{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:51:22Z","timestamp":1793728282098,"version":"4.6.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T00:00:00Z","timestamp":1487203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Health Services","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EJNMMI Res"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13550-017-0264-5","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T06:52:35Z","timestamp":1487227955000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["3D skeletal uptake of 18F sodium fluoride in PET\/CT images is associated with overall survival in patients with prostate cancer"],"prefix":"10.1186","volume":"7","author":[{"given":"Sarah","family":"Lindgren Belal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May","family":"Sadik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Kaboteh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nezar","family":"Hasani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"Enqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linus","family":"Sv\u00e4rm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Kahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Simonsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads H.","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Ohlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poul F.","family":"H\u00f8ilund-Carlsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Edenbrandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin","family":"Tr\u00e4g\u00e5rdh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,16]]},"reference":[{"key":"264_CR1","doi-asserted-by":"publisher","first-page":"15024","DOI":"10.1038\/boneres.2015.24","volume":"3","author":"D Ulmert","year":"2015","unstructured":"Ulmert D, Solnes L, Thorek DLJ. Contemporary approaches for imaging skeletal metastasis. Bone Res. 2015;3:15024.","journal-title":"Bone Res"},{"issue":"1","key":"264_CR2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.2967\/jnumed.115.160085","volume":"57","author":"A Anand","year":"2016","unstructured":"Anand A, Morris MJ, Kaboteh R, Bath L, Sadik M, Gjertsson P, et al. Analytic validation of the automated bone scan index as an imaging biomarker to standardize quantitative changes in bone scans of patients with metastatic prostate cancer. J Nucl Med. 2016;57(1):41\u20135.","journal-title":"J Nucl Med"},{"issue":"1","key":"264_CR3","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.eururo.2012.01.037","volume":"62","author":"D Ulmert","year":"2012","unstructured":"Ulmert D, Kaboteh R, Fox JJ, Savage C, Evans MJ, Lilja H, et al. A novel automated platform for quantifying the extent of skeletal tumour involvement in prostate cancer patients using the Bone Scan Index. Eur Urol. 2012;62(1):78\u201384.","journal-title":"Eur Urol"},{"key":"264_CR4","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s13550-014-0058-y","volume":"4","author":"M Reza","year":"2014","unstructured":"Reza M, Bjartell A, Ohlsson M, Kaboteh R, Wollmer P, Edenbrandt L, et al. Bone Scan Index as a prognostic imaging biomarker during androgen deprivation therapy. EJNMMI Res. 2014;4:58.","journal-title":"EJNMMI Res"},{"key":"264_CR5","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/2191-219X-3-64","volume":"3","author":"R Kaboteh","year":"2013","unstructured":"Kaboteh R, Gjertsson P, Leek H, Lomsky M, Ohlsson M, Sj\u00f6strand K, et al. Progression of bone metastases in patients with prostate cancer\u2014automated detection of new lesions and calculation of bone scan index. EJNMMI Res. 2013;3:64.","journal-title":"EJNMMI Res"},{"issue":"5","key":"264_CR6","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.euf.2016.02.013","volume":"2","author":"Mariana Reza","year":"2016","unstructured":"Reza M, Ohlsson M, Kaboteh R, Anand A, Franck-Lissbrant I, Damber J-E, et al. Bone scan index as an imaging biomarker in metastatic castration-resistant prostate cancer: a multicenter study based on patients treated with abiraterone acetate (Zytiga) in clinical practice. Eur Urol Focus. 2016; doi:\n                    10.1016\/j.euf.2016.02.013\n                    \n                  .","journal-title":"European Urology Focus"},{"issue":"1","key":"264_CR7","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s12885-016-2160-1","volume":"16","author":"K Uemura","year":"2016","unstructured":"Uemura K, Miyoshi Y, Kawahara T, Yoneyama S, Hattori Y, Teranishi J-i, et al. Prognostic value of a computer-aided diagnosis system involving bone scans among men treated with docetaxel for metastatic castration-resistant prostate cancer. BMC Cancer. 2016;16(1):109.","journal-title":"BMC Cancer"},{"issue":"6","key":"264_CR8","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1053\/j.semnuclmed.2007.07.002","volume":"37","author":"E Even-Sapir","year":"2007","unstructured":"Even-Sapir E, Mishani E, Flusser G, Metser U. 18\u00a0F-Fluoride positron emission tomography and positron emission tomography\/computed tomography. Semin Nucl Med. 2007;37(6):462\u20139.","journal-title":"Semin Nucl Med"},{"issue":"10","key":"264_CR9","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1097\/MNM.0b013e328364918a","volume":"34","author":"M Wondergem","year":"2013","unstructured":"Wondergem M, van der Zant FM, van der Ploeg T, Knol RJ. A literature review of 18\u00a0F-fluoride PET\/CT and 18\u00a0F-choline or 11C-choline PET\/CT for detection of bone metastases in patients with prostate cancer. Nucl Med Commun. 2013;34(10):935\u201345.","journal-title":"Nucl Med Commun"},{"issue":"6","key":"264_CR10","doi-asserted-by":"publisher","first-page":"886","DOI":"10.2967\/jnumed.115.166512","volume":"57","author":"AB Apolo","year":"2016","unstructured":"Apolo AB, Lindenberg L, Shih JH, Mena E, Kim JW, Park JC, et al. Prospective study evaluating Na18F PET\/CT in predicting clinical outcomes and survival in advanced prostate cancer. J Nucl Med. 2016;57(6):886\u201392.","journal-title":"J Nucl Med"},{"issue":"12","key":"264_CR11","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1200\/JCO.2015.64.2702","volume":"34","author":"HI Scher","year":"2016","unstructured":"Scher HI, Morris MJ, Stadler WM, Higano C, Basch E, Fizazi K, et al. Trial design and objectives for castration-resistant prostate cancer: updated recommendations from the prostate cancer clinical trials working group 3. J Clin Oncol. 2016;34(12):1402\u201318.","journal-title":"J Clin Oncol"},{"issue":"6","key":"264_CR12","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1111\/bju.12599","volume":"114","author":"Mads H. Poulsen","year":"2014","unstructured":"Poulsen MH, Petersen H, Hoilund-Carlsen PF, Jakobsen JS, Gerke O, Karstoft J, et al. Spine metastases in prostate cancer: comparison of technetium-99m-MDP whole-body bone scintigraphy, [(18) F]choline positron emission tomography (PET)\/computed tomography (CT) and [(18) F]NaF PET\/CT. BJU Int. 2014;114(6):818\u201323.","journal-title":"BJU International"},{"key":"264_CR13","doi-asserted-by":"publisher","unstructured":"Report of the task group on reference man. Ann ICRP. 1973; doi:\n                    10.1016\/0146-6453(79)90123-4\n                    \n                  .","DOI":"10.1016\/0146-6453(79)90123-4"},{"issue":"Pt 3","key":"264_CR14","first-page":"603","volume":"14","author":"A Top","year":"2011","unstructured":"Top A, Hamarneh G, Abugharbieh R. Active learning for interactive 3D image segmentation. Med Image Comput Comput Assist Interv. 2011;14(Pt 3):603\u201310.","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"264_CR15","unstructured":"TurtleSeg 3D Image Segmentation Software, Oxipita Inc. Available from: \n                    www.TurtleSeg.org\n                    \n                  . Accessed 1 Nov 2016"},{"key":"264_CR16","first-page":"204","volume":"6533","author":"A Top","year":"2010","unstructured":"Top A, Hamarneh G, Abugharbieh R. Spotlight: automated confidence-based user guidance for increasing efficiency in interactive 3D image segmentation. Med Image Comput Comput Assist Interv. 2010;6533:204\u201313.","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"264_CR17","unstructured":"Goodfellow I, Bengio Y, Courville A. Deep Learning. Cambridge: MIT Press; 2016."},{"key":"264_CR18","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/978-3-319-46723-8_49","volume-title":"Medical Image Computing and Computer-Assisted Intervention \u2013 MICCAI 2016","author":"\u00d6zg\u00fcn \u00c7i\u00e7ek","year":"2016","unstructured":"\u00c7i\u00e7ek \u00d6, Abdulkadir A, Lienkamp SS, Brox T, Ronneberger O. 3D U-Net: learning dense volumetric segmentation from sparse annotation. International Conference on Medical Image Computing and Computer-Assisted Intervention.\u00a02016. doi:\n                    10.1007\/978-3-319-46723-8_49\n                    \n                  ."},{"issue":"12","key":"264_CR19","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.2967\/jnumed.116.177295","volume":"57","author":"C. Lin","year":"2016","unstructured":"Lin C, Bradshaw TJ, Perk TG, Harmon S, Eickhoff J, Jallow N, et al. Repeatability of quantitative 18F-NaF PET: a multicenter study. J Nucl Med. 2016; doi:\n                    10.2967\/jnumed.116.177295\n                    \n                  .","journal-title":"Journal of Nuclear Medicine"},{"issue":"19","key":"264_CR20","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1093\/bioinformatics\/btn374","volume":"24","author":"B Haibe-Kains","year":"2008","unstructured":"Haibe-Kains B, Desmedt C, Sotiriou C, Bontempi G. A comparative study of survival models for breast cancer prognostication based on microarray data: does a single gene beat them all? Bioinformatics. 2008;24(19):2200\u20138.","journal-title":"Bioinformatics"},{"key":"264_CR21","unstructured":"A language and environment for statistical computing, R Core Team. Available from: \n                    https:\/\/www.R-project.org\n                    \n                  . Accessed 8 Nov 2016"},{"issue":"3","key":"264_CR22","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1200\/JCO.1999.17.3.948","volume":"17","author":"P Sabbatini","year":"1999","unstructured":"Sabbatini P, Larson SM, Kremer A, Zhang ZF, Sun M, Yeung H, et al. Prognostic significance of extent of disease in bone in patients with androgen-independent prostate cancer. J Clin Oncol. 1999;17(3):948\u201357.","journal-title":"J Clin Oncol"},{"issue":"5","key":"264_CR23","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1148\/rg.345130061","volume":"34","author":"S Bastawrous","year":"2014","unstructured":"Bastawrous S, Bhargava P, Behnia F, Haseley DR. Newer PET application with an old tracer: role of 18F-NaF skeletal PET\/CT in oncologic practice. Radiographics. 2014;34(5):1295\u2013316.","journal-title":"Radiographics"},{"issue":"9","key":"264_CR24","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1097\/01.rlu.0000174200.67064.28","volume":"30","author":"A Aydin","year":"2005","unstructured":"Aydin A, Yu JQ, Zhuang H, Alavi A. Detection of bone marrow metastases by FDG-PET and missed by bone scintigraphy in widespread melanoma. Clin Nucl Med. 2005;30(9):606\u20137.","journal-title":"Clin Nucl Med"},{"issue":"1","key":"264_CR25","first-page":"3","volume":"35","author":"M Caglar","year":"2016","unstructured":"Caglar M, Kupik O, Karabulut E, H\u00f8ilund-Carlsen PF. Detection of bone metastases in breast cancer patients in the PET\/CT era: do we still need the bone scan? Nucl Imagen Mol. 2016;35(1):3\u201311.","journal-title":"Nucl Imagen Mol"},{"key":"264_CR26","doi-asserted-by":"publisher","unstructured":"Miyoshi Y, Yoneyama S, Kawahara T, Hattori Y, Teranishi J, Kondo K, et al. Prognostic value of the bone scan index using a computer-aided diagnosis system for bone scans in hormone-naive prostate cancer patients with bone metastases. BMC Cancer. 2016; doi: \n                    10.1186\/s12885-016-2176-6\n                    \n                  .","DOI":"10.1186\/s12885-016-2176-6"},{"issue":"9","key":"264_CR27","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1007\/s12149-013-0749-x","volume":"27","author":"Hiroshi Wakabayashi","year":"2013","unstructured":"Wakabayashi H, Nakajima K, Mizokami A, Namiki M, Inaki A, Taki J, et al. Bone scintigraphy as a new imaging biomarker: the relationship between bone scan index and bone metabolic markers in prostate cancer patients with bone metastases. Ann Nucl Med. 2013;27(9):802\u20137.","journal-title":"Annals of Nuclear Medicine"},{"issue":"24","key":"264_CR28","doi-asserted-by":"publisher","first-page":"6093","DOI":"10.1158\/1078-0432.CCR-10-1357","volume":"16","author":"GS Meirelles","year":"2010","unstructured":"Meirelles GS, Schoder H, Ravizzini GC, Gonen M, Fox JJ, Humm J, et al. Prognostic value of baseline [18F] fluorodeoxyglucose positron emission tomography and 99mTc-MDP bone scan in progressing metastatic prostate cancer. Clin Cancer Res. 2010;16(24):6093\u20139.","journal-title":"Clin Cancer Res"},{"issue":"1","key":"264_CR29","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13550-016-0173-z","volume":"6","author":"A Anand","year":"2016","unstructured":"Anand A, Morris MJ, Larson SM, Minarik D, Josefsson A, Helgstrand JT, et al. Automated Bone Scan Index as a quantitative imaging biomarker in metastatic castration-resistant prostate cancer patients being treated with enzalutamide. EJNMMI Res. 2016;6(1):23.","journal-title":"EJNMMI Res"},{"issue":"1","key":"264_CR30","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/2191-219X-3-9","volume":"3","author":"R Kaboteh","year":"2013","unstructured":"Kaboteh R, Damber JE, Gjertsson P, Hoglund P, Lomsky M, Ohlsson M, et al. Bone Scan Index: a prognostic imaging biomarker for high-risk prostate cancer patients receiving primary hormonal therapy. EJNMMI Res. 2013;3(1):9.","journal-title":"EJNMMI Res"}],"updated-by":[{"DOI":"10.1186\/s13550-019-0510-0","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000}}],"container-title":["EJNMMI Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13550-017-0264-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13550-017-0264-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13550-017-0264-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T07:05:25Z","timestamp":1558335925000},"score":1,"resource":{"primary":{"URL":"https:\/\/ejnmmires.springeropen.com\/articles\/10.1186\/s13550-017-0264-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,16]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["264"],"URL":"https:\/\/doi.org\/10.1186\/s13550-017-0264-5","relation":{"correction":[{"id-type":"doi","id":"10.1186\/s13550-019-0510-0","asserted-by":"object"}]},"ISSN":["2191-219X"],"issn-type":[{"value":"2191-219X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,16]]},"assertion":[{"value":"30 November 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2019","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Following publication of the original article [1], the authors flagged the that the Kaplan-Meier curve in Fig. 6 is a duplication of the Kaplan-Meier curve in Fig. 5, which is not correct.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"15"}}