{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:28:03Z","timestamp":1791836883744,"version":"4.3.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Multi center Clinical Research Project for Major Diseases in Suzhou","award":["DZXYJ202302"],"award-info":[{"award-number":["DZXYJ202302"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82200283"],"award-info":[{"award-number":["82200283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Innovation and Entrepreneurship Team in Jiangsu Province","award":["JSSCT202353"],"award-info":[{"award-number":["JSSCT202353"]}]},{"name":"the Scientific Research Project of Gusu Health Talents Program of Suzhou","award":["GSWS2022017"],"award-info":[{"award-number":["GSWS2022017"]}]},{"name":"Scientific Research Project of Health Commission in Jiangsu Province","award":["K2023080"],"award-info":[{"award-number":["K2023080"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-026-04897-7","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:22:19Z","timestamp":1767846139000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunomodulatory effect of mesenchymal stromal cell overexpressing HLA-G1 in cell-based therapy for myocardial infarction"],"prefix":"10.1186","volume":"17","author":[{"given":"Wei","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Bo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Jia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cao","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"4897_CR1","first-page":"e41","volume":"151","author":"SS Martin","year":"2025","unstructured":"Martin SS, Aday AW, Allen NB, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, Baker-Smith CM, Bansal N, Beaton AZ, Commodore-Mensah Y, Currie ME, Elkind MSV, Fan W, Generoso G, Gibbs BB, Heard DG, Hiremath S, Johansen MC, Kazi DS, Ko D, Leppert MH, Magnani JW, Michos ED, Mussolino ME, Parikh NI, Perman SM, Rezk-Hanna M, Roth GA, Shah NS, Springer MV, St-Onge MP, Thacker EL, Urbut SM, Van Spall HGC, Voeks JH, Whelton SP, Wong ND, Wong SS, Yaffe K, Palaniappan LP, American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Committee. 2025 heart disease and stroke statistics: A report of US and global data from the American heart association. Circulation. 2025;151:e41\u2013660.","journal-title":"Circulation"},{"key":"4897_CR2","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.jchf.2014.10.007","volume":"3","author":"L Desta","year":"2015","unstructured":"Desta L, Jernberg T, L\u00f6fman I, Hofman-Bang C, Hagerman I, Spaak J, Persson H. Incidence, Temporal trends, and prognostic impact of heart failure complicating acute myocardial infarction. The SWEDEHEART registry (Swedish Web-System for enhancement and development of Evidence-Based care in heart disease evaluated according to recommended Therapies): a study of 199,851 patients admitted with index acute myocardial infarctions, 1996 to 2008. JACC Heart Fail. 2015;3:234\u201342.","journal-title":"JACC Heart Fail"},{"key":"4897_CR3","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1016\/S0140-6736(14)60107-0","volume":"383","author":"G Heusch","year":"2014","unstructured":"Heusch G, Libby P, Gersh B, Yellon D, B\u00f6hm M, Lopaschuk G, Opie L. Cardiovascular remodelling in coronary artery disease and heart failure. Lancet. 2014;383:1933\u201343.","journal-title":"Lancet"},{"key":"4897_CR4","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1093\/eurheartj\/ehac223","volume":"43","author":"S Frantz","year":"2022","unstructured":"Frantz S, Hundertmark MJ, Schulz-Menger J, Bengel FM, Bauersachs J. Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies. Eur Heart J. 2022;43:2549\u201361.","journal-title":"Eur Heart J"},{"key":"4897_CR5","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1016\/j.jacc.2021.09.019","volume":"78","author":"J Zhang","year":"2021","unstructured":"Zhang J, Bolli R, Garry DJ, Marb\u00e1n E, Menasch\u00e9 P, Zimmermann WH, Kamp TJ, Wu JC, Dzau VJ. Basic and translational research in cardiac repair and regeneration: JACC State-of-the-Art review. J Am Coll Cardiol. 2021;78:2092\u2013105.","journal-title":"J Am Coll Cardiol"},{"key":"4897_CR6","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1038\/s41569-018-0013-0","volume":"15","author":"P Menasch\u00e9","year":"2018","unstructured":"Menasch\u00e9 P. Cell therapy trials for heart regeneration - lessons learned and future directions. Nat Rev Cardiol. 2018;15:659\u201371.","journal-title":"Nat Rev Cardiol"},{"key":"4897_CR7","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/s41569-024-01098-8","volume":"22","author":"JJ Zhang","year":"2025","unstructured":"Zhang JJ, Pogwizd SM, Fukuda K, Zimmermann WH, Fan C, Hare JM, Bolli R, Menasch\u00e9 P. Trials and tribulations of cell therapy for heart failure: an update on ongoing trials. Nat Rev Cardiol. 2025;22:372\u201385.","journal-title":"Nat Rev Cardiol"},{"key":"4897_CR8","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1038\/s42003-021-02237-4","volume":"4","author":"S Petrus-Reurer","year":"2021","unstructured":"Petrus-Reurer S, Romano M, Howlett S, Jones JL, Lombardi G, Saeb-Parsy K. Immunological considerations and challenges for regenerative cellular therapies. Commun Biol. 2021;4:798.","journal-title":"Commun Biol"},{"key":"4897_CR9","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1126\/science.1256864","volume":"344","author":"L Chatenoud","year":"2014","unstructured":"Chatenoud L, Immunology. Teaching the immune system self respect and tolerance. Science. 2014;344:1343\u20134.","journal-title":"Science"},{"key":"4897_CR10","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1126\/science.adg6425","volume":"380","author":"CC Brown","year":"2023","unstructured":"Brown CC, Rudensky AY. Spatiotemporal regulation of peripheral T cell tolerance. Science. 2023;380:472\u20138.","journal-title":"Science"},{"key":"4897_CR11","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/nbt.2960","volume":"32","author":"JL Zakrzewski","year":"2014","unstructured":"Zakrzewski JL, van den Brink MR, Hubbell JA. Overcoming immunological barriers in regenerative medicine. Nat Biotechnol. 2014;32:786\u201394.","journal-title":"Nat Biotechnol"},{"key":"4897_CR12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s13287-020-02066-y","volume":"12","author":"Y Jiang","year":"2021","unstructured":"Jiang Y, Sun SJ, Zhen Z, Wei R, Zhang N, Liao SY, Tse HF. Myocardial repair of bioengineered cardiac patches with decellularized placental scaffold and human-induced pluripotent stem cells in a rat model of myocardial infarction. Stem Cell Res Ther. 2021;12:13.","journal-title":"Stem Cell Res Ther"},{"key":"4897_CR13","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/s41577-019-0200-1","volume":"19","author":"R Lanza","year":"2019","unstructured":"Lanza R, Russell DW, Nagy A. Engineering universal cells that evade immune detection. Nat Rev Immunol. 2019;19:723\u201333.","journal-title":"Nat Rev Immunol"},{"key":"4897_CR14","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.7150\/thno.46119","volume":"11","author":"SJ Sun","year":"2021","unstructured":"Sun SJ, Lai WH, Jiang Y, Zhen Z, Wei R, Lian Q, Liao SY, Tse HF. Immunomodulation by systemic administration of human-induced pluripotent stem cell-derived mesenchymal stromal cells to enhance the therapeutic efficacy of cell-based therapy for treatment of myocardial infarction. Theranostics. 2021;11:1641\u201354.","journal-title":"Theranostics"},{"key":"4897_CR15","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/s42003-022-03833-8","volume":"5","author":"SJ Sun","year":"2022","unstructured":"Sun SJ, Li F, Dong M, Liang WH, Lai WH, Ho WI, Wei R, Huang Y, Liao SY, Tse HF. Repeated intravenous administration of hiPSC-MSCs enhance the efficacy of cell-based therapy in tissue regeneration. Commun Biol. 2022;5:867.","journal-title":"Commun Biol"},{"key":"4897_CR16","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.it.2017.01.009","volume":"38","author":"LMR Ferreira","year":"2017","unstructured":"Ferreira LMR, Meissner TB, Tilburgs T, Strominger JL. HLA-G: at the interface of Maternal-Fetal tolerance. Trends Immunol. 2017;38:272\u201386.","journal-title":"Trends Immunol"},{"key":"4897_CR17","doi-asserted-by":"publisher","first-page":"e2425339122","DOI":"10.1073\/pnas.2425339122","volume":"122","author":"B Gu","year":"2025","unstructured":"Gu B, Ferreira LMR, Herrera S, Brown L, Lieberman J, Sherwood RI, Meissner TB, Strominger JL. The TEA domain transcription factors TEAD1 and TEAD3 and WNT signaling determine HLA-G expression in human extravillous trophoblasts. Proc Natl Acad Sci USA. 2025;122:e2425339122.","journal-title":"Proc Natl Acad Sci USA"},{"key":"4897_CR18","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.neuroscience.2011.06.006","volume":"190","author":"M Nikodemova","year":"2011","unstructured":"Nikodemova M, Watters JJ. Outbred ICR\/CD1 mice display more severe neuroinflammation mediated by microglial TLR4\/CD14 activation than inbred C57BL\/6 mice. Neuroscience. 2011;190:67\u201374.","journal-title":"Neuroscience"},{"key":"4897_CR19","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/cvr\/cvaa110","volume":"117","author":"S Zacchigna","year":"2021","unstructured":"Zacchigna S, Paldino A, Falcao-Pires I, Daskalopoulos EP, Dal Ferro M, Vodret S, Lesizza P, Cannata A, Miranda-Silva D, Lourenco AP, Pinamonti B, Sinagra G, Weinberger F, Eschenhagen T, Carrier L, Kehat I, Tocchetti CG, Russo M, Ghigo A, Cimino J, Hirsch E, Dawson D, Ciccarelli M, Oliveti M, Linke WA, Cuijpers I, Heymans S, Hamdani N, de Boer M, Duncker DJ, Kuster D, van der Velden J, Beauloye C, Bertrand L, Mayr M, Giacca M, Leuschner F, Backs J, Thum T. Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC working group on myocardial function. Cardiovascular Res. 2021;117:43\u201359.","journal-title":"Cardiovascular Res"},{"key":"4897_CR20","doi-asserted-by":"publisher","first-page":"5364","DOI":"10.1073\/pnas.1602886113","volume":"113","author":"LM Ferreira","year":"2016","unstructured":"Ferreira LM, Meissner TB, Mikkelsen TS, Mallard W, O\u2019Donnell CW, Tilburgs T, Gomes HA, Camahort R, Sherwood RI, Gifford DK, Rinn JL, Cowan CA, Strominger JL. A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface. Proc Natl Acad Sci USA. 2016;113:5364\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"key":"4897_CR21","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1038\/s42003-024-06740-2","volume":"7","author":"RCV Lintao","year":"2024","unstructured":"Lintao RCV, Richardson LS, Kammala AK, Chapa J, Yunque-Yap DA, Khanipov K, Golovko G, Dalmacio LMM, Menon R. PGRMC2 and HLA-G regulate immune homeostasis in a microphysiological model of human maternal-fetal membrane interface. Commun Biol. 2024;7:1041.","journal-title":"Commun Biol"},{"key":"4897_CR22","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1182\/blood.V110.11.1195.1195","volume":"110","author":"C Takashi Yamagami","year":"2007","unstructured":"Takashi Yamagami C, Sanada H, Wiendl ED, Zanjani CD, Porada. Gra\u00e7a Almeida-Porada; expression of HLA-G1 and G5 enables human mesenchymal stem cells to engraft at high levels across xenogeneic barriers following transplantation into immunocompetent recipients. Blood. 2007;110:1195.","journal-title":"Blood"},{"key":"4897_CR23","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.3390\/cells11081339","volume":"11","author":"B Zoehler","year":"2022","unstructured":"Zoehler B, Fracaro L, Boldrini-Leite LM, da Silva JS, Travers PJ, Brofman PRS, Bicalho MDG, Senegaglia AC. HLA-G and CD152 expression levels encourage the use of umbilical cord Tissue-Derived mesenchymal stromal cells as an alternative for immunosuppressive therapy. Cells. 2022;11:1339.","journal-title":"Cells"},{"key":"4897_CR24","doi-asserted-by":"publisher","first-page":"104539","DOI":"10.1016\/j.ebiom.2023.104539","volume":"90","author":"ME Raeber","year":"2023","unstructured":"Raeber ME, Sahin D, Karakus U, Boyman O. A systematic review of interleukin-2-based immunotherapies in clinical trials for cancer and autoimmune diseases. EBioMedicine. 2023;90:104539.","journal-title":"EBioMedicine"},{"key":"4897_CR25","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.tips.2020.06.009","volume":"41","author":"N Song","year":"2020","unstructured":"Song N, Scholtemeijer M, Shah K. Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential. Trends Pharmacol Sci. 2020;41:653\u201364.","journal-title":"Trends Pharmacol Sci"},{"key":"4897_CR26","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1161\/CIRCRESAHA.117.310712","volume":"121","author":"J Bartolucci","year":"2017","unstructured":"Bartolucci J, Verdugo FJ, Gonz\u00e1lez PL, Larrea RE, Abarzua E, Goset C, Rojo P, Palma I, Lamich R, Pedreros PA, Valdivia G, Lopez VM, Nazzal C, Alcayaga-Miranda F, Cuenca J, Brobeck MJ, Patel AN, Figueroa FE, Khoury M. Safety and efficacy of the intravenous infusion of umbilical cord mesenchymal stem cells in patients with heart failure: A phase 1\/2 randomized controlled trial (RIMECARD trial [Randomized clinical trial of intravenous infusion umbilical cord mesenchymal stem cells on Cardiopathy]). Circ Res. 2017;121:1192\u2013204.","journal-title":"Circ Res"},{"key":"4897_CR27","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1161\/CIRCRESAHA.117.310599","volume":"120","author":"D Luger","year":"2017","unstructured":"Luger D, Lipinski MJ, Westman PC, Glover DK, Dimastromatteo J, Frias JC, Albelda MT, Sikora S, Kharazi A, Vertelov G, Waksman R, Epstein SE. Intravenously delivered mesenchymal stem cells: systemic Anti-Inflammatory effects improve left ventricular dysfunction in acute myocardial infarction and ischemic cardiomyopathy. Circ Res. 2017;120:1598\u2013613.","journal-title":"Circ Res"},{"key":"4897_CR28","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1161\/CIRCULATIONAHA.122.061736","volume":"148","author":"YC Cheng","year":"2023","unstructured":"Cheng YC, Hsieh ML, Lin CJ, Chang CMC, Huang CY, Puntney R, Wu Moy A, Ting CY, Herr Chan DZ, Nicholson MW, Lin PJ, Chen HC, Kim GC, Zhang J, Coonen J, Basu P, Simmons HA, Liu YW, Hacker TA, Kamp TJ, Hsieh PCH. Combined treatment of human induced pluripotent stem Cell-Derived cardiomyocytes and endothelial cells regenerate the infarcted heart in mice and Non-Human primates. Circulation. 2023;148:1395\u2013409.","journal-title":"Circulation"},{"key":"4897_CR29","doi-asserted-by":"publisher","first-page":"15772","DOI":"10.1073\/pnas.2000484117","volume":"117","author":"H Papuchova","year":"2020","unstructured":"Papuchova H, Kshirsagar S, Xu L, Bougleux Gomes HA, Li Q, Iyer V, Norwitz ER, Strominger JL, Tilburgs T. Three types of HLA-G\u2009+\u2009extravillous trophoblasts that have distinct immune regulatory properties. Proc Natl Acad Sci USA. 2020;117:15772\u20137.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Stem Cell Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-026-04897-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-026-04897-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-026-04897-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T13:56:03Z","timestamp":1770386163000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13287-026-04897-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4897"],"URL":"https:\/\/doi.org\/10.1186\/s13287-026-04897-7","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]},"assertion":[{"value":"25 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"73"}}