{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:49:58Z","timestamp":1785890998460,"version":"3.56.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":67,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82272291"],"award-info":[{"award-number":["82272291"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82302807"],"award-info":[{"award-number":["82302807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Clinical Project at the Fourth Military Medical University","award":["2024LC2420"],"award-info":[{"award-number":["2024LC2420"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-026-05072-8","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T10:43:56Z","timestamp":1780137836000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanical stretch loading of BMSCs-PLCL composite scaffolds accelerate diabetic wound healing by protecting endothelial cells and promoting angiogenesis"],"prefix":"10.1186","volume":"17","author":[{"given":"Zhe","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5184-0099","authenticated-orcid":false,"given":"Yuqian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4952-0283","authenticated-orcid":false,"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,30]]},"reference":[{"issue":"1","key":"5072_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.2337\/dci22-0043","volume":"46","author":"K McDermott","year":"2023","unstructured":"McDermott K, Fang M, Boulton AJM, Selvin E, Hicks CW. Etiology, Epidemiology, and Disparities in the Burden of Diabetic Foot Ulcers. Diabetes Care. 2023;46(1):209\u201321.","journal-title":"Diabetes Care"},{"issue":"1","key":"5072_CR2","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1001\/jama.2023.10578","volume":"330","author":"DG Armstrong","year":"2023","unstructured":"Armstrong DG, Tan TW, Boulton AJM, Bus SA. Diabetic Foot Ulcers: A Review. JAMA. 2023;330(1):62\u201375.","journal-title":"JAMA"},{"issue":"7","key":"5072_CR3","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.3390\/ijms18071419","volume":"18","author":"UA Okonkwo","year":"2017","unstructured":"Okonkwo UA, DiPietro LA. Diabetes and Wound Angiogenesis. Int J Mol Sci. 2017;18(7):1419.","journal-title":"Int J Mol Sci"},{"key":"5072_CR4","doi-asserted-by":"publisher","first-page":"tkae052","DOI":"10.1093\/burnst\/tkae052","volume":"13","author":"K Huang","year":"2025","unstructured":"Huang K, Mi B, Xiong Y, Fu Z, Zhou W, Liu W, et al. Angiogenesis during diabetic wound repair: from mechanism to therapy opportunity. Burns Trauma. 2025;13:tkae052.","journal-title":"Burns Trauma"},{"issue":"11","key":"5072_CR5","doi-asserted-by":"publisher","first-page":"111400","DOI":"10.4239\/wjd.v16.i11.111400","volume":"16","author":"YL Guo","year":"2025","unstructured":"Guo YL, Niu WJ, Jiao HR, Li YP, Xu C, Zhou X, et al. Crosstalk between oxidative stress and inflammatory pathways: Natural therapeutic approaches for diabetic wound healing. World J Diabetes. 2025;16(11):111400.","journal-title":"World J Diabetes"},{"issue":"17","key":"5072_CR6","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.3390\/cells12172162","volume":"12","author":"F Mohamad Yusoff","year":"2023","unstructured":"Mohamad Yusoff F, Higashi Y. Mesenchymal Stem\/Stromal Cells for Therapeutic Angiogenesis. Cells. 2023;12(17):2162.","journal-title":"Cells"},{"issue":"4","key":"5072_CR7","doi-asserted-by":"publisher","first-page":"743","DOI":"10.3390\/biomedicines12040743","volume":"12","author":"S Wu","year":"2024","unstructured":"Wu S, Sun S, Fu W, Yang Z, Yao H, Zhang Z. The Role and Prospects of Mesenchymal Stem Cells in Skin Repair and Regeneration. Biomedicines. 2024;12(4):743.","journal-title":"Biomedicines"},{"issue":"1","key":"5072_CR8","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s13287-022-02770-x","volume":"13","author":"M Wu","year":"2022","unstructured":"Wu M, Chen L, Qi Y, Ci H, Mou S, Yang J, et al. for off-the-shelf breast tissue engineering. Stem Cell Res Ther. 2022;13(1):99. Human umbilical cord mesenchymal stem cell promotes angiogenesis via integrin \u03b21\/ERK1\/2\/HIF-1\u03b1\/VEGF-A signaling pathway.","journal-title":"Stem Cell Res Ther"},{"issue":"19","key":"5072_CR9","doi-asserted-by":"publisher","first-page":"10890","DOI":"10.3390\/ijms221910890","volume":"22","author":"S Rautiainen","year":"2021","unstructured":"Rautiainen S, Laaksonen T, Koivuniemi R. Angiogenic Effects and Crosstalk of Adipose-Derived Mesenchymal Stem\/Stromal Cells and Their Extracellular Vesicles with Endothelial Cells. Int J Mol Sci. 2021;22(19):10890.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"5072_CR10","doi-asserted-by":"publisher","first-page":"e0218081","DOI":"10.1371\/journal.pone.0218081","volume":"14","author":"O Ben Menachem-Zidon","year":"2019","unstructured":"Ben Menachem-Zidon O, Gropp M, Ben Shushan E, Reubinoff B, Shveiky D. Systemically transplanted mesenchymal stem cells induce vascular-like structure formation in a rat model of vaginal injury. PLoS ONE. 2019;14(6):e0218081.","journal-title":"PLoS ONE"},{"issue":"1","key":"5072_CR11","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1186\/s13287-022-03009-5","volume":"13","author":"B Ma","year":"2022","unstructured":"Ma B, Wang T, Li J, Wang Q. Extracellular matrix derived from Wharton\u2019s Jelly-derived mesenchymal stem cells promotes angiogenesis via integrin \u03b1V\u03b23\/c-Myc\/P300\/VEGF. Stem Cell Res Ther. 2022;13(1):327.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"5072_CR12","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s13287-020-1584-3","volume":"11","author":"S Jin","year":"2020","unstructured":"Jin S, Yang C, Huang J, Liu L, Zhang Y, Li S, et al. Conditioned medium derived from FGF-2-modified GMSCs enhances migration and angiogenesis of human umbilical vein endothelial cells. Stem Cell Res Ther. 2020;11(1):68.","journal-title":"Stem Cell Res Ther"},{"issue":"14","key":"5072_CR13","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.1007\/s00018-020-03454-6","volume":"77","author":"XL Fan","year":"2020","unstructured":"Fan XL, Zhang Y, Li X, Fu QL. Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy. Cell Mol Life Sci. 2020;77(14):2771\u201394.","journal-title":"Cell Mol Life Sci"},{"key":"5072_CR14","doi-asserted-by":"publisher","first-page":"110201","DOI":"10.1016\/j.diabres.2022.110201","volume":"195","author":"G Dama","year":"2023","unstructured":"Dama G, Du J, Zhu X, Liu Y, Lin J. Bone marrow-derived mesenchymal stem cells: a promising therapeutic option for the treatment of diabetic foot ulcers. Diabetes Res Clin Pract. 2023;195:110201.","journal-title":"Diabetes Res Clin Pract"},{"issue":"5","key":"5072_CR15","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1007\/s12015-023-10518-0","volume":"19","author":"F Shu","year":"2023","unstructured":"Shu F, Lu J, Zhang W, Huang H, Lin J, Jiang L, et al. JAM-A Overexpression in Human Umbilical Cord-Derived Mesenchymal Stem Cells Accelerated the Angiogenesis of Diabetic Wound By Enhancing Both Paracrine Function and Survival of Mesenchymal Stem Cells. Stem Cell Rev Rep. 2023;19(5):1554\u201375.","journal-title":"Stem Cell Rev Rep"},{"issue":"1","key":"5072_CR16","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12951-021-00894-5","volume":"19","author":"Y Hu","year":"2021","unstructured":"Hu Y, Tao R, Chen L, Xiong Y, Xue H, Hu L, et al. Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis. J Nanobiotechnol. 2021;19(1):150.","journal-title":"J Nanobiotechnol"},{"key":"5072_CR17","doi-asserted-by":"publisher","first-page":"tkac001","DOI":"10.1093\/burnst\/tkac001","volume":"10","author":"S Xia","year":"2022","unstructured":"Xia S, Weng T, Jin R, Yang M, Yu M, Zhang W, et al. Curcumin-incorporated 3D bioprinting gelatin methacryloyl hydrogel reduces reactive oxygen species-induced adipose-derived stem cell apoptosis and improves implanting survival in diabetic wounds. Burns Trauma. 2022;10:tkac001.","journal-title":"Burns Trauma"},{"key":"5072_CR18","doi-asserted-by":"publisher","first-page":"rbaf073","DOI":"10.1093\/rb\/rbaf073","volume":"12","author":"W Liu","year":"2025","unstructured":"Liu W, Li Q, Song G, Lin Z, Gong X, Feng H, et al. A novel paclitaxel eluting bioresorbable vascular stent with a super flexible stent structure and round cross section struts fabricated using 3D printing technology with a rotating platform. Regen Biomater. 2025;12:rbaf073.","journal-title":"Regen Biomater"},{"key":"5072_CR19","doi-asserted-by":"publisher","first-page":"114337","DOI":"10.1016\/j.colsurfb.2024.114337","volume":"245","author":"Y Zhu","year":"2025","unstructured":"Zhu Y, Liu X, Zhang K, El-Newehy M, Abdulhameed MM, Mo X, et al. Application of electrospinning and 3D-printing based bilayer composite scaffold in the skull base reconstruction during transnasal surgery. Colloids Surf B Biointerfaces. 2025;245:114337.","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"1","key":"5072_CR20","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40580-022-00329-3","volume":"9","author":"SH Lee","year":"2022","unstructured":"Lee SH, Jeon S, Qu X, Kang MS, Lee JH, Han DW, et al. Ternary MXene-loaded PLCL\/collagen nanofibrous scaffolds that promote spontaneous osteogenic differentiation. Nano Converg. 2022;9(1):38.","journal-title":"Nano Converg"},{"key":"5072_CR21","doi-asserted-by":"crossref","unstructured":"Bar JK, Kowalczyk T, Grelewski PG, Stamnitz S, Paprocka M, Lis J et al. Characterization of Biological Properties of Dental Pulp Stem Cells Grown on an Electrospun Poly(l-lactide-co-caprolactone) Scaffold. Materials (Basel). 2022;15(5): 1900.","DOI":"10.3390\/ma15051900"},{"key":"5072_CR22","doi-asserted-by":"publisher","first-page":"114734","DOI":"10.1016\/j.biopha.2023.114734","volume":"162","author":"G Wang","year":"2023","unstructured":"Wang G, Ju S, Li X, Cai Y, Li Y, Li W, et al. Preclinical animal study of electrospun poly (l-lactide-co-caprolactone) and formulated porcine fibrinogen for full-thickness diabetic wound regeneration. Biomed Pharmacother. 2023;162:114734.","journal-title":"Biomed Pharmacother"},{"key":"5072_CR23","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.ijbiomac.2021.11.146","volume":"194","author":"A Li","year":"2022","unstructured":"Li A, Li L, Zhao B, Li X, Liang W, Lang M, et al. Antibacterial, antioxidant and anti-inflammatory PLCL\/gelatin nanofiber membranes to promote wound healing. Int J Biol Macromol. 2022;194:914\u201323.","journal-title":"Int J Biol Macromol"},{"key":"5072_CR24","doi-asserted-by":"crossref","unstructured":"Zhao Y, Liu H. Application of PLCL as a biodegradable polymer in biomedical engineering. J Mater Sci Mater Med. 2026;37(1).","DOI":"10.1007\/s10856-026-07016-3"},{"key":"5072_CR25","doi-asserted-by":"publisher","first-page":"1446050","DOI":"10.3389\/fcell.2024.1446050","volume":"12","author":"H Zhuo","year":"2024","unstructured":"Zhuo H, Chen Y, Zhao G. Advances in application of hypoxia-preconditioned mesenchymal stem cell-derived exosomes. Front Cell Dev Biol. 2024;12:1446050.","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"5072_CR26","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13287-025-04207-7","volume":"16","author":"Q Deng","year":"2025","unstructured":"Deng Q, Du F, Pan S, Xia Y, Zhu Y, Zhang J, et al. Activation of angiopoietin-1 signaling with engineering mesenchymal stem cells promoted efficient angiogenesis in diabetic wound healing. Stem Cell Res Ther. 2025;16(1):75.","journal-title":"Stem Cell Res Ther"},{"key":"5072_CR27","doi-asserted-by":"publisher","first-page":"177574","DOI":"10.1016\/j.ejphar.2025.177574","volume":"996","author":"B Isildar","year":"2025","unstructured":"Isildar B, Ozkan S, Neccar D, Koyuturk M. Preconditioning and post-preconditioning states of mesenchymal stem cells with deferoxamine: A comprehensive analysis. Eur J Pharmacol. 2025;996:177574.","journal-title":"Eur J Pharmacol"},{"key":"5072_CR28","doi-asserted-by":"publisher","first-page":"112026","DOI":"10.1016\/j.biopha.2021.112026","volume":"142","author":"K Moeinabadi-Bidgoli","year":"2021","unstructured":"Moeinabadi-Bidgoli K, Babajani A, Yazdanpanah G, Farhadihosseinabadi B, Jamshidi E, Bahrami S, et al. Translational insights into stem cell preconditioning: From molecular mechanisms to preclinical applications. Biomed Pharmacother. 2021;142:112026.","journal-title":"Biomed Pharmacother"},{"key":"5072_CR29","doi-asserted-by":"crossref","unstructured":"Dong Y, Zhang Y, Lin Z, Li X, Guo Z, Li T et al. Negative pressure mechanical signal increases the phosphorylation of eNOS Ser1177 by upregulating HSP90 expression to promote wound angiogenesis. J Adv Res. 2025.","DOI":"10.1016\/j.jare.2025.07.041"},{"issue":"1","key":"5072_CR30","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1186\/s13287-022-03070-0","volume":"13","author":"X Zhang","year":"2022","unstructured":"Zhang X, Zhang S, Wang T. How the mechanical microenvironment of stem cell growth affects their differentiation: a review. Stem Cell Res Ther. 2022;13(1):415.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"5072_CR31","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s13578-021-00601-9","volume":"11","author":"Y Sun","year":"2021","unstructured":"Sun Y, Yuan Y, Wu W, Lei L, Zhang L. The effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation. Cell Biosci. 2021;11(1):88.","journal-title":"Cell Biosci"},{"issue":"21","key":"5072_CR32","doi-asserted-by":"publisher","first-page":"e2300670","DOI":"10.1002\/advs.202300670","volume":"10","author":"Y Shou","year":"2023","unstructured":"Shou Y, Teo XY, Wu KZ, Bai B, Kumar ARK, Low J, et al. Dynamic Stimulations with Bioengineered Extracellular Matrix-Mimicking Hydrogels for Mechano Cell Reprogramming and Therapy. Adv Sci (Weinh). 2023;10(21):e2300670.","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"5072_CR33","doi-asserted-by":"publisher","first-page":"114461","DOI":"10.1016\/j.yexcr.2025.114461","volume":"446","author":"N Ma","year":"2025","unstructured":"Ma N, Huang L, Zhou Q, Zhang X, Luo Q, Song G. Mechanical stretch promotes the migration of mesenchymal stem cells via Piezo1\/F-actin\/YAP axis. Exp Cell Res. 2025;446(1):114461.","journal-title":"Exp Cell Res"},{"issue":"6","key":"5072_CR34","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/s10237-010-0285-8","volume":"10","author":"TM Maul","year":"2011","unstructured":"Maul TM, Chew DW, Nieponice A, Vorp DA. Mechanical stimuli differentially control stem cell behavior: morphology, proliferation, and differentiation. Biomech Model Mechanobiol. 2011;10(6):939\u201353.","journal-title":"Biomech Model Mechanobiol"},{"issue":"4","key":"5072_CR35","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.bbrc.2015.10.157","volume":"468","author":"Z Zhu","year":"2015","unstructured":"Zhu Z, Gan X, Fan H, Yu H. Mechanical stretch endows mesenchymal stem cells stronger angiogenic and anti-apoptotic capacities via NF\u03baB activation. Biochem Biophys Res Commun. 2015;468(4):601\u20135.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"5072_CR36","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/s41551-020-00674-w","volume":"5","author":"J Lee","year":"2021","unstructured":"Lee J, Henderson K, Massidda MW, Armenta-Ochoa M, Im BG, Veith A, et al. Mechanobiological conditioning of mesenchymal stem cells for enhanced vascular regeneration. Nat Biomed Eng. 2021;5(1):89\u2013102.","journal-title":"Nat Biomed Eng"},{"key":"5072_CR37","doi-asserted-by":"publisher","first-page":"tkaf022","DOI":"10.1093\/burnst\/tkaf022","volume":"13","author":"W Dai","year":"2025","unstructured":"Dai W, Zhou H, Du J, Xiao R, Su J, Liu Z, et al. Mechanical stretching enhances the cellular and paracrine effects of bone marrow mesenchymal stem cells on diabetic wound healing. Burns Trauma. 2025;13:tkaf022.","journal-title":"Burns Trauma"},{"issue":"1","key":"5072_CR38","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12958-022-00988-1","volume":"20","author":"L Yuan","year":"2022","unstructured":"Yuan L, Cao J, Hu M, Xu D, Li Y, Zhao S, et al. Bone marrow mesenchymal stem cells combined with estrogen synergistically promote endometrial regeneration and reverse EMT via Wnt\/\u03b2-catenin signaling pathway. Reprod Biol Endocrinol. 2022;20(1):121.","journal-title":"Reprod Biol Endocrinol"},{"issue":"35","key":"5072_CR39","doi-asserted-by":"publisher","first-page":"45989","DOI":"10.1021\/acsami.4c08174","volume":"16","author":"F Huang","year":"2024","unstructured":"Huang F, Gao T, Feng Y, Xie Y, Tai C, Huang Y, et al. Bioinspired Collagen Scaffold Loaded with bFGF-Overexpressing Human Mesenchymal Stromal Cells Accelerating Diabetic Skin Wound Healing via HIF-1 Signal Pathway Regulated Neovascularization. ACS Appl Mater Interfaces. 2024;16(35):45989\u20136004.","journal-title":"ACS Appl Mater Interfaces"},{"key":"5072_CR40","doi-asserted-by":"publisher","first-page":"112700","DOI":"10.1016\/j.colsurfb.2022.112700","volume":"218","author":"J Li","year":"2022","unstructured":"Li J, Hou W, Yang Y, Deng Q, Fu H, Yin Y, et al. Micro\/nano-topography promotes osteogenic differentiation of bone marrow stem cells by regulating periostin expression. Colloids Surf B Biointerfaces. 2022;218:112700.","journal-title":"Colloids Surf B Biointerfaces"},{"key":"5072_CR41","doi-asserted-by":"publisher","first-page":"115975","DOI":"10.1016\/j.intimp.2025.115975","volume":"169","author":"W Li","year":"2025","unstructured":"Li W, Li Z, Guo Z, Guo F, Tang K, Zhang Y, et al. Periostin drives rheumatoid arthritis progression by regulating integrin \u03b1v\u03b23-mediated transforming growth factor-\u03b21\/SMAD signaling. Int Immunopharmacol. 2025;169:115975.","journal-title":"Int Immunopharmacol"},{"issue":"11","key":"5072_CR42","doi-asserted-by":"publisher","first-page":"a041244","DOI":"10.1101\/cshperspect.a041244","volume":"14","author":"AM Overmiller","year":"2022","unstructured":"Overmiller AM, Sawaya AP, Hope ED, Morasso MI. Intrinsic Networks Regulating Tissue Repair: Comparative Studies of Oral and Skin Wound Healing. Cold Spring Harb Perspect Biol. 2022;14(11):a041244.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"10","key":"5072_CR43","doi-asserted-by":"publisher","first-page":"e2305076","DOI":"10.1002\/smll.202305076","volume":"20","author":"J Liu","year":"2024","unstructured":"Liu J, Chen Z, Liu H, Qin S, Li M, Shi L, et al. Nickel-Based Metal-Organic Frameworks Promote Diabetic Wound Healing via Scavenging Reactive Oxygen Species and Enhancing Angiogenesis. Small. 2024;20(10):e2305076.","journal-title":"Small"},{"issue":"1","key":"5072_CR44","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s13287-021-02288-8","volume":"12","author":"J Yan","year":"2021","unstructured":"Yan J, Liang J, Cao Y, El Akkawi MM, Liao X, Chen X, et al. Efficacy of topical and systemic transplantation of mesenchymal stem cells in a rat model of diabetic ischemic wounds. Stem Cell Res Ther. 2021;12(1):220.","journal-title":"Stem Cell Res Ther"},{"key":"5072_CR45","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.ijbiomac.2022.10.157","volume":"224","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Jiang W, Kong L, Fu J, Zhang Q, Liu H. PLGA@IL-8 nanoparticles-loaded acellular dermal matrix as a delivery system for exogenous MSCs in diabetic wound healing. Int J Biol Macromol. 2023;224:688\u201398.","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"5072_CR46","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1186\/s13287-022-03115-4","volume":"13","author":"S Du","year":"2022","unstructured":"Du S, Zeugolis DI, O\u2019Brien T. Scaffold-based delivery of mesenchymal stromal cells to diabetic wounds. Stem Cell Res Ther. 2022;13(1):426.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"5072_CR47","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1021\/acsami.6b14020","volume":"9","author":"M Suhaeri","year":"2017","unstructured":"Suhaeri M, Subbiah R, Kim SH, Kim CH, Oh SJ, Kim SH, et al. Novel Platform of Cardiomyocyte Culture and Coculture via Fibroblast-Derived Matrix-Coupled Aligned Electrospun Nanofiber. ACS Appl Mater Interfaces. 2017;9(1):224\u201335.","journal-title":"ACS Appl Mater Interfaces"},{"key":"5072_CR48","doi-asserted-by":"publisher","first-page":"111872","DOI":"10.1016\/j.msec.2021.111872","volume":"121","author":"X Wang","year":"2021","unstructured":"Wang X, Liu J, Jing H, Li B, Sun Z, Li B, et al. Biofabrication of poly(l-lactide-co-\u03b5-caprolactone)\/silk fibroin scaffold for the application as superb anti-calcification tissue engineered prosthetic valve. Mater Sci Eng C Mater Biol Appl. 2021;121:111872.","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"issue":"1","key":"5072_CR49","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s13287-025-04249-x","volume":"16","author":"SK Kureel","year":"2025","unstructured":"Kureel SK, Maroto R, Davis K, Sheetz M. Cellular mechanical memory: a potential tool for mesenchymal stem cell-based therapy. Stem Cell Res Ther. 2025;16(1):159.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"5072_CR50","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1186\/s12951-023-02073-0","volume":"21","author":"Y Yu","year":"2023","unstructured":"Yu Y, Jin H, Li L, Zhang X, Zheng C, Gao X, et al. An injectable, activated neutrophil-derived exosome mimetics\/extracellular matrix hybrid hydrogel with antibacterial activity and wound healing promotion effect for diabetic wound therapy. J Nanobiotechnol. 2023;21(1):308.","journal-title":"J Nanobiotechnol"},{"key":"5072_CR51","doi-asserted-by":"publisher","first-page":"116035","DOI":"10.1016\/j.biopha.2023.116035","volume":"170","author":"X Wang","year":"2024","unstructured":"Wang X, Li R, Zhao H. Enhancing angiogenesis: Innovative drug delivery systems to facilitate diabetic wound healing. Biomed Pharmacother. 2024;170:116035.","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"5072_CR52","doi-asserted-by":"publisher","first-page":"312","DOI":"10.3390\/cells9020312","volume":"9","author":"G Merckx","year":"2020","unstructured":"Merckx G, Hosseinkhani B, Kuypers S, Deville S, Irobi J, Nelissen I, et al. Angiogenic Effects of Human Dental Pulp and Bone Marrow-Derived Mesenchymal Stromal Cells and their Extracellular Vesicles. Cells. 2020;9(2):312.","journal-title":"Cells"},{"issue":"1","key":"5072_CR53","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s13287-022-02865-5","volume":"13","author":"J Xiang","year":"2022","unstructured":"Xiang J, Zhou L, Xie Y, Zhu Y, Xiao L, Chen Y, et al. Mesh-like electrospun membrane loaded with atorvastatin facilitates cutaneous wound healing by promoting the paracrine function of mesenchymal stem cells. Stem Cell Res Ther. 2022;13(1):190.","journal-title":"Stem Cell Res Ther"},{"issue":"4","key":"5072_CR54","doi-asserted-by":"publisher","first-page":"e25234","DOI":"10.1016\/j.heliyon.2024.e25234","volume":"10","author":"K Li","year":"2024","unstructured":"Li K, Shen C, Wen N, Han Y, Guo L. EPO regulates the differentiation and homing of bone marrow mesenchymal stem cells through Notch1\/Jagged pathway to treat pulmonary hypertension. Heliyon. 2024;10(4):e25234.","journal-title":"Heliyon"},{"issue":"6","key":"5072_CR55","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1039\/C9LC01170F","volume":"20","author":"WY Wang","year":"2020","unstructured":"Wang WY, Lin D, Jarman EH, Polacheck WJ, Baker BM. Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation. Lab Chip. 2020;20(6):1153\u201366.","journal-title":"Lab Chip"},{"issue":"1","key":"5072_CR56","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s12933-023-01965-7","volume":"22","author":"Y An","year":"2023","unstructured":"An Y, Xu BT, Wan SR, Ma XM, Long Y, Xu Y, et al. The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction. Cardiovasc Diabetol. 2023;22(1):237.","journal-title":"Cardiovasc Diabetol"},{"key":"5072_CR57","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.mvr.2012.10.005","volume":"85","author":"B Sharma","year":"2013","unstructured":"Sharma B, Albig AR. Matrix Gla protein reinforces angiogenic resolution. Microvasc Res. 2013;85:24\u201333.","journal-title":"Microvasc Res"},{"key":"5072_CR58","doi-asserted-by":"publisher","first-page":"4581954","DOI":"10.1155\/2020\/4581954","volume":"2020","author":"P Liu","year":"2020","unstructured":"Liu P, Zhu Y, Li Q, Cheng B. Comprehensive Analysis of Differentially Expressed miRNAs and mRNAs Reveals That miR-181a-5p Plays a Key Role in Diabetic Dermal Fibroblasts. J Diabetes Res. 2020;2020:4581954.","journal-title":"J Diabetes Res"},{"issue":"26","key":"5072_CR59","doi-asserted-by":"publisher","first-page":"24200","DOI":"10.1074\/jbc.M302028200","volume":"278","author":"CG Lin","year":"2003","unstructured":"Lin CG, Leu SJ, Chen N, Tebeau CM, Lin SX, Yeung CY, et al. CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family. J Biol Chem. 2003;278(26):24200\u20138.","journal-title":"J Biol Chem"},{"issue":"7","key":"5072_CR60","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1016\/j.jid.2019.11.026","volume":"140","author":"P Henrot","year":"2020","unstructured":"Henrot P, Moisan F, Laurent P, Manicki P, Kaulanjan-Checkmodine P, Jolivel V, et al. Decreased CCN3 in Systemic Sclerosis Endothelial Cells Contributes to Impaired Angiogenesis. J Invest Dermatol. 2020;140(7):1427\u2013e345.","journal-title":"J Invest Dermatol"},{"key":"5072_CR61","doi-asserted-by":"publisher","first-page":"6275","DOI":"10.2147\/IJN.S431725","volume":"18","author":"H Yu","year":"2023","unstructured":"Yu H, Wu Y, Zhang B, Xiong M, Yi Y, Zhang Q, et al. Exosomes Derived from E2F1(-\/-) Adipose-Derived Stem Cells Promote Skin Wound Healing via miR-130b-5p\/TGFBR3 Axis. Int J Nanomed. 2023;18:6275\u201392.","journal-title":"Int J Nanomed"},{"issue":"4","key":"5072_CR62","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s12079-022-00674-2","volume":"16","author":"Z Wang","year":"2022","unstructured":"Wang Z, An J, Zhu D, Chen H, Lin A, Kang J, et al. Periostin: an emerging activator of multiple signaling pathways. J Cell Commun Signal. 2022;16(4):515\u201330.","journal-title":"J Cell Commun Signal"},{"issue":"2","key":"5072_CR63","doi-asserted-by":"publisher","first-page":"e70354","DOI":"10.1096\/fj.202402944R","volume":"39","author":"Y Liu","year":"2025","unstructured":"Liu Y, Yang Z, Na J, Chen X, Wang Z, Zheng L, et al. In vitro stretch modulates mitochondrial dynamics and energy metabolism to induce smooth muscle differentiation in mesenchymal stem cells. Faseb j. 2025;39(2):e70354.","journal-title":"Faseb j"},{"issue":"18","key":"5072_CR64","doi-asserted-by":"publisher","first-page":"9862","DOI":"10.7150\/thno.118364","volume":"15","author":"Y Xiao","year":"2025","unstructured":"Xiao Y, Shi Z, Yuan Y, Yao D, Feng R, Zhang Y, et al. Cyclic mechanical stretching enhances mitophagy and oxidative stress resistance in adipose-derived stem cells via the Piezo1\/ATP axis to accelerate wound healing. Theranostics. 2025;15(18):9862\u201384.","journal-title":"Theranostics"},{"issue":"9","key":"5072_CR65","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.3390\/pharmaceutics15092285","volume":"15","author":"K Li","year":"2023","unstructured":"Li K, Zhu Z, Zhai Y, Chen S. Recent Advances in Electrospun Nanofiber-Based Strategies for Diabetic Wound Healing Application. Pharmaceutics. 2023;15(9):2285.","journal-title":"Pharmaceutics"},{"issue":"7","key":"5072_CR66","doi-asserted-by":"publisher","first-page":"983","DOI":"10.3390\/pharmaceutics13070983","volume":"13","author":"AM Gon\u00e7alves","year":"2021","unstructured":"Gon\u00e7alves AM, Moreira A, Weber A, Williams GR, Costa PF. Osteochondral Tissue Engineering: The Potential of Electrospinning and Additive Manufacturing. Pharmaceutics. 2021;13(7):983.","journal-title":"Pharmaceutics"},{"issue":"1","key":"5072_CR67","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1038\/s42003-021-02237-4","volume":"4","author":"S Petrus-Reurer","year":"2021","unstructured":"Petrus-Reurer S, Romano M, Howlett S, Jones JL, Lombardi G, Saeb-Parsy K. Immunological considerations and challenges for regenerative cellular therapies. Commun Biol. 2021;4(1):798.","journal-title":"Commun Biol"}],"container-title":["Stem Cell Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-026-05072-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-026-05072-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-026-05072-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:07:34Z","timestamp":1785888454000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13287-026-05072-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,30]]},"references-count":67,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5072"],"URL":"https:\/\/doi.org\/10.1186\/s13287-026-05072-8","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,30]]},"assertion":[{"value":"10 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Animal ethics: (1) Title of approved project: Study on mechanical reprogramming modulating paracrine signaling of BMSCs to promote personalized repair of ECM in chronic wounds (2). Committee and affiliation: the Ethics Committee for Experimental Animal Center of the Fourth Military Medical University (3). Approval No. 20240252 (4). Date of approval: 29 February 2024. The work has been reported in line with the ARRIVE guidelines 2.0.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"266"}}