{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:32:58Z","timestamp":1792276378799,"version":"4.4.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/J500525\/1"],"award-info":[{"award-number":["BB\/J500525\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s13567-016-0367-4","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T02:21:09Z","timestamp":1471400469000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Interactions between natural killer cells and dendritic cells favour T helper1-type responses to BCG in calves"],"prefix":"10.1186","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2487-6838","authenticated-orcid":false,"given":"Carly A.","family":"Hamilton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Mahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Entrican","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayne C.","family":"Hope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,17]]},"reference":[{"key":"367_CR1","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0140-6736(06)68507-3","volume":"367","author":"BB Trunz","year":"2006","unstructured":"Trunz BB, Fine P, Dye C (2006) Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness. Lancet 367:1173\u20131180","journal-title":"Lancet"},{"key":"367_CR2","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1016\/j.vaccine.2005.12.044","volume":"24","author":"E Bonifachich","year":"2006","unstructured":"Bonifachich E, Chort M, Astigarraga A, Diaz N, Brunet B, Pezzotto SM, Bottasso O (2006) Protective effect of Bacillus Calmette-Guerin (BCG) vaccination in children with extra-pulmonary tuberculosis, but not the pulmonary disease. A case-control study in Rosario, Argentina. Vaccine 24:2894\u20132899","journal-title":"Vaccine"},{"key":"367_CR3","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/0264-410X(94)00055-R","volume":"13","author":"BM Buddle","year":"1995","unstructured":"Buddle BM, de Lisle GW, Pfeffer A, Aldwell FE (1995) Immunological responses and protection against Mycobacterium bovis in calves vaccinated with a low dose of BCG. Vaccine 13:1123\u20131130","journal-title":"Vaccine"},{"key":"367_CR4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1365-2249.2005.02668.x","volume":"139","author":"JC Hope","year":"2005","unstructured":"Hope JC, Thom ML, Villarreal-Ramos B, Vordermeier HM, Hewinson RG, Howard CJ (2005) Vaccination of neonatal calves with Mycobacterium bovis BCG induces protection against intranasal challenge with virulent M. bovis. Clin Exp Immunol 139:48\u201356","journal-title":"Clin Exp Immunol"},{"key":"367_CR5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1128\/CVI.00543-10","volume":"18","author":"JC Hope","year":"2011","unstructured":"Hope JC, Thom ML, McAulay M, Mead E, Vordermeier HM, Clifford D, Hewinson RG, Villarreal-Ramos B (2011) Identification of surrogates and correlates of protection in protective immunity against Mycobacterium bovis infection induced in neonatal calves by vaccination with M. bovis BCG Pasteur and M. bovis BCG Danish. Clin Vaccine Immunol 18:373\u2013379","journal-title":"Clin Vaccine Immunol"},{"key":"367_CR6","doi-asserted-by":"crossref","first-page":"e77334","DOI":"10.1371\/journal.pone.0077334","volume":"8","author":"C Zufferey","year":"2013","unstructured":"Zufferey C, Germano S, Dutta B, Ritz N, Curtis N (2013) The contribution of non-conventional T cells and NK cells in the mycobacterial-specific IFN\u03b3 response in Bacille Calmette-Guerin (BCG)-immunized infants. PLoS One 8:e77334","journal-title":"PLoS One"},{"key":"367_CR7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.vetimm.2009.05.002","volume":"132","author":"EM Graham","year":"2009","unstructured":"Graham EM, Thom ML, Howard CJ, Boysen P, Storset AK, Sopp P, Hope JC (2009) Natural killer cell number and phenotype in bovine peripheral blood is influenced by age. Vet Immunol Immunopathol 132:101\u2013108","journal-title":"Vet Immunol Immunopathol"},{"key":"367_CR8","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.dci.2004.02.004","volume":"28","author":"S Kulberg","year":"2004","unstructured":"Kulberg S, Boysen P, Storset AK (2004) Reference values for relative numbers of natural killer cells in cattle blood. Dev Comp Immunol 28:941\u2013948","journal-title":"Dev Comp Immunol"},{"key":"367_CR9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1051\/vetres\/2009037","volume":"40","author":"J Elhmouzi-Younes","year":"2009","unstructured":"Elhmouzi-Younes J, Storset AK, Boysen P, Laurent F, Drouet F (2009) Bovine neonate natural killer cells are fully functional and highly responsive to interleukin-15 and to NKp46 receptor stimulation. Vet Res 40:54","journal-title":"Vet Res"},{"key":"367_CR10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0022-3476(05)80430-5","volume":"120","author":"FM Erkeller-Yuksel","year":"1992","unstructured":"Erkeller-Yuksel FM, Deneys V, Yuksel B, Hannet I, Hulstaert F, Hamilton C, Mackinnon H, Stokes LT, Munhyeshuli V, Vanlangendonck F, De Bruy\u00e8re M, Bach BA, Lydyard PM (1992) Age-related changes in human blood lymphocyte subpopulations. J Pediatr 120:216\u2013222","journal-title":"J Pediatr"},{"key":"367_CR11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1365-3083.2007.01980.x","volume":"66","author":"Y Sundstrom","year":"2007","unstructured":"Sundstrom Y, Nilsson C, Lilja G, Karre K, Troye-Blomberg M, Berg L (2007) The expression of human natural killer cell receptors in early life. Scand J Immunol 66:335\u2013344","journal-title":"Scand J Immunol"},{"key":"367_CR12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/eji.1830050209","volume":"5","author":"R Kiessling","year":"1975","unstructured":"Kiessling R, Klein E, Pross H, Wigzell H (1975) \u201cNatural\u201d killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell. Eur J Immunol 5:117\u2013121","journal-title":"Eur J Immunol"},{"key":"367_CR13","doi-asserted-by":"crossref","first-page":"6039","DOI":"10.4049\/jimmunol.171.11.6039","volume":"171","author":"AP Junqueira-Kipnis","year":"2003","unstructured":"Junqueira-Kipnis AP, Kipnis A, Jamieson A, Juarrero MG, Diefenbach A, Raulet DH, Turner J, Orme IM (2003) NK cells respond to pulmonary infection with Mycobacterium tuberculosis, but play a minimal role in protection. J Immunol 171:6039\u20136045","journal-title":"J Immunol"},{"key":"367_CR14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/35095564","volume":"1","author":"A Cerwenka","year":"2001","unstructured":"Cerwenka A, Lanier LL (2001) Natural killer cells, viruses and cancer. Nat Rev Immunol 1:41\u201349","journal-title":"Nat Rev Immunol"},{"key":"367_CR15","doi-asserted-by":"crossref","first-page":"6817","DOI":"10.1128\/IAI.72.12.6817-6825.2004","volume":"72","author":"T Lieke","year":"2004","unstructured":"Lieke T, Graefe SE, Klauenberg U, Fleischer B, Jacobs T (2004) NK cells contribute to the control of Trypanosoma cruzi infection by killing free parasites by perforin-independent mechanisms. Infect Immun 72:6817\u20136825","journal-title":"Infect Immun"},{"key":"367_CR16","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.4049\/jimmunol.169.6.2956","volume":"169","author":"K Artavanis-Tsakonas","year":"2002","unstructured":"Artavanis-Tsakonas K, Riley EM (2002) Innate immune response to malaria: rapid induction of IFN-gamma from human NK cells by live Plasmodium falciparum-infected erythrocytes. J Immunol 169:2956\u20132963","journal-title":"J Immunol"},{"key":"367_CR17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.coi.2007.04.004","volume":"19","author":"T Walzer","year":"2007","unstructured":"Walzer T, Jaeger S, Chaix J, Vivier E (2007) Natural killer cells: from CD3(\u2212)NKp46(+) to post-genomics meta-analyses. Curr Opin Immunol 19:365\u2013372","journal-title":"Curr Opin Immunol"},{"key":"367_CR18","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/eji.200324504","volume":"34","author":"AK Storset","year":"2004","unstructured":"Storset AK, Kulberg S, Berg I, Boysen P, Hope JC, Dissen E (2004) NKp46 defines a subset of bovine leukocytes with natural killer cell characteristics. Eur J Immunol 34:669\u2013676","journal-title":"Eur J Immunol"},{"key":"367_CR19","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3389\/fimmu.2013.00395","volume":"4","author":"H Lund","year":"2013","unstructured":"Lund H, Boysen P, Hope JC, Sjurseth SK, Storset AK (2013) Natural killer cells in afferent lymph express an activated phenotype and readily produce IFN-gamma. Front Immunol 4:395","journal-title":"Front Immunol"},{"key":"367_CR20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2172-7-10","volume":"7","author":"P Boysen","year":"2006","unstructured":"Boysen P, Olsen I, Berg I, Kulberg S, Johansen GM, Storset AK (2006) Bovine CD2\u2212\/NKp46+ cells are fully functional natural killer cells with a high activation status. BMC Immunol 7:10","journal-title":"BMC Immunol"},{"key":"367_CR21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.vetimm.2005.08.002","volume":"108","author":"BM Buddle","year":"2005","unstructured":"Buddle BM, Wedlock DN, Denis M, Skinner MA (2005) Identification of immune response correlates for protection against bovine tuberculosis. Vet Immunol Immunopathol 108:45\u201351","journal-title":"Vet Immunol Immunopathol"},{"key":"367_CR22","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1189\/jlb.71.2.184","volume":"71","author":"JC Hope","year":"2002","unstructured":"Hope JC, Sopp P, Howard CJ (2002) NK-like CD8(+) cells in immunologically naive neonatal calves that respond to dendritic cells infected with Mycobacterium bovis BCG. J Leukoc Biol 71:184\u2013194","journal-title":"J Leukoc Biol"},{"key":"367_CR23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/eji.201242736","volume":"43","author":"N Siddiqui","year":"2013","unstructured":"Siddiqui N, Hope J (2013) Differential recruitment and activation of natural killer cell sub-populations by Mycobacterium bovis-infected dendritic cells. Eur J Immunol 43:159\u2013169","journal-title":"Eur J Immunol"},{"key":"367_CR24","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/jlb.66.1.50","volume":"66","author":"D Werling","year":"1999","unstructured":"Werling D, Hope JC, Chaplin P, Collins RA, Taylor G, Howard CJ (1999) Involvement of caveolae in the uptake of respiratory syncytial virus antigen by dendritic cells. J Leukoc Biol 66:50\u201358","journal-title":"J Leukoc Biol"},{"key":"367_CR25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0022-1759(02)00113-8","volume":"266","author":"JC Hope","year":"2002","unstructured":"Hope JC, Kwong LS, Entrican G, Wattegedera S, Vordermeier HM, Sopp P, Howard CJ (2002) Development of detection methods for ruminant interleukin (IL)-12. J Immunol Methods 266:117\u2013126","journal-title":"J Immunol Methods"},{"key":"367_CR26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0165-2427(99)00020-3","volume":"68","author":"RA Collins","year":"1999","unstructured":"Collins RA, Howard CJ, Duggan SE, Werling D (1999) Bovine interleukin-12 and modulation of IFNgamma production. Vet Immunol Immunopathol 68:193\u2013207","journal-title":"Vet Immunol Immunopathol"},{"key":"367_CR27","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.4049\/jimmunol.1302464","volume":"192","author":"TK Connelley","year":"2014","unstructured":"Connelley TK, Longhi C, Burrells A, Degnan K, Hope J, Allan AJ, Hammond JA, Storset AK, Morrison WI (2014) NKp46+ CD3+ cells: a novel nonconventional T cell subset in cattle exhibiting both NK cell and T cell features. J Immunol 192:3868\u20133880","journal-title":"J Immunol"},{"key":"367_CR28","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1084\/jem.20021468","volume":"197","author":"L Tailleux","year":"2003","unstructured":"Tailleux L, Schwartz O, Herrmann JL, Pivert E, Jackson M, Amara A, Legres L, Dreher D, Nicod LP, Gluckman JC, Lagrange PH, Gicquel B, Neyrolles O (2003) DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells. J Exp Med 197:121\u2013127","journal-title":"J Exp Med"},{"key":"367_CR29","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.4049\/jimmunol.163.7.3920","volume":"163","author":"TK Means","year":"1999","unstructured":"Means TK, Wang S, Lien E, Yoshimura A, Golenbock DT, Fenton MJ (1999) Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J Immunol 163:3920\u20133927","journal-title":"J Immunol"},{"key":"367_CR30","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.1128\/IAI.68.12.6883-6890.2000","volume":"68","author":"S Tsuji","year":"2000","unstructured":"Tsuji S, Matsumoto M, Takeuchi O, Akira S, Azuma I, Hayashi A, Toyoshima K, Seya T (2000) Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guerin: involvement of toll-like receptors. Infect Immun 68:6883\u20136890","journal-title":"Infect Immun"},{"key":"367_CR31","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.imbio.2006.05.004","volume":"211","author":"F Meyenn von","year":"2006","unstructured":"von Meyenn F, Schaefer M, Weighardt H, Bauer S, Kirschning CJ, Wagner H, Sparwasser T (2006) Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guerin by Flt3-ligand generated dendritic cells. Immunobiology 211:557\u2013565","journal-title":"Immunobiology"},{"key":"367_CR32","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1189\/jlb.0807523","volume":"83","author":"Y Yamakawa","year":"2008","unstructured":"Yamakawa Y, Pennelegion C, Willcocks S, Stalker A, Machugh N, Burt D, Coffey TJ, Werling D (2008) Identification and functional characterization of a bovine orthologue to DC-SIGN. J Leukoc Biol 83:1396\u20131403","journal-title":"J Leukoc Biol"},{"key":"367_CR33","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev.iy.09.040191.001415","volume":"9","author":"RM Steinman","year":"1991","unstructured":"Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271\u2013296","journal-title":"Annu Rev Immunol"},{"key":"367_CR34","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.vetimm.2004.04.007","volume":"100","author":"JC Hope","year":"2004","unstructured":"Hope JC, Thom ML, McCormick PA, Howard CJ (2004) Interaction of antigen presenting cells with mycobacteria. Vet Immunol Immunopathol 100:187\u2013195","journal-title":"Vet Immunol Immunopathol"},{"key":"367_CR35","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.immuni.2009.05.001","volume":"30","author":"L Zhou","year":"2009","unstructured":"Zhou L, Chong MM, Littman DR (2009) Plasticity of CD4\u00a0+\u00a0T cell lineage differentiation. Immunity 30:646\u2013655","journal-title":"Immunity"},{"key":"367_CR36","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/ni1138","volume":"5","author":"A Martin-Fontecha","year":"2004","unstructured":"Martin-Fontecha A, Thomsen LL, Brett S, Gerard C, Lipp M, Lanzavecchia A, Sallusto F (2004) Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat Immunol 5:1260\u20131265","journal-title":"Nat Immunol"},{"key":"367_CR37","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1084\/jem.20010938","volume":"195","author":"F Gerosa","year":"2002","unstructured":"Gerosa F, Baldani-Guerra B, Nisii C, Marchesini V, Carra G, Trinchieri G (2002) Reciprocal activating interaction between natural killer cells and dendritic cells. J Exp Med 195:327\u2013333","journal-title":"J Exp Med"},{"key":"367_CR38","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2567.2004.01858.x","volume":"112","author":"S Esin","year":"2004","unstructured":"Esin S, Batoni G, Pardini M, Favilli F, Bottai D, Maisetta G, Florio W, Vanacore R, Wigzell H, Campa M (2004) Functional characterization of human natural killer cells responding to Mycobacterium bovis Bacille Calmette-Guerin. Immunology 112:143\u2013152","journal-title":"Immunology"},{"key":"367_CR39","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1128\/IAI.00870-07","volume":"76","author":"S Esin","year":"2008","unstructured":"Esin S, Batoni G, Counoupas C, Stringaro A, Brancatisano FL, Colone M, Maisetta G, Florio W, Arancia G, Campa M (2008) Direct binding of human NK cell natural cytotoxicity receptor NKp44 to the surfaces of mycobacteria and other bacteria. Infect Immun 76:1719\u20131727","journal-title":"Infect Immun"},{"key":"367_CR40","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1093\/intimm\/dxn073","volume":"20","author":"E Marcenaro","year":"2008","unstructured":"Marcenaro E, Ferranti B, Falco M, Moretta L, Moretta A (2008) Human NK cells directly recognize Mycobacterium bovis via TLR2 and acquire the ability to kill monocyte-derived DC. Int Inmunol 20:1155\u20131167","journal-title":"Int Inmunol"},{"key":"367_CR41","unstructured":"Hammond J, Connelley T, Birch J, Ellis SA, Hope J (2012) Cattle NKp30 is an NK cell receptor differentially expressed between individuals and upregulated on activated NK cells. 12th Meeting of the Society for Natural Immunity, Asilomar"},{"key":"367_CR42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/ar.10039","volume":"266","author":"M Vitale","year":"2002","unstructured":"Vitale M, Bassini A, Secchiero P, Mirandola P, Ponti C, Zamai L, Mariani AR, Falconi M, Azzali G (2002) NK-active cytokines IL-2, IL-12, and IL-15 selectively modulate specific protein kinase C (PKC) isoforms in primary human NK cells. Anat Rec 266:87\u201392","journal-title":"Anat Rec"},{"key":"367_CR43","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1002\/eji.201040496","volume":"40","author":"CH Elssen Van","year":"2010","unstructured":"Van Elssen CH, Vanderlocht J, Frings PW, Senden-Gijsbers BL, Schnijderberg MC, van Gelder M, Meek B, Libon C, Ferlazzo G, Germeraad WT, Bos GM (2010) Klebsiella pneumoniae-triggered DC recruit human NK cells in a CCR5-dependent manner leading to increased CCL19-responsiveness and activation of NK cells. Eur J Immunol 40:3138\u20133149","journal-title":"Eur J Immunol"},{"key":"367_CR44","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.dci.2007.11.006","volume":"32","author":"P Boysen","year":"2008","unstructured":"Boysen P, Gunnes G, Pende D, Valheim M, Storset AK (2008) Natural killer cells in lymph nodes of healthy calves express CD16 and show both cytotoxic and cytokine-producing properties. Dev Comp Immunol 32:773\u2013783","journal-title":"Dev Comp Immunol"}],"container-title":["Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13567-016-0367-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T18:03:21Z","timestamp":1692468201000},"score":1,"resource":{"primary":{"URL":"http:\/\/veterinaryresearch.biomedcentral.com\/articles\/10.1186\/s13567-016-0367-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,17]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["367"],"URL":"https:\/\/doi.org\/10.1186\/s13567-016-0367-4","relation":{},"ISSN":["1297-9716"],"issn-type":[{"value":"1297-9716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,17]]},"article-number":"85"}}