{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:43:48Z","timestamp":1792788228164,"version":"4.5.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81871231"],"award-info":[{"award-number":["81871231"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China","award":["82172574"],"award-info":[{"award-number":["82172574"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Natural Science Foundation of Shandong Province","award":["ZR2023MH082"],"award-info":[{"award-number":["ZR2023MH082"]}]},{"name":"Natural Science Foundation of Shandong Province","award":["ZR2024MH083\uff0cZR2025MS1420"],"award-info":[{"award-number":["ZR2024MH083\uff0cZR2025MS1420"]}]},{"name":"Shandong Taishan Scholars Young Experts Program","award":["TSQN202103056"],"award-info":[{"award-number":["TSQN202103056"]}]},{"name":"the Qingdao Natural Science Foundation Key Project","award":["24-8-4-ZRJJ-8-JCH"],"award-info":[{"award-number":["24-8-4-ZRJJ-8-JCH"]}]},{"name":"2024 Health and medical leading innovation team program of Shandong province"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-026-05261-5","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:52:28Z","timestamp":1790340748000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["BMSC-derived EVs alleviate doxorubicin-induced cardiotoxicity via miR-210-3p involving the ACVR1B-SMAD3-PGC-1\u03b1 signaling axis"],"prefix":"10.1186","volume":"17","author":[{"given":"Ruolan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luning","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huhu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yice","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4755-162X","authenticated-orcid":false,"given":"Xian-Ming","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"5261_CR1","doi-asserted-by":"publisher","first-page":"5797","DOI":"10.1038\/s41467-022-33598-x","volume":"13","author":"L Monteran","year":"2022","unstructured":"Monteran L, Ershaid N, Doron H, Zait Y, Scharff Y, Ben-Yosef S, Avivi C, Barshack I. Sonnenblick A and Erez N. Chemotherapy-induced complement signaling modulates immunosuppression and metastatic relapse in breast cancer. Nat Commun. 2022;13:5797.","journal-title":"Nat Commun"},{"key":"5261_CR2","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1200\/JCO.22.01900","volume":"41","author":"UA Matulonis","year":"2023","unstructured":"Matulonis UA, Lorusso D, Oaknin A, Pignata S, Dean A, Denys H, Colombo N, Van Gorp T, Konner JA, Marin MR, Harter P, Murphy CG, Wang J, Noble E, Esteves B, Method M, Coleman RL. Efficacy and Safety of Mirvetuximab Soravtansine in Patients With Platinum-Resistant Ovarian Cancer With High Folate Receptor Alpha Expression: Results From the SORAYA Study. J Clin Oncol. 2023;41:2436\u201345.","journal-title":"J Clin Oncol"},{"key":"5261_CR3","doi-asserted-by":"publisher","first-page":"101205","DOI":"10.1016\/j.mam.2023.101205","volume":"93","author":"R Mattioli","year":"2023","unstructured":"Mattioli R, Ilari A, Colotti B, Mosca L, Fazi F, Colotti G. Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming. Mol Aspects Med. 2023;93:101205.","journal-title":"Mol Aspects Med"},{"key":"5261_CR4","first-page":"101332","volume":"50","author":"C Belger","year":"2024","unstructured":"Belger C, Abrahams C, Imamdin A, Lecour S. Doxorubicin-induced cardiotoxicity and risk factors. Int J Cardiol Heart Vasc. 2024;50:101332.","journal-title":"Int J Cardiol Heart Vasc"},{"key":"5261_CR5","doi-asserted-by":"publisher","first-page":"e2415227","DOI":"10.1002\/advs.202415227","volume":"12","author":"J Huang","year":"2025","unstructured":"Huang J, Yang J, Yang Y, Lu X, Xu J, Lu S, Pan H, Zhou W, Li W, Chen S. Mitigating Doxorubicin-Induced Cardiotoxicity and Enhancing Anti-Tumor Efficacy with a Metformin-Integrated Self-Assembled Nanomedicine. Adv Sci (Weinh). 2025;12:e2415227.","journal-title":"Adv Sci (Weinh)"},{"key":"5261_CR6","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1007\/s11906-010-0146-y","volume":"12","author":"CA Geisberg","year":"2010","unstructured":"Geisberg CA, Sawyer DB. Mechanisms of anthracycline cardiotoxicity and strategies to decrease cardiac damage. Curr Hypertens Rep. 2010;12:404\u201310.","journal-title":"Curr Hypertens Rep"},{"key":"5261_CR7","doi-asserted-by":"publisher","first-page":"102120","DOI":"10.1016\/j.redox.2021.102120","volume":"46","author":"JA Pan","year":"2021","unstructured":"Pan JA, Zhang H, Lin H, Gao L, Zhang HL, Zhang JF, Wang CQ, Gu J. Irisin ameliorates doxorubicin-induced cardiac perivascular fibrosis through inhibiting endothelial-to-mesenchymal transition by regulating ROS accumulation and autophagy disorder in endothelial cells. Redox Biol. 2021;46:102120.","journal-title":"Redox Biol"},{"key":"5261_CR8","doi-asserted-by":"publisher","first-page":"e2206007","DOI":"10.1002\/advs.202206007","volume":"10","author":"J Pan","year":"2023","unstructured":"Pan J, Xiong W, Zhang A, Zhang H, Lin H, Gao L, Ke J, Huang S, Zhang J, Gu J, Chang ACY, Wang C. The Imbalance of p53-Park7 Signaling Axis Induces Iron Homeostasis Dysfunction in Doxorubicin-Challenged Cardiomyocytes. Adv Sci (Weinh). 2023;10:e2206007.","journal-title":"Adv Sci (Weinh)"},{"key":"5261_CR9","doi-asserted-by":"publisher","first-page":"919","DOI":"10.3724\/SP.J.1260.2013.30126","volume":"29","author":"C Zhao","year":"2013","unstructured":"Zhao C, Sun W, Zhang P, Chang Y, Li Y. The Characteristics of Exosomes and Their Roles in Intercellular Communication. Acta Biophys Sinica. 2013;29:919\u201324.","journal-title":"Acta Biophys Sinica"},{"key":"5261_CR10","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","volume":"30","author":"M Colombo","year":"2014","unstructured":"Colombo M, Raposo G, Th\u00e9ry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30:255\u201389.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"5261_CR11","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.7150\/ijbs.58786","volume":"17","author":"C Tian","year":"2021","unstructured":"Tian C, Yang Y, Bai B, Wang S, Liu M, Sun RC, Yu T, Chu XM. Potential of exosomes as diagnostic biomarkers and therapeutic carriers for doxorubicin-induced cardiotoxicity. Int J Biol Sci. 2021;17:1328\u201338.","journal-title":"Int J Biol Sci"},{"key":"5261_CR12","doi-asserted-by":"publisher","first-page":"2852251","DOI":"10.1155\/2022\/2852251","volume":"2022","author":"G Zhang","year":"2022","unstructured":"Zhang G, Yang X, Su X, An N, Yang F, Li X, Jiang Y, Xing Y. Understanding the Protective Role of Exosomes in Doxorubicin-Induced Cardiotoxicity. Oxid Med Cell Longev. 2022;2022:2852251.","journal-title":"Oxid Med Cell Longev"},{"key":"5261_CR13","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jare.2023.12.014","volume":"66","author":"Z Zhang","year":"2024","unstructured":"Zhang Z, Zou Y, Song C, Cao K, Cai K, Chen S, Wu Y, Geng D, Sun G, Zhang N, Zhang X, Zhang Y, Sun Y, Zhang Y. Advances in the study of exosomes in cardiovascular diseases. J Adv Res. 2024;66:133\u201353.","journal-title":"J Adv Res"},{"key":"5261_CR14","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13287-020-1563-8","volume":"11","author":"Z Wen","year":"2020","unstructured":"Wen Z, Mai Z, Zhu X, Wu T, Chen Y, Geng D, Wang J. Mesenchymal stem cell-derived exosomes ameliorate cardiomyocyte apoptosis in hypoxic conditions through microRNA144 by targeting the PTEN\/AKT pathway. Stem Cell Res Ther. 2020;11:36.","journal-title":"Stem Cell Res Ther"},{"key":"5261_CR15","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.7150\/ijbs.32262","volume":"15","author":"MJ Kuang","year":"2019","unstructured":"Kuang MJ, Huang Y, Zhao XG, Zhang R, Ma JX, Wang DC, Ma XL. Exosomes derived from Wharton\u2019s jelly of human umbilical cord mesenchymal stem cells reduce osteocyte apoptosis in glucocorticoid-induced osteonecrosis of the femoral head in rats via the miR-21-PTEN-AKT signalling pathway. Int J Biol Sci. 2019;15:1861\u201371.","journal-title":"Int J Biol Sci"},{"key":"5261_CR16","doi-asserted-by":"publisher","first-page":"1476865","DOI":"10.3389\/fimmu.2024.1476865","volume":"15","author":"D Guo","year":"2024","unstructured":"Guo D, Yan J, Yang Z, Chen M, Zhong W, Yuan X, Yu S. The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure. Front Immunol. 2024;15:1476865.","journal-title":"Front Immunol"},{"key":"5261_CR17","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/s41392-021-00779-x","volume":"6","author":"C Li","year":"2021","unstructured":"Li C, Ni YQ, Xu H, Xiang QY, Zhao Y, Zhan JK, He JY, Li S, Liu YS. Roles and mechanisms of exosomal non-coding RNAs in human health and diseases. Signal Transduct Target Ther. 2021;6:383.","journal-title":"Signal Transduct Target Ther"},{"key":"5261_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2019.03.016","volume":"285","author":"AS Moghaddam","year":"2019","unstructured":"Moghaddam AS, Afshari JT, Esmaeili SA, Saburi E, Joneidi Z, Momtazi-Borojeni AA. Cardioprotective microRNAs: Lessons from stem cell-derived exosomal microRNAs to treat cardiovascular disease. Atherosclerosis. 2019;285:1\u20139.","journal-title":"Atherosclerosis"},{"key":"5261_CR19","doi-asserted-by":"publisher","first-page":"110709","DOI":"10.1016\/j.biopha.2020.110709","volume":"131","author":"JD Pereira","year":"2020","unstructured":"Pereira JD, Tosatti JAG, Simoes R, Luizon MR, Gomes KB, Alves MT. microRNAs associated to anthracycline-induced cardiotoxicity in women with breast cancer: A systematic review and pathway analysis. Biomed Pharmacother. 2020;131:110709.","journal-title":"Biomed Pharmacother"},{"key":"5261_CR20","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jaccao.2023.12.009","volume":"6","author":"HM Boen","year":"2024","unstructured":"Boen HM, Cherubin M, Franssen C, Gevaert AB, Witvrouwen I, Bosman M, Guns PJ, Heidbuchel H, Loeys B, Alaerts M, Van Craenenbroeck EM. Circulating MicroRNA as Biomarkers of Anthracycline-Induced Cardiotoxicity: JACC: CardioOncology State-of-the-Art Review. JACC CardioOncol. 2024;6:183\u201399.","journal-title":"JACC CardioOncol"},{"key":"5261_CR21","doi-asserted-by":"publisher","first-page":"4467","DOI":"10.2147\/JIR.S358471","volume":"15","author":"C Tian","year":"2022","unstructured":"Tian C, Yang Y, Li B, Liu M, He X, Zhao L, Song X, Yu T, Chu XM. Doxorubicin-Induced Cardiotoxicity May Be Alleviated by Bone Marrow Mesenchymal Stem Cell-Derived Exosomal lncRNA via Inhibiting Inflammation. J Inflamm Res. 2022;15:4467\u201386.","journal-title":"J Inflamm Res"},{"key":"5261_CR22","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1161\/CIRCULATIONAHA.121.056929","volume":"145","author":"R Song","year":"2022","unstructured":"Song R, Dasgupta C, Mulder C, Zhang L. MicroRNA-210 Controls Mitochondrial Metabolism and Protects Heart Function in Myocardial Infarction. Circulation. 2022;145:1140\u201353.","journal-title":"Circulation"},{"key":"5261_CR23","first-page":"0327","volume":"7","author":"Y Bei","year":"2024","unstructured":"Bei Y, Wang H, Liu Y, Su Z, Li X, Zhu Y, Zhang Z, Yin M, Chen C, Li L, Wei M, Meng X, Liang X, Huang Z, Cao RY, Wang L, Li G. Cretoiu D and Xiao J. Exercise-Induced miR-210 Promotes Cardiomyocyte Proliferation and Survival and Mediates Exercise-Induced Cardiac Protection against Ischemia\/Reperfusion Injury. Res (Wash D C). 2024;7:0327.","journal-title":"Res (Wash D C)"},{"key":"5261_CR24","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1158\/2159-8290.CD-11-0080","volume":"1","author":"MR Spitz","year":"2011","unstructured":"Spitz MR, Gorlov IP, Amos CI, Dong Q, Chen W, Etzel CJ, Gorlova OY, Chang DW, Pu X, Zhang D, Wang L, Cunningham JM, Yang P, Wu X. Variants in inflammation genes are implicated in risk of lung cancer in never smokers exposed to second-hand smoke. Cancer Discov. 2011;1:420\u20139.","journal-title":"Cancer Discov"},{"key":"5261_CR25","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1161\/01.CIR.0000165133.84978.E2","volume":"111","author":"J Rodr\u00edguez-Vita","year":"2005","unstructured":"Rodr\u00edguez-Vita J, S\u00e1nchez-L\u00f3pez E, Esteban V, Rup\u00e9rez M, Egido J, Ruiz-Ortega M. Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism. Circulation. 2005;111:2509\u201317.","journal-title":"Circulation"},{"key":"5261_CR26","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.ajpath.2012.11.014","volume":"182","author":"NL Rosin","year":"2013","unstructured":"Rosin NL, Falkenham A, Sopel MJ, Lee TD, L\u00e9gar\u00e9 JF. Regulation and role of connective tissue growth factor in AngII-induced myocardial fibrosis. Am J Pathol. 2013;182:714\u201326.","journal-title":"Am J Pathol"},{"key":"5261_CR27","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.2147\/DDDT.S414179","volume":"17","author":"M Yao","year":"2023","unstructured":"Yao M, Lian D, Wu M, Zhou Y, Fang Y, Zhang S, Zhang W, Yang Y, Li R, Chen H, Chen Y, Shen A, Peng J. Isoliensinine Attenuates Renal Fibrosis and Inhibits TGF-\u03b21\/Smad2\/3 Signaling Pathway in Spontaneously Hypertensive Rats. Drug Des Devel Ther. 2023;17:2749\u201362.","journal-title":"Drug Des Devel Ther"},{"key":"5261_CR28","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1161\/CIRCRESAHA.123.322596","volume":"133","author":"L Weng","year":"2023","unstructured":"Weng L, Ye J, Yang F, Jia S, Leng M, Jia B, Xu C, Zhao Y, Liu R, Xiong Y, Zhou Y, Zhao J, Zheng M. TGF-\u03b21\/SMAD3 Regulates Programmed Cell Death 5 That Suppresses Cardiac Fibrosis Post-Myocardial Infarction by Inhibiting HDAC3. Circ Res. 2023;133:237\u201351.","journal-title":"Circ Res"},{"key":"5261_CR29","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1161\/01.RES.0000141774.29937.e3","volume":"95","author":"JM Huss","year":"2004","unstructured":"Huss JM, Kelly DP. Nuclear receptor signaling and cardiac energetics. Circ Res. 2004;95:568\u201378.","journal-title":"Circ Res"},{"key":"5261_CR30","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.cell.2004.09.016","volume":"119","author":"SM Houten","year":"2004","unstructured":"Houten SM, Auwerx J. PGC-1alpha: turbocharging mitochondria. Cell. 2004;119:5\u20137.","journal-title":"Cell"},{"key":"5261_CR31","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1038\/s44161-025-00729-8","volume":"4","author":"R Tian","year":"2025","unstructured":"Tian R. Interaction of PGC-1\u03b1 and GDF15 in the stressed heart. Nat Cardiovasc Res. 2025;4:1216\u20138.","journal-title":"Nat Cardiovasc Res"},{"key":"5261_CR32","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1161\/CIRCULATIONAHA.121.055727","volume":"145","author":"L Zhuang","year":"2022","unstructured":"Zhuang L, Jia K, Chen C, Li Z, Zhao J, Hu J, Zhang H, Fan Q, Huang C, Xie H, Lu L, Shen W, Ning G, Wang J, Zhang R, Chen K. and Yan X. DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics. Circulation. 2022;145:829\u201346.","journal-title":"Circulation"},{"key":"5261_CR33","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.cmet.2011.04.013","volume":"14","author":"H Yadav","year":"2011","unstructured":"Yadav H, Quijano C, Kamaraju AK, Gavrilova O, Malek R, Chen W, Zerfas P, Zhigang D, Wright EC, Stuelten C, Sun P, Lonning S, Skarulis M, Sumner AE, Finkel T, Rane SG. Protection from obesity and diabetes by blockade of TGF-\u03b2\/Smad3 signaling. Cell Metab. 2011;14:67\u201379.","journal-title":"Cell Metab"},{"key":"5261_CR34","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1186\/s12951-022-01630-3","volume":"20","author":"L Mao","year":"2022","unstructured":"Mao L, Li YD, Chen RL, Li G, Zhou XX, Song F, Wu C, Hu Y, Hong YX, Dang X, Li GR, Wang Y. Heart-targeting exosomes from human cardiosphere-derived cells improve the therapeutic effect on cardiac hypertrophy. J Nanobiotechnol. 2022;20:435.","journal-title":"J Nanobiotechnol"}],"container-title":["Stem Cell Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-026-05261-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-026-05261-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-026-05261-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:03:05Z","timestamp":1790384585000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13287-026-05261-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5261"],"URL":"https:\/\/doi.org\/10.1186\/s13287-026-05261-5","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"assertion":[{"value":"28 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"\u201cThis study, entitled \u2018BMSC-derived EVs alleviate doxorubicin-induced cardiotoxicity through miR-210-3p by targeting the ACVR1B\u2013p-SMAD3\u2013PGC-1\u03b1 pathway,\u2019 is conducted as a subproject of the National Natural Science Foundation of China (NSFC, No. 82172574), which focuses on the mechanism by which bone marrow mesenchymal stem cell-derived exosomal piRNA (DICAPIR) mitigates anthracycline-induced cardiotoxicity through the regulation of ferroptosis.\u201d All the animal procedures were performed following the Declaration of Helsinki and were approved by the Laboratory Animal Management and Ethics Committee of Qingdao University (Approval No. 20240822C573220240907219). Date of approval was August 22, 2024.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"340"}}