{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:59:57Z","timestamp":1781650797789,"version":"3.54.5"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"South African Technology Innovation Agency","award":["TAHIC13-00023-CC"],"award-info":[{"award-number":["TAHIC13-00023-CC"]}]},{"DOI":"10.13039\/501100001323","name":"Poliomyelitis Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001323","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001332","name":"Council for Scientific and Industrial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13567-018-0600-4","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T09:44:55Z","timestamp":1539251095000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses"],"prefix":"10.1186","volume":"49","author":[{"given":"Susan J.","family":"Dennis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha M.","family":"O\u2019Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Rutkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsepo","family":"Tsekoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina W.","family":"Lourens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga I.","family":"Hitzeroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2116-7913","authenticated-orcid":false,"given":"Ann E.","family":"Meyers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward P.","family":"Rybicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,11]]},"reference":[{"key":"600_CR1","first-page":"1231","volume-title":"Infectious diseases of livestock","author":"JAW Coetzer","year":"2004","unstructured":"Coetzer JAW, Guthrie AJ (2004) African horse sickness. In: Coetzer JAW, Tustin RC (eds) Infectious diseases of livestock. Oxford University Press, Cape Town, pp 1231\u20131246"},{"key":"600_CR2","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1051\/vetres:2004021","volume":"35","author":"PS Mellor","year":"2004","unstructured":"Mellor PS, Hamblin C (2004) African horse sickness. Vet Res 35:445\u2013466","journal-title":"Vet Res"},{"key":"600_CR3","first-page":"375","volume":"2","author":"RA Alexander","year":"1934","unstructured":"Alexander RA (1934) The immunization of horses and mules against horse sickness by means of the neurotropic virus of mice and guinea-pigs. Onderstepoort J Vet Sci Anim Ind 2:375\u2013391","journal-title":"Onderstepoort J Vet Sci Anim Ind"},{"key":"600_CR4","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.3201\/eid2212.160718","volume":"22","author":"CT Weyer","year":"2016","unstructured":"Weyer CT, Grewar JD, Burger P, Rossouw E, Lourens C, Joone C, le Grange M, Coetzee P, Venter E, Martin DP, MacLachlan NJ, Guthrie AJ (2016) African horse sickness caused by genome reassortment and reversion to virulence of live, attenuated vaccine viruses, South Africa, 2004\u20132014. Emerg Infect Dis 22:2087\u20132096","journal-title":"Emerg Infect Dis"},{"key":"600_CR5","doi-asserted-by":"publisher","first-page":"4434","DOI":"10.1016\/j.vaccine.2009.05.044","volume":"27","author":"AJ Guthrie","year":"2009","unstructured":"Guthrie AJ, Quan M, Lourens CW, Audonnet JC, Minke JM, Yao J, He L, Nordgren R, Gardner IA, Maclachlan NJ (2009) Protective immunization of horses with a recombinant canarypox virus vectored vaccine co-expressing genes encoding the outer capsid proteins of African horse sickness virus. Vaccine 27:4434\u20134438","journal-title":"Vaccine"},{"key":"600_CR6","doi-asserted-by":"publisher","first-page":"6024","DOI":"10.1016\/j.vaccine.2017.04.005","volume":"35","author":"NM Manning","year":"2017","unstructured":"Manning NM, Bachanek-Bankowska K, Mertens PPC, Castillo-Olivares J (2017) Vaccination with recombinant modified vaccinia ankara (MVA) viruses expressing single African horse sickness virus VP2 antigens induced cross-reactive virus neutralising antibodies (VNAb) in horses when administered in combination. Vaccine 35:6024\u20136029","journal-title":"Vaccine"},{"key":"600_CR7","doi-asserted-by":"publisher","first-page":"4262","DOI":"10.1016\/j.vaccine.2017.06.023","volume":"35","author":"V Lulla","year":"2017","unstructured":"Lulla V, Losada A, Lecollinet S, Kerviel A, Lilin T, Sailleau C, Beck C, Zientara S, Roy P (2017) Protective efficacy of multivalent replication-abortive vaccine strains in horses against African horse sickness virus challenge. Vaccine 35:4262\u20134269","journal-title":"Vaccine"},{"key":"600_CR8","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1016\/j.vaccine.2018.03.003","volume":"36","author":"PA Rijn van","year":"2018","unstructured":"van Rijn PA, Maris-Veldhuis MA, Potgieter CA, van Gennip RGP (2018) African horse sickness virus (AHSV) with a deletion of 77 amino acids in NS3\/NS3a protein is not virulent and a safe promising AHS disabled infectious single animal (DISA) vaccine platform. Vaccine 36:1925\u20131933","journal-title":"Vaccine"},{"key":"600_CR9","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/S0966-842X(03)00208-7","volume":"11","author":"R Noad","year":"2003","unstructured":"Noad R, Roy P (2003) Virus-like particles as immunogens. Trends Microbiol 11:438\u2013444","journal-title":"Trends Microbiol"},{"key":"600_CR10","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/pbi.12783","volume":"16","author":"SJ Dennis","year":"2018","unstructured":"Dennis SJ, Meyers AE, Guthrie AJ, Hitzeroth II, Rybicki EP (2018) Immunogenicity of plant-produced African horse sickness virus-like particles: implications for a novel vaccine. Plant Biotechnol J 16:442\u2013450","journal-title":"Plant Biotechnol J"},{"key":"600_CR11","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1111\/j.1467-7652.2009.00434.x","volume":"7","author":"F Sainsbury","year":"2009","unstructured":"Sainsbury F, Thuenemann EC, Lomonossoff GP (2009) pEAQ: versatile expression vectors for easy and quick transient expression of heterologous proteins in plants. Plant Biotechnol J 7:682\u2013693","journal-title":"Plant Biotechnol J"},{"key":"600_CR12","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1099\/0022-1317-73-4-925","volume":"73","author":"T Chuma","year":"1992","unstructured":"Chuma T, Le Blois H, Sanchez-Vizcaino JM, Diaz-Laviada M, Roy P (1992) Expression of the major core antigen VP7 of African horsesickness virus by a recombinant baculovirus and its use as a group-specific diagnostic reagent. J Gen Virol 73:925\u2013931","journal-title":"J Gen Virol"},{"key":"600_CR13","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.virusres.2017.02.001","volume":"232","author":"S Bekker","year":"2017","unstructured":"Bekker S, Burger P, van Staden V (2017) Analysis of the three-dimensional structure of the African horse sickness virus VP7 trimer by homology modelling. Virus Res 232:80\u201395","journal-title":"Virus Res"},{"key":"600_CR14","doi-asserted-by":"publisher","first-page":"6505","DOI":"10.1016\/j.vaccine.2010.06.105","volume":"28","author":"BF Teichman von","year":"2010","unstructured":"von Teichman BF, Dungu B, Smit TK (2010) In vivo cross-protection to African horse sickness serotypes 5 and 9 after vaccination with serotypes 8 and 6. Vaccine 28:6505\u20136517","journal-title":"Vaccine"},{"key":"600_CR15","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1016\/j.vaccine.2017.03.005","volume":"35","author":"CT Weyer","year":"2017","unstructured":"Weyer CT, Grewar JD, Burger P, Joone C, Lourens C, MacLachlan NJ, Guthrie AJ (2017) Dynamics of African horse sickness virus nucleic acid and antibody in horses following immunization with a commercial polyvalent live attenuated vaccine. Vaccine 35:2504\u20132510","journal-title":"Vaccine"},{"key":"600_CR16","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.1016\/j.vaccine.2014.04.087","volume":"32","author":"JE Crafford","year":"2014","unstructured":"Crafford JE, Lourens CW, Smit TK, Gardner IA, MacLachlan NJ, Guthrie AJ (2014) Serological response of foals to polyvalent and monovalent live-attenuated African horse sickness virus vaccines. Vaccine 32:3611\u20133616","journal-title":"Vaccine"}],"container-title":["Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13567-018-0600-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13567-018-0600-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13567-018-0600-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T19:29:27Z","timestamp":1570735767000},"score":1,"resource":{"primary":{"URL":"https:\/\/veterinaryresearch.biomedcentral.com\/articles\/10.1186\/s13567-018-0600-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,11]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["600"],"URL":"https:\/\/doi.org\/10.1186\/s13567-018-0600-4","relation":{},"ISSN":["1297-9716"],"issn-type":[{"value":"1297-9716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,11]]},"assertion":[{"value":"20 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"105"}}