{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:22:57Z","timestamp":1781659377121,"version":"3.54.5"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EJNMMI Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Identifying the correct location of a parathyroid adenoma in patients with primary hyperparathyroidism (pHPT) is crucial as it can guide surgical treatment. This study aimed to determine the diagnostic performance of <jats:sup>11<\/jats:sup>C-choline PET\/CT in patients with pHPT as a next in-line scan after primary negative or discordant first-line imaging.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This was a retrospective single-center cohort study. All patients with pHPT that were scanned utilizing <jats:sup>11<\/jats:sup>C-choline PET\/CT, after prior negative or discordant imaging, between 2015 and 2019 and who subsequently underwent parathyroid surgery were included. The results of the <jats:sup>11<\/jats:sup>C-choline PET\/CT were evaluated lesion-based, with surgical exploration and histopathological examination as the gold standard.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In total, 36 patients were included of which three patients were known to have Multiple Endocrine Neoplasia (MEN) syndrome. In these 36 patients, 40 lesions were identified on <jats:sup>11<\/jats:sup>C-choline PET\/CT and 37 parathyroid lesions were surgically removed. In 34\/36 (94%) patients a focused parathyroidectomy was performed, in one patient a cervical exploration due to an ectopically identified adenoma, and in one patient a bilateral exploration was performed because of a double adenoma. Overall, per-lesion sensitivity of <jats:sup>11<\/jats:sup>C-choline PET\/CT was 97%, the positive predictive value was 95% and the accuracy was 94% for all parathyroid lesions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In patients with pHPT and prior negative or discordant first-line imaging results, pathological parathyroid glands can be localized by <jats:sup>11<\/jats:sup>C-choline PET\/CT with high sensitivity and accuracy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13550-021-00778-7","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T13:03:04Z","timestamp":1616763784000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A retrospective analysis of the diagnostic performance of 11C-choline PET\/CT for detection of hyperfunctioning parathyroid glands after prior negative or discordant imaging in primary hyperparathyroidism"],"prefix":"10.1186","volume":"11","author":[{"given":"M. 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A no objection notice was obtained (opt-out) from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and informed consent"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32"}}