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The IRF-Frederick is part of the National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID). All animal procedures were approved by the NIAID Animal Care and Use Committee (ACUC) and conducted in compliance with the Animal Welfare Act regulations, Public Health Service policy, and the Guide for the Care and Use of Laboratory Animals (Eighth Edition). This study utilized animals that were subsequently assigned to unrelated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) studies. Leveraging existing baseline (pre-exposure) imaging data from these animals adheres to the principles of reducing the number of animals used for research, as part of the \"Three Rs\u201d (Replacement, Reduction, and Refinement) [\n                      \n                      ].","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"DHO is a co-founder and Managing Member of Pathogenuity LLC, a consultancy whose services include providing expert guidance on nonhuman primate study design. In the last 24 months he has consulted for Moderna and University of Southern California. He has received unrestricted funding and in-kind equipment donations from Heart of Racing. He also receives funding from Inkfish, National Institutes of Health, and Centers for Disease Control and Prevention.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"120"}}