{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:01:58Z","timestamp":1790294518669,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":83,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EJNMMI Res"],"DOI":"10.1186\/s13550-026-01471-3","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:04:24Z","timestamp":1783152264000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying genetics biomarkers in correlation with pathological and PSMA PET\/CT characteristics in prostate cancer"],"prefix":"10.1186","volume":"16","author":[{"given":"Lili","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadi","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujie","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuekai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Hacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-6233","authenticated-orcid":false,"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"issue":"3","key":"1471_CR1","first-page":"209","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209\u201349.","journal-title":"CA Cancer J Clin"},{"issue":"6","key":"1471_CR2","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.euo.2021.09.006","volume":"4","author":"G Gandaglia","year":"2021","unstructured":"Gandaglia G, Leni R, Bray F, Fleshner N, Freedland SJ, Kibel A, et al. Epidemiology and prevention of prostate cancer. Eur Urol Oncol. 2021;4(6):877\u201392.","journal-title":"Eur Urol Oncol"},{"issue":"10","key":"1471_CR3","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1007\/s12094-024-03508-2","volume":"26","author":"V Dahiya","year":"2024","unstructured":"Dahiya V, Hans S, Kumari R, Bagchi G. Prostate cancer biomarkers: from early diagnosis to precision treatment. Clin Transl Oncol. 2024;26(10):2444\u201356.","journal-title":"Clin Transl Oncol"},{"key":"1471_CR4","doi-asserted-by":"crossref","unstructured":"\u0160amija I, Fr\u00f6be A. GENOMICS OF PROSTATE CANCER: CLINICAL UTILITY AND CHALLENGES. Acta Clin Croat. 2022;61(Suppl 3):86.","DOI":"10.20471\/acc.2022.61.s3.13"},{"issue":"3","key":"1471_CR5","first-page":"365","volume":"4","author":"T Chandrasekar","year":"2015","unstructured":"Chandrasekar T, Yang JC, Gao AC, Evans CP. Mechanisms of resistance in castration-resistant prostate cancer (CRPC). Transl Androl Urol. 2015;4(3):365\u201380.","journal-title":"Transl Androl Urol"},{"key":"1471_CR6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13059-016-0893-4","volume":"17","author":"R McGranahan","year":"2016","unstructured":"McGranahan R, Herrero N, Taylor J, Swanton BS. DeconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution. Genome Biol. 2016;17:31.","journal-title":"Genome Biol"},{"issue":"6","key":"1471_CR7","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/s41571-018-0002-6","volume":"15","author":"MF Berger","year":"2018","unstructured":"Berger MF, Mardis ER. The emerging clinical relevance of genomics in cancer medicine. Nat Rev Clin Oncol. 2018;15(6):353\u201365.","journal-title":"Nat Rev Clin Oncol"},{"issue":"7","key":"1471_CR8","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.3390\/cancers15072096","volume":"15","author":"A Kohan","year":"2023","unstructured":"Kohan A, Kulanthaivelu R, Hinzpeter R, et al. Disparity and Diversity in NSCLC Imaging and Genomics: Evaluation of a Mature, Multicenter Database. Cancers (Basel). 2023;15(7):2096.","journal-title":"Cancers (Basel)"},{"issue":"2","key":"1471_CR9","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/s41585-020-00400-w","volume":"18","author":"MC Haffner","year":"2020","unstructured":"Haffner MC, Zwart W, Roudier MP, True LD, Nelson WG, Epstein JI, et al. Genomic and phenotypic heterogeneity in prostate cancer. Nat Rev Urol. 2020;18(2):79\u201392.","journal-title":"Nat Rev Urol"},{"issue":"16","key":"1471_CR10","doi-asserted-by":"publisher","first-page":"3603","DOI":"10.1158\/1078-0432.CCR-21-4272","volume":"28","author":"G Chakraborty","year":"2022","unstructured":"Chakraborty G, Nandakumar S, Hirani R, Nguyen B, Stopsack KH, Kreitzer C, et al. The Impact of PIK3R1 mutations and insulin\u2013PI3K\u2013glycolytic pathway regulation in prostate cancer. Clin Cancer Res. 2022;28(16):3603\u201317.","journal-title":"Clin Cancer Res"},{"issue":"24","key":"1471_CR11","doi-asserted-by":"publisher","first-page":"3532","DOI":"10.1091\/mbc.e17-07-0450","volume":"28","author":"F Okumura","year":"2017","unstructured":"Okumura F, Joo-Okumura A, Obara K, Petersen A, Nishikimi A, Fukui Y, et al. Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2. Mol Biol Cell. 2017;28(24):3532\u201341.","journal-title":"Mol Biol Cell"},{"issue":"24","key":"1471_CR12","doi-asserted-by":"publisher","first-page":"7933","DOI":"10.1021\/jm801055h","volume":"51","author":"Y Chen","year":"2008","unstructured":"Chen Y, Foss CA, Byun Y, Nimmagadda S, Pullambhatla M, Fox JJ, et al. Radiohalogenated prostate-specific membrane antigen (PSMA)-based ureas as imaging agents for prostate cancer. J Med Chem. 2008;51(24):7933\u201343.","journal-title":"J Med Chem"},{"key":"1471_CR13","doi-asserted-by":"crossref","unstructured":"Combes AD, Palma CA, Calopedos R, et al. PSMA PET-CT in the Diagnosis and Staging of Prostate Cancer. Diagnostics (Basel). 2022;12(11):2594.","DOI":"10.3390\/diagnostics12112594"},{"key":"1471_CR14","doi-asserted-by":"crossref","unstructured":"Cao G, Li Y, Wang J, et al. Gleason score, surgical and distant metastasis are associated with cancer-specific survival and overall survival in middle aged high-risk prostate cancer: A population-based study. Front Public Health. 2022;10:1028905.","DOI":"10.3389\/fpubh.2022.1028905"},{"issue":"5","key":"1471_CR15","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1093\/ajcp\/aqaa130","volume":"155","author":"GP Swanson","year":"2021","unstructured":"Swanson GP, Trevathan S, Hammonds KAP, Speights VO, Hermans MR. Gleason score evolution and the effect on prostate cancer outcomes. Am J Clin Pathol. 2021;155(5):711\u20137.","journal-title":"Am J Clin Pathol"},{"key":"1471_CR16","doi-asserted-by":"crossref","unstructured":"Chen DC, Huang S, Papa N, et al. Impact of intraprostatic PSMA maximum standardised uptake value following prostatectomy: a systematic review and meta-analysis. BJU Int. 2025;135(5):720-32.","DOI":"10.1111\/bju.16608"},{"issue":"1","key":"1471_CR17","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41585-022-00670-6","volume":"20","author":"MJ Roberts","year":"2022","unstructured":"Roberts MJ, Maurer T, Perera M, Eiber M, Hope TA, Ost P, et al. Using PSMA imaging for prognostication in localized and advanced prostate cancer. Nat Rev Urol. 2022;20(1):23\u201347.","journal-title":"Nat Rev Urol"},{"issue":"9","key":"1471_CR18","first-page":"4","volume":"22","author":"D Garcia-Gallastegi","year":"2021","unstructured":"Garcia-Gallastegi D, Crende P. GeromiRs Are Downregulated in the Tumor Microenvironment during Colon Cancer Colonization of the Liver in a Murine Metastasis Model. Int J Mol Sci. 2021;22(9):4.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1471_CR19","doi-asserted-by":"publisher","first-page":"2287120","DOI":"10.1080\/15384047.2023.2287120","volume":"25","author":"XB Niu","year":"2024","unstructured":"Niu XB, Li YP, Wang J, Mei XL, Zhao XY, Liu TT, et al. Diagnostic value of 18F-PSMA-1007 PET\/CT for predicting the pathological grade of prostate cancer. Cancer Biol Ther. 2024;25(1):2287120.","journal-title":"Cancer Biol Ther"},{"issue":"2","key":"1471_CR20","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s00259-021-05430-z","volume":"49","author":"EL Solari","year":"2022","unstructured":"Solari EL, Gafita A, Schachoff S, Bogdanovi\u0107 B, Villagr\u00e1n Asiares A, Amiel T, et al. The added value of PSMA PET\/MR radiomics for prostate cancer staging. Eur J Nucl Med Mol Imaging. 2022;49(2):527\u201338.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"5","key":"1471_CR21","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1007\/s00259-022-06089-w","volume":"50","author":"WP Fendler","year":"2023","unstructured":"Fendler WP, Eiber M, Beheshti M, Bomanji J, Calais J, Ceci F, et al. PSMA PET\/CT: joint EANM procedure guideline\/SNMMI procedure standard for prostate cancer imaging 2.0. Eur J Nucl Med Mol Imaging. 2023;50(5):1466\u201386.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"12","key":"1471_CR22","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.2967\/jnumed.117.193581","volume":"58","author":"S Schmuck","year":"2017","unstructured":"Schmuck S, Von Klot CA, Henkenberens C, Sohns JM, Christiansen H, Wester HJ, et al. Initial experience with volumetric 68Ga-PSMA I&T PET\/CT for assessment of whole-body tumor burden as a quantitative imaging biomarker in patients with prostate cancer. J Nucl Med. 2017;58(12):1961\u20137.","journal-title":"J Nucl Med"},{"key":"1471_CR23","doi-asserted-by":"crossref","unstructured":"Acar E, \u00d6zdo\u011fan \u00d6, Aksu A, Derebek E, Beki\u015f R, \u00c7apa Kaya G. The use of molecular volumetric parameters for the evaluation of Lu-177 PSMA I&T therapy response and survival. Ann Nucl Med. 2019;33(9):681-88.","DOI":"10.1007\/s12149-019-01376-3"},{"issue":"4","key":"1471_CR24","first-page":"1025","volume":"51","author":"A Pozdnyakov","year":"2024","unstructured":"Pozdnyakov A, Kulanthaivelu R, Jhaveri K, Berlin A, van der Kwast T, Veit-Haibach P. Histology and PSMA expression on immunohistochemistry in GS\u2009>\u20097 prostate cancer patients: comparison with 68Ga-PSMA PET\/CT features in primary staging. Eur J Nucl Med Mol Imaging. 2024;51(4):1025\u201335.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1471_CR25","doi-asserted-by":"crossref","unstructured":"Kustrimovic N, Bombelli R, Baci D, Mortara L. Microbiome and Prostate Cancer: A Novel Target for Prevention and Treatment. Int J Mol Sci. 2023;24(2):1511.","DOI":"10.3390\/ijms24021511"},{"issue":"6","key":"1471_CR26","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1111\/his.14214","volume":"77","author":"G Leenders","year":"2020","unstructured":"Leenders G, Verhoef EI, Hollemans E. Prostate cancer growth patterns beyond the Gleason score: entering a new era of comprehensive tumour grading. Histopathology. 2020;77(6):850\u201361.","journal-title":"Histopathology"},{"issue":"2","key":"1471_CR27","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00259-020-04934-4","volume":"48","author":"S Fanti","year":"2021","unstructured":"Fanti S, Goffin K, Hadaschik BA, Herrmann K, Maurer T, MacLennan S, et al. Consensus statements on PSMA PET\/CT response assessment criteria in prostate cancer. Eur J Nucl Med Mol Imaging. 2021;48(2):469\u201376.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1471_CR28","doi-asserted-by":"crossref","unstructured":"Mu S, Shi D, Ai L, et al. International Prognostic Index-Based Immune Prognostic Model for Diffuse Large B-Cell Lymphoma. Front Immunol. 2021;12:732006.","DOI":"10.3389\/fimmu.2021.732006"},{"issue":"9","key":"1471_CR29","doi-asserted-by":"publisher","first-page":"e0139484","DOI":"10.1371\/journal.pone.0139484","volume":"10","author":"C Kumar-Sinha","year":"2015","unstructured":"Kumar-Sinha C, Jokerst JV, Chen Z, Xu L, Nolley R, Chang E, et al. A magnetic bead-based sensor for the quantification of multiple prostate cancer biomarkers. PLoS ONE. 2015;10(9):e0139484.","journal-title":"PLoS ONE"},{"key":"1471_CR30","doi-asserted-by":"crossref","unstructured":"Mokkawes T, de Visser SP. Melatonin Activation by Cytochrome P450 Isozymes: How Does CYP1A2 Compare to CYP1A1?. Int J Mol Sci. 2023;24(4):3651.","DOI":"10.3390\/ijms24043651"},{"issue":"2","key":"1471_CR31","first-page":"78","volume":"6","author":"AP Shaik","year":"2009","unstructured":"Shaik AP, Jamil K, Das P. CYP1A1 polymorphisms and risk of prostate cancer: a meta-analysis. Urol J. 2009;6(2):78\u201386.","journal-title":"Urol J"},{"issue":"12","key":"1471_CR32","doi-asserted-by":"publisher","first-page":"10273","DOI":"10.1007\/s11033-012-1904-5","volume":"39","author":"H Li","year":"2012","unstructured":"Li H, Xiao D, Hu L, He T. Association of CYP1A1 polymorphisms with prostate cancer risk: an updated meta-analysis. Mol Biol Rep. 2012;39(12):10273\u201384.","journal-title":"Mol Biol Rep"},{"issue":"7","key":"1471_CR33","doi-asserted-by":"publisher","first-page":"108382","DOI":"10.1016\/j.celrep.2020.108382","volume":"33","author":"PC Kerstein","year":"2020","unstructured":"Kerstein PC, Leffler J, Sivyer B, Taylor WR, Wright KM. Gbx2 identifies two amacrine cell subtypes with distinct molecular, morphological, and physiological properties. Cell Rep. 2020;33(7):108382.","journal-title":"Cell Rep"},{"issue":"5","key":"1471_CR34","doi-asserted-by":"publisher","first-page":"e12949","DOI":"10.1111\/bpa.12949","volume":"31","author":"TS Zimmer","year":"2021","unstructured":"Zimmer TS, Korotkov A, Zwakenberg S, Jansen FE, Zwartkruis FJT, Rensing NR, et al. Upregulation of the pathogenic transcription factor SPI1\/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress. Brain Pathol. 2021;31(5):e12949.","journal-title":"Brain Pathol"},{"issue":"1","key":"1471_CR35","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1080\/15476286.2020.1790140","volume":"18","author":"X Li","year":"2021","unstructured":"Li X, Zhang F, Ma J, Ruan X, Liu X, Zheng J, et al. NCBP3\/SNHG6 inhibits GBX2 transcription in a histone modification manner to facilitate the malignant biological behaviour of glioma cells. RNA Biol. 2021;18(1):47\u201363.","journal-title":"RNA Biol"},{"issue":"3","key":"1471_CR36","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.euo.2018.08.003","volume":"2","author":"R Jeyapala","year":"2019","unstructured":"Jeyapala R, Savio AJ, Olkhov-Mitsel E, Kamdar S, Zhao F, Cuizon C, et al. GBX2 Methylation Is a Novel Prognostic Biomarker and Improves Prediction of Biochemical Recurrence Among Patients with Prostate Cancer Negative for Intraductal Carcinoma and Cribriform Architecture. Eur Urol Oncol. 2019;2(3):231\u20138.","journal-title":"Eur Urol Oncol"},{"issue":"10","key":"1471_CR37","first-page":"5443","volume":"35","author":"Y Tolkach","year":"2015","unstructured":"Tolkach Y, Merseburger A, Herrmann T, Kuczyk M, Serth J, Imkamp F. Signatures of adverse pathological features, androgen insensitivity and metastatic potential in prostate cancer. anticancer res. 2015;35(10):5443\u201351.","journal-title":"Anticancer Res"},{"key":"1471_CR38","doi-asserted-by":"crossref","unstructured":"Huang S, Dong C, Zhang J, Fu S, Lv Y, Wu J. A comprehensive prognostic and immunological analysis of ephrin family genes in hepatocellular carcinoma. Front Mol Biosci. 2022;9:943384.","DOI":"10.3389\/fmolb.2022.943384"},{"issue":"2","key":"1471_CR39","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.molonc.2014.10.008","volume":"9","author":"MD Basson","year":"2014","unstructured":"Basson MD, Zeng B, Downey C, Sirivelu MP, Tepe JJ. Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PK-\u03b2. Mol Oncol. 2014;9(2):513\u201326.","journal-title":"Mol Oncol"},{"key":"1471_CR40","doi-asserted-by":"publisher","first-page":"251686572110517","DOI":"10.1177\/25168657211051755","volume":"14","author":"A Naik","year":"2021","unstructured":"Naik A, Dalpatraj N, Thakur N. Global Histone H3 Lysine 4 Trimethylation (H3K4me3) Landscape Changes in Response to TGF\u03b2. Epigenet Insights. 2021;14:25168657211051755.","journal-title":"Epigenet Insights"},{"issue":"5","key":"1471_CR41","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/s43018-023-00539-6","volume":"4","author":"MK Bakht","year":"2023","unstructured":"Bakht MK, Yamada Y, Ku SY, Venkadakrishnan VB, Korsen JA, Kalidindi TM, et al. Landscape of prostate-specific membrane antigen heterogeneity and regulation in AR-positive and AR-negative metastatic prostate cancer. Nat Cancer. 2023;4(5):699\u2013715.","journal-title":"Nat Cancer"},{"key":"1471_CR42","doi-asserted-by":"crossref","unstructured":"Bakht MK, Beltran H. Biological determinants of PSMA expression, regulation and heterogeneity in prostate cancer. Nat Rev Urol. 2025;22(1):26-45.","DOI":"10.1038\/s41585-024-00900-z"},{"issue":"1","key":"1471_CR43","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s40644-025-00938-1","volume":"25","author":"K Min","year":"2025","unstructured":"Min K, Lin Q, Qiu D. Precision medicine in prostate cancer: individualized treatment through radiomics, genomics, and biomarkers. Cancer Imaging. 2025;25(1):116.","journal-title":"Cancer Imaging"},{"key":"1471_CR44","doi-asserted-by":"crossref","unstructured":"Al Saffar H, Chen DC, Delgado C, et al. The Current Landscape of Prostate-Specific Membrane Antigen (PSMA) Imaging Biomarkers for Aggressive Prostate Cancer. Cancers (Basel). 2024;16(5):939.","DOI":"10.3390\/cancers16050939"}],"container-title":["EJNMMI Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13550-026-01471-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13550-026-01471-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13550-026-01471-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:42:54Z","timestamp":1790293374000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13550-026-01471-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,4]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1471"],"URL":"https:\/\/doi.org\/10.1186\/s13550-026-01471-3","relation":{},"ISSN":["2191-219X"],"issn-type":[{"value":"2191-219X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,4]]},"assertion":[{"value":"25 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Qilu Hospital, Shandong University (Ethics number: KYLL-2017-573).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"was obtained from all individual participants included in the study.","order":2,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors affirm that human research participants provided informed consent for publication of the images in Figures.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":4,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"139"}}