{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:33:41Z","timestamp":1787013221989,"version":"build-2736575974"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IDT Biologika GmbH"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BA 4730\/3-1"],"award-info":[{"award-number":["BA 4730\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13567-018-0544-8","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T02:01:06Z","timestamp":1529028066000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Streptococcus suis cps7: an emerging virulent sequence type (ST29) shows a distinct, IgM-determined pattern of bacterial survival in blood of piglets during the early adaptive immune response after weaning"],"prefix":"10.1186","volume":"49","author":[{"given":"Karoline","family":"Rieckmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Seydel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Szewczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Klimke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Rungelrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9149-1615","authenticated-orcid":false,"given":"Christoph Georg","family":"Baums","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,15]]},"reference":[{"key":"544_CR1","unstructured":"Gottschalk M (2012) Streptococcosis. In: Zimmermann JJ, Karriker LA, Ramirez A, Schwartz KJ SG (eds) Diseases of swine, 10th edition, pp 841\u2013855"},{"key":"544_CR2","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1177\/104063879500700322","volume":"7","author":"R Higgins","year":"1995","unstructured":"Higgins R, Gottschalk M, Boudreau M, Lebrun A (1995) Description of six new capsular types (29\u201334) of Streptococcus suis. J Vet Diagn Invest 7:405\u2013406","journal-title":"J Vet Diagn Invest"},{"key":"544_CR3","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1128\/JCM.27.12.2633-2636.1989","volume":"27","author":"M Gottschalk","year":"1989","unstructured":"Gottschalk M, Higgins R, Jacques M, Mittal KR, Henrichsen J (1989) Description of 14 new capsular types of Streptococcus suis. J Clin Microbiol 27:2633\u20132636","journal-title":"J Clin Microbiol"},{"key":"544_CR4","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1128\/JCM.29.11.2590-2594.1991","volume":"29","author":"M Gottschalk","year":"1991","unstructured":"Gottschalk M, Higgins R, Jacques M, Beaudoin M, Henrichsen J (1991) Characterization of six new capsular types (23 through 28) of Streptococcus suis. J Clin Microbiol 29:2590\u20132594","journal-title":"J Clin Microbiol"},{"key":"544_CR5","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1128\/JCM.17.6.993-996.1983","volume":"17","author":"B Perch","year":"1983","unstructured":"Perch B, Pedersen KB, Henrichsenl J (1983) Serology of capsulated streptococci pathogenic for pigs: six new serotypes of Streptococcus suis. J Clin Microbiol 17:993\u2013996","journal-title":"J Clin Microbiol"},{"key":"544_CR6","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1038\/emi.2014.45","volume":"3","author":"G Goyette-Desjardins","year":"2014","unstructured":"Goyette-Desjardins G, Auger J-P, Xu J, Segura M, Gottschalk M (2014) Streptococcus suis, an important pig pathogen and emerging zoonotic agent-an update on the worldwide distribution based on serotyping and sequence typing. Emerg Microbes Infect 3:e45","journal-title":"Emerg Microbes Infect"},{"key":"544_CR7","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.vetmic.2012.11.001","volume":"162","author":"LHT Tien","year":"2013","unstructured":"Tien LHT, Nishibori T, Nishitani Y, Nomoto R, Osawa R (2013) Reappraisal of the taxonomy of Streptococcus suis serotypes 20, 22, 26, and 33 based on DNA\u2013DNA homology and sodA and recN phylogenies. Vet Microbiol 162:842\u2013849","journal-title":"Vet Microbiol"},{"key":"544_CR8","first-page":"161","volume":"12","author":"V Blume","year":"2009","unstructured":"Blume V, Luque I, Vela AI, Borge C, Maldonado A, Dominguez L, Tarradas C, Fernandez-Garayzabal JF (2009) Genetic and virulence-phenotype characterization of serotypes 2 and 9 of Streptococcus suis swine isolates. Int Microbiol 12:161\u2013166","journal-title":"Int Microbiol"},{"key":"544_CR9","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.mimet.2006.10.010","volume":"68","author":"CKY Luey","year":"2006","unstructured":"Luey CKY, Chu YW, Cheung TKM, Law CCP, Chu MY, Cheung DTL, Kam KM (2006) Rapid pulsed-field gel electrophoresis protocol for subtyping of Streptococcus suis serotype 2. J Microbiol Methods 68:648\u2013650","journal-title":"J Microbiol Methods"},{"key":"544_CR10","doi-asserted-by":"publisher","first-page":"3671","DOI":"10.1128\/JCM.40.10.3671-3680.2002","volume":"40","author":"SJ King","year":"2002","unstructured":"King SJ, Leigh JA, Heath PJ, Luque I, Tarradas C, Dowson CG, Whatmore AM (2002) Development of a multilocus sequence typing scheme for the pig pathogen Streptococcus suis: identification of virulent clones and potential capsular serotype exchange. J Clin Microbiol 40:3671\u20133680","journal-title":"J Clin Microbiol"},{"key":"544_CR11","doi-asserted-by":"publisher","first-page":"e33854","DOI":"10.1371\/journal.pone.0033854","volume":"7","author":"C Schultsz","year":"2012","unstructured":"Schultsz C, Jansen E, Keijzers W, Rothkamp A, Duim B, Wagenaar JA, van der Ende A (2012) Differences in the population structure of invasive Streptococcus suis strains isolated from pigs and from humans in the Netherlands. Plos One 7:e33854","journal-title":"Plos One"},{"key":"544_CR12","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0378-1135(00)00188-7","volume":"74","author":"HJ Wisselink","year":"2000","unstructured":"Wisselink HJ, Smith HE, Stockhofe-Zurwieden N, Peperkamp K, Vecht U (2000) Distribution of capsular types and production of muramidase-released protein (MRP) and extracellular factor (EF) of Streptococcus suis strains isolated from diseased pigs in seven European countries. Vet Microbiol 74:237\u2013248","journal-title":"Vet Microbiol"},{"key":"544_CR13","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0378-1135(98)00147-3","volume":"60","author":"FM Aarestrup","year":"1998","unstructured":"Aarestrup FM, Jorsal SE, Jensen NE (1998) Serological characterization and antimicrobial susceptibility of Streptococcus suis isolates from diagnostic samples in Denmark during 1995 and 1996. Vet Microbiol 60:59\u201366","journal-title":"Vet Microbiol"},{"key":"544_CR14","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1128\/IAI.60.2.550-556.1992","volume":"60","author":"U Vecht","year":"1992","unstructured":"Vecht U, Wisselink HJ, Van Dijk JE, Smith HE (1992) Virulence of Streptococcus suis type 2 strains in newborn germfree pigs depends on phenotype. Infect Immun 60:550\u2013556","journal-title":"Infect Immun"},{"key":"544_CR15","doi-asserted-by":"publisher","first-page":"7572","DOI":"10.1128\/IAI.69.12.7572-7582.2001","volume":"69","author":"SJ King","year":"2001","unstructured":"King SJ, Heath PJ, Luque I, Tarradas C, Dowson CG, Whatmore AM (2001) Distribution and genetic diversity of suilysin in Streptococcus suis isolated from different diseases of pigs and characterization of the genetic basis of suilysin absence. Infect Immun 69:7572\u20137582","journal-title":"Infect Immun"},{"key":"544_CR16","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.vetmic.2009.06.024","volume":"139","author":"N Fittipaldi","year":"2009","unstructured":"Fittipaldi N, Fuller TE, Teel JF, Wilson TL, Wolfram TJ, Lowery DE, Gottschalk M (2009) Serotype distribution and production of muramidase-released protein, extracellular factor and suilysin by field strains of Streptococcus suis isolated in the United States. Vet Microbiol 139:310\u2013317","journal-title":"Vet Microbiol"},{"key":"544_CR17","first-page":"1001","volume":"6","author":"J Wang","year":"2015","unstructured":"Wang J, Kong D, Zhang S, Jiang H, Zheng Y, Zang Y, Hao H, Jiang Y (2015) Interaction of fibrinogen and muramidase-released protein promotes the development of Streptococcus suis meningitis. Front Microbiol 6:1001","journal-title":"Front Microbiol"},{"key":"544_CR18","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fcimb.2015.00019","volume":"5","author":"Y Pian","year":"2015","unstructured":"Pian Y, Wang P, Liu P, Zheng Y, Zhu L, Wang H, Xu B, Yuan Y, Jiang Y (2015) Proteomics identification of novel fibrinogen-binding proteins of Streptococcus suis contributing to antiphagocytosis. Front Cell Infect Microbiol 5:19","journal-title":"Front Cell Infect Microbiol"},{"key":"544_CR19","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.vetmic.2005.12.013","volume":"115","author":"LMG Silva","year":"2006","unstructured":"Silva LMG, Baums CG, Rehm T, Wisselink HJ, Goethe R, Valentin-Weigand P (2006) Virulence-associated gene profiling of Streptococcus suis isolates by PCR. Vet Microbiol 115:117\u2013127","journal-title":"Vet Microbiol"},{"key":"544_CR20","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1128\/JB.01875-12","volume":"195","author":"J Seele","year":"2013","unstructured":"Seele J, Singpiel A, Spoerry C, von Pawel-Rammingen U, Valentin-Weigand P, Baums CG (2013) Identification of a novel host-specific IgM protease in Streptococcus suis. J Bacteriol 195:930\u2013940","journal-title":"J Bacteriol"},{"key":"544_CR21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s13567-015-0171-6","volume":"46","author":"J Seele","year":"2015","unstructured":"Seele J, Beineke A, Hillermann LM, Jaschok-Kentner B, von Pawel-Rammingen U, Valentin-Weigand P, Baums CG (2015) The immunoglobulin M-degrading enzyme of Streptococcus suis, IdeSsuis, is involved in complement evasion. Vet Res 46:45","journal-title":"Vet Res"},{"key":"544_CR22","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1079\/PNS19730041","volume":"32","author":"FJ Bourne","year":"1973","unstructured":"Bourne FJ (1973) Symposium on \u201cnutrition of the young farm animal\u201d. The immunoglobulin system of the suckling pig. Proc Nutr Soc 32:205\u2013215","journal-title":"Proc Nutr Soc"},{"key":"544_CR23","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1099\/jmm.0.46616-0","volume":"56","author":"T Rehm","year":"2007","unstructured":"Rehm T, Baums CG, Strommenger B, Beyerbach M, Valentin-Weigand P, Goethe R (2007) Amplified fragment length polymorphism of Streptococcus suis strains correlates with their profile of virulence-associated genes and clinical background. J Med Microbiol 56:102\u2013109","journal-title":"J Med Microbiol"},{"key":"544_CR24","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1128\/IAI.64.10.4409-4412.1996","volume":"64","author":"HE Smith","year":"1996","unstructured":"Smith HE, Vecht U, Wisselink HJ, Stockhofe-Zurwieden N, Biermann Y, Smits MA (1996) Mutants of Streptococcus suis types 1 and 2 impaired in expression of muramidase-released protein and extracellular protein induce disease in newborn germfree pigs. Infect Immun 64:4409\u20134412","journal-title":"Infect Immun"},{"key":"544_CR25","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1128\/IAI.67.4.1750-1756.1999","volume":"67","author":"HE Smith","year":"1999","unstructured":"Smith HE, Damman M, van der Velde J, Wagenaar F, Wisselink HJ, Stockhofe-Zurwieden N, Smits MA (1999) Identification and characterization of the cps locus of Streptococcus suis serotype 2: the capsule protects against phagocytosis and is an important virulence factor. Infect Immun 67:1750\u20131756","journal-title":"Infect Immun"},{"key":"544_CR26","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.vetmic.2007.10.028","volume":"128","author":"A Beineke","year":"2008","unstructured":"Beineke A, Bennecke K, Neis C, Schr\u00f6der C, Waldmann K-H, Baumg\u00e4rtner W, Valentin-Weigand P, Baums CG (2008) Comparative evaluation of virulence and pathology of Streptococcus suis serotypes 2 and 9 in experimentally infected growers. Vet Microbiol 128:423\u2013430","journal-title":"Vet Microbiol"},{"key":"544_CR27","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1128\/CVI.00371-08","volume":"16","author":"CG Baums","year":"2009","unstructured":"Baums CG, Kock C, Beineke A, Bennecke K, Goethe R, Schr\u00f6der C, Waldmann K-H, Valentin-Weigand P (2009) Streptococcus suis bacterin and subunit vaccine immunogenicities and protective efficacies against serotypes 2 and 9. Clin Vaccine Immunol 16:200\u2013208","journal-title":"Clin Vaccine Immunol"},{"key":"544_CR28","doi-asserted-by":"publisher","first-page":"6154","DOI":"10.1128\/IAI.00359-06","volume":"74","author":"CG Baums","year":"2006","unstructured":"Baums CG, Kaim U, Fulde M, Ramachandran G, Goethe R, Valentin-Weigand P (2006) Identification of a novel virulence determinant with serum opacification activity in Streptococcus suis. Infect Immun 74:6154\u20136162","journal-title":"Infect Immun"},{"key":"544_CR29","doi-asserted-by":"publisher","first-page":"259","DOI":"10.2217\/fmb.11.149","volume":"7","author":"N Fittipaldi","year":"2012","unstructured":"Fittipaldi N, Segura M, Grenier D, Gottschalk M (2012) Virulence factors involved in the pathogenesis of the infection caused by the swine pathogen and zoonotic agent Streptococcus suis. Future Microbiol 7:259\u2013279","journal-title":"Future Microbiol"},{"key":"544_CR30","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.vetmic.2004.07.009","volume":"103","author":"Y Tian","year":"2004","unstructured":"Tian Y, Aarestrup FM, Lu CP (2004) Characterization of Streptococcus suis serotype 7 isolates from diseased pigs in Denmark. Vet Microbiol 103:55\u201362","journal-title":"Vet Microbiol"},{"key":"544_CR31","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1128\/IAI.60.6.2361-2367.1992","volume":"60","author":"HE Smith","year":"1992","unstructured":"Smith HE, Vecht U, Gielkens ALJ, Smits MA (1992) Cloning and nucleotide sequence of the gene encoding the 136-kilodalton surface protein (muramidase-released protein) of Streptococcus suis type 2. Infect Immun 60:2361\u20132367","journal-title":"Infect Immun"},{"key":"544_CR32","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.immuni.2005.04.011","volume":"23","author":"KM Haas","year":"2005","unstructured":"Haas KM, Poe JC, Steeber DA, Tedder TF (2005) B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae. Immunity 23:7\u201318","journal-title":"Immunity"},{"key":"544_CR33","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1099\/00222615-46-8-675","volume":"46","author":"M Yokota","year":"1997","unstructured":"Yokota M, Morshed MG, Nakazawa T, Konishi H (1997) Protective activity of Borrelia duttonii-specific immunoglobulin subclasses in mice. J Med Microbiol 46:675\u2013680","journal-title":"J Med Microbiol"},{"key":"544_CR34","doi-asserted-by":"publisher","first-page":"3819","DOI":"10.4049\/jimmunol.170.7.3819","volume":"170","author":"KR Alugupalli","year":"2003","unstructured":"Alugupalli KR, Gerstein RM, Chen J, Szomolanyi-Tsuda E, Woodland RT, Leong JM (2003) The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol 170:3819\u20133827","journal-title":"J Immunol"},{"key":"544_CR35","first-page":"233","volume":"95","author":"AG Boetner","year":"1987","unstructured":"Boetner AG, Binder M, Bille-Hansen V (1987) Streptococcus suis infections in Danish pigs and experimental infection with Streptococcus suis serotype 7. Acta Pathol Microbiol Immunol Scand B 95:233\u2013239","journal-title":"Acta Pathol Microbiol Immunol Scand B"}],"container-title":["Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13567-018-0544-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13567-018-0544-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13567-018-0544-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T17:22:28Z","timestamp":1604424148000},"score":1,"resource":{"primary":{"URL":"https:\/\/veterinaryresearch.biomedcentral.com\/articles\/10.1186\/s13567-018-0544-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,15]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["544"],"URL":"https:\/\/doi.org\/10.1186\/s13567-018-0544-8","relation":{},"ISSN":["1297-9716"],"issn-type":[{"value":"1297-9716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,15]]},"assertion":[{"value":"5 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"48"}}