","key":"4752_CR213","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41392-023-01704-0","volume":"9","author":"F Tan","year":"2024","unstructured":"Tan F, Li X, Wang Z, Li J, Shahzad K, Zheng J. Clinical applications of stem cell-derived exosomes. Signal Transduct Target Ther. 2024;9(1):17.","journal-title":"Signal Transduct Target Ther"},{"key":"4752_CR214","doi-asserted-by":"crossref","unstructured":"Guo Y, Wang H, Huang L, Ou L, Zhu J, Liu S, Xu X. Small extracellular vesicles-based cell-free strategies for therapy. MedComm (2020) 2021, 2(1):17\u201326.","DOI":"10.1002\/mco2.57"},{"issue":"5","key":"4752_CR215","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.jacc.2016.11.009","volume":"69","author":"JM Hare","year":"2017","unstructured":"Hare JM, DiFede DL, Rieger AC, Florea V, Landin AM, El-Khorazaty J, Khan A, Mushtaq M, Lowery MH, Byrnes JJ, et al. Randomized comparison of allogeneic versus autologous mesenchymal stem cells for nonischemic dilated cardiomyopathy: POSEIDON-DCM trial. J Am Coll Cardiol. 2017;69(5):526\u201337.","journal-title":"J Am Coll Cardiol"},{"issue":"24","key":"4752_CR216","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1016\/j.jacc.2009.06.055","volume":"54","author":"JM Hare","year":"2009","unstructured":"Hare JM, Traverse JH, Henry TD, Dib N, Strumpf RK, Schulman SP, Gerstenblith G, DeMaria AN, Denktas AE, Gammon RS, et al. A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol. 2009;54(24):2277\u201386.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"4752_CR217","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13054-022-04287-4","volume":"27","author":"F Wang","year":"2023","unstructured":"Wang F, Li Y, Wang B, Li J, Peng Z. The safety and efficacy of mesenchymal stromal cells in ARDS: a meta-analysis of randomized controlled trials. Crit Care. 2023;27(1):31.","journal-title":"Crit Care"},{"key":"4752_CR218","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.ajem.2020.11.035","volume":"46","author":"C Premer","year":"2021","unstructured":"Premer C, Schulman IH, Jackson JS. The role of mesenchymal stem\/stromal cells in the acute clinical setting. Am J Emerg Med. 2021;46:572\u20138.","journal-title":"Am J Emerg Med"},{"issue":"6","key":"4752_CR219","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1016\/j.chest.2023.06.024","volume":"164","author":"AL Lightner","year":"2023","unstructured":"Lightner AL, Sengupta V, Qian S, Ransom JT, Suzuki S, Park DJ, Melson TI, Williams BP, Walsh JJ, Awili M. Bone marrow mesenchymal stem Cell-Derived extracellular vesicle infusion for the treatment of respiratory failure from COVID-19: A Randomized, Placebo-Controlled dosing clinical trial. Chest. 2023;164(6):1444\u201353.","journal-title":"Chest"},{"issue":"1","key":"4752_CR220","doi-asserted-by":"publisher","first-page":"12520","DOI":"10.1038\/s41598-023-39268-2","volume":"13","author":"B Soetjahjo","year":"2023","unstructured":"Soetjahjo B, Malueka RG, Nurudhin A, Purwoko, Sumardi, Wisaksana R, Adhiputri A, Sudadi, Soeroto AY, Sidharta BRA, et al. Effectiveness and safety of normoxic allogenic umbilical cord mesenchymal stem cells administered as adjunctive treatment in patients with severe COVID-19. Sci Rep. 2023;13(1):12520.","journal-title":"Sci Rep"},{"issue":"1","key":"4752_CR221","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s12967-024-05358-6","volume":"22","author":"W Lu","year":"2024","unstructured":"Lu W, Yan L, Tang X, Wang X, Du J, Zou Z, Li L, Ye J, Zhou L. Efficacy and safety of mesenchymal stem cells therapy in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials. J Transl Med. 2024;22(1):550.","journal-title":"J Transl Med"},{"key":"4752_CR222","doi-asserted-by":"crossref","unstructured":"Sanchez-Diaz M, Qui\u00f1ones-Vico MI, de la Sanabria R, Montero-V\u00edlchez T, Sierra-S\u00e1nchez A, Molina-Leyva A, Arias-Santiago S. Biodistribution of mesenchymal stromal cells after administration in animal models and humans: A systematic review. J Clin Med 2021, 10(13):2925.","DOI":"10.3390\/jcm10132925"},{"issue":"7","key":"4752_CR223","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.nucmedbio.2015.12.003","volume":"43","author":"L Lezaic","year":"2016","unstructured":"Lezaic L, Socan A, Peitl PK, Poglajen G, Sever M, Cukjati M, Cernelc P, Vrtovec B. Imaging and 1-day kinetics of intracoronary stem cell transplantation in patients with idiopathic dilated cardiomyopathy. Nucl Med Biol. 2016;43(7):410\u20134.","journal-title":"Nucl Med Biol"},{"key":"4752_CR224","doi-asserted-by":"publisher","first-page":"101476","DOI":"10.1016\/j.mtbio.2025.101476","volume":"31","author":"C An","year":"2025","unstructured":"An C, Zhao Y, Guo L, Zhang Z, Yan C, Zhang S, Zhang Y, Shao F, Qi Y, Wang X, et al. Innovative approaches to boost mesenchymal stem cells efficacy in myocardial infarction therapy. Mater Today Bio. 2025;31:101476.","journal-title":"Mater Today Bio"},{"issue":"7","key":"4752_CR225","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.nucmedbio.2011.03.008","volume":"38","author":"A Gholamrezanezhad","year":"2011","unstructured":"Gholamrezanezhad A, Mirpour S, Bagheri M, Mohamadnejad M, Alimoghaddam K, Abdolahzadeh L, Saghari M, Malekzadeh R. In vivo tracking of 111In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis. Nucl Med Biol. 2011;38(7):961\u20137.","journal-title":"Nucl Med Biol"},{"issue":"1","key":"4752_CR226","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13287-024-04127-y","volume":"16","author":"WC Huang","year":"2025","unstructured":"Huang WC, Li YC, Chen PX, Ma KS, Wang LT. Mesenchymal stem cell therapy as a game-changer in liver diseases: review of current clinical trials. Stem Cell Res Ther. 2025;16(1):3.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"4752_CR227","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1186\/s13287-018-1076-x","volume":"9","author":"L Scarfe","year":"2018","unstructured":"Scarfe L, Taylor A, Sharkey J, Harwood R, Barrow M, Comenge J, Beeken L, Astley C, Santeramo I, Hutchinson C, et al. Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration. Stem Cell Res Ther. 2018;9(1):332.","journal-title":"Stem Cell Res Ther"},{"key":"4752_CR228","doi-asserted-by":"publisher","first-page":"112732","DOI":"10.1016\/j.intimp.2024.112732","volume":"139","author":"F Ahangari","year":"2024","unstructured":"Ahangari F, Soudi S, Ghaffari Khaligh S, Mirsanei Z, Soufihasanabad S, Ebadi Asl P, Mahmoud Hashemi S. Combinational therapy of mesenchymal stem cell-derived extracellular vesicles and Azithromycin improves clinical and histopathological recovery in CLP sepsis model. Int Immunopharmacol. 2024;139:112732.","journal-title":"Int Immunopharmacol"},{"key":"4752_CR229","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/s13287-015-0192-0","volume":"6","author":"F Alcayaga-Miranda","year":"2015","unstructured":"Alcayaga-Miranda F, Cuenca J, Martin A, Contreras L, Figueroa FE, Khoury M. Combination therapy of menstrual derived mesenchymal stem cells and antibiotics ameliorates survival in sepsis. Stem Cell Res Ther. 2015;6:199.","journal-title":"Stem Cell Res Ther"},{"key":"4752_CR230","doi-asserted-by":"crossref","unstructured":"Zheng Z, Wang X, Ouyang L, Chen W, Zhang L, Cao Y. Antioxidants improve the proliferation and efficacy of hUC-MSCs against H(2)O(2)-Induced senescence. Antioxid (Basel) 2023, 12(7):1334.","DOI":"10.3390\/antiox12071334"},{"issue":"1","key":"4752_CR231","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13287-024-03641-3","volume":"15","author":"W Li","year":"2024","unstructured":"Li W, Xiang Z, Yu W, Huang X, Jiang Q, Abumansour A, Yang Y, Chen C. Natural compounds and mesenchymal stem cells: implications for inflammatory-impaired tissue regeneration. Stem Cell Res Ther. 2024;15(1):34.","journal-title":"Stem Cell Res Ther"},{"issue":"32","key":"4752_CR232","doi-asserted-by":"publisher","first-page":"3766","DOI":"10.3748\/wjg.v30.i32.3766","volume":"30","author":"Y Xu","year":"2024","unstructured":"Xu Y, Wang XS, Zhou XL, Lu WM, Tang XK, Jin Y, Ye JS. Mesenchymal stem cell therapy for liver fibrosis need partner: results based on a meta-analysis of preclinical studies. World J Gastroenterol. 2024;30(32):3766\u201382.","journal-title":"World J Gastroenterol"},{"issue":"3","key":"4752_CR233","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1007\/s12016-021-08892-z","volume":"64","author":"X Zhuang","year":"2023","unstructured":"Zhuang X, Hu X, Zhang S, Li X, Yuan X, Wu Y. Mesenchymal stem Cell-Based therapy as a new approach for the treatment of systemic sclerosis. Clin Rev Allergy Immunol. 2023;64(3):284\u2013320.","journal-title":"Clin Rev Allergy Immunol"},{"issue":"1","key":"4752_CR234","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13045-021-01037-x","volume":"14","author":"T Zhou","year":"2021","unstructured":"Zhou T, Yuan Z, Weng J, Pei D, Du X, He C, Lai P. Challenges and advances in clinical applications of mesenchymal stromal cells. J Hematol Oncol. 2021;14(1):24.","journal-title":"J Hematol Oncol"},{"issue":"1","key":"4752_CR235","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s13287-019-1224-y","volume":"10","author":"NC Noronha","year":"2019","unstructured":"Noronha NC, Mizukami A, Cali\u00e1ri-Oliveira C, Cominal JG, Rocha JLM, Covas DT, Swiech K, Malmegrim KCR. Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies. Stem Cell Res Ther. 2019;10(1):131.","journal-title":"Stem Cell Res Ther"},{"issue":"7","key":"4752_CR236","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1177\/0963689719837897","volume":"28","author":"A Musia\u0142-Wysocka","year":"2019","unstructured":"Musia\u0142-Wysocka A, Kot M, Majka M. The pros and cons of mesenchymal stem Cell-Based therapies. Cell Transpl. 2019;28(7):801\u201312.","journal-title":"Cell Transpl"},{"key":"4752_CR237","doi-asserted-by":"publisher","first-page":"918565","DOI":"10.3389\/fimmu.2022.918565","volume":"13","author":"ME Fern\u00e1ndez-Santos","year":"2022","unstructured":"Fern\u00e1ndez-Santos ME, Garcia-Arranz M, Andreu EJ, Garc\u00eda-Hern\u00e1ndez AM, L\u00f3pez-Parra M, Villar\u00f3n E, Sep\u00falveda P, Fern\u00e1ndez-Avil\u00e9s F, Garc\u00eda-Olmo D, Prosper F, et al. Optimization of mesenchymal stromal cell (MSC) manufacturing processes for a better therapeutic outcome. Front Immunol. 2022;13:918565.","journal-title":"Front Immunol"},{"issue":"1","key":"4752_CR238","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1186\/s13287-024-03935-6","volume":"15","author":"CA Garc\u00eda-Guerrero","year":"2024","unstructured":"Garc\u00eda-Guerrero CA, Fuentes P, Araya MJ, Djouad F, Luz-Crawford P, Vega-Letter AM, Altamirano C. How to enhance MSCs therapeutic properties? An insight on potentiation methods. Stem Cell Res Ther. 2024;15(1):331.","journal-title":"Stem Cell Res Ther"},{"issue":"23","key":"4752_CR239","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1182\/blood.V126.23.2220.2220","volume":"126","author":"GM Galstian","year":"2015","unstructured":"Galstian GM, Parovichnikova EN, Makarova PM, Kuzmina LA, Troitskaya VV, Gemdzhian E, Drize NI, Savchenko VG. The results of the Russian clinical trial of mesenchymal stromal cells (MSCs) in severe neutropenic patients (pts) with septic shock (SS)(RUMCESS trial). Blood. 2015;126(23):2220.","journal-title":"Blood"},{"key":"4752_CR240","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.trsl.2018.04.006","volume":"199","author":"X He","year":"2018","unstructured":"He X, Ai S, Guo W, Yang Y, Wang Z, Jiang D, Xu X. Umbilical cord-derived mesenchymal stem (stromal) cells for treatment of severe sepsis: aphase 1 clinical trial. Transl Res. 2018;199:52\u201361.","journal-title":"Transl Res"},{"issue":"11","key":"4752_CR241","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1002\/stem.2891","volume":"36","author":"D Perlee","year":"2018","unstructured":"Perlee D, van Vught LA, Scicluna BP, Maag A, Lutter R, Kemper EM, van \u2018t Veer C, Punchard MA, Gonz\u00e1lez J, Richard MP, et al. Intravenous infusion of human adipose mesenchymal stem cells modifies the host response to lipopolysaccharide in humans: A Randomized, Single-Blind, parallel Group, placebo controlled trial. Stem Cells. 2018;36(11):1778\u201388.","journal-title":"Stem Cells"},{"issue":"7","key":"4752_CR242","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1097\/CCM.0000000000003657","volume":"47","author":"K Schlosser","year":"2019","unstructured":"Schlosser K, Wang JP, Dos Santos C, Walley KR, Marshall J, Fergusson DA, Winston BW, Granton J, Watpool I, Stewart DJ, et al. Effects of mesenchymal stem cell treatment on systemic cytokine levels in a phase 1 dose escalation safety trial of septic shock patients. Crit Care Med. 2019;47(7):918\u201325.","journal-title":"Crit Care Med"},{"issue":"3","key":"4752_CR243","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1164\/rccm.201705-1006OC","volume":"197","author":"LA McIntyre","year":"2018","unstructured":"McIntyre LA, Stewart DJ, Mei SHJ, Courtman D, Watpool I, Granton J, Marshall J, Dos Santos C, Walley KR, Winston BW, et al. Cellular immunotherapy for septic Shock. A phase I clinical trial. Am J Respir Crit Care Med. 2018;197(3):337\u201347.","journal-title":"Am J Respir Crit Care Med"},{"key":"4752_CR244","doi-asserted-by":"crossref","unstructured":"Alp E, Gonen ZB, Gundogan K, Esmaoglu A, Kaynar L, Cetin A, Karakukcu M, Cetin M, Kalin G, Doganay M. The Effect of Mesenchymal Stromal Cells on the Mortality of Patients with Sepsis and Septic Shock: A Promising Therapy. Emerg Med Int 2022, 2022:9222379.","DOI":"10.1155\/2022\/9222379"},{"issue":"6","key":"4752_CR245","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1016\/j.jcyt.2024.04.018","volume":"26","author":"S Mei","year":"2024","unstructured":"Mei S, Callahan M, dos Santos C, Marshall J, Soliman K, Sales V, Fernando S, Thirugnanam S, Stewart D, Champagne J, THE AMETHYST (ADVANCED MESENCHYMAL ENHANCED CELL THERAPY FOR SEPTIC) TRIAL. A FIRST-IN-HUMAN, DOSE-ESCALATION PHASE 1 SAFETY TRIAL OF GENETICALLY ENHANCED MSCS (GEM00220) APPEARED SAFE AND WELL TOLERATED IN PATIENTS WITH SEPTIC SHOCK. Cytotherapy. 2024;26(6):e5.","journal-title":"Cytotherapy"},{"key":"4752_CR246","doi-asserted-by":"publisher","first-page":"154446","DOI":"10.1016\/j.jcrc.2023.154446","volume":"79","author":"PF Laterre","year":"2024","unstructured":"Laterre PF, S\u00e1nchez Garc\u00eda M, van der Poll T, Wittebole X, Mart\u00ednez-Sagasti F, Hernandez G, Ferrer R, Caballero J, Cadogan KA, Sullivan A, et al. The safety and efficacy of stem cells for the treatment of severe community-acquired bacterial pneumonia: A randomized clinical trial. J Crit Care. 2024;79:154446.","journal-title":"J Crit Care"},{"issue":"3","key":"4752_CR247","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.stemcr.2018.01.029","volume":"10","author":"D Wang","year":"2018","unstructured":"Wang D, Zhang H, Liang J, Wang H, Hua B, Feng X, Gilkeson GS, Farge D, Shi S, Sun L. A Long-Term Follow-Up study of allogeneic mesenchymal Stem\/Stromal cell transplantation in patients with Drug-Resistant systemic lupus erythematosus. Stem Cell Rep. 2018;10(3):933\u201341.","journal-title":"Stem Cell Rep"},{"issue":"1","key":"4752_CR248","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1186\/s13287-024-03891-1","volume":"15","author":"H Lee","year":"2024","unstructured":"Lee H, Cho HJ, Han Y, Lee SH. Mid- to long-term efficacy and safety of stem cell therapy for acute myocardial infarction: a systematic review and meta-analysis. Stem Cell Res Ther. 2024;15(1):290.","journal-title":"Stem Cell Res Ther"},{"key":"4752_CR249","unstructured":"Cellular immunotherapy for septic shock (CISS2). A phase II randomized controlled trial. National Library of Medicine (US). 2017. Available at: https:\/\/clinicaltrials.gov\/study\/NCT03369275"},{"key":"4752_CR250","unstructured":"Umbilical mesenchymal stromal cells as cellular immunotherapy for septic shock. A multi-center, double blind, phase II randomized controlled trial. National Library of Medicine (US). 2024. Available at: https:\/\/clinicaltrials.gov\/study\/NCT05969275"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-025-04752-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-025-04752-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-025-04752-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T13:09:22Z","timestamp":1762348162000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-025-04752-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,5]]},"references-count":250,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4752"],"URL":"https:\/\/doi.org\/10.1186\/s13287-025-04752-1","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,5]]},"assertion":[{"value":"10 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All the authors approved the final manuscript and consented to its publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"615"}}