{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:19:57Z","timestamp":1778717997478,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"National Key R & D Program","award":["2017YFD0500203"],"award-info":[{"award-number":["2017YFD0500203"]}]},{"name":"the National Transgenic Major Program","award":["2014ZX0800946B"],"award-info":[{"award-number":["2014ZX0800946B"]}]},{"name":"the Special Fund for Agro-scientific Research in the Public Interest","award":["201403054"],"award-info":[{"award-number":["201403054"]}]},{"name":"the Jiangsu Agricultural Science and Technology Innovation Fund","award":["CX(15)1056"],"award-info":[{"award-number":["CX(15)1056"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13567-018-0510-5","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T12:20:30Z","timestamp":1518006030000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Swinepox virus vector-based vaccines: attenuation and biosafety assessments following subcutaneous prick inoculation"],"prefix":"10.1186","volume":"49","author":[{"given":"Xiaomin","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huixing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kongwang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjie","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,2,7]]},"reference":[{"key":"510_CR1","doi-asserted-by":"publisher","first-page":"11341","DOI":"10.1073\/pnas.93.21.11341","volume":"93","author":"B Moss","year":"1996","unstructured":"Moss B (1996) Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety. Proc Natl Acad Sci U S A 93:11341\u201311348","journal-title":"Proc Natl Acad Sci U S A"},{"key":"510_CR2","doi-asserted-by":"publisher","first-page":"11349","DOI":"10.1073\/pnas.93.21.11349","volume":"93","author":"E Paoletti","year":"1996","unstructured":"Paoletti E (1996) Applications of pox virus vectors to vaccination: an update. Proc Natl Acad Sci U S A 93:11349\u201311353","journal-title":"Proc Natl Acad Sci U S A"},{"key":"510_CR3","doi-asserted-by":"publisher","first-page":"43990","DOI":"10.1038\/srep43990","volume":"7","author":"H Lin","year":"2017","unstructured":"Lin H, Ma Z, Hou X, Chen L, Fan H (2017) Construction and immunogenicity of a recombinant swinepox virus expressing a multi-epitope peptide for porcine reproductive and respiratory syndrome virus. Sci Rep 7:43990","journal-title":"Sci Rep"},{"key":"510_CR4","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.vetmic.2012.11.026","volume":"162","author":"J Xu","year":"2013","unstructured":"Xu J, Huang D, Liu S, Lin H, Zhu H, Liu B, Chen W, Lu C (2013) Immune responses and protective efficacy of a recombinant swinepox virus co-expressing HA1 genes of H3N2 and H1N1 swine influenza virus in mice and pigs. Vet Microbiol 162:259\u2013264","journal-title":"Vet Microbiol"},{"key":"510_CR5","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1016\/j.vaccine.2012.02.028","volume":"30","author":"J Xu","year":"2012","unstructured":"Xu J, Huang D, Liu S, Lin H, Zhu H, Liu B, Lu C (2012) Immune responses and protective efficacy of a recombinant swinepox virus expressing HA1 against swine H1N1 influenza virus in mice and pigs. Vaccine 30:3119\u20133125","journal-title":"Vaccine"},{"key":"510_CR6","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.virusres.2012.04.014","volume":"167","author":"J Xu","year":"2012","unstructured":"Xu J, Huang D, Liu S, Lin H, Zhu H, Liu B, Lu C (2012) Immune responses and protection efficacy of a recombinant swinepox virus expressing HA1 against swine H3N2 influenza virus in mice and pigs. Virus Res 167:188\u2013195","journal-title":"Virus Res"},{"key":"510_CR7","first-page":"144","volume":"125","author":"D Huang","year":"2012","unstructured":"Huang D, Zhu H, Lin H, Xu J, Lu C (2012) First insights into the protective effects of a recombinant swinepox virus expressing truncated MRP of Streptococcus suis type 2 in mice. Berl Munch Tierarztl Wochenschr 125:144\u2013152","journal-title":"Berl Munch Tierarztl Wochenschr"},{"key":"510_CR8","doi-asserted-by":"publisher","first-page":"3900","DOI":"10.1016\/j.vaccine.2015.06.057","volume":"33","author":"X Yuan","year":"2015","unstructured":"Yuan X, Lin H, Fan H (2015) Efficacy and immunogenicity of recombinant swinepox virus expressing the A epitope of the TGEV S protein. Vaccine 33:3900\u20133906","journal-title":"Vaccine"},{"key":"510_CR9","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/0042-6822(91)90039-E","volume":"180","author":"RF Massung","year":"1991","unstructured":"Massung RF, Moyer RW (1991) The molecular biology of swinepox virus. I. A characterization of the viral DNA. Virology 180:347\u2013354","journal-title":"Virology"},{"key":"510_CR10","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1128\/JVI.76.2.783-790.2002","volume":"76","author":"CL Afonso","year":"2002","unstructured":"Afonso CL, Tulman ER, Lu Z, Zsak L, Osorio FA, Balinsky C, Kutish GF, Rock DL (2002) The genome of swinepox virus. J Virol 76:783\u2013790","journal-title":"J Virol"},{"key":"510_CR11","doi-asserted-by":"publisher","first-page":"4927","DOI":"10.1073\/pnas.79.16.4927","volume":"79","author":"D Panicali","year":"1982","unstructured":"Panicali D, Paoletti E (1982) Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus. Proc Natl Acad Sci U S A 79:4927\u20134931","journal-title":"Proc Natl Acad Sci U S A"},{"key":"510_CR12","doi-asserted-by":"publisher","first-page":"4222","DOI":"10.4049\/jimmunol.169.8.4222","volume":"169","author":"X Shen","year":"2002","unstructured":"Shen X, Wong SB, Buck CB, Zhang J, Siliciano RF (2002) Direct priming and cross-priming contribute differentially to the induction of CD8+ CTL following exposure to vaccinia virus via different routes. J Immunol 169:4222\u20134229","journal-title":"J Immunol"},{"key":"510_CR13","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/S0161-5890(03)00024-5","volume":"39","author":"K Ito","year":"2003","unstructured":"Ito K, Shinohara N, Kato S (2003) DNA immunization via intramuscular and intradermal routes using a gene gun provides different magnitudes and durations on immune response. Mol Immunol 39:847\u2013854","journal-title":"Mol Immunol"},{"key":"510_CR14","doi-asserted-by":"publisher","first-page":"6906","DOI":"10.1128\/IAI.71.12.6906-6914.2003","volume":"71","author":"EL Taracha","year":"2003","unstructured":"Taracha EL, Bishop R, Musoke AJ, Hill AV, Gilbert SC (2003) Heterologous priming-boosting immunization of cattle with Mycobacterium tuberculosis 85A induces antigen-specific T-cell responses. Infect Immun 71:6906\u20136914","journal-title":"Infect Immun"},{"key":"510_CR15","doi-asserted-by":"publisher","first-page":"3094","DOI":"10.4049\/jimmunol.172.5.3094","volume":"172","author":"RJ Anderson","year":"2004","unstructured":"Anderson RJ, Hannan CM, Gilbert SC, Laidlaw SM, Sheu EG, Korten S, Sinden R, Butcher GA, Skinner MA, Hill AV (2004) Enhanced CD8+ T cell immune responses and protection elicited against Plasmodium berghei malaria by prime boost immunization regimens using a novel attenuated fowlpox virus. J Immunol 172:3094\u20133100","journal-title":"J Immunol"},{"key":"510_CR16","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1172\/JCI3986","volume":"102","author":"JJ Kim","year":"1998","unstructured":"Kim JJ, Nottingham LK, Sin JI, Tsai A, Morrison L, Oh J, Dang K, Hu Y, Kazahaya K, Bennett M, Dentchev T, Wilson DM, Chalian AA, Boyer JD, Agadjanyan MG, Weiner DB (1998) CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines. J Clin Invest 102:1112\u20131124","journal-title":"J Clin Invest"},{"issue":"Suppl 2","key":"510_CR17","doi-asserted-by":"publisher","first-page":"S53","DOI":"10.1016\/S0264-410X(99)00235-2","volume":"17","author":"JD Boyer","year":"1999","unstructured":"Boyer JD, Kim J, Ugen K, Cohen AD, Ahn L, Schumann K, Lacy K, Bagarazzi ML, Javadian A, Ciccarelli RB, Ginsberg RS, MacGregor RR, Weiner DB (1999) HIV-1 DNA vaccines and chemokines. Vaccine 17(Suppl 2):S53\u2013S64","journal-title":"Vaccine"},{"key":"510_CR18","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1006\/clim.1999.4730","volume":"92","author":"KQ Xin","year":"1999","unstructured":"Xin KQ, Lu Y, Hamajima K, Fukushima J, Yang J, Inamura K, Okuda K (1999) Immunization of RANTES expression plasmid with a DNA vaccine enhances HIV-1-specific immunity. Clin Immunol 92:90\u201396","journal-title":"Clin Immunol"},{"key":"510_CR19","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1172\/JCI6024","volume":"103","author":"JJ Kim","year":"1999","unstructured":"Kim JJ, Tsai A, Nottingham LK, Morrison L, Cunning DM, Oh J, Lee DJ, Dang K, Dentchev T, Chalian AA, Agadjanyan MG, Weiner DB (1999) Intracellular adhesion molecule-1 modulates beta-chemokines and directly costimulates T cells in vivo. J Clin Invest 103:869\u2013877","journal-title":"J Clin Invest"},{"key":"510_CR20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1046\/j.1365-2249.1999.00793.x","volume":"115","author":"Y Lu","year":"1999","unstructured":"Lu Y, Xin KQ, Hamajima K, Tsuji T, Aoki I, Yang J, Sasaki S, Fukushima J, Yoshimura T, Toda S, Okada E, Okuda K (1999) Macrophage inflammatory protein-1alpha (MIP-1\u03b1) expression plasmid enhances DNA vaccine-induced immune response against HIV-1. Clin Exp Immunol 115:335\u2013341","journal-title":"Clin Exp Immunol"},{"key":"510_CR21","doi-asserted-by":"publisher","first-page":"6278","DOI":"10.1128\/JVI.74.14.6278-6286.2000","volume":"74","author":"MM Gherardi","year":"2000","unstructured":"Gherardi MM, Ramirez JC, Esteban M (2000) Interleukin-12 (IL-12) enhancement of the cellular immune response against human immunodeficiency virus type 1 env antigen in a DNA prime\/vaccinia virus boost vaccine regimen is time and dose dependent: suppressive effects of IL-12 boost are mediated by nitric oxide. J Virol 74:6278\u20136286","journal-title":"J Virol"},{"key":"510_CR22","doi-asserted-by":"publisher","first-page":"3427","DOI":"10.1128\/JVI.74.7.3427-3429.2000","volume":"74","author":"JJ Kim","year":"2000","unstructured":"Kim JJ, Yang JS, VanCott TC, Lee DJ, Manson KH, Wyand MS, Boyer JD, Ugen KE, Weiner DB (2000) Modulation of antigen-specific humoral responses in rhesus macaques by using cytokine cDNAs as DNA vaccine adjuvants. J Virol 74:3427\u20133429","journal-title":"J Virol"},{"key":"510_CR23","doi-asserted-by":"publisher","first-page":"285","DOI":"10.2174\/1566524033479843","volume":"3","author":"JD Ahlers","year":"2003","unstructured":"Ahlers JD, Belyakov IM, Berzofsky JA (2003) Cytokine, chemokine, and costimulatory molecule modulation to enhance efficacy of HIV vaccines. Curr Mol Med 3:285\u2013301","journal-title":"Curr Mol Med"},{"key":"510_CR24","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1600-065X.2010.00975.x","volume":"239","author":"B Moss","year":"2011","unstructured":"Moss B (2011) Smallpox vaccines: targets of protective immunity. Immunol Rev 239:8\u201326","journal-title":"Immunol Rev"},{"key":"510_CR25","first-page":"225","volume":"41","author":"A Mayr","year":"1978","unstructured":"Mayr A, Danner K (1978) Vaccination against pox diseases under immunosuppressive conditions. Dev Biol Stand 41:225\u2013234","journal-title":"Dev Biol Stand"},{"key":"510_CR26","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1055\/s-0028-1108143","volume":"99","author":"H Stickl","year":"1974","unstructured":"Stickl H, Hochstein-Mintzel V, Mayr A, Huber HC, Schafer H, Holzner A (1974) MVA vaccination against smallpox: clinical tests with an attenuated live vaccinia virus strain (MVA) (author\u2019s transl). Dtsch Med Wochenschr 99:2386\u20132392 (in German)","journal-title":"Dtsch Med Wochenschr"},{"key":"510_CR27","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1006\/viro.1998.9123","volume":"244","author":"G Antoine","year":"1998","unstructured":"Antoine G, Scheiflinger F, Dorner F, Falkner FG (1998) The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxviruses. Virology 244:365\u2013396","journal-title":"Virology"},{"key":"510_CR28","doi-asserted-by":"publisher","first-page":"3249","DOI":"10.1099\/vir.0.83156-0","volume":"88","author":"C Meisinger-Henschel","year":"2007","unstructured":"Meisinger-Henschel C, Schmidt M, Lukassen S, Linke B, Krause L, Konietzny S, Goesmann A, Howley P, Chaplin P, Suter M, Hausmann J (2007) Genomic sequence of chorioallantois vaccinia virus Ankara, the ancestor of modified vaccinia virus Ankara. J Gen Virol 88:3249\u20133259","journal-title":"J Gen Virol"},{"key":"510_CR29","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1099\/0022-1317-72-5-1031","volume":"72","author":"H Meyer","year":"1991","unstructured":"Meyer H, Sutter G, Mayr A (1991) Mapping of deletions in the genome of the highly attenuated vaccinia virus MVA and their influence on virulence. J Gen Virol 72:1031\u20131038","journal-title":"J Gen Virol"},{"key":"510_CR30","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1073\/pnas.79.5.1593","volume":"79","author":"E Nakano","year":"1982","unstructured":"Nakano E, Panicali D, Paoletti E (1982) Molecular genetics of vaccinia virus: demonstration of marker rescue. Proc Natl Acad Sci U S A 79:1593\u20131596","journal-title":"Proc Natl Acad Sci U S A"},{"key":"510_CR31","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1128\/JVI.02165-08","volume":"83","author":"N Prabhu","year":"2009","unstructured":"Prabhu N, Prabakaran M, Ho HT, Velumani S, Qiang J, Goutama M, Kwang J (2009) Monoclonal antibodies against the fusion peptide of hemagglutinin protect mice from lethal influenza A virus H5N1 infection. J Virol 83:2553\u20132562","journal-title":"J Virol"},{"key":"510_CR32","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13567-015-0146-7","volume":"46","author":"X Xie","year":"2015","unstructured":"Xie X, Lin Y, Pang M, Zhao Y, Kalhoro DH, Lu C, Liu Y (2015) Monoclonal antibody specific to HA2 glycopeptide protects mice from H3N2 influenza virus infection. Vet Res 46:33","journal-title":"Vet Res"},{"key":"510_CR33","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/1743-422X-9-291","volume":"9","author":"H Tian","year":"2012","unstructured":"Tian H, Wu J, Chen Y, Zhang K, Shang Y, Liu X (2012) Development of a SYBR green real-time PCR method for rapid detection of sheep pox virus. Virol J 9:291","journal-title":"Virol J"},{"key":"510_CR34","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1007\/s00705-002-0870-y","volume":"147","author":"M Tang","year":"2002","unstructured":"Tang M, Harp JA, Wesley RD (2002) Recombinant adenovirus encoding the HA gene from swine H3N2 influenza virus partially protects mice from challenge with heterologous virus: A\/HK\/1\/68 (H3N2). Arch Virol 147:2125\u20132141","journal-title":"Arch Virol"},{"key":"510_CR35","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jviromet.2007.12.018","volume":"149","author":"Y Du","year":"2008","unstructured":"Du Y, Li Y, He H, Qi J, Jiang W, Wang X, Tang B, Cao J, Jiang P (2008) Enhanced immunogenicity of multiple-epitopes of foot-and-mouth disease virus fused with porcine interferon alpha in mice and protective efficacy in guinea pigs and swine. J Virol Methods 149:144\u2013152","journal-title":"J Virol Methods"},{"key":"510_CR36","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/0006-3002(59)90389-0","volume":"35","author":"RM Smellie","year":"1959","unstructured":"Smellie RM, Keir HM, Davidson JN (1959) Studies on the biosynthesis of deoxyribonucleic acid by extracts of mammalian cells. I. Incorporation of tritium-labelled thymidine. Biochim Biophys Acta 35:389\u2013404","journal-title":"Biochim Biophys Acta"},{"key":"510_CR37","first-page":"369","volume":"2","author":"S Kit","year":"1985","unstructured":"Kit S (1985) Thymidine kinase. Microbiol Sci 2:369\u2013375","journal-title":"Microbiol Sci"},{"key":"510_CR38","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1128\/MMBR.00027-06","volume":"70","author":"MA Garcia","year":"2006","unstructured":"Garcia MA, Gil J, Ventoso I, Guerra S, Domingo E, Rivas C, Esteban M (2006) Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action. Microbiol Mol Biol Rev 70:1032\u20131060","journal-title":"Microbiol Mol Biol Rev"},{"key":"510_CR39","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","volume":"140","author":"GS Hotamisligil","year":"2010","unstructured":"Hotamisligil GS (2010) Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140:900\u2013917","journal-title":"Cell"},{"key":"510_CR40","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1034\/j.1600-065X.2002.19008.x","volume":"190","author":"JK Kulski","year":"2002","unstructured":"Kulski JK, Shiina T, Anzai T, Kohara S, Inoko H (2002) Comparative genomic analysis of the MHC: the evolution of class I duplication blocks, diversity and complexity from shark to man. Immunol Rev 190:95\u2013122","journal-title":"Immunol Rev"}],"container-title":["Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13567-018-0510-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:54:51Z","timestamp":1549500891000},"score":1,"resource":{"primary":{"URL":"https:\/\/veterinaryresearch.biomedcentral.com\/articles\/10.1186\/s13567-018-0510-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,7]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["510"],"URL":"https:\/\/doi.org\/10.1186\/s13567-018-0510-5","relation":{},"ISSN":["1297-9716"],"issn-type":[{"value":"1297-9716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,7]]},"assertion":[{"value":"17 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"14"}}