{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:08:16Z","timestamp":1790024896371,"version":"4.0.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T00:00:00Z","timestamp":1532476800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"R\u00e9gion Centre, France","award":["2013 00082862"],"award-info":[{"award-number":["2013 00082862"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13567-018-0564-4","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T13:05:20Z","timestamp":1532523920000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Host factors determine the evolution of infection with Staphylococcus aureus to gangrenous mastitis in goats"],"prefix":"10.1186","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5477-2626","authenticated-orcid":false,"given":"Pascal","family":"Rainard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Gitton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Chaumeil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Fassier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Huau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mickael","family":"Riou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenola","family":"Tosser-Klopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Krupova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Chaize","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence B.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Rupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,25]]},"reference":[{"key":"564_CR1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0301-6226(99)00128-1","volume":"64","author":"B Heringstad","year":"2000","unstructured":"Heringstad B, Klemetsdal G, Ruane J (2000) Selection for mastitis resistance in dairy cattle: a review with focus on the situation in the Nordic countries. Livest Prod Sci 64:95\u2013106","journal-title":"Livest Prod Sci"},{"key":"564_CR2","unstructured":"Rupp R, Boichard D, Barbat A, Astruc JM, Lagriffoul G, Barillet F (2002) Selection for mastitis resistance in French dairy sheep. Paper presented at the 7th World congress on genetics applied to livestock production, Montpellier, France, August 19\u201323"},{"key":"564_CR3","unstructured":"Cl\u00e9ment V, De Cr\u00e9moux R, Caillat H, Huau C, Bouvier F, Palhi\u00e8re I, Larroque H, Martin P, Rupp R (2016) Somatic cell counts as a selection criterion for goat mastitis resistance. Paper presented at the 6th IDF mastitis conference, Nantes, France, September 07\u201309"},{"key":"564_CR4","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.3168\/jds.2008-1435","volume":"92","author":"R Rupp","year":"2009","unstructured":"Rupp R, Bergonier D, Dion S, Hygonenq MC, Aurel MR, Robert-Granie C, Foucras G (2009) Response to somatic cell count-based selection for mastitis resistance in a divergent selection experiment in sheep. J Dairy Sci 92:1203\u20131219","journal-title":"J Dairy Sci"},{"key":"564_CR5","unstructured":"Caillat H, Bouvier F, Gu\u00e9ry E, Martin P, Rainard P, Rupp R (2011) Response to a divergent selection based on somatic cell counts in Alpine dairy goats. Paper presented at the 62nd annual meeting EAAP, Stavanger, Norway, August 29\u2013September 2"},{"key":"564_CR6","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.smallrumres.2006.09.011","volume":"68","author":"A Contreras","year":"2007","unstructured":"Contreras A, Sierra D, Sanchez A, Corrales JC, Marco JC, Paape MJ, Gonzalo C (2007) Mastitis in small ruminants. Small Rumin Res 68:145\u2013153","journal-title":"Small Rumin Res"},{"key":"564_CR7","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1051\/vetres:2003030","volume":"34","author":"D Bergonier","year":"2003","unstructured":"Bergonier D, de Cremoux R, Rupp R, Lagriffoul G, Berthelot X (2003) Mastitis of dairy small ruminants. Vet Res 34:689\u2013716","journal-title":"Vet Res"},{"key":"564_CR8","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/1471-2164-12-208","volume":"12","author":"CM Bonnefont","year":"2011","unstructured":"Bonnefont CM, Toufeer M, Caubet C, Foulon E, Tasca C, Aurel MR, Bergonier D, Boullier S, Robert-Granie C, Foucras G, Rupp R (2011) Transcriptomic analysis of milk somatic cells in mastitis resistant and susceptible sheep upon challenge with Staphylococcus epidermidis and Staphylococcus aureus. BMC Genomics 12:208","journal-title":"BMC Genomics"},{"key":"564_CR9","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2018-14593","author":"P Rainard","year":"2018","unstructured":"Rainard P, Foucras G, Boichard D, Rupp R (2018) Invited review: low milk somatic cell count and susceptibility to mastitis. J Dairy Sci. https:\/\/doi.org\/10.3168\/jds.2018-14593 (in press)","journal-title":"J Dairy Sci"},{"key":"564_CR10","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1186\/1471-2164-13-540","volume":"13","author":"P Cremonesi","year":"2012","unstructured":"Cremonesi P, Capoferri R, Pisoni G, Del Corvo M, Strozzi F, Rupp R, Caillat H, Modesto P, Moroni P, Williams JL, Castiglioni B, Stella A (2012) Response of the goat mammary gland to infection with Staphylococcus aureus revealed by gene expression profiling in milk somatic and white blood cells. BMC Genomics 13:540","journal-title":"BMC Genomics"},{"key":"564_CR11","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1051\/vetres:2007026","volume":"38","author":"P Rainard","year":"2007","unstructured":"Rainard P (2007) Staphylococcus aureus leucotoxin LukM\/F\u2032 is secreted and stimulates neutralising antibody response in the course of intramammary infection. Vet Res 38:685\u2013696","journal-title":"Vet Res"},{"key":"564_CR12","doi-asserted-by":"publisher","first-page":"37759","DOI":"10.1038\/srep37759","volume":"6","author":"M Vrieling","year":"2016","unstructured":"Vrieling M, Boerhout EM, van Wigcheren GF, Koymans KJ, Mols-Vorstermans TG, de Haas CJ, Aerts PC, Daemen IJ, van Kessel KP, Koets AP, Rutten VP, Nuijten PJ, van Strijp JA, Benedictus L (2016) LukMF\u2032 is the major secreted leukocidin of bovine Staphylococcus aureus and is produced in vivo during bovine mastitis. Sci Rep 6:37759","journal-title":"Sci Rep"},{"key":"564_CR13","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/tbed.12698","volume":"65","author":"P Rainard","year":"2018","unstructured":"Rainard P, Foucras G, Fitzgerald JR, Watts JL, Koop G, Middleton JR (2018) Knowledge gaps and research priorities in Staphylococcus aureus mastitis control. Transbound Emerg Dis 65:149\u2013165","journal-title":"Transbound Emerg Dis"},{"key":"564_CR14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0076-6879(88)65004-X","volume":"165","author":"S Harshman","year":"1988","unstructured":"Harshman S, Sugg N, Cassidy P (1988) Preparation and purification of staphylococcal alpha toxin. Methods Enzymol 165:3\u20137","journal-title":"Methods Enzymol"},{"key":"564_CR15","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.3168\/jds.S0022-0302(97)76147-2","volume":"80","author":"C Herbelin","year":"1997","unstructured":"Herbelin C, Poutrel B, Gilbert FB, Rainard P (1997) Immune recruitment and bactericidal activity of neutrophils in milk of cows vaccinated with staphylococcal alpha-toxin. J Dairy Sci 80:2025\u20132034","journal-title":"J Dairy Sci"},{"key":"564_CR16","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1016\/S0264-410X(00)00402-3","volume":"19","author":"C Burgeot","year":"2001","unstructured":"Burgeot C, Gilbert FB, Poutrel B (2001) Immunopotentiation of Staphylococcus aureus type 5 capsular polysaccharide co-entrapped in liposomes with alpha-toxin. Vaccine 19:2092\u20132099","journal-title":"Vaccine"},{"key":"564_CR17","doi-asserted-by":"publisher","first-page":"4020","DOI":"10.1016\/j.molimm.2008.06.010","volume":"45","author":"P Rainard","year":"2008","unstructured":"Rainard P, Riollet C, Berthon P, Cunha P, Fromageau A, Rossignol C, Gilbert FB (2008) The chemokine CXCL3 is responsible for the constitutive chemotactic activity of bovine milk for neutrophils. Mol Immunol 45:4020\u20134027","journal-title":"Mol Immunol"},{"key":"564_CR18","doi-asserted-by":"publisher","first-page":"e63471","DOI":"10.1371\/journal.pone.0063471","volume":"8","author":"P Rainard","year":"2013","unstructured":"Rainard P, Cunha P, Bougarn S, Fromageau A, Rossignol C, Gilbert BF, Berthon P (2013) T helper 17-associated cytokines are produced during antigen-specific inflammation in the mammary gland. PLoS One 8:e63471","journal-title":"PLoS One"},{"key":"564_CR19","first-page":"231","volume":"28","author":"P Rainard","year":"1997","unstructured":"Rainard P, Paape MJ (1997) Sensitization of the bovine mammary gland to Escherichia coli endotoxin. Vet Res 28:231\u2013238","journal-title":"Vet Res"},{"key":"564_CR20","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.domaniend.2010.04.001","volume":"39","author":"TL Dow","year":"2010","unstructured":"Dow TL, Rogers-Nieman G, Holaskova I, Elsasser TH, Dailey RA (2010) Tumor necrosis factor-alpha and acute-phase proteins in early pregnant ewes after challenge with peptidoglycan-polysaccharide. Domest Anim Endocrinol 39:147\u2013154","journal-title":"Domest Anim Endocrinol"},{"key":"564_CR21","doi-asserted-by":"publisher","first-page":"3441","DOI":"10.1038\/s41598-017-03724-7","volume":"7","author":"V Herry","year":"2017","unstructured":"Herry V, Gitton C, Tabouret G, Reperant M, Forge L, Tasca C, Gilbert FB, Guitton E, Barc C, Staub C, Smith DGE, Germon P, Foucras G, Rainard P (2017) Local immunization impacts the response of dairy cows to Escherichia coli mastitis. Sci Rep 7:3441","journal-title":"Sci Rep"},{"key":"564_CR22","doi-asserted-by":"publisher","first-page":"6130","DOI":"10.3168\/jds.2012-5604","volume":"95","author":"P Brenaut","year":"2012","unstructured":"Brenaut P, Bangera R, Bevilacqua C, Rebours E, Cebo C, Martin P (2012) Validation of RNA isolated from milk fat globules to profile mammary epithelial cell expression during lactation and transcriptional response to a bacterial infection. J Dairy Sci 95:6130\u20136144","journal-title":"J Dairy Sci"},{"key":"564_CR23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1471-2199-7-3","volume":"7","author":"A Schroeder","year":"2006","unstructured":"Schroeder A, Mueller O, Stocker S, Salowsky R, Leiber M, Gassmann M, Lightfoot S, Menzel W, Granzow M, Ragg T (2006) The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol 7:3","journal-title":"BMC Mol Biol"},{"key":"564_CR24","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1297-9716-45-16","volume":"45","author":"P Brenaut","year":"2014","unstructured":"Brenaut P, Lefevre L, Rau A, Laloe D, Pisoni G, Moroni P, Bevilacqua C, Martin P (2014) Contribution of mammary epithelial cells to the immune response during early stages of a bacterial infection to Staphylococcus aureus. Vet Res 45:16","journal-title":"Vet Res"},{"key":"564_CR25","doi-asserted-by":"publisher","first-page":"R19","DOI":"10.1186\/gb-2007-8-2-r19","volume":"8","author":"J Hellemans","year":"2007","unstructured":"Hellemans J, Mortier G, De Paepe A, Speleman F, Vandesompele J (2007) qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data. Genome Biol 8:R19","journal-title":"Genome Biol"},{"key":"564_CR26","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1128\/CDLI.10.2.272-277.2003","volume":"10","author":"P Rainard","year":"2003","unstructured":"Rainard P, Corrales JC, Barrio MB, Cochard T, Poutrel B (2003) Leucotoxic activities of Staphylococcus aureus strains isolated from cows, ewes, and goats with mastitis: importance of LukM\/LukF\u2032-PV leukotoxin. Clin Diagn Lab Immunol 10:272\u2013277","journal-title":"Clin Diagn Lab Immunol"},{"key":"564_CR27","doi-asserted-by":"publisher","first-page":"e00335","DOI":"10.1128\/mBio.00335-15","volume":"6","author":"M Vrieling","year":"2015","unstructured":"Vrieling M, Koymans KJ, Heesterbeek DA, Aerts PC, Rutten VP, de Haas CJ, van Kessel KP, Koets AP, Nijland R, van Strijp JA (2015) Bovine Staphylococcus aureus secretes the leukocidin LukMF\u2032 to kill migrating neutrophils through CCR1. MBio 6:e00335","journal-title":"MBio"},{"key":"564_CR28","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1128\/JCM.26.7.1331-1334.1988","volume":"26","author":"DA Loeffler","year":"1988","unstructured":"Loeffler DA, Creasy MT, Norcross NL, Paape MJ (1988) Enzyme-linked immunosorbent assay for detection of leukocidin toxin from Staphylococcus aureus in bovine milk samples. J Clin Microbiol 26:1331\u20131334","journal-title":"J Clin Microbiol"},{"key":"564_CR29","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0008-8749(86)90274-1","volume":"98","author":"MJ Steinbeck","year":"1986","unstructured":"Steinbeck MJ, Roth JA, Kaeberle ML (1986) Activation of bovine neutrophils by recombinant interferon-gamma. Cell Immunol 98:137\u2013144","journal-title":"Cell Immunol"},{"key":"564_CR30","doi-asserted-by":"publisher","first-page":"951","DOI":"10.2460\/ajvr.2000.61.951","volume":"61","author":"P Rainard","year":"2000","unstructured":"Rainard P, Riollet C, Poutrel B, Paape MJ (2000) Phagocytosis and killing of Staphylococcus aureus by bovine neutrophils after priming by tumor necrosis factor-alpha and the des-arginine derivative of C5a. Am J Vet Res 61:951\u2013959","journal-title":"Am J Vet Res"},{"key":"564_CR31","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.cyto.2011.09.020","volume":"56","author":"S Bougarn","year":"2011","unstructured":"Bougarn S, Cunha P, Gilbert FB, Harmache A, Foucras G, Rainard P (2011) Staphylococcal-associated molecular patterns enhance expression of immune defense genes induced by IL-17 in mammary epithelial cells. Cytokine 56:749\u2013759","journal-title":"Cytokine"},{"key":"564_CR32","doi-asserted-by":"publisher","first-page":"12768","DOI":"10.1073\/pnas.1300318110","volume":"110","author":"CL Zindl","year":"2013","unstructured":"Zindl CL, Lai JF, Lee YK, Maynard CL, Harbour SN, Ouyang W, Chaplin DD, Weaver CT (2013) IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis. Proc Natl Acad Sci U S A 110:12768\u201312773","journal-title":"Proc Natl Acad Sci U S A"},{"key":"564_CR33","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/nri1200","volume":"3","author":"T Calandra","year":"2003","unstructured":"Calandra T, Roger T (2003) Macrophage migration inhibitory factor: a regulator of innate immunity. Nat Rev Immunol 3:791\u2013800","journal-title":"Nat Rev Immunol"},{"key":"564_CR34","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1203\/00006450-200205000-00013","volume":"51","author":"B Magi","year":"2002","unstructured":"Magi B, Ietta F, Romagnoli R, Liberatori S, Pallini V, Bini L, Tripodi SA, Cintorino M, Chellini F, Arcuri F, De Felice C, Paulesu L (2002) Presence of macrophage migration inhibitory factor in human milk: evidence in the aqueous phase and milk fat globules. Pediatr Res 51:619\u2013624","journal-title":"Pediatr Res"},{"key":"564_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-0625.2010.01194.x","volume":"20","author":"SC Gilliver","year":"2011","unstructured":"Gilliver SC, Emmerson E, Bernhagen J, Hardman MJ (2011) MIF: a key player in cutaneous biology and wound healing. Exp Dermatol 20:1\u20136","journal-title":"Exp Dermatol"},{"key":"564_CR36","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s00441-010-1018-0","volume":"343","author":"L Deban","year":"2011","unstructured":"Deban L, Jaillon S, Garlanda C, Bottazzi B, Mantovani A (2011) Pentraxins in innate immunity: lessons from PTX3. Cell Tissue Res 343:237\u2013249","journal-title":"Cell Tissue Res"},{"key":"564_CR37","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1746-6148-4-18","volume":"4","author":"YC Lutzow","year":"2008","unstructured":"Lutzow YC, Donaldson L, Gray CP, Vuocolo T, Pearson RD, Reverter A, Byrne KA, Sheehy PA, Windon R, Tellam RL (2008) Identification of immune genes and proteins involved in the response of bovine mammary tissue to Staphylococcus aureus infection. BMC Vet Res 4:18","journal-title":"BMC Vet Res"},{"key":"564_CR38","doi-asserted-by":"publisher","first-page":"3182","DOI":"10.1128\/IAI.00291-13","volume":"81","author":"MF Addis","year":"2013","unstructured":"Addis MF, Pisanu S, Marogna G, Cubeddu T, Pagnozzi D, Cacciotto C, Campesi F, Schianchi G, Rocca S, Uzzau S (2013) Production and release of antimicrobial and immune defense proteins by mammary epithelial cells following Streptococcus uberis infection of sheep. Infect Immun 81:3182\u20133197","journal-title":"Infect Immun"},{"key":"564_CR39","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0007-1935(17)34682-1","volume":"132","author":"JC Anderson","year":"1976","unstructured":"Anderson JC (1976) Mechanisms of staphylococcal virulence in relation to bovine mastitis. Br Vet J 132:229\u2013245","journal-title":"Br Vet J"},{"key":"564_CR40","doi-asserted-by":"publisher","first-page":"e27354","DOI":"10.1371\/journal.pone.0027354","volume":"6","author":"C Marechal Le","year":"2011","unstructured":"Le Marechal C, Seyffert N, Jardin J, Hernandez D, Jan G, Rault L, Azevedo V, Francois P, Schrenzel J, van de Guchte M, Even S, Berkova N, Thiery R, Fitzgerald JR, Vautor E, Le Loir Y (2011) Molecular basis of virulence in Staphylococcus aureus mastitis. PLoS One 6:e27354","journal-title":"PLoS One"},{"key":"564_CR41","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1297-9716-42-35","volume":"42","author":"C Marechal Le","year":"2011","unstructured":"Le Marechal C, Jardin J, Jan G, Even S, Pulido C, Guibert JM, Hernandez D, Francois P, Schrenzel J, Demon D, Meyer E, Berkova N, Thiery R, Vautor E, Le Loir Y (2011) Staphylococcus aureus seroproteomes discriminate ruminant isolates causing mild or severe mastitis. Vet Res 42:35","journal-title":"Vet Res"},{"key":"564_CR42","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1086\/524689","volume":"197","author":"CM Guinane","year":"2008","unstructured":"Guinane CM, Sturdevant DE, Herron-Olson L, Otto M, Smyth DS, Villaruz AE, Kapur V, Hartigan PJ, Smyth CJ, Fitzgerald JR (2008) Pathogenomic analysis of the common bovine Staphylococcus aureus clone (ET3): emergence of a virulent subtype with potential risk to public health. J Infect Dis 197:205\u2013213","journal-title":"J Infect Dis"},{"key":"564_CR43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0034-5288(18)33769-X","volume":"16","author":"JC Anderson","year":"1974","unstructured":"Anderson JC, Mason AJ (1974) The effect of cell-free staphylococcal toxin on the mammary gland of the mouse. Res Vet Sci 16:23\u201326","journal-title":"Res Vet Sci"},{"key":"564_CR44","doi-asserted-by":"publisher","first-page":"e18428","DOI":"10.1371\/journal.pone.0018428","volume":"6","author":"X Liang","year":"2011","unstructured":"Liang X, Hall JW, Yang J, Yan M, Doll K, Bey R, Ji Y (2011) Identification of single nucleotide polymorphisms associated with hyperproduction of alpha-toxin in Staphylococcus aureus. PLoS One 6:e18428","journal-title":"PLoS One"},{"key":"564_CR45","first-page":"439","volume":"98","author":"M Plommet","year":"1960","unstructured":"Plommet M (1960) Staphylococcal mammitis of sheep. Experimental infection. Ann Inst Pasteur (Paris) 98:439\u2013455. (in French)","journal-title":"Ann Inst Pasteur (Paris)"},{"key":"564_CR46","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.femsre.2003.09.003","volume":"28","author":"S Bronner","year":"2004","unstructured":"Bronner S, Monteil H, Prevost G (2004) Regulation of virulence determinants in Staphylococcus aureus: complexity and applications. FEMS Microbiol Rev 28:183\u2013200","journal-title":"FEMS Microbiol Rev"},{"key":"564_CR47","first-page":"354","volume":"19","author":"RW Brown","year":"1958","unstructured":"Brown RW, Scherer RK (1958) A study of the necrotizing action of staphylococcic alpha toxin. Am J Vet Res 19:354\u2013362","journal-title":"Am J Vet Res"}],"container-title":["Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13567-018-0564-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13567-018-0564-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13567-018-0564-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T17:43:28Z","timestamp":1604684608000},"score":1,"resource":{"primary":{"URL":"https:\/\/veterinaryresearch.biomedcentral.com\/articles\/10.1186\/s13567-018-0564-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,25]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["564"],"URL":"https:\/\/doi.org\/10.1186\/s13567-018-0564-4","relation":{},"ISSN":["1297-9716"],"issn-type":[{"value":"1297-9716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,25]]},"assertion":[{"value":"29 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"72"}}