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Plasma-treated CSs were assessed for cell viability and contractile function and subjected to immunofluorescence staining and imaging. A quantitative proteomic analysis of plasma samples was conducted (controls\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921; GH\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095; PE\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Contraction frequency (CF) was increased in PE-treated CSs (CF: 45.5\u2009\u00b1\u20093.4 contractions\/minute,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and GH-treated CSs (CF:\u00a045.7\u2009\u00b1\u20094.0 contractions\/minute,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), compared to controls (CF\u2009=\u200921.8\u2009\u00b1\u20092.6 contractions\/min). Only PE-treated CSs presented significantly increased fractional shortening (FS) % (9.95\u2009\u00b1\u20091.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) compared to controls (3.7\u2009\u00b1\u20091.1%). GH-treated CSs showed a reduction in cell viability (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and an increase in \u03b1-SMA expression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Proteomics analyses identified twenty differentially abundant proteins, with hemoglobin A2 being the only protein perturbed in both GH and PE versus control plasma\u00a0(\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The innovative patient-relevant CS platforms led to the discovery of biomarkers\/targets linked to cell death signaling and cardiac remodeling in GH-induced CVD and vascular\/endothelial cell dysfunction in PE-induced CVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13293-024-00672-6","type":"journal-article","created":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T23:02:22Z","timestamp":1732489342000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["3D in vitro modelling of post-partum cardiovascular health reveals unique characteristics and signatures following hypertensive disorders in pregnancy"],"prefix":"10.1186","volume":"15","author":[{"given":"Clara Liu","family":"Chung Ming","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dillan","family":"Pienaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Ghorbanpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne Margaret","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Cole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine C.","family":"McGrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P.","family":"Padula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Henry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmine","family":"Gentile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lana","family":"McClements","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"issue":"1","key":"672_CR1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","volume":"72","author":"MA Brown","year":"2018","unstructured":"Brown MA, Magee LA, Kenny LC, Karumanchi SA, McCarthy FP, Saito S, et al. 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