{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:44:30Z","timestamp":1784306670485,"version":"3.55.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001700","name":"the Ministry of Education, Culture, Sports, Science and Technology of Japan.","doi-asserted-by":"crossref","award":["25K11361"],"award-info":[{"award-number":["25K11361"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-026-05023-3","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T05:53:12Z","timestamp":1776577992000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adipose-derived regenerative cell therapy mitigates sepsis-induced cardiomyopathy through the induction of cardiac reparative lymphangiogenesis"],"prefix":"10.1186","volume":"17","author":[{"given":"Haihang","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuuki","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuimi","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shukuro","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyoaki","family":"Murohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,19]]},"reference":[{"key":"5023_CR1","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.1093\/eurheartj\/ehaf340","volume":"46","author":"N Aissaoui","year":"2025","unstructured":"Aissaoui N, Boissier F, Chew M, Singer M, Vignon P. Sepsis-induced cardiomyopathy. Eur Heart J. 2025;46:3339\u201353. https:\/\/doi.org\/10.1093\/eurheartj\/ehaf340.","journal-title":"Eur Heart J"},{"key":"5023_CR2","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40779-016-0099-9","volume":"3","author":"X Lv","year":"2016","unstructured":"Lv X, Wang H. Pathophysiology of sepsis-induced myocardial dysfunction. Mil Med Res. 2016;3:30. https:\/\/doi.org\/10.1186\/s40779-016-0099-9.","journal-title":"Mil Med Res"},{"key":"5023_CR3","doi-asserted-by":"publisher","unstructured":"Palmieri V, Innocenti F, Guzzo A, Guerrini E, Vignaroli D, Pini R. Left ventricular systolic longitudinal function as predictor of outcome in patients with sepsis. Circ Cardiovasc Imaging. 2015;8:e003865; discussion e003865. https:\/\/doi.org\/10.1161\/CIRCIMAGING.115.003865","DOI":"10.1161\/CIRCIMAGING.115.003865"},{"key":"5023_CR4","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1093\/eurheartj\/ehr351","volume":"33","author":"G Landesberg","year":"2012","unstructured":"Landesberg G, Gilon D, Meroz Y, Georgieva M, Levin PD, Goodman S, et al. Diastolic dysfunction and mortality in severe sepsis and septic shock. Eur Heart J. 2012;33:895\u2013903. https:\/\/doi.org\/10.1093\/eurheartj\/ehr351.","journal-title":"Eur Heart J"},{"key":"5023_CR5","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1007\/s00134-015-3748-7","volume":"41","author":"F Sanfilippo","year":"2015","unstructured":"Sanfilippo F, Corredor C, Fletcher N, Landesberg G, Benedetto U, Foex P, et al. Diastolic dysfunction and mortality in septic patients: a systematic review and meta-analysis. Intensive Care Med. 2015;41:1004\u201313. https:\/\/doi.org\/10.1007\/s00134-015-3748-7.","journal-title":"Intensive Care Med"},{"key":"5023_CR6","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1042\/CS20120334","volume":"124","author":"A Rudiger","year":"2013","unstructured":"Rudiger A, Dyson A, Felsmann K, Carre JE, Taylor V, Hughes S, et al. Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis. Clin Sci (Lond). 2013;124:391\u2013401. https:\/\/doi.org\/10.1042\/CS20120334.","journal-title":"Clin Sci (Lond)"},{"key":"5023_CR7","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1097\/SHK.0000000000001395","volume":"53","author":"F Vasques-Novoa","year":"2020","unstructured":"Vasques-Novoa F, Laundos TL, Madureira A, Bettencourt N, Nunes JPL, Carneiro F, et al. Myocardial Edema: An overlooked mechanism of septic cardiomyopathy? Shock. 2020;53:616\u20139. https:\/\/doi.org\/10.1097\/SHK.0000000000001395.","journal-title":"Shock"},{"key":"5023_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113511","volume":"143","author":"CH Wu","year":"2024","unstructured":"Wu CH, Guan MQ, Lu WH, Jiang XG, Zhang PH. Lymphatic vessels are necessary for cardiac function and inflammation resolution in sepsis-induced cardiomyopathy. Int Immunopharmacol. 2024;143:113511. https:\/\/doi.org\/10.1016\/j.intimp.2024.113511.","journal-title":"Int Immunopharmacol"},{"key":"5023_CR9","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1038\/nm.2545","volume":"17","author":"K Alitalo","year":"2011","unstructured":"Alitalo K. The lymphatic vasculature in disease. Nat Med. 2011;17:1371\u201380. https:\/\/doi.org\/10.1038\/nm.2545.","journal-title":"Nat Med"},{"key":"5023_CR10","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009565","volume":"7","author":"Y Shimizu","year":"2018","unstructured":"Shimizu Y, Polavarapu R, Eskla KL, Pantner Y, Nicholson CK, Ishii M, et al. Impact of lymphangiogenesis on cardiac remodeling after ischemia and reperfusion injury. J Am Heart Assoc. 2018;7:e009565. https:\/\/doi.org\/10.1161\/JAHA.118.009565.","journal-title":"J Am Heart Assoc"},{"key":"5023_CR11","doi-asserted-by":"publisher","first-page":"16045","DOI":"10.1038\/s41598-020-73096-y","volume":"10","author":"T Katagiri","year":"2020","unstructured":"Katagiri T, Kondo K, Shibata R, Hayashida R, Shintani S, Yamaguchi S, et al. Therapeutic angiogenesis using autologous adipose-derived regenerative cells in patients with critical limb ischaemia in Japan: a clinical pilot study. Sci Rep. 2020;10:16045. https:\/\/doi.org\/10.1038\/s41598-020-73096-y.","journal-title":"Sci Rep"},{"key":"5023_CR12","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s10456-022-09844-7","volume":"25","author":"Y Shimizu","year":"2022","unstructured":"Shimizu Y, Kondo K, Hayashida R, Sasaki KI, Ohtsuka M, Fukumoto Y, et al. Therapeutic angiogenesis for patients with no-option critical limb ischemia by adipose-derived regenerative cells: TACT-ADRC multicenter trial. Angiogenesis. 2022;25:535\u201346. https:\/\/doi.org\/10.1007\/s10456-022-09844-7.","journal-title":"Angiogenesis"},{"key":"5023_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/cells14050343","author":"Y Che","year":"2025","unstructured":"Che Y, Shimizu Y, Murohara T. Therapeutic potential of adipose-derived regenerative cells for ischemic diseases. Cells. 2025. https:\/\/doi.org\/10.3390\/cells14050343.","journal-title":"Cells"},{"key":"5023_CR14","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.000877","volume":"1","author":"Y Shimizu","year":"2012","unstructured":"Shimizu Y, Shibata R, Shintani S, Ishii M, Murohara T. Therapeutic lymphangiogenesis with implantation of adipose-derived regenerative cells. J Am Heart Assoc. 2012;1:e000877. https:\/\/doi.org\/10.1161\/JAHA.112.000877.","journal-title":"J Am Heart Assoc"},{"key":"5023_CR15","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1161\/ATVBAHA.121.316191","volume":"41","author":"Z Pu","year":"2021","unstructured":"Pu Z, Shimizu Y, Tsuzuki K, Suzuki J, Hayashida R, Kondo K, et al. Important role of concomitant lymphangiogenesis for reparative angiogenesis in hindlimb ischemia. Arterioscler Thromb Vasc Biol. 2021;41:2006\u201318. https:\/\/doi.org\/10.1161\/ATVBAHA.121.316191.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"5023_CR16","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.jacbts.2023.01.008","volume":"8","author":"Z Pu","year":"2023","unstructured":"Pu Z, Shimizu Y, Hayashi T, Che Y, Suzuki J, Tsuzuki K, et al. Cardiac lymphatic insufficiency leads to diastolic dysfunction via myocardial morphologic change. JACC Basic Transl Sci. 2023;8:958\u201372. https:\/\/doi.org\/10.1016\/j.jacbts.2023.01.008.","journal-title":"JACC Basic Transl Sci"},{"key":"5023_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24097774","author":"Y Shimizu","year":"2023","unstructured":"Shimizu Y, Che Y, Murohara T. Therapeutic lymphangiogenesis is a promising strategy for secondary lymphedema. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms24097774.","journal-title":"Int J Mol Sci"},{"key":"5023_CR18","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1161\/ATVBAHA.117.309524","volume":"38","author":"P Robinet","year":"2018","unstructured":"Robinet P, Milewicz DM, Cassis LA, Leeper NJ, Lu HS, Smith JD. Consideration of sex differences in design and reporting of experimental arterial pathology studies-statement from ATVB council. Arterioscler Thromb Vasc Biol. 2018;38:292\u2013303. https:\/\/doi.org\/10.1161\/ATVBAHA.117.309524.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"5023_CR19","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1007\/s00246-010-9877-4","volume":"32","author":"E Murphy","year":"2011","unstructured":"Murphy E, Lagranha C, Deschamps A, Kohr M, Nguyen T, Wong R, et al. Mechanism of cardioprotection: what can we learn from females? Pediatr Cardiol. 2011;32:354\u20139. https:\/\/doi.org\/10.1007\/s00246-010-9877-4.","journal-title":"Pediatr Cardiol"},{"key":"5023_CR20","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s10456-025-10001-z","volume":"28","author":"Y Che","year":"2025","unstructured":"Che Y, Shimizu Y, Hayashi T, Suzuki J, Pu Z, Tsuzuki K, et al. Mitochondrial transfer from adipose-derived regenerative cells contributes therapeutic angiogenesis in a murine hindlimb ischemia model. Angiogenesis. 2025;28:49. https:\/\/doi.org\/10.1007\/s10456-025-10001-z.","journal-title":"Angiogenesis"},{"key":"5023_CR21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1161\/ATVBAHA.108.166496","volume":"29","author":"K Kondo","year":"2009","unstructured":"Kondo K, Shintani S, Shibata R, Murakami H, Murakami R, Imaizumi M, et al. Implantation of adipose-derived regenerative cells enhances ischemia-induced angiogenesis. Arterioscler Thromb Vasc Biol. 2009;29:61\u20136. https:\/\/doi.org\/10.1161\/ATVBAHA.108.166496.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"5023_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tox.2019.04.011","volume":"422","author":"R Wang","year":"2019","unstructured":"Wang R, Li D, Ouyang J, Tian X, Zhao Y, Peng X, et al. Leonurine alleviates LPS-induced myocarditis through suppressing the NF-small ka. CyrillicB Signaling Pathway Toxicol. 2019;422:1\u201313. https:\/\/doi.org\/10.1016\/j.tox.2019.04.011.","journal-title":"CyrillicB Signaling Pathway Toxicol"},{"key":"5023_CR23","doi-asserted-by":"publisher","DOI":"10.4081\/ejh.2023.3816","author":"L Shen","year":"2023","unstructured":"Shen L, Lu K, Chen Z, Zhu Y, Zhang C, Zhang L. Pre-treatment with galectin-1 attenuates lipopolysaccharide-induced myocarditis by regulating the Nrf2 pathway. Eur J Histochem. 2023. https:\/\/doi.org\/10.4081\/ejh.2023.3816.","journal-title":"Eur J Histochem"},{"key":"5023_CR24","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3349\/ymj.2022.63.3.220","volume":"63","author":"Z Liu","year":"2022","unstructured":"Liu Z, Gao S, Bu Y, Zheng X. Luteolin protects cardiomyocytes cells against lipopolysaccharide-induced apoptosis and inflammatory damage by modulating Nlrp3. Yonsei Med J. 2022;63:220\u20138. https:\/\/doi.org\/10.3349\/ymj.2022.63.3.220.","journal-title":"Yonsei Med J"},{"key":"5023_CR25","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1038\/s41467-018-03692-0","volume":"9","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Ulvmar MH, Stanczuk L, Martinez-Corral I, Frye M, Alitalo K, et al. Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms. Nat Commun. 2018;9:1296. https:\/\/doi.org\/10.1038\/s41467-018-03692-0.","journal-title":"Nat Commun"},{"key":"5023_CR26","doi-asserted-by":"publisher","first-page":"10777","DOI":"10.1038\/s41598-024-61710-2","volume":"14","author":"Y Che","year":"2024","unstructured":"Che Y, Shimizu Y, Hayashi T, Suzuki J, Pu Z, Tsuzuki K, et al. Chronic circadian rhythm disorder induces heart failure with preserved ejection fraction-like phenotype through the Clock-sGC-cGMP-PKG1 signaling pathway. Sci Rep. 2024;14:10777. https:\/\/doi.org\/10.1038\/s41598-024-61710-2.","journal-title":"Sci Rep"},{"key":"5023_CR27","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.026889","volume":"11","author":"J Suzuki","year":"2022","unstructured":"Suzuki J, Shimizu Y, Hayashi T, Che Y, Pu Z, Tsuzuki K, et al. Hydrogen sulfide attenuates lymphedema via the induction of lymphangiogenesis through a PI3K\/Akt-dependent mechanism. J Am Heart Assoc. 2022;11:e026889. https:\/\/doi.org\/10.1161\/JAHA.122.026889.","journal-title":"J Am Heart Assoc"},{"key":"5023_CR28","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014691","volume":"9","author":"Y Shimizu","year":"2020","unstructured":"Shimizu Y, Nicholson CK, Polavarapu R, Pantner Y, Husain A, Naqvi N, et al. Role of DJ-1 in modulating glycative stress in heart failure. J Am Heart Assoc. 2020;9:e014691. https:\/\/doi.org\/10.1161\/JAHA.119.014691.","journal-title":"J Am Heart Assoc"},{"key":"5023_CR29","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.020896","volume":"10","author":"K Tsuzuki","year":"2021","unstructured":"Tsuzuki K, Shimizu Y, Suzuki J, Pu Z, Yamaguchi S, Fujikawa Y, et al. Adverse effect of circadian rhythm disorder on reparative angiogenesis in hind limb ischemia. J Am Heart Assoc. 2021;10:e020896. https:\/\/doi.org\/10.1161\/JAHA.121.020896.","journal-title":"J Am Heart Assoc"},{"key":"5023_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10102388","author":"Y Imai","year":"2022","unstructured":"Imai Y, Mori N, Nihashi Y, Kumagai Y, Shibuya Y, Oshima J, et al. Therapeutic potential of adipose stem cell-derived conditioned medium on scar contraction model. Biomedicines. 2022. https:\/\/doi.org\/10.3390\/biomedicines10102388.","journal-title":"Biomedicines."},{"key":"5023_CR31","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.yjmcc.2016.04.008","volume":"97","author":"Y Shimizu","year":"2016","unstructured":"Shimizu Y, Lambert JP, Nicholson CK, Kim JJ, Wolfson DW, Cho HC, et al. DJ-1 protects the heart against ischemia-reperfusion injury by regulating mitochondrial fission. J Mol Cell Cardiol. 2016;97:56\u201366. https:\/\/doi.org\/10.1016\/j.yjmcc.2016.04.008.","journal-title":"J Mol Cell Cardiol"},{"key":"5023_CR32","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.ejphar.2013.10.019","volume":"723","author":"Y Tang","year":"2014","unstructured":"Tang Y, Chen Y, Chu Z, Yan B, Xu L. Protective effect of cryptotanshinone on lipopolysaccharide-induced acute lung injury in mice. Eur J Pharmacol. 2014;723:494\u2013500. https:\/\/doi.org\/10.1016\/j.ejphar.2013.10.019.","journal-title":"Eur J Pharmacol"},{"key":"5023_CR33","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s11886-020-01277-2","volume":"22","author":"M L'Heureux","year":"2020","unstructured":"L\u2019Heureux M, Sternberg M, Brath L, Turlington J, Kashiouris MG. Sepsis-induced cardiomyopathy: a comprehensive review. Curr Cardiol Rep. 2020;22:35. https:\/\/doi.org\/10.1007\/s11886-020-01277-2.","journal-title":"Curr Cardiol Rep"},{"key":"5023_CR34","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s13613-022-01089-3","volume":"12","author":"YM Lin","year":"2022","unstructured":"Lin YM, Lee MC, Toh HS, Chang WT, Chen SY, Kuo FH, et al. Association of sepsis-induced cardiomyopathy and mortality: a systematic review and meta-analysis. Ann Intensive Care. 2022;12:112. https:\/\/doi.org\/10.1186\/s13613-022-01089-3.","journal-title":"Ann Intensive Care"},{"key":"5023_CR35","doi-asserted-by":"publisher","unstructured":"Nam H, Cha JH, Choi KH, Chung CR, Yang JH, Suh GY, Park S, Lim CM, Ko RE, Korean Sepsis Alliance I. Association Between Initial Left Ventricular Systolic Dysfunction and Clinical Outcome in Sepsis: A Multicenter Cohort Study. Crit Care Med. 2025;53:e1759-e1769. https:\/\/doi.org\/10.1097\/CCM.0000000000006771","DOI":"10.1097\/CCM.0000000000006771"},{"key":"5023_CR36","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/jcm12093188","volume":"2023","author":"M Guarino","year":"2023","unstructured":"Guarino M, Perna B, Cesaro AE, Maritati M, Spampinato MD, Contini C, et al. Update on sepsis and septic shock in adult patients: management in the emergency department. J Clin Med. 2023;2023:12. https:\/\/doi.org\/10.3390\/jcm12093188.","journal-title":"J Clin Med"},{"key":"5023_CR37","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s10741-024-10449-z","volume":"30","author":"B Ponikowska","year":"2025","unstructured":"Ponikowska B, Fudim M, Iwanek G, Zymlinski R, Biegus J. Harnessing the lymphatic system. Heart Fail Rev. 2025;30:673\u201383. https:\/\/doi.org\/10.1007\/s10741-024-10449-z.","journal-title":"Heart Fail Rev"},{"key":"5023_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251910656","author":"Y Shimizu","year":"2024","unstructured":"Shimizu Y, Luo H, Murohara T. Disease-specific alteration of cardiac lymphatics: a review from animal disease models to clinics. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms251910656.","journal-title":"Int J Mol Sci"},{"key":"5023_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237810","volume":"15","author":"T Iwamiya","year":"2020","unstructured":"Iwamiya T, Segard BD, Matsuoka Y, Imamura T. Human cardiac fibroblasts expressing VCAM1 improve heart function in postinfarct heart failure rat models by stimulating lymphangiogenesis. PLoS ONE. 2020;15:e0237810. https:\/\/doi.org\/10.1371\/journal.pone.0237810.","journal-title":"PLoS ONE"},{"key":"5023_CR40","doi-asserted-by":"publisher","first-page":"32098","DOI":"10.1038\/s41598-025-17224-6","volume":"15","author":"Y Matsuoka","year":"2025","unstructured":"Matsuoka Y, Shimizu Y, Luo H, Segard BD, Matsuyama M, Hayashi T, et al. Adrenomedullin production by adult cardiac fibroblasts via NF-kappaB\/STAT6 signaling enhances post-infarction lymphangiogenesis and cardiac repair. Sci Rep. 2025;15:32098. https:\/\/doi.org\/10.1038\/s41598-025-17224-6.","journal-title":"Sci Rep"},{"key":"5023_CR41","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.21037\/jtd.2016.07.34","volume":"8","author":"P Goichberg","year":"2016","unstructured":"Goichberg P. Therapeutic lymphangiogenesis after myocardial infarction: vascular endothelial growth factor-C paves the way. J Thorac Dis. 2016;8:1904\u20137. https:\/\/doi.org\/10.21037\/jtd.2016.07.34.","journal-title":"J Thorac Dis"},{"key":"5023_CR42","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.immuni.2014.01.013","volume":"40","author":"Y Zhang","year":"2014","unstructured":"Zhang Y, Lu Y, Ma L, Cao X, Xiao J, Chen J, et al. Activation of vascular endothelial growth factor receptor-3 in macrophages restrains TLR4-NF-kappaB signaling and protects against endotoxin shock. Immunity. 2014;40:501\u201314. https:\/\/doi.org\/10.1016\/j.immuni.2014.01.013.","journal-title":"Immunity"},{"key":"5023_CR43","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.173440","author":"PH Zhang","year":"2024","unstructured":"Zhang PH, Zhang WW, Wang SS, Wu CH, Ding YD, Wu XY, et al. Efficient pulmonary lymphatic drainage is necessary for inflammation resolution in ARDS. JCI Insight. 2024. https:\/\/doi.org\/10.1172\/jci.insight.173440.","journal-title":"JCI Insight"},{"key":"5023_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11030746","author":"I Lakbar","year":"2023","unstructured":"Lakbar I, Einav S, Lalevee N, Martin-Loeches I, Pastene B, Leone M. Interactions between gender and sepsis-implications for the future. Microorganisms. 2023. https:\/\/doi.org\/10.3390\/microorganisms11030746.","journal-title":"Microorganisms"},{"key":"5023_CR45","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.jinf.2022.04.035","volume":"84","author":"KJ Thompson","year":"2022","unstructured":"Thompson KJ, Finfer SR, Woodward M, Leong RNF, Liu B. Sex differences in sepsis hospitalisations and outcomes in older women and men: a prospective cohort study. J Infect. 2022;84:770\u20136. https:\/\/doi.org\/10.1016\/j.jinf.2022.04.035.","journal-title":"J Infect"},{"key":"5023_CR46","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13050836","author":"C Mewes","year":"2023","unstructured":"Mewes C, Runzheimer J, Bohnke C, Buttner B, Hinz J, Quintel M, et al. Association of sex differences with mortality and organ dysfunction in patients with sepsis and septic shock. J Pers Med. 2023. https:\/\/doi.org\/10.3390\/jpm13050836.","journal-title":"J Pers Med"},{"key":"5023_CR47","doi-asserted-by":"publisher","first-page":"C458","DOI":"10.1152\/ajpcell.00134.2022","volume":"324","author":"CA Shields","year":"2023","unstructured":"Shields CA, Wang X, Cornelius DC. Sex differences in cardiovascular response to sepsis. Am J Physiol Cell Physiol. 2023;324:C458\u201366. https:\/\/doi.org\/10.1152\/ajpcell.00134.2022.","journal-title":"Am J Physiol Cell Physiol"},{"key":"5023_CR48","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1021\/acsptsci.9b00051","volume":"2","author":"CE Trincot","year":"2019","unstructured":"Trincot CE, Caron KM. Lymphatic function and dysfunction in the context of sex differences. ACS Pharmacol Transl Sci. 2019;2:311\u201324. https:\/\/doi.org\/10.1021\/acsptsci.9b00051.","journal-title":"ACS Pharmacol Transl Sci"},{"key":"5023_CR49","doi-asserted-by":"publisher","first-page":"H215","DOI":"10.1152\/ajpheart.00895.2011","volume":"302","author":"ZX Yan","year":"2012","unstructured":"Yan ZX, Jiang ZH, Liu NF. Angiopoietin-2 promotes inflammatory lymphangiogenesis and its effect can be blocked by the specific inhibitor L1\u201310. Am J Physiol Heart Circ Physiol. 2012;302:H215-223. https:\/\/doi.org\/10.1152\/ajpheart.00895.2011.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"5023_CR50","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1038\/sj.leu.2403355","volume":"18","author":"C Scavelli","year":"2004","unstructured":"Scavelli C, Vacca A, Di Pietro G, Dammacco F, Ribatti D. Crosstalk between angiogenesis and lymphangiogenesis in tumor progression. Leukemia. 2004;18:1054\u20138. https:\/\/doi.org\/10.1038\/sj.leu.2403355.","journal-title":"Leukemia"}],"container-title":["Stem Cell Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-026-05023-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-026-05023-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-026-05023-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T01:41:48Z","timestamp":1780278108000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13287-026-05023-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,19]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5023"],"URL":"https:\/\/doi.org\/10.1186\/s13287-026-05023-3","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,19]]},"assertion":[{"value":"14 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal ethics declaration"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"203"}}