{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:55:24Z","timestamp":1783014924450,"version":"3.54.6"},"reference-count":105,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Shenyang City School Joint Funding Project","award":["2400022093"],"award-info":[{"award-number":["2400022093"]}]},{"name":"Liaoning Provincial Science and Technology Department Natural Science Foundation Doctoral Start-up Project","award":["2025-BS-0539"],"award-info":[{"award-number":["2025-BS-0539"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304564"],"award-info":[{"award-number":["82304564"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-025-04784-7","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:23:01Z","timestamp":1764166981000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Stem cell revolution: bridging the gap between research and clinical application"],"prefix":"10.1186","volume":"16","author":[{"given":"Fengfeng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"4784_CR1","doi-asserted-by":"crossref","unstructured":"Segunda MN, Diaz C, Torres CG, Parraguez VH, De Los Reyes M, Peralta OA. Comparative analysis of the potential for germ cell (GC) differentiation of bovine peripheral blood Derived-Mesenchymal stem cells (PB-MSC) and spermatogonial stem cells (SSC) in Co-Culture system with Sertoli cells (SC). Anim (Basel) 2023, 13.","DOI":"10.3390\/ani13020318"},{"key":"4784_CR2","doi-asserted-by":"publisher","first-page":"1414156","DOI":"10.3389\/fbioe.2024.1414156","volume":"12","author":"R Cancedda","year":"2024","unstructured":"Cancedda R, Mastrogiacomo M. The Phoenix of stem cells: pluripotent cells in adult tissues and peripheral blood. Front Bioeng Biotechnol. 2024;12:1414156.","journal-title":"Front Bioeng Biotechnol"},{"key":"4784_CR3","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1089\/scd.2018.0034","volume":"27","author":"YJ Hong","year":"2018","unstructured":"Hong YJ, Hong K, Byun S, Choi HW, Do JT. Reprogramming of extraembryonic trophoblast stem cells into embryonic pluripotent state by fusion with embryonic stem cells. Stem Cells Dev. 2018;27:1350\u20139.","journal-title":"Stem Cells Dev"},{"key":"4784_CR4","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1016\/j.cell.2022.04.005","volume":"185","author":"TT Wei","year":"2022","unstructured":"Wei TT, Chandy M, Nishiga M, Zhang A, Kumar KK, Thomas D, Manhas A, Rhee S, Justesen JM, Chen IY, et al. Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation. Cell. 2022;185:1676\u2013e16931623.","journal-title":"Cell"},{"key":"4784_CR5","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/B978-0-12-385493-3.00003-6","volume":"103","author":"MZ Ratajczak","year":"2011","unstructured":"Ratajczak MZ, Liu R, Marlicz W, Blogowski W, Starzynska T, Wojakowski W, Zuba-Surma E. Identification of very small embryonic\/epiblast-like stem cells (VSELs) Circulating in peripheral blood during organ\/tissue injuries. Methods Cell Biol. 2011;103:31\u201354.","journal-title":"Methods Cell Biol"},{"key":"4784_CR6","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1089\/cell.2022.0147","volume":"25","author":"S Ma","year":"2023","unstructured":"Ma S, Jiang Y, Qian Y, Du J, Yu X, Luo S, Chen Z. The emerging biological functions of exosomes from dental Tissue-Derived mesenchymal stem cells. Cell Reprogram. 2023;25:53\u201364.","journal-title":"Cell Reprogram"},{"key":"4784_CR7","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1038\/s42003-022-03964-y","volume":"5","author":"M Katayama","year":"2022","unstructured":"Katayama M, Fukuda T, Kaneko T, Nakagawa Y, Tajima A, Naito M, Ohmaki H, Endo D, Asano M, Nagamine T, et al. Induced pluripotent stem cells of endangered avian species. Commun Biol. 2022;5:1049.","journal-title":"Commun Biol"},{"key":"4784_CR8","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.jcyt.2023.05.002","volume":"25","author":"H Vallabhaneni","year":"2023","unstructured":"Vallabhaneni H, Shah T, Shah P, Hursh DA. Suspension culture on microcarriers and as aggregates enables expansion and differentiation of pluripotent stem cells (PSCs). Cytotherapy. 2023;25:993\u20131005.","journal-title":"Cytotherapy"},{"key":"4784_CR9","doi-asserted-by":"publisher","first-page":"10","DOI":"10.21037\/sci-2022-043","volume":"10","author":"W Isono","year":"2023","unstructured":"Isono W, Kawasaki T, Ichida JK, Nagasaka K, Hiraike O, Umezawa A, Akutsu H. Transcriptomic analysis of feeder-free culture system for maintaining naive-state pluripotency in human pluripotent stem cells. Stem Cell Investig. 2023;10:10.","journal-title":"Stem Cell Investig"},{"key":"4784_CR10","doi-asserted-by":"crossref","unstructured":"Alanazi RF, Alhwity BS, Almahlawi RM, Alatawi BD, Albalawi SA, Albalawi RA, Albalawi AA, Abdel-Maksoud MS, Elsherbiny N. Multilineage differentiating stress enduring (Muse) cells: A new era of stem Cell-Based therapy. Cells 2023, 12.","DOI":"10.3390\/cells12131676"},{"key":"4784_CR11","first-page":"591","volume":"44","author":"Y Guo","year":"2022","unstructured":"Guo Y, Yang LL, Qi HY. Transcriptome analysis of mouse male germline stem cells reveals characteristics of mature spermatogonial stem cells. Yi Chuan. 2022;44:591\u2013608.","journal-title":"Yi Chuan"},{"key":"4784_CR12","doi-asserted-by":"publisher","first-page":"262","DOI":"10.2174\/22123946MTA5ENTcF1","volume":"16","author":"HF Bahmad","year":"2021","unstructured":"Bahmad HF, Elajami MK, Daouk R, Jalloul H, Darwish B, Chalhoub RM, Assi S, Chamaa F, Abou-Kheir W. Stem cells: in sickness and in health. Curr Stem Cell Res Ther. 2021;16:262\u201376.","journal-title":"Curr Stem Cell Res Ther"},{"key":"4784_CR13","doi-asserted-by":"publisher","first-page":"540","DOI":"10.4252\/wjsc.v6.i5.540","volume":"6","author":"F Vasuri","year":"2014","unstructured":"Vasuri F, Fittipaldi S, Pasquinelli G. Arterial calcification: Finger-pointing at resident and Circulating stem cells. World J Stem Cells. 2014;6:540\u201351.","journal-title":"World J Stem Cells"},{"key":"4784_CR14","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1098\/rsnr.2011.0023","volume":"65","author":"AH Maehle","year":"2011","unstructured":"Maehle AH. Ambiguous cells: the emergence of the stem cell concept in the nineteenth and twentieth centuries. Notes Rec R Soc Lond. 2011;65:359\u201378.","journal-title":"Notes Rec R Soc Lond"},{"key":"4784_CR15","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s00438-018-1519-1","volume":"294","author":"U Hossfeld","year":"2019","unstructured":"Hossfeld U, Levit GS, Watts E. 100 years of phenogenetics: Valentin Haecker and his examination of the phenotype. Mol Genet Genomics. 2019;294:445\u201356.","journal-title":"Mol Genet Genomics"},{"key":"4784_CR16","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1080\/15592294.2016.1277299","volume":"12","author":"U Hossfeld","year":"2017","unstructured":"Hossfeld U, Watts E, Levit GS. Valentin Haecker (1864\u20131927) as a pioneer of phenogenetics: Building the Bridge between genotype and phenotype. Epigenetics. 2017;12:247\u201353.","journal-title":"Epigenetics"},{"key":"4784_CR17","doi-asserted-by":"publisher","first-page":"4373","DOI":"10.1158\/0008-5472.CAN-21-0301","volume":"81","author":"N Cieri","year":"2021","unstructured":"Cieri N, Maurer K, Wu CJ. 60 years young: the evolving role of allogeneic hematopoietic stem cell transplantation in cancer immunotherapy. Cancer Res. 2021;81:4373\u201384.","journal-title":"Cancer Res"},{"key":"4784_CR18","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.humimm.2022.08.007","volume":"83","author":"OA Timofeeva","year":"2022","unstructured":"Timofeeva OA, Philogene MC, Zhang QJ. Current donor selection strategies for allogeneic hematopoietic cell transplantation. Hum Immunol. 2022;83:674\u201386.","journal-title":"Hum Immunol"},{"key":"4784_CR19","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s40259-024-00661-6","volume":"38","author":"AL Lightner","year":"2024","unstructured":"Lightner AL, Irving PM, Lord GM, Betancourt A. Stem cells and stem Cell-Derived factors for the treatment of inflammatory bowel disease with a particular focus on perianal fistulizing disease: A minireview on future perspectives. BioDrugs. 2024;38:527\u201339.","journal-title":"BioDrugs"},{"key":"4784_CR20","doi-asserted-by":"crossref","unstructured":"Chourasiya S, Patel P, Kumar GS, Soni A. A new vision for ocular disease: stem cell strategies in regenerative ophthalmology. Stem Cell Rev Rep 2025.","DOI":"10.1007\/s12015-025-10990-w"},{"key":"4784_CR21","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13048-016-0279-y","volume":"9","author":"M Guida","year":"2016","unstructured":"Guida M, Castaldi MA, Rosamilio R, Giudice V, Orio F, Selleri C. Reproductive issues in patients undergoing hematopoietic stem cell transplantation: an update. J Ovarian Res. 2016;9:72.","journal-title":"J Ovarian Res"},{"key":"4784_CR22","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.tmrv.2005.02.006","volume":"19","author":"J Jansen","year":"2005","unstructured":"Jansen J. The first successful allogeneic bone-marrow transplant: Georges Mathe. Transfus Med Rev. 2005;19:246\u20138.","journal-title":"Transfus Med Rev"},{"key":"4784_CR23","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1084\/jem.130.1.91","volume":"130","author":"RG Worton","year":"1969","unstructured":"Worton RG, McCulloch EA, Till JE. Physical separation of Hemopoietic stem cells differing in their capacity for self-renewal. J Exp Med. 1969;130:91\u2013103.","journal-title":"J Exp Med"},{"key":"4784_CR24","doi-asserted-by":"publisher","first-page":"1405210","DOI":"10.3389\/fimmu.2024.1405210","volume":"15","author":"K Faltusova","year":"2024","unstructured":"Faltusova K, Bajecny M, Heizer T, Paral P, Chen CL, Szikszai K, Klener P, Necas E. Second bone marrow transplantation into regenerating hematopoiesis enhances reconstitution of immune system. Front Immunol. 2024;15:1405210.","journal-title":"Front Immunol"},{"key":"4784_CR25","doi-asserted-by":"publisher","first-page":"e0129855","DOI":"10.1371\/journal.pone.0129855","volume":"10","author":"C Takenaka","year":"2015","unstructured":"Takenaka C, Miyajima H, Yoda Y, Imazato H, Yamamoto T, Gomi S, Ohshima Y, Kagawa K, Sasaki T, Kawamata S. Controlled growth and the maintenance of human pluripotent stem cells by cultivation with defined medium on extracellular Matrix-Coated micropatterned dishes. PLoS ONE. 2015;10:e0129855.","journal-title":"PLoS ONE"},{"key":"4784_CR26","doi-asserted-by":"crossref","unstructured":"Nath SC, Menendez L, Friedrich Ben-Nun I. Overcoming the variability of iPSCs in the manufacturing of Cell-Based therapies. Int J Mol Sci 2023, 24.","DOI":"10.3390\/ijms242316929"},{"key":"4784_CR27","doi-asserted-by":"publisher","first-page":"e16734","DOI":"10.1371\/journal.pone.0016734","volume":"6","author":"M Fujiwara","year":"2011","unstructured":"Fujiwara M, Yan P, Otsuji TG, Narazaki G, Uosaki H, Fukushima H, Kuwahara K, Harada M, Matsuda H, Matsuoka S, et al. Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-A. PLoS ONE. 2011;6:e16734.","journal-title":"PLoS ONE"},{"key":"4784_CR28","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.anl.2008.11.009","volume":"36","author":"M Hayashi","year":"2009","unstructured":"Hayashi M, Fujihara K, Beder LB, Yamamoto Y, Hotomi M, Yamanaka N. Pathogenic role of tonsillar lymphocytes in associated with HSP60\/65 in pustulosis palmaris et plantaris. Auris Nasus Larynx. 2009;36:578\u201385.","journal-title":"Auris Nasus Larynx"},{"key":"4784_CR29","doi-asserted-by":"publisher","first-page":"43","DOI":"10.2353\/ajpath.2007.061207","volume":"171","author":"Y Yamanaka","year":"2007","unstructured":"Yamanaka Y, Akiyama M, Sugiyama-Nakagiri Y, Sakai K, Goto M, McMillan JR, Ota M, Sawamura D, Shimizu H. Expression of the keratinocyte lipid transporter ABCA12 in developing and reconstituted human epidermis. Am J Pathol. 2007;171:43\u201352.","journal-title":"Am J Pathol"},{"key":"4784_CR30","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1038\/jid.2013.7","volume":"133","author":"O Veraitch","year":"2013","unstructured":"Veraitch O, Kobayashi T, Imaizumi Y, Akamatsu W, Sasaki T, Yamanaka S, Amagai M, Okano H, Ohyama M. Human induced pluripotent stem cell-derived ectodermal precursor cells contribute to hair follicle morphogenesis in vivo. J Invest Dermatol. 2013;133:1479\u201388.","journal-title":"J Invest Dermatol"},{"key":"4784_CR31","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.neulet.2009.04.035","volume":"458","author":"Y Hirami","year":"2009","unstructured":"Hirami Y, Osakada F, Takahashi K, Okita K, Yamanaka S, Ikeda H, Yoshimura N, Takahashi M. Generation of retinal cells from mouse and human induced pluripotent stem cells. Neurosci Lett. 2009;458:126\u201331.","journal-title":"Neurosci Lett"},{"key":"4784_CR32","doi-asserted-by":"publisher","first-page":"503","DOI":"10.5966\/sctm.2012-0005","volume":"1","author":"ZB Jin","year":"2012","unstructured":"Jin ZB, Okamoto S, Xiang P, Takahashi M. Integration-free induced pluripotent stem cells derived from retinitis pigmentosa patient for disease modeling. Stem Cells Transl Med. 2012;1:503\u20139.","journal-title":"Stem Cells Transl Med"},{"key":"4784_CR33","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1056\/NEJMoa1608368","volume":"376","author":"M Mandai","year":"2017","unstructured":"Mandai M, Watanabe A, Kurimoto Y, Hirami Y, Morinaga C, Daimon T, Fujihara M, Akimaru H, Sakai N, Shibata Y, et al. Autologous induced Stem-Cell-Derived retinal cells for macular degeneration. N Engl J Med. 2017;376:1038\u201346.","journal-title":"N Engl J Med"},{"key":"4784_CR34","doi-asserted-by":"publisher","first-page":"8785","DOI":"10.1167\/iovs.11-8129","volume":"52","author":"S Okamoto","year":"2011","unstructured":"Okamoto S, Takahashi M. Induction of retinal pigment epithelial cells from monkey iPS cells. Invest Ophthalmol Vis Sci. 2011;52:8785\u201390.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4784_CR35","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1167\/iovs.14-15619","volume":"56","author":"S Sugita","year":"2015","unstructured":"Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M. Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest Ophthalmol Vis Sci. 2015;56:1051\u201362.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4784_CR36","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.bbmt.2013.11.001","volume":"20","author":"J Kurtzberg","year":"2014","unstructured":"Kurtzberg J, Prockop S, Teira P, Bittencourt H, Lewis V, Chan KW, Horn B, Yu L, Talano JA, Nemecek E, et al. Allogeneic human mesenchymal stem cell therapy (remestemcel-L, Prochymal) as a rescue agent for severe refractory acute graft-versus-host disease in pediatric patients. Biol Blood Marrow Transpl. 2014;20:229\u201335.","journal-title":"Biol Blood Marrow Transpl"},{"key":"4784_CR37","first-page":"61","volume":"4","author":"AN Patel","year":"2011","unstructured":"Patel AN, Genovese J. Potential clinical applications of adult human mesenchymal stem cell (Prochymal(R)) therapy. Stem Cells Cloning. 2011;4:61\u201372.","journal-title":"Stem Cells Cloning"},{"key":"4784_CR38","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.bbmt.2010.04.014","volume":"17","author":"VK Prasad","year":"2011","unstructured":"Prasad VK, Lucas KG, Kleiner GI, Talano JA, Jacobsohn D, Broadwater G, Monroy R, Kurtzberg J. Efficacy and safety of ex vivo cultured adult human mesenchymal stem cells (Prochymal) in pediatric patients with severe refractory acute graft-versus-host disease in a compassionate use study. Biol Blood Marrow Transpl. 2011;17:534\u201341.","journal-title":"Biol Blood Marrow Transpl"},{"key":"4784_CR39","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1111\/codi.16239","volume":"24","author":"AL Lightner","year":"2022","unstructured":"Lightner AL, Dadgar N, Matyas C, Elliott K, Fulmer C, Khaitan N, Ream J, Nachand D, Steele SR. A phase IB\/IIA study of remestemcel-L, an allogeneic bone marrow-derived mesenchymal stem cell product, for the treatment of medically refractory ulcerative colitis: an interim analysis. Colorectal Dis. 2022;24:1358\u201370.","journal-title":"Colorectal Dis"},{"key":"4784_CR40","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1093\/bjs\/znac078","volume":"109","author":"AL Lightner","year":"2022","unstructured":"Lightner AL, Ream J, Nachand D, Fulmer C, Regueiro M, Steele SR. Remestemcel-L allogeneic bone marrow-derived mesenchymal stem cell product to treat medically refractory crohn\u2019s colitis: preliminary phase IB\/IIA study. Br J Surg. 2022;109:653\u20135.","journal-title":"Br J Surg"},{"key":"4784_CR41","doi-asserted-by":"publisher","first-page":"232596712097305","DOI":"10.1177\/2325967120973052","volume":"9","author":"HC Lim","year":"2021","unstructured":"Lim HC, Park YB, Ha CW, Cole BJ, Lee BK, Jeong HJ, Kim MK, Bin SI, Choi CH, Choi CH, et al. Allogeneic umbilical cord Blood-Derived mesenchymal stem cell implantation versus microfracture for Large, Full-Thickness cartilage defects in older patients: A multicenter randomized clinical trial and extended 5-Year clinical Follow-up. Orthop J Sports Med. 2021;9:2325967120973052.","journal-title":"Orthop J Sports Med"},{"key":"4784_CR42","doi-asserted-by":"publisher","first-page":"1148444","DOI":"10.3389\/fnagi.2023.1148444","volume":"15","author":"JY Nam","year":"2023","unstructured":"Nam JY, Chun S, Lee TY, Seo Y, Kim K, Park J, Sung W, Oh KW, Lee S, Park JS, et al. Long-term survival benefits of intrathecal autologous bone marrow-derived mesenchymal stem cells (Neuronata-R(R): lenzumestrocel) treatment in ALS: Propensity-score-matched control, surveillance study. Front Aging Neurosci. 2023;15:1148444.","journal-title":"Front Aging Neurosci"},{"key":"4784_CR43","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1186\/s13063-022-06327-4","volume":"23","author":"JY Nam","year":"2022","unstructured":"Nam JY, Lee TY, Kim K, Chun S, Kim MS, Shin JH, Sung JJ, Kim BJ, Kim BJ, Oh KW, et al. Efficacy and safety of Lenzumestrocel (Neuronata-R(R) inj.) in patients with amyotrophic lateral sclerosis (ALSUMMIT study): study protocol for a multicentre, randomized, double-blind, parallel-group, Sham procedure-controlled, phase III trial. Trials. 2022;23:415.","journal-title":"Trials"},{"key":"4784_CR44","doi-asserted-by":"publisher","first-page":"590","DOI":"10.5966\/sctm.2014-0212","volume":"4","author":"KW Oh","year":"2015","unstructured":"Oh KW, Moon C, Kim HY, Oh SI, Park J, Lee JH, Chang IY, Kim KS, Kim SH. Phase I trial of repeated intrathecal autologous bone marrow-derived mesenchymal stromal cells in amyotrophic lateral sclerosis. Stem Cells Transl Med. 2015;4:590\u20137.","journal-title":"Stem Cells Transl Med"},{"key":"4784_CR45","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/978-3-031-30040-0_9","volume":"1420","author":"S Torrents","year":"2023","unstructured":"Torrents S, Grau-Vorster M, Vives J. Illustrative potency assay examples from approved therapies. Adv Exp Med Biol. 2023;1420:139\u201349.","journal-title":"Adv Exp Med Biol"},{"key":"4784_CR46","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1177\/13524585221122156","volume":"29","author":"JA Cohen","year":"2023","unstructured":"Cohen JA, Lublin FD, Lock C, Pelletier D, Chitnis T, Mehra M, Gothelf Y, Aricha R, Lindborg S, Lebovits C, et al. Evaluation of neurotrophic factor secreting mesenchymal stem cells in progressive multiple sclerosis. Mult Scler. 2023;29:92\u2013106.","journal-title":"Mult Scler"},{"key":"4784_CR47","doi-asserted-by":"publisher","first-page":"e2294","DOI":"10.1212\/WNL.0000000000008620","volume":"93","author":"JD Berry","year":"2019","unstructured":"Berry JD, Cudkowicz ME, Windebank AJ, Staff NP, Owegi M, Nicholson K, McKenna-Yasek D, Levy YS, Abramov N, Kaspi H, et al. NurOwn, phase 2, randomized, clinical trial in patients with ALS: Safety, clinical, and biomarker results. Neurology. 2019;93:e2294\u2013305.","journal-title":"Neurology"},{"key":"4784_CR48","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/2001-1326-3-21","volume":"3","author":"Y Gothelf","year":"2014","unstructured":"Gothelf Y, Abramov N, Harel A, Offen D. Safety of repeated transplantations of neurotrophic factors-secreting human mesenchymal stromal stem cells. Clin Transl Med. 2014;3:21.","journal-title":"Clin Transl Med"},{"key":"4784_CR49","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1186\/s13287-017-0692-1","volume":"8","author":"Y Gothelf","year":"2017","unstructured":"Gothelf Y, Kaspi H, Abramov N, Aricha R. MiRNA profiling of NurOwn(R): mesenchymal stem cells secreting neurotrophic factors. Stem Cell Res Ther. 2017;8:249.","journal-title":"Stem Cell Res Ther"},{"key":"4784_CR50","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13287-021-02143-w","volume":"12","author":"H Kaspi","year":"2021","unstructured":"Kaspi H, Semo J, Abramov N, Dekel C, Lindborg S, Kern R, Lebovits C, Aricha R. MSC-NTF (NurOwn(R)) exosomes: a novel therapeutic modality in the mouse LPS-induced ARDS model. Stem Cell Res Ther. 2021;12:72.","journal-title":"Stem Cell Res Ther"},{"key":"4784_CR51","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.bbr.2017.03.047","volume":"331","author":"N Perets","year":"2017","unstructured":"Perets N, Segal-Gavish H, Gothelf Y, Barzilay R, Barhum Y, Abramov N, Hertz S, Morozov D, London M, Offen D. Long term beneficial effect of neurotrophic factors-secreting mesenchymal stem cells transplantation in the BTBR mouse model of autism. Behav Brain Res. 2017;331:254\u201360.","journal-title":"Behav Brain Res"},{"key":"4784_CR52","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/459146a","volume":"459","author":"D Cyranoski","year":"2009","unstructured":"Cyranoski D. Stem-cell therapy faces more scrutiny in China. Nature. 2009;459:146\u20137.","journal-title":"Nature"},{"key":"4784_CR53","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1089\/hum.2017.224","volume":"29","author":"L Hu","year":"2018","unstructured":"Hu L, Zhao B, Wang S. Stem-Cell therapy advances in China. Hum Gene Ther. 2018;29:188\u201396.","journal-title":"Hum Gene Ther"},{"key":"4784_CR54","doi-asserted-by":"publisher","first-page":"e12937","DOI":"10.1111\/cpr.12937","volume":"53","author":"J Lv","year":"2020","unstructured":"Lv J, Su Y, Song L, Gong X, Peng Y. Stem cell \u2018therapy\u2019 advertisements in china: Infodemic, regulations and recommendations. Cell Prolif. 2020;53:e12937.","journal-title":"Cell Prolif"},{"key":"4784_CR55","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1097\/CCO.0000000000001067","volume":"36","author":"LB Kwantwi","year":"2024","unstructured":"Kwantwi LB, Rosen ST, Querfeld C. The role of signaling lymphocyte activation molecule family receptors in hematologic malignancies. Curr Opin Oncol. 2024;36:449\u201355.","journal-title":"Curr Opin Oncol"},{"key":"4784_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/hum.2023.29263.bfs","volume":"35","author":"A Philippidis","year":"2024","unstructured":"Philippidis A. CASGEVY makes history as FDA approves first CRISPR\/Cas9 genome edited therapy. Hum Gene Ther. 2024;35:1\u20134.","journal-title":"Hum Gene Ther"},{"key":"4784_CR57","doi-asserted-by":"publisher","first-page":"e944204","DOI":"10.12659\/MSM.944204","volume":"30","author":"DV Parums","year":"2024","unstructured":"Parums DV. Editorial: first regulatory approvals for CRISPR-Cas9 therapeutic gene editing for sickle cell disease and Transfusion-Dependent beta-Thalassemia. Med Sci Monit. 2024;30:e944204.","journal-title":"Med Sci Monit"},{"key":"4784_CR58","doi-asserted-by":"publisher","first-page":"1329712","DOI":"10.3389\/fbioe.2024.1329712","volume":"12","author":"L Yang","year":"2024","unstructured":"Yang L, Liu SC, Liu YY, Zhu FQ, Xiong MJ, Hu DX, Zhang WJ. Therapeutic role of neural stem cells in neurological diseases. Front Bioeng Biotechnol. 2024;12:1329712.","journal-title":"Front Bioeng Biotechnol"},{"key":"4784_CR59","doi-asserted-by":"crossref","unstructured":"Beghini DG, Kasai-Brunswick TH, Henriques-Pons A. Induced pluripotent stem cells in drug discovery and neurodegenerative disease modelling. Int J Mol Sci 2024, 25.","DOI":"10.3390\/ijms25042392"},{"key":"4784_CR60","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1002\/mds.28187","volume":"35","author":"J Jankovic","year":"2020","unstructured":"Jankovic J, Okun MS, Kordower JH. Stem cells: scientific and ethical quandaries of a personalized approach to parkinson\u2019s disease. Mov Disord. 2020;35:1312\u20134.","journal-title":"Mov Disord"},{"key":"4784_CR61","doi-asserted-by":"publisher","first-page":"e2303041","DOI":"10.1002\/adhm.202303041","volume":"13","author":"MS Kim","year":"2024","unstructured":"Kim MS, Kim H, Lee G. Precision medicine in parkinson\u2019s disease using induced pluripotent stem cells. Adv Healthc Mater. 2024;13:e2303041.","journal-title":"Adv Healthc Mater"},{"key":"4784_CR62","doi-asserted-by":"crossref","unstructured":"Albert K, Niskanen J, Kalvala S, Lehtonen S. Utilising induced pluripotent stem cells in neurodegenerative disease research: focus on glia. Int J Mol Sci 2021, 22.","DOI":"10.3390\/ijms22094334"},{"key":"4784_CR63","unstructured":"Continued Evaluation of Patients With Parkinson\u2019s Disease Who. Previously Received BRT-DA01 [https:\/\/clinicaltrials.gov\/study\/NCT05897957?term=BRT-DA01&rank=1]"},{"key":"4784_CR64","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1007\/s11427-015-4997-y","volume":"59","author":"Y Yan","year":"2016","unstructured":"Yan Y, Li Y, Fu Y, Yang L, Su L, Shi K, Li M, Liu Q, Borazanci A, Liu Y, et al. Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD. Sci China Life Sci. 2016;59:1270\u201381.","journal-title":"Sci China Life Sci"},{"key":"4784_CR65","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1007\/s12264-020-00525-3","volume":"36","author":"W Zhu","year":"2020","unstructured":"Zhu W, Zhang Y, Wang Z, Fu Y, Yan Y. Monoclonal Antibody-Based treatments for neuromyelitis Optica spectrum disorders: from bench to bedside. Neurosci Bull. 2020;36:1213\u201324.","journal-title":"Neurosci Bull"},{"key":"4784_CR66","doi-asserted-by":"publisher","first-page":"788","DOI":"10.4103\/1673-5374.382220","volume":"19","author":"RS Duncan","year":"2024","unstructured":"Duncan RS, Riordan SM, Gernon MC, Koulen P. Cannabinoids and endocannabinoids as therapeutics for nervous system disorders: preclinical models and clinical studies. Neural Regen Res. 2024;19:788\u201399.","journal-title":"Neural Regen Res"},{"key":"4784_CR67","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12967-018-1433-7","volume":"16","author":"NH Riordan","year":"2018","unstructured":"Riordan NH, Morales I, Fernandez G, Allen N, Fearnot NE, Leckrone ME, Markovich DJ, Mansfield D, Avila D, Patel AN, et al. Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis. J Transl Med. 2018;16:57.","journal-title":"J Transl Med"},{"key":"4784_CR68","doi-asserted-by":"crossref","unstructured":"Heald AH, Bassett J, Puente-Ruiz N, Clayton P, Stepien KM. Endocrine disorders in adult patients with inherited metabolic diseases: their diagnosis and long-term management. Clin Endocrinol (Oxf) 2024.","DOI":"10.1530\/endoabs.99.EP275"},{"key":"4784_CR69","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.tips.2018.12.002","volume":"40","author":"Y Luo","year":"2019","unstructured":"Luo Y, Ye S, Li X, Lu W. Emerging Structure-Function paradigm of endocrine FGFs in metabolic diseases. Trends Pharmacol Sci. 2019;40:142\u201353.","journal-title":"Trends Pharmacol Sci"},{"key":"4784_CR70","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.4239\/wjd.v15.i6.1142","volume":"15","author":"A Annicchiarico","year":"2024","unstructured":"Annicchiarico A, Barile B, Buccoliero C, Nicchia GP, Brunetti G. Alternative therapeutic strategies in diabetes management. World J Diabetes. 2024;15:1142\u201361.","journal-title":"World J Diabetes"},{"key":"4784_CR71","doi-asserted-by":"crossref","unstructured":"Maestas MM, Bui MH, Millman JR. Recent progress in modeling and treating diabetes using stem cell-derived Islets. Stem Cells Transl Med 2024.","DOI":"10.1093\/stcltm\/szae059"},{"key":"4784_CR72","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1055\/a-2166-4546","volume":"56","author":"F Yun","year":"2024","unstructured":"Yun F, Zhaorigen B, Han X, Li X, Yun S. Islet like cells induced from umbilical cord mesenchymal stem cells with neonatal bovine pancreatic mesenchymal exosomes for treatment of diabetes mellitus. Horm Metab Res. 2024;56:463\u201370.","journal-title":"Horm Metab Res"},{"key":"4784_CR73","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.stemcr.2023.11.010","volume":"19","author":"M Tsukamoto","year":"2024","unstructured":"Tsukamoto M, Kimura K, Yoshida T, Tanaka M, Kuwamura M, Ayabe T, Ishihara G, Watanabe K, Okada M, Iijima M, et al. Generation of canine induced pluripotent stem cells under feeder-free conditions using Sendai virus vector encoding six canine reprogramming factors. Stem Cell Rep. 2024;19:141\u201357.","journal-title":"Stem Cell Rep"},{"key":"4784_CR74","unstructured":"Safety A. Tolerability, and efficacy study of VX-264 in participants with type 1 diabetes [https:\/\/clinicaltrials.gov\/study\/NCT05791201?term=VX-264&rank=1]"},{"key":"4784_CR75","unstructured":"Safety A. Tolerability, and efficacy study of VX-880 in participants with type 1 diabetes [https:\/\/clinicaltrials.gov\/study\/NCT04786262?term=VX-880&rank=1]"},{"key":"4784_CR76","doi-asserted-by":"crossref","unstructured":"Seixas-Lopes FA, Lopes C, Marques M, Agostinho C, Jardim-Goncalves R. Musculoskeletal Disorder (MSD) Health Data Collection, Personalized Management and Exchange Using Fast Healthcare Interoperability Resources (FHIR). Sensors (Basel) 2024, 24.","DOI":"10.3390\/s24165175"},{"key":"4784_CR77","doi-asserted-by":"crossref","unstructured":"Shchaslyvyi AY, Antonenko SV, Telegeev GD. Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. Int J Environ Res Public Health 2024, 21.","DOI":"10.3390\/ijerph21081077"},{"key":"4784_CR78","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1097\/TP.0000000000000678","volume":"99","author":"A Vega","year":"2015","unstructured":"Vega A, Martin-Ferrero MA, Del Canto F, Alberca M, Garcia V, Munar A, Orozco L, Soler R, Fuertes JJ, Huguet M, et al. Treatment of knee osteoarthritis with allogeneic bone marrow mesenchymal stem cells: A randomized controlled trial. Transplantation. 2015;99:1681\u201390.","journal-title":"Transplantation"},{"key":"4784_CR79","unstructured":"Allogenic Adipose Tissue. -Derived Mesenchymal Progenitor Cells for the Treatment of Knee Osteoarthritis [https:\/\/clinicaltrials.gov\/study\/NCT04208646?term=AlloJoin&rank=3"},{"key":"4784_CR80","unstructured":"Allogenic Adipose-Derived. Mesenchymal Progenitor Cells for the Treatment of Knee Osteoarthritis [https:\/\/clinicaltrials.gov\/study\/NCT06570291?term=AlloJoin&rank=1"},{"key":"4784_CR81","doi-asserted-by":"crossref","unstructured":"Mlynarska E, Hajdys J, Czarnik W, Fularski P, Leszto K, Majchrowicz G, Lisinska W, Rysz J, Franczyk B. The role of antioxidants in the therapy of cardiovascular Diseases-A literature review. Nutrients 2024, 16.","DOI":"10.3390\/nu16162587"},{"key":"4784_CR82","doi-asserted-by":"crossref","unstructured":"Jin S, Kang PM. A systematic review on advances in management of oxidative Stress-Associated cardiovascular diseases. Antioxid (Basel) 2024, 13.","DOI":"10.37766\/inplasy2024.7.0064"},{"key":"4784_CR83","unstructured":"A Study of iPS. Cell-derived cardiomyocyte spheroids (HS-001) in patients with heart failure (LAPiS Study) (LAPiS) [https:\/\/clinicaltrials.gov\/study\/NCT04945018?term=HS-001&rank=1"},{"key":"4784_CR84","unstructured":"Epicardial Injection of hiPSC-CMs to Treat Severe. Chronic Ischemic Heart Failure [https:\/\/clinicaltrials.gov\/study\/NCT06340048?term=HiCM-188&rank=1"},{"key":"4784_CR85","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.jacc.2022.12.019","volume":"81","author":"P Menasche","year":"2023","unstructured":"Menasche P. Mesenchymal stromal cell therapy for heart failure: never stop dreaming. J Am Coll Cardiol. 2023;81:864\u20136.","journal-title":"J Am Coll Cardiol"},{"key":"4784_CR86","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.jacc.2022.11.061","volume":"81","author":"EC Perin","year":"2023","unstructured":"Perin EC, Borow KM, Henry TD, Mendelsohn FO, Miller LW, Swiggum E, Adler ED, Chang DH, Fish RD, Bouchard A, et al. Randomized trial of targeted transendocardial mesenchymal precursor cell therapy in patients with heart failure. J Am Coll Cardiol. 2023;81:849\u201363.","journal-title":"J Am Coll Cardiol"},{"key":"4784_CR87","doi-asserted-by":"crossref","unstructured":"Goetzl EJ, Alpert JS, Chen QM. Human stem cells in regenerative medicine. Am J Med 2024.","DOI":"10.1016\/j.amjmed.2024.05.024"},{"key":"4784_CR88","first-page":"7902","volume":"16","author":"W Li","year":"2024","unstructured":"Li W, Du D, Huang Y, Xu C, Liu Y, Wu X, Yang J, Liu Z, Ma J, Huangfu C. Improvement of skin wound healing by giant salamander skin mucus gel wrapped with bone marrow mesenchymal stem cells via affecting integrin family molecules. Aging. 2024;16:7902\u201314.","journal-title":"Aging"},{"key":"4784_CR89","doi-asserted-by":"crossref","unstructured":"Ozhava D, Bektas C, Lee K, Jackson A, Mao Y. Human Mesenchymal Stem Cells on Size-Sorted Gelatin Hydrogel Microparticles Show Enhanced In Vitro Wound Healing Activities. Gels 2024, 10.","DOI":"10.3390\/gels10020097"},{"key":"4784_CR90","doi-asserted-by":"crossref","unstructured":"Shanehband N, Naghib SM. Microfluidics-assisted tumor cell separation approaches for clinical applications: an overview on emerging devices. Comb Chem High Throughput Screen 2024.","DOI":"10.2174\/0113862073277130231110111933"},{"key":"4784_CR91","doi-asserted-by":"publisher","first-page":"3773","DOI":"10.2147\/IJN.S456268","volume":"19","author":"L Shi","year":"2024","unstructured":"Shi L, Zhou Y, Yin Y, Zhang J, Chen K, Liu S, Chen P, Jiang H, Liu J, Wu Y. Advancing tissue damage repair in geriatric diseases: prospects of combining stem Cell-Derived exosomes with hydrogels. Int J Nanomed. 2024;19:3773\u2013804.","journal-title":"Int J Nanomed"},{"key":"4784_CR92","unstructured":"Stem Cells Market Size. Share & Trends Analysis Report By Product (Adult Stem Cells, Human Embryonic Stem Cells), By Application (Regenerative Medicine, Drug Discovery & Development), By Technology, Therapy, By End-use, By Region, And Segment Forecasts, 2024\u20132030 [https:\/\/www.grandviewresearch.com\/industry-analysis\/stem-cells-market"},{"key":"4784_CR93","doi-asserted-by":"publisher","first-page":"2060724","DOI":"10.1080\/19420862.2022.2060724","volume":"14","author":"J Xu","year":"2022","unstructured":"Xu J, Ou J, McHugh KP, Borys MC, Khetan A. Upstream cell culture process characterization and in-process control strategy development at pandemic speed. MAbs. 2022;14:2060724.","journal-title":"MAbs"},{"key":"4784_CR94","unstructured":"Pluripotent stem cell. expansion and scale-up [https:\/\/www.cytivalifesciences.com\/en\/us\/solutions\/emerging-biotech\/knowledge-center\/upstream-processing-stem-cells"},{"key":"4784_CR95","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1038\/s41587-019-0159-2","volume":"37","author":"MA Kinney","year":"2019","unstructured":"Kinney MA, Vo LT, Frame JM, Barragan J, Conway AJ, Li S, Wong KK, Collins JJ, Cahan P, North TE, et al. A systems biology pipeline identifies regulatory networks for stem cell engineering. Nat Biotechnol. 2019;37:810\u20138.","journal-title":"Nat Biotechnol"},{"key":"4784_CR96","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1097\/j.pain.0000000000003193","volume":"165","author":"PSH Smulders","year":"2024","unstructured":"Smulders PSH, Heikamp K, Hermanides J, Hollmann MW, Ten Hoope W, Weber NC. Chemotherapy-induced peripheral neuropathy models constructed from human induced pluripotent stem cells and directly converted cells: a systematic review. Pain. 2024;165:1914\u201325.","journal-title":"Pain"},{"key":"4784_CR97","doi-asserted-by":"crossref","unstructured":"Satheka AC. Upscaling of Clinical Grade Stem Cell Production: Upstream Processing (USP) and Downstream Processing (DSP) Operations of Cell Expansion, Harvesting, Detachment, Separation, Washing and Concentration Steps, and the Regulatory Requirements. In Stem Cell Production: Processes, Practices and Regulations. Edited by Khan FA. Singapore: Springer Singapore; 2022: 159\u2013184.","DOI":"10.1007\/978-981-16-7589-8_7"},{"key":"4784_CR98","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1007\/s00701-012-1338-9","volume":"154","author":"RM Heywood","year":"2012","unstructured":"Heywood RM, Marcus HJ, Ryan DJ, Piccirillo SG, Al-Mayhani TM, Watts C. A review of the role of stem cells in the development and treatment of glioma. Acta Neurochir (Wien). 2012;154:951\u201369. discussion 969.","journal-title":"Acta Neurochir (Wien)"},{"key":"4784_CR99","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/978-3-031-39027-2_11","volume":"72","author":"H Kondoh","year":"2024","unstructured":"Kondoh H. Molecular basis of cell reprogramming into iPSCs with exogenous transcription factors. Results Probl Cell Differ. 2024;72:193\u2013218.","journal-title":"Results Probl Cell Differ"},{"key":"4784_CR100","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/978-1-0716-1484-6_23","volume":"2320","author":"M Nishiga","year":"2021","unstructured":"Nishiga M, Qi LS, Wu JC. CRISPRi\/a screening with human iPSCs. Methods Mol Biol. 2021;2320:261\u201381.","journal-title":"Methods Mol Biol"},{"key":"4784_CR101","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.stemcr.2021.12.009","volume":"17","author":"N Shiraki","year":"2022","unstructured":"Shiraki N, Maruyama K, Hayashi R, Oguchi A, Murakawa Y, Katayama T, Takigawa T, Sakimoto S, Quantock AJ, Tsujikawa M, Nishida K. PAX6-positive microglia evolve locally in hiPSC-derived ocular organoids. Stem Cell Rep. 2022;17:221\u201330.","journal-title":"Stem Cell Rep"},{"key":"4784_CR102","doi-asserted-by":"publisher","first-page":"1023340","DOI":"10.3389\/fcell.2022.1023340","volume":"10","author":"A Neaverson","year":"2022","unstructured":"Neaverson A, Andersson MHL, Arshad OA, Foulser L, Goodwin-Trotman M, Hunter A, Newman B, Patel M, Roth C, Thwaites T, et al. Differentiation of human induced pluripotent stem cells into cortical neural stem cells. Front Cell Dev Biol. 2022;10:1023340.","journal-title":"Front Cell Dev Biol"},{"key":"4784_CR103","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/978-1-4939-9524-0_9","volume":"2005","author":"A De Los Angeles","year":"2019","unstructured":"De Los Angeles A, Sakurai M, Wu J. Embryonic chimeras with human pluripotent stem cells. Methods Mol Biol. 2019;2005:125\u201351.","journal-title":"Methods Mol Biol"},{"key":"4784_CR104","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1080\/10520295.2023.2225225","volume":"98","author":"Z Gong","year":"2023","unstructured":"Gong Z, Shu Z, Zhou Y, Chen Y, Zhu H. KLF2 regulates stemness of human mesenchymal stem cells by targeting FGFR3. Biotech Histochem. 2023;98:447\u201355.","journal-title":"Biotech Histochem"},{"key":"4784_CR105","doi-asserted-by":"crossref","unstructured":"Majumder P, Lee JT, Rahmberg AR, Kumar G, Mi T, Scharer CD, Boss JM. A super enhancer controls expression and chromatin architecture within the MHC class II locus. J Exp Med 2020, 217.","DOI":"10.1084\/jem.20190668"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-025-04784-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-025-04784-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-025-04784-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:10:53Z","timestamp":1764173453000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-025-04784-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":105,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4784"],"URL":"https:\/\/doi.org\/10.1186\/s13287-025-04784-7","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"20 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No ethics approval was required for this review that did not involve patients or patient data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors approved this manuscript for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"661"}}