{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T04:57:38Z","timestamp":1794027458624,"version":"4.8.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2022-I2M-1-025"],"award-info":[{"award-number":["2022-I2M-1-025"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Sex Differ"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Obstructive sleep apnea (OSA) is associated with increased risks of glucolipid metabolic disruption, endocrine disturbances and psychological distress. There is scarce research regarding the influence of sex on these associations. The current study aimed to evaluate the effects of sex on metabolic, endocrine and psychological changes in patients with OSA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>One hundred sixty-four young adult women and one hundred sixty-two age-matched men with OSA completed polysomnography assessments, questionnaires (including the Epworth Sleepiness Scale [ESS], Self-Reported Anxiety Scale [SAS], Self-Rating Depression Scale [SDS], and 12-Item Short-Form Health Survey [SF-12]) and biochemical analyses for glucolipid metabolism and endocrine function, including the pituitary-adrenal (PA), pituitary thyroid (PT), and pituitary\u2013gonadal (PG) axes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Homeostasis model assessment of insulin resistance (HOMA-IR), thyroid hormone and midnight PA axis activity levels were greater in female patients with severe OSA compared to those with mild-to-moderate OSA, and these metabolic and endocrine changes were associated with nocturnal hypoxia only in female patients. Additionally, midnight cortisol was associated with HOMA-IR (independent of anthropometry and sleep disturbance parameters) in females (\u03b2\u2009=\u20090.545, P\u2009=\u20090.012, adjusted R<jats:sup>2<\/jats:sup>\u2009=\u20090.217). ESS was higher for male patients with severe OSA compared to females with the same level of OSA (P\u2009=\u20090.003), and ESS was associated with nocturnal hypoxia in males (\u03b2\u2009=\u2009\u2212\u00a00.494, P\u2009=\u20090.001, adjusted R<jats:sup>2<\/jats:sup>\u2009=\u20090.224). SAS was higher for female patients with severe OSA compared to males with the same level of disease (P\u2009=\u20090.001).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The metabolic, endocrine and psychological consequences of OSA may differ across sexes. The associations of nocturnal hypoxia with glucose metabolic disturbance and the activation of the PA and PT axes were observed in females, whereas the association of nocturnal hypoxia with ESS was limited to males. This could indicate a distinct metabolic, endocrine and psychological phenotype for female patients with OSA, who may require different disease management strategies compared to males.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s13293-025-00730-7","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T13:36:02Z","timestamp":1751376962000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sex differences in endocrine, metabolic and psychological disturbance in obese patients with OSA"],"prefix":"10.1186","volume":"16","author":[{"given":"Cheng","family":"Zi Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yi Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Lin Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Xiao Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"issue":"1","key":"730_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/cen.14685","volume":"98","author":"M Akset","year":"2023","unstructured":"Akset M, Poppe KG, Kleynen P, Bold I, Bruyneel M. Endocrine disorders in obstructive sleep apnea syndrome: a bidirectional relationship. Clin Endocrinol (Oxf). 2023;98(1):3\u201313.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"14","key":"730_CR2","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1001\/jama.2020.3514","volume":"323","author":"DJ Gottlieb","year":"2020","unstructured":"Gottlieb DJ, Punjabi NM. Diagnosis and management of obstructive sleep apnea: a review. JAMA. 2020;323(14):1389\u2013400.","journal-title":"JAMA"},{"issue":"12","key":"730_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.792633","volume":"14","author":"FO Martins","year":"2021","unstructured":"Martins FO, Conde SV. Gender differences in the context of obstructive sleep apnea and metabolic diseases. Front Physiol. 2021;14(12): 792633.","journal-title":"Front Physiol"},{"issue":"5","key":"730_CR4","doi-asserted-by":"publisher","first-page":"zsz274","DOI":"10.1093\/sleep\/zsz274","volume":"43","author":"CHJ Won","year":"2020","unstructured":"Won CHJ, Reid M, Sofer T, et al. Sex differences in obstructive sleep apnea phenotypes, the multi-ethnic study of atherosclerosis. Sleep. 2020;43(5):zsz274.","journal-title":"Sleep"},{"key":"730_CR5","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.smrv.2017.03.003","volume":"38","author":"J Theorell-Hagl\u00f6w","year":"2018","unstructured":"Theorell-Hagl\u00f6w J, Miller CB, Bartlett DJ, Yee BJ, Openshaw HD, Grunstein RR. Gender differences in obstructive sleep apnea, insomnia and restless legs syndrome in adults - What do we know? A clinical update. Sleep Med Rev. 2018;38:28\u201338.","journal-title":"Sleep Med Rev"},{"key":"730_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2019.101246","volume":"49","author":"SE Schiza","year":"2020","unstructured":"Schiza SE, Bouloukaki I. Sex differences in obstructive sleep apnea: is it a menopause issue? Sleep Med Rev. 2020;49: 101246.","journal-title":"Sleep Med Rev"},{"issue":"154","key":"730_CR7","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0030-2019","volume":"28","author":"MR Bonsignore","year":"2019","unstructured":"Bonsignore MR, Saaresranta T, Riha RL. Sex differences in obstructive sleep apnea. Eur Respir Rev. 2019;28(154): 190030.","journal-title":"Eur Respir Rev"},{"key":"730_CR8","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.bbi.2016.09.005","volume":"59","author":"C Hirotsu","year":"2017","unstructured":"Hirotsu C, Albuquerque RG, Nogueira H, et al. The relationship between sleep apnea, metabolic dysfunction and inflammation: the gender influence. Brain Behav Immun. 2017;59:211\u20138.","journal-title":"Brain Behav Immun"},{"key":"730_CR9","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.smrv.2018.08.009","volume":"42","author":"J Gaines","year":"2018","unstructured":"Gaines J, Vgontzas AN, Fernandez-Mendoza J, Bixler EO. Obstructive sleep apnea and the metabolic syndrome: the road to clinically-meaningful phenotyping, improved prognosis, and personalized treatment. Sleep Med Rev. 2018;42:211\u20139.","journal-title":"Sleep Med Rev"},{"issue":"1","key":"730_CR10","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13293-024-00613-3","volume":"15","author":"S Mabry","year":"2024","unstructured":"Mabry S, Bradshaw JL, Gardner JJ, Wilson EN, Cunningham RL. Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea. Biol Sex Differ. 2024;15(1):38.","journal-title":"Biol Sex Differ"},{"issue":"6","key":"730_CR11","doi-asserted-by":"publisher","first-page":"871","DOI":"10.5664\/jcsm.11012","volume":"20","author":"JP Christ","year":"2024","unstructured":"Christ JP, Shinkai K, Corley J, Pasch L, Cedars MI, Huddleston HG. Metabolic and endocrine status associate with obstructive sleep apnea risk among patients with polycystic ovary syndrome. J Clin Sleep Med. 2024;20(6):871\u20137.","journal-title":"J Clin Sleep Med"},{"key":"730_CR12","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3389\/fendo.2018.00376","volume":"9","author":"KA Temple","year":"2018","unstructured":"Temple KA, Leproult R, Morselli L, Ehrmann DA, Cauter EV, Mokhlesi B. Sex differences in the impact of obstructive sleep apnea on glucose metabolism. Front Endocrinol (Lausanne). 2018;9:376.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"12","key":"730_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/life12122003","volume":"12","author":"M Bublitz","year":"2022","unstructured":"Bublitz M, Adra N, Hijazi L, Shaib F, Attarian H, Bourjeily G. A narrative review of sex and gender differences in sleep disordered breathing: gaps and opportunities. Life. 2022;12(12): 2003.","journal-title":"Life"},{"issue":"10","key":"730_CR14","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1136\/jnnp-2018-318810","volume":"89","author":"S Liu","year":"2018","unstructured":"Liu S, Huang Y, Tai H, et al. Excessive daytime sleepiness in Chinese patients with sporadic amyotrophic lateral sclerosis and its association with cognitive and behavioural impairments. J Neurol Neurosurg Psychiatry. 2018;89(10):1038\u201343.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"730_CR15","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1142\/S0192415X22500446","volume":"50","author":"Y Lin","year":"2022","unstructured":"Lin Y, Hou R, Zhang T, Chung JPW, Wang CC, Zhao R. Efficacy and safety of Chinese herbal medicine for endometriosis associated pain. Am J Chin Med. 2022;50(4):1095\u2013111.","journal-title":"Am J Chin Med"},{"issue":"1","key":"730_CR16","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1210\/clinem\/dgaa750","volume":"106","author":"X Guo","year":"2021","unstructured":"Guo X, Wang K, Yu S, et al. Quality of life and its determinants in patients with treated acromegaly: a cross-sectional nationwide study in China. J Clin Endocrinol Metab. 2021;106(1):211\u201325.","journal-title":"J Clin Endocrinol Metab"},{"key":"730_CR17","unstructured":"Troester MM, Quan SF, Berry RB, et al; for the American Academy of Sleep Medicine. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. Version 3. Darien, IL: American Academy of Sleep Medicine; 2023."},{"issue":"4","key":"730_CR18","doi-asserted-by":"publisher","first-page":"zsab281","DOI":"10.1093\/sleep\/zsab281","volume":"45","author":"L Sanapo","year":"2022","unstructured":"Sanapo L, Bublitz MH, Bai A, et al. Association between sleep disordered breathing in early pregnancy and glucose metabolism. Sleep. 2022;45(4):zsab281.","journal-title":"Sleep"},{"issue":"9","key":"730_CR19","doi-asserted-by":"publisher","first-page":"e679","DOI":"10.1210\/clinem\/dgad184","volume":"108","author":"L Gan","year":"2023","unstructured":"Gan L, Li N, Heizhati M, et al. Diurnal cortisol features and type 2 diabetes risk in patients with hypertension and obstructive sleep apnea: a cohort study. J Clin Endocrinol Metab. 2023;108(9):e679\u201386.","journal-title":"J Clin Endocrinol Metab"},{"key":"730_CR20","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.sleep.2022.11.025","volume":"101","author":"S Votteler","year":"2023","unstructured":"Votteler S, Knaack L, Janicki J, Fink GR, Burghaus L. Sex differences in polysomnographic findings in patients with obstructive sleep apnea. Sleep Med. 2023;101:429\u201336.","journal-title":"Sleep Med"},{"key":"730_CR21","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.sleep.2024.12.018","volume":"126","author":"A Pihtili","year":"2025","unstructured":"Pihtili A, Kiyan E, Balcan B, et al. Sex differences in clinical and polysomnographic features of obstructive sleep apnea: the Turkish sleep apnea database (TURKAPNE) cohort. Sleep Med. 2025;126:228\u201334.","journal-title":"Sleep Med"},{"issue":"3","key":"730_CR22","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1152\/japplphysiol.00440.2018","volume":"125","author":"PB Dominelli","year":"2018","unstructured":"Dominelli PB, Ripoll JG, Cross TJ, et al. Sex differences in large conducting airway anatomy. J Appl Physiol. 2018;125(3):960\u20135.","journal-title":"J Appl Physiol"},{"key":"730_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2022.101588","volume":"62","author":"RJ Dressle","year":"2022","unstructured":"Dressle RJ, Feige B, Spiegelhalder K, et al. HPA axis activity in patients with chronic insomnia: a systematic review and meta-analysis of case-control studies. Sleep Med Rev. 2022;62: 101588.","journal-title":"Sleep Med Rev"},{"issue":"1","key":"730_CR24","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12991-022-00390-6","volume":"21","author":"L Dell'Osso","year":"2022","unstructured":"Dell\u2019Osso L, Massoni L, Battaglini S, Cremone IM, Carmassi C, Carpita B. Biological correlates of altered circadian rhythms, autonomic functions and sleep problems in autism spectrum disorder. Ann Gen Psychiatry. 2022;21(1):13.","journal-title":"Ann Gen Psychiatry"},{"key":"730_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2023.101117","volume":"72","author":"MA Schalla","year":"2024","unstructured":"Schalla MA, Stengel A. The role of stress in perinatal depression and anxiety\u2014a systematic review. Front Neuroendocrinol. 2024;72: 101117.","journal-title":"Front Neuroendocrinol"},{"issue":"5","key":"730_CR26","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1016\/j.chest.2021.12.669","volume":"161","author":"SQC Giamp\u00e1","year":"2022","unstructured":"Giamp\u00e1 SQC, Furlan SF, Freitas LS, et al. Effects of CPAP on metabolic syndrome in patients with OSA: a randomized trial. Chest. 2022;161(5):1370\u201381.","journal-title":"Chest"},{"issue":"4","key":"730_CR27","doi-asserted-by":"publisher","first-page":"1601731","DOI":"10.1183\/13993003.01731-2016","volume":"49","author":"AM Murphy","year":"2017","unstructured":"Murphy AM, Thomas A, Crinion SJ, et al. Intermittent hypoxia in obstructive sleep apnea mediates insulin resistance through adipose tissue inflammation. Eur Respir J. 2017;49(4):1601731.","journal-title":"Eur Respir J"},{"key":"730_CR28","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.sleep.2018.04.016","volume":"51","author":"R Heinzer","year":"2018","unstructured":"Heinzer R, Marti-Soler H, Marques-Vidal P, et al. Impact of sex and menopausal status on the prevalence, clinical presentation, and comorbidities of sleep-disordered breathing. Sleep Med. 2018;51:29\u201336.","journal-title":"Sleep Med"},{"issue":"3","key":"730_CR29","doi-asserted-by":"publisher","first-page":"244","DOI":"10.5664\/jcsm.27821","volume":"6","author":"YT Celen","year":"2010","unstructured":"Celen YT, Hedner J, Carlson J, Peker Y. Impact of gender on incident diabetes mellitus in obstructive sleep apnea: a 16-year follow-up. J Clin Sleep Med. 2010;6(3):244\u201350.","journal-title":"J Clin Sleep Med"},{"issue":"2","key":"730_CR30","doi-asserted-by":"publisher","first-page":"E316","DOI":"10.1152\/ajpendo.00272.2020","volume":"320","author":"F Marcouiller","year":"2021","unstructured":"Marcouiller F, Jochmans-Lemoine A, Ganouna-Cohen G, et al. Metabolic responses to intermittent hypoxia are regulated by sex and estradiol in mice. Am J Physiol Endocrinol Metab. 2021;320(2):E316\u201325.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"6","key":"730_CR31","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1378\/chest.12-1652","volume":"143","author":"W Trzepizur","year":"2013","unstructured":"Trzepizur W, Le Vaillant M, Meslier N, et al. Independent association between nocturnal intermittent hypoxemia and metabolic dyslipidemia. Chest. 2013;143(6):1584\u20139.","journal-title":"Chest"},{"issue":"4","key":"730_CR32","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1007\/s11325-021-02290-7","volume":"25","author":"WA Silva","year":"2021","unstructured":"Silva WA, Almeida-Pititto B, Santos RB, et al. Obstructive sleep apnea is associated with lower adiponectin and higher cholesterol levels independently of traditional factors and other sleep disorders in middle-aged adults: the ELSA-Brasil cohort. Sleep Breath. 2021;25(4):1935\u201344.","journal-title":"Sleep Breath"},{"issue":"1","key":"730_CR33","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1365-2265.2004.01938.x","volume":"60","author":"F Lanfranco","year":"2004","unstructured":"Lanfranco F, Gianotti L, Pivetti S, et al. Obese patients with obstructive sleep apnea syndrome show a peculiar alteration of the corticotroph but not of the thyrotroph and lactotroph function. Clin Endocrinol (Oxf). 2004;60(1):41\u20138.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"730_CR34","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s11325-010-0415-7","volume":"15","author":"B Panaree","year":"2011","unstructured":"Panaree B, Chantana M, Wasana S, Chairat N. Effects of obstructive sleep apnea on serum brain-derived neurotrophic factor protein, cortisol, and lipid levels. Sleep Breath. 2011;15(4):649\u201356.","journal-title":"Sleep Breath"},{"issue":"2","key":"730_CR35","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.sleep.2012.10.013","volume":"14","author":"Z Karaca","year":"2013","unstructured":"Karaca Z, Ismailogullari S, Korkmaz S, et al. Obstructive sleep apnea syndrome is associated with relative hypocortisolemia and decreased hypothalamo-pituitary-adrenal axis response to 1 and 250\u03bcg ACTH and glucagon stimulation tests. Sleep Med. 2013;14(2):160\u20134.","journal-title":"Sleep Med"},{"issue":"2","key":"730_CR36","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1183\/13993003.00319-2015","volume":"47","author":"I Kritikou","year":"2016","unstructured":"Kritikou I, Basta M, Vgontzas AN, et al. Sleep apnea and the hypothalamic-pituitary-adrenal axis in men and women: effects of continuous positive airway pressure. Eur Respir J. 2016;47(2):531\u201340.","journal-title":"Eur Respir J"},{"issue":"1","key":"730_CR37","doi-asserted-by":"publisher","first-page":"4","DOI":"10.4103\/0972-6748.98407","volume":"20","author":"R Verma","year":"2011","unstructured":"Verma R, Balhara YPS, Gupta CS. Gender differences in stress response: role of developmental and biological determinants. Indian J Psychiatry. 2011;20(1):4\u201310.","journal-title":"Indian J Psychiatry"},{"key":"730_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.725829","volume":"12","author":"ME Green","year":"2021","unstructured":"Green ME, Bernet V, Cheung J. Thyroid dysfunction and sleep disorders. Front Endocrinol (Lausanne). 2021;12: 725829.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"49","key":"730_CR39","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000036531","volume":"102","author":"J Xiong","year":"2023","unstructured":"Xiong J, Hu HX, Huang YY, Zhang JX, He J. Lack of associations between thyroid dysfunction and obstructive sleep apnea-hypopnea syndrome: a meta-analysis. Medicine (Baltimore). 2023;102(49): e36531.","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"730_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102899","volume":"42","author":"RM Mostafa","year":"2021","unstructured":"Mostafa RM, Kamel NM, Elsayed EM, Saad HM. Assessment of sexual functions in male patients with obstructive sleep apnea. Am J Otolaryngol. 2021;42(2): 102899.","journal-title":"Am J Otolaryngol"},{"issue":"3","key":"730_CR41","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/MED.0000000000000069","volume":"21","author":"G Wittert","year":"2014","unstructured":"Wittert G. The relationship between sleep disorders and testosterone. Curr Opin Endocrinol Diabetes Obes. 2014;21(3):239\u201343.","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"5","key":"730_CR42","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1177\/19322968221080199","volume":"17","author":"D Mewes","year":"2023","unstructured":"Mewes D, W\u00e4ldchen M, Knoll C, Raile K, Braune K. Variability of glycemic outcomes and insulin requirements throughout the menstrual cycle: a qualitative study on women with type 1 diabetes using an open-source automated insulin delivery system. J Diabetes Sci Technol. 2023;17(5):1304\u201316.","journal-title":"J Diabetes Sci Technol"},{"issue":"6","key":"730_CR43","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1080\/10615806.2020.1802434","volume":"33","author":"DR Shayani","year":"2020","unstructured":"Shayani DR, Arditte Hall KA, Isley BC, Rohan KJ, Zvolensky MJ, Nillni YI. The role of health anxiety in the experience of perceived stress across the menstrual cycle. Anxiety Stress Coping. 2020;33(6):706\u201315.","journal-title":"Anxiety Stress Coping"}],"container-title":["Biology of Sex Differences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13293-025-00730-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13293-025-00730-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13293-025-00730-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:02:23Z","timestamp":1751382143000},"score":1,"resource":{"primary":{"URL":"https:\/\/bsd.biomedcentral.com\/articles\/10.1186\/s13293-025-00730-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["730"],"URL":"https:\/\/doi.org\/10.1186\/s13293-025-00730-7","relation":{},"ISSN":["2042-6410"],"issn-type":[{"value":"2042-6410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"30 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Review Board of China-Japan Friendship Hospital, and written informed consent was obtained from all study participants before study enrollment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"No datasets were generated or analysed during the current study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"48"}}