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Angiotensin II type I receptor agonistic autoantibodies (AT1-AAs) are elevated in women with PE during pregnancy and up to 2-year postpartum (PP), and in the reduced uterine perfusion pressure (RUPP) rat model of PE. Blockade of AT1-AA with a specific 7 amino acid peptide binding sequence (\u2018n7AAc\u2019) improves pathophysiology observed in RUPP rats; however, the long-term effects of AT1-AA inhibition in PP is unknown. Pregnant Sprague Dawley rats were divided into three groups: normal pregnant (NP) (<jats:italic>n<\/jats:italic>\u2009=\u200916), RUPP (<jats:italic>n<\/jats:italic>\u2009=\u200915), and RUPP\u2009+\u2009\u2018n7AAc\u2019 (<jats:italic>n<\/jats:italic>\u2009=\u200916). Gestational day 14, RUPP surgery was performed and \u2018n7AAc\u2019 (144\u00a0\u03bcg\/day) administered via osmotic minipump. At 10-week PP, mean arterial pressure (MAP), renal glomerular filtration rate (GFR) and cardiac functions, and cardiac mitochondria function were assessed. MAP was elevated PP in RUPP vs. NP (126\u2009\u00b1\u20094 vs. 116\u2009\u00b1\u20093\u00a0mmHg, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), but was normalized in in RUPP\u2009+\u2009\u2018n7AAc\u2019 (109\u2009\u00b1\u20093\u00a0mmHg) vs. RUPP (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). PP heart size was reduced by RUPP\u2009+\u2009\u2019n7AAc\u2019 vs. RUPP rats (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Complex IV protein abundance and enzymatic activity, along with glutamate\/malate-driven respiration (complexes I, III, and IV), were reduced in the heart of RUPP vs. NP rats which was prevented with \u2018n7AAc\u2019. AT1-AA inhibition during pregnancy not only improves blood pressure and pathophysiology of PE in rats during pregnancy, but also long-term changes in blood pressure, cardiac hypertrophy, and cardiac mitochondrial function PP.<\/jats:p>","DOI":"10.1186\/s13293-021-00396-x","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T07:03:14Z","timestamp":1635836594000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Angiotensin II type 1 receptor agonistic autoantibody blockade improves postpartum hypertension and cardiac mitochondrial function in rat model of preeclampsia"],"prefix":"10.1186","volume":"12","author":[{"given":"George W.","family":"Booz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bowling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taprieka","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Azubuike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Chinthakuntla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc H.","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Hosler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Mark W.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"issue":"3","key":"396_CR1","doi-asserted-by":"publisher","first-page":"R521","DOI":"10.1152\/ajpregu.00218.2017","volume":"315","author":"MW Cunningham Jr","year":"2018","unstructured":"Cunningham MW Jr, LaMarca B. 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