{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:17:34Z","timestamp":1788787054310,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":76,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82402893"],"award-info":[{"award-number":["82402893"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82402760"],"award-info":[{"award-number":["82402760"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Postdoctoral Fellowship Program of China Postdoctoral Science Foundation","award":["GZC20240144"],"award-info":[{"award-number":["GZC20240144"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2025-PUMCH-A-115"],"award-info":[{"award-number":["2025-PUMCH-A-115"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2025-PUMCH-D-001"],"award-info":[{"award-number":["2025-PUMCH-D-001"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2025-I2M-XHXX-020"],"award-info":[{"award-number":["2025-I2M-XHXX-020"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2021-I2M-1-052"],"award-info":[{"award-number":["2021-I2M-1-052"]}]},{"name":"National Key Research and Development Program of China","award":["2022YFC2703901"],"award-info":[{"award-number":["2022YFC2703901"]}]},{"name":"Beijing Municipal Science & Technology Commission, Administrative Commission of Zhongguancun Science Park","award":["Z251100004625001"],"award-info":[{"award-number":["Z251100004625001"]}]},{"name":"Independent Research Fund of the State Key Laboratory of Complex, Severe, and Rare Diseases","award":["2025-I-PY-006"],"award-info":[{"award-number":["2025-I-PY-006"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-026-05112-3","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:46:18Z","timestamp":1782211578000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SIRT6 enhances the therapeutic potential of extracellular vesicles in mitigating osteoarthritis in rat models"],"prefix":"10.1186","volume":"17","author":[{"given":"Guihua","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huitian","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifa","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"issue":"10472","key":"5112_CR1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0140-6736(24)02322-5","volume":"405","author":"M Kloppenburg","year":"2025","unstructured":"Kloppenburg M, Namane M, Cicuttini F, Osteoarthritis. Lancet. 2025;405(10472):71\u201385.","journal-title":"Lancet"},{"issue":"3","key":"5112_CR2","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s40265-024-02138-w","volume":"85","author":"N Fuggle","year":"2025","unstructured":"Fuggle N, Laslop A, Rizzoli R, Al-Daghri N, Alokail M, Balkowiec-Iskra E, et al. Treatment of Osteoporosis and Osteoarthritis in the Oldest Old. Drugs. 2025;85(3):343\u201360.","journal-title":"Drugs"},{"issue":"2","key":"5112_CR3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.joca.2024.08.014","volume":"33","author":"TV Pereira","year":"2025","unstructured":"Pereira TV, Saadat P, Bobos P, Iskander SM, Bodmer NS, Rudnicki M, et al. Effectiveness and safety of intra-articular interventions for knee and hip osteoarthritis based on large randomized trials: A systematic review and network meta-analysis. Osteoarthritis Cartilage. 2025;33(2):207\u201317.","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"5112_CR4","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1001\/jama.2020.22171","volume":"325","author":"JN Katz","year":"2021","unstructured":"Katz JN, Arant KR, Loeser RF. Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review. JAMA. 2021;325(6):568\u201378.","journal-title":"JAMA"},{"issue":"1","key":"5112_CR5","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12951-021-01236-1","volume":"20","author":"K Li","year":"2022","unstructured":"Li K, Yan G, Huang H, Zheng M, Ma K, Cui X, et al. Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages. J Nanobiotechnol. 2022;20(1):38.","journal-title":"J Nanobiotechnol"},{"issue":"1","key":"5112_CR6","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1186\/s13287-024-03905-y","volume":"15","author":"Q Fu","year":"2024","unstructured":"Fu Q, Han M, Dai X, Lu R, Deng E, Shen X, et al. Therapeutic effect of three-dimensional hanging drop cultured human umbilical cord mesenchymal stem cells on osteoarthritis in rabbits. Stem Cell Res Ther. 2024;15(1):311.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"5112_CR7","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1186\/s13287-022-03005-9","volume":"13","author":"H Zhou","year":"2022","unstructured":"Zhou H, Shen X, Yan C, Xiong W, Ma Z, Tan Z, et al. Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage. Stem Cell Res Ther. 2022;13(1):322.","journal-title":"Stem Cell Res Ther"},{"key":"5112_CR8","doi-asserted-by":"publisher","first-page":"115203","DOI":"10.1016\/j.addr.2024.115203","volume":"207","author":"M van Griensven","year":"2024","unstructured":"van Griensven M, Balmayor ER. Extracellular vesicles are key players in mesenchymal stem cells\u2019 dual potential to regenerate and modulate the immune system. Adv Drug Deliv Rev. 2024;207:115203.","journal-title":"Adv Drug Deliv Rev"},{"key":"5112_CR9","first-page":"423","volume":"22","author":"Z Liu","year":"2023","unstructured":"Liu Z, Zhuang Y, Fang L, Yuan C, Wang X, Lin K. Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis. Bioact Mater. 2023;22:423\u201352.","journal-title":"Bioact Mater"},{"issue":"6","key":"5112_CR10","doi-asserted-by":"publisher","first-page":"337","DOI":"10.4252\/wjsc.v11.i6.337","volume":"11","author":"JA Fafi\u00e1n-Labora","year":"2019","unstructured":"Fafi\u00e1n-Labora JA, Morente-L\u00f3pez M, Arufe MC. Effect of aging on behaviour of mesenchymal stem cells. World J Stem Cells. 2019;11(6):337\u201346.","journal-title":"World J Stem Cells"},{"key":"5112_CR11","doi-asserted-by":"crossref","unstructured":"Chanda D, Rehan M, Smith SR, Dsouza KG, Wang Y, Bernard K et al. Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells. Elife. 2021;10:e68049.","DOI":"10.7554\/eLife.68049"},{"issue":"12","key":"5112_CR12","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.tcb.2021.06.009","volume":"31","author":"A Korotkov","year":"2021","unstructured":"Korotkov A, Seluanov A, Gorbunova V. Sirtuin 6: linking longevity with genome and epigenome stability. Trends Cell Biol. 2021;31(12):994\u20131006.","journal-title":"Trends Cell Biol"},{"issue":"6","key":"5112_CR13","doi-asserted-by":"publisher","first-page":"2680","DOI":"10.1016\/j.apsb.2023.03.019","volume":"13","author":"K Peng","year":"2023","unstructured":"Peng K, Zeng C, Gao Y, Liu B, Li L, Xu K, et al. Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling. Acta Pharm Sin B. 2023;13(6):2680\u2013700.","journal-title":"Acta Pharm Sin B"},{"issue":"10","key":"5112_CR14","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.jcyt.2019.08.002","volume":"21","author":"S Viswanathan","year":"2019","unstructured":"Viswanathan S, Shi Y, Galipeau J, Krampera M, Leblanc K, Martin I, et al. Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT\u00ae) Mesenchymal Stromal Cell committee position statement on nomenclature. Cytotherapy. 2019;21(10):1019\u201324.","journal-title":"Cytotherapy"},{"issue":"735","key":"5112_CR15","doi-asserted-by":"publisher","first-page":"eadh9751","DOI":"10.1126\/scitranslmed.adh9751","volume":"16","author":"R Deng","year":"2024","unstructured":"Deng R, Zhao R, Zhang Z, Chen Y, Yang M, Lin Y, et al. Chondrocyte membrane-coated nanoparticles promote drug retention and halt cartilage damage in rat and canine osteoarthritis. Sci Transl Med. 2024;16(735):eadh9751.","journal-title":"Sci Transl Med"},{"issue":"2","key":"5112_CR16","doi-asserted-by":"publisher","first-page":"165","DOI":"10.4142\/jvs.2015.16.2.165","volume":"16","author":"YH Kim","year":"2015","unstructured":"Kim YH, Kang JS. Micro-computed tomography evaluation and pathological analyses of female rats with collagen-induced arthritis. J Vet Sci. 2015;16(2):165\u201371.","journal-title":"J Vet Sci"},{"issue":"11","key":"5112_CR17","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1136\/ard-2023-224385","volume":"82","author":"JA Collins","year":"2023","unstructured":"Collins JA, Kim CJ, Coleman A, Little A, Perez MM, Clarke EJ, et al. Cartilage-specific Sirt6 deficiency represses IGF-1 and enhances osteoarthritis severity in mice. Ann Rheum Dis. 2023;82(11):1464\u201373.","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"5112_CR18","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.joca.2021.01.006","volume":"29","author":"AR Armstrong","year":"2021","unstructured":"Armstrong AR, Carlson CS, Rendahl AK, Loeser RF. Optimization of histologic grading schemes in spontaneous and surgically-induced murine models of osteoarthritis. Osteoarthritis Cartilage. 2021;29(4):536\u201346.","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"5112_CR19","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1177\/1947603511402665","volume":"2","author":"MA McNulty","year":"2011","unstructured":"McNulty MA, Loeser RF, Davey C, Callahan MF, Ferguson CM, Carlson CS. A Comprehensive Histological Assessment of Osteoarthritis Lesions in Mice. Cartilage. 2011;2(4):354\u201363.","journal-title":"Cartilage"},{"issue":"23","key":"5112_CR20","first-page":"1987","volume":"118","author":"L Ma","year":"2005","unstructured":"Ma L, Feng XY, Cui BL, Law F, Jiang XW, Yang LY, et al. Human umbilical cord Wharton\u2019s Jelly-derived mesenchymal stem cells differentiation into nerve-like cells. Chin Med J (Engl). 2005;118(23):1987\u201393.","journal-title":"Chin Med J (Engl)"},{"issue":"1","key":"5112_CR21","doi-asserted-by":"publisher","first-page":"e70029","DOI":"10.1002\/jev2.70029","volume":"14","author":"W Liu","year":"2025","unstructured":"Liu W, Wang X, Chen Y, Yuan J, Zhang H, Jin X, et al. Distinct molecular properties and functions of small EV subpopulations isolated from human umbilical cord MSCs using tangential flow filtration combined with size exclusion chromatography. J Extracell Vesicles. 2025;14(1):e70029.","journal-title":"J Extracell Vesicles"},{"issue":"11","key":"5112_CR22","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/s41584-023-01010-7","volume":"19","author":"GM Bertolino","year":"2023","unstructured":"Bertolino GM, Maumus M, Jorgensen C, No\u00ebl D. Therapeutic potential in rheumatic diseases of extracellular vesicles derived from mesenchymal stromal cells. Nat Rev Rheumatol. 2023;19(11):682\u201394.","journal-title":"Nat Rev Rheumatol"},{"key":"5112_CR23","doi-asserted-by":"crossref","unstructured":"Lei Q, Gao F, Liu T, Ren W, Chen L, Cao Y et al. Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow-derived mesenchymal stem cells and slow age-related degeneration. Sci Transl Med. 2021;13(578):eaaz8697.","DOI":"10.1126\/scitranslmed.aaz8697"},{"issue":"7","key":"5112_CR24","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.tibtech.2024.01.001","volume":"42","author":"GS Major","year":"2024","unstructured":"Major GS, Doan VK, Longoni A, Bilek MMM, Wise SG, Rnjak-Kovacina J, et al. Mapping the microcarrier design pathway to modernise clinical mesenchymal stromal cell expansion. Trends Biotechnol. 2024;42(7):859\u201376.","journal-title":"Trends Biotechnol"},{"key":"5112_CR25","doi-asserted-by":"publisher","first-page":"204173142312003","DOI":"10.1177\/20417314231200328","volume":"14","author":"Q Chen","year":"2023","unstructured":"Chen Q, Jin M, Wang S, Wang K, Chen L, Zhu X, et al. Establishing an hTERT-driven immortalized umbilical cord-derived mesenchymal stem cell line and its therapeutic application in mice with liver failure. J Tissue Eng. 2023;14:20417314231200328.","journal-title":"J Tissue Eng"},{"key":"5112_CR26","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.jbiotec.2026.03.010","volume":"414","author":"A Brancolini","year":"2026","unstructured":"Brancolini A, Bobbili MR, Pultar M, Mazidi Z, Wieser M, Gamauf J, et al. Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles. J Biotechnol. 2026;414:124\u201345.","journal-title":"J Biotechnol"},{"key":"5112_CR27","doi-asserted-by":"crossref","unstructured":"Carius P, Jungmann A, Bechtel M, Gri\u00dfmer A, Boese A, Gasparoni G et al. A monoclonal human alveolar epithelial cell line (Arlo) with pronounced barrier function for studying drug permeability and viral infections. Adv Sci. 2023;10(8):2207301.","DOI":"10.1002\/advs.202207301"},{"issue":"43","key":"5112_CR28","doi-asserted-by":"publisher","first-page":"4579","DOI":"10.1093\/eurheartj\/ehac431","volume":"43","author":"C Chi","year":"2022","unstructured":"Chi C, Fu H, Li YH, Zhang GY, Zeng FY, Ji QX, et al. Exerkine fibronectin type-III domain-containing protein 5\/irisin-enriched extracellular vesicles delay vascular ageing by increasing SIRT6 stability. Eur Heart J. 2022;43(43):4579\u201395.","journal-title":"Eur Heart J"},{"issue":"1","key":"5112_CR29","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1186\/s13287-025-04743-2","volume":"16","author":"Y Tong","year":"2025","unstructured":"Tong Y, Sun J, Jiang X, Jia X, Jia Y, Wang H, et al. Stable production of immortalized hPC-MSC-derived extracellular vesicles: integrated cargo analysis and functional validation. Stem Cell Res Ther. 2025;16(1):619.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"5112_CR30","doi-asserted-by":"publisher","first-page":"13434","DOI":"10.1038\/s41598-018-31829-0","volume":"8","author":"T Wagner","year":"2018","unstructured":"Wagner T, Gschwandtner M, Strajeriu A, Elbe-B\u00fcrger A, Grillari J, Grillari-Voglauer R, et al. Establishment of keratinocyte cell lines from human hair follicles. Sci Rep. 2018;8(1):13434.","journal-title":"Sci Rep"},{"issue":"5","key":"5112_CR31","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/jbm4.10050","volume":"2","author":"NA Twine","year":"2018","unstructured":"Twine NA, Harkness L, Adjaye J, Aldahmash A, Wilkins MR, Kassem M. Molecular Phenotyping of Telomerized Human Bone Marrow Skeletal Stem Cells Reveals a Genetic Program of Enhanced Proliferation and Maintenance of Differentiation Responses. JBMR Plus. 2018;2(5):257\u201367.","journal-title":"JBMR Plus"},{"issue":"1","key":"5112_CR32","doi-asserted-by":"publisher","first-page":"7658","DOI":"10.1038\/s41467-022-35424-w","volume":"13","author":"ML Ji","year":"2022","unstructured":"Ji ML, Jiang H, Li Z, Geng R, Hu JZ, Lin YC, et al. Sirt6 attenuates chondrocyte senescence and osteoarthritis progression. Nat Commun. 2022;13(1):7658.","journal-title":"Nat Commun"},{"issue":"1","key":"5112_CR33","doi-asserted-by":"publisher","first-page":"2638000","DOI":"10.1080\/07853890.2026.2638000","volume":"58","author":"N Ding","year":"2026","unstructured":"Ding N, He Z, Yang Q. Critical role of Sirtuin 6 (SIRT6) in osteoarthritis chondrocytes: the interaction among various biological processes. Ann Med. 2026;58(1):2638000.","journal-title":"Ann Med"},{"issue":"1","key":"5112_CR34","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41467-017-02586-x","volume":"9","author":"I Santos-Barriopedro","year":"2018","unstructured":"Santos-Barriopedro I, Bosch-Presegu\u00e9 L, Marazuela-Duque A, de la Torre C, Colomer C, Vazquez BN, et al. SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-\u03baB pathway. Nat Commun. 2018;9(1):101.","journal-title":"Nat Commun"},{"issue":"1","key":"5112_CR35","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1186\/s13287-022-03060-2","volume":"13","author":"QY Huang","year":"2022","unstructured":"Huang QY, Chen SR, Zhao YX, Chen JM, Chen WH, Lin S, et al. Melatonin enhances autologous adipose-derived stem cells to improve mouse ovarian function in relation to the SIRT6\/NF-\u03baB pathway. Stem Cell Res Ther. 2022;13(1):399.","journal-title":"Stem Cell Res Ther"},{"key":"5112_CR36","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3389\/fmicb.2019.00355","volume":"10","author":"W Dantoft","year":"2019","unstructured":"Dantoft W, Robertson KA, Watkins WJ, Strobl B, Ghazal P. Metabolic Regulators Nampt and Sirt6 Serially Participate in the Macrophage Interferon Antiviral Cascade. Front Microbiol. 2019;10:355.","journal-title":"Front Microbiol"},{"issue":"1","key":"5112_CR37","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41419-022-05542-w","volume":"14","author":"D Smirnov","year":"2023","unstructured":"Smirnov D, Eremenko E, Stein D, Kaluski S, Jasinska W, Cosentino C, et al. SIRT6 is a key regulator of mitochondrial function in the brain. Cell Death Dis. 2023;14(1):35.","journal-title":"Cell Death Dis"},{"issue":"13","key":"5112_CR38","doi-asserted-by":"publisher","first-page":"4767","DOI":"10.1074\/jbc.M117.816785","volume":"293","author":"T Sheikh","year":"2018","unstructured":"Sheikh T, Gupta P, Gowda P, Patrick S, Sen E. Hexokinase 2 and nuclear factor erythroid 2-related factor 2 transcriptionally coactivate xanthine oxidoreductase expression in stressed glioma cells. J Biol Chem. 2018;293(13):4767\u201377.","journal-title":"J Biol Chem"},{"issue":"7","key":"5112_CR39","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1302\/2046-3758.107.BJR-2019-0251.R4","volume":"10","author":"J Yang","year":"2021","unstructured":"Yang J, Zhou Y, Liang X, Jing B, Zhao Z. MicroRNA-486 promotes a more catabolic phenotype in chondrocyte-like cells by targeting SIRT6: possible involvement in cartilage degradation in osteoarthritis. Bone Joint Res. 2021;10(7):459\u201366.","journal-title":"Bone Joint Res"},{"issue":"6358","key":"5112_CR40","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1126\/science.aao0535","volume":"357","author":"K Chiba","year":"2017","unstructured":"Chiba K, Lorbeer FK, Shain AH, McSwiggen DT, Schruf E, Oh A, et al. Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism. Science. 2017;357(6358):1416\u201320.","journal-title":"Science"},{"issue":"1","key":"5112_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nar\/gkac479","volume":"51","author":"SC Ak\u0131nc\u0131lar","year":"2023","unstructured":"Ak\u0131nc\u0131lar SC, Chua JYH, Ng QF, Chan CHT, Eslami SZ, Chen K, et al. Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer. Nucleic Acids Res. 2023;51(1):1\u201316.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"5112_CR42","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41392-023-01456-x","volume":"8","author":"YN Ding","year":"2023","unstructured":"Ding YN, Wang TT, Lv SJ, Tang X, Wei ZY, Yao F, et al. SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence. Signal Transduct Target Ther. 2023;8(1):255.","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"5112_CR43","doi-asserted-by":"publisher","first-page":"e13026","DOI":"10.1111\/acel.13026","volume":"18","author":"J Li","year":"2019","unstructured":"Li J, Li SH, Dong J, Alibhai FJ, Zhang C, Shao ZB, et al. Long-term repopulation of aged bone marrow stem cells using young Sca-1 cells promotes aged heart rejuvenation. Aging Cell. 2019;18(6):e13026.","journal-title":"Aging Cell"},{"issue":"17","key":"5112_CR44","doi-asserted-by":"publisher","first-page":"7991","DOI":"10.1039\/D3NR00795B","volume":"15","author":"Y Wang","year":"2023","unstructured":"Wang Y, Sheng H, Cong M, Wang W, He Q, Li H, et al. Spatio-temporally deciphering peripheral nerve regeneration in vivo after extracellular vesicle therapy under NIR-II fluorescence imaging. Nanoscale. 2023;15(17):7991\u20138005.","journal-title":"Nanoscale"},{"issue":"14","key":"5112_CR45","doi-asserted-by":"publisher","first-page":"e2311420","DOI":"10.1002\/adma.202311420","volume":"36","author":"M Huang","year":"2024","unstructured":"Huang M, Zheng M, Song Q, Ma X, Zhang Q, Chen H, et al. Comparative Proteomics Inspired Self-Stimulated Release Hydrogel Reinforces the Therapeutic Effects of MSC-EVs on Alzheimer\u2019s Disease. Adv Mater. 2024;36(14):e2311420.","journal-title":"Adv Mater"},{"issue":"6","key":"5112_CR46","doi-asserted-by":"publisher","first-page":"e2411571","DOI":"10.1002\/adma.202411571","volume":"37","author":"S Li","year":"2025","unstructured":"Li S, Yang Y, Yu B, Gao X, Gao X, Nie S, et al. A Novel Deer Antler-Inspired Bone Graft Triggers Rapid Bone Regeneration. Adv Mater. 2025;37(6):e2411571.","journal-title":"Adv Mater"}],"container-title":["Stem Cell Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-026-05112-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-026-05112-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-026-05112-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:03:46Z","timestamp":1788786226000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13287-026-05112-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5112"],"URL":"https:\/\/doi.org\/10.1186\/s13287-026-05112-3","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]},"assertion":[{"value":"17 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The use of hUC-MSCs in this study was approved by the Ethics Committee of Peking Union Medical College Hospital (Approval No.: JS-2613) on 27 October 2020. The approved project title was \u201cCytological Study of Human Umbilical Cord Multipotent Mesenchymal Stromal Cells\u201d. The use of human knee cartilage samples in this study was approved by the Ethics Committee of Wangjing Hospital, China Academy of Chinese Medical Sciences (Approval No.: WJEC-KT-2021-035-P003) on 12 February 2024. The approved project title was \u201cMultimodal Analysis of Knee Cartilage in Osteoarthritis of the Human Joints\u201d. All human samples were obtained with written informed consent from all donors, in accordance with the Declaration of Helsinki. All animal experiments were approved by the Ethics Committee of Peking Union Medical College Hospital (Approval No.: XHDW-2023-072) on 1 August 2023. The approved project title was \u201cMechanism and Application Research of Engineering Stem Cells and Exosomal Vectors in the Treatment of Osteoarthritis\u201d. All procedures were complied with the guide for the care and use of laboratory animals.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"308"}}