{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T17:38:19Z","timestamp":1768412299629,"version":"3.49.0"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31402055"],"award-info":[{"award-number":["31402055"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yangtze Youth Talents Fund","award":["2015cqr12"],"award-info":[{"award-number":["2015cqr12"]}]},{"name":"Yangtze Youth Fund","award":["2015cqn39"],"award-info":[{"award-number":["2015cqn39"]}]},{"name":"Scientific Research Starting Foundation for the Returned Overseas Chinese Scholars of the Ministry of Education of China"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13567-018-0616-9","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T11:49:51Z","timestamp":1544615391000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Regulators of Salmonella-host interaction identified by peripheral blood transcriptome profiling: roles of TGFB1 and TRP53 in intracellular Salmonella replication in pigs"],"prefix":"10.1186","volume":"49","author":[{"given":"Tinghua","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiali","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bomei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenzhao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9867-7372","authenticated-orcid":false,"given":"Min","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,12]]},"reference":[{"key":"616_CR1","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1089\/fpd.2010.0787","volume":"8","author":"RS Hendriksen","year":"2011","unstructured":"Hendriksen RS, Vieira AR, Karlsmose S, Lo Fo Wong DM, Jensen AB, Wegener HC, Aarestrup FM (2011) Global monitoring of Salmonella serovar distribution from the World Health Organization Global Foodborne Infections Network Country Data Bank: results of quality assured laboratories from 2001 to 2007. Foodborne Pathog Dis 8:887\u2013900","journal-title":"Foodborne Pathog Dis"},{"key":"616_CR2","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.tim.2012.04.004","volume":"20","author":"S Gopinath","year":"2012","unstructured":"Gopinath S, Carden S, Monack D (2012) Shedding light on Salmonella carriers. Trends Microbiol 20:320\u2013327","journal-title":"Trends Microbiol"},{"key":"616_CR3","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.meegid.2013.03.022","volume":"16","author":"SM Bearson","year":"2013","unstructured":"Bearson SM, Allen HK, Bearson BL, Looft T, Brunelle BW, Kich JD, Tuggle CK, Bayles DO, Alt D, Levine UY, Stanton TB (2013) Profiling the gastrointestinal microbiota in response to Salmonella: low versus high Salmonella shedding in the natural porcine host. Infect Genet Evol 16:330\u2013340","journal-title":"Infect Genet Evol"},{"key":"616_CR4","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1128\/JCM.02726-12","volume":"51","author":"CS Chiou","year":"2013","unstructured":"Chiou CS, Wei HL, Mu JJ, Liao YS, Liang SY, Liao CH, Tsao CS, Wang SC (2013) Salmonella enterica serovar Typhi variants in long-term carriers. J Clin Microbiol 51:669\u2013672","journal-title":"J Clin Microbiol"},{"key":"616_CR5","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0966-842X(01)02098-4","volume":"9","author":"JR Forbes","year":"2001","unstructured":"Forbes JR, Gros P (2001) Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions. Trends Microbiol 9:397\u2013403","journal-title":"Trends Microbiol"},{"key":"616_CR6","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/35021228","volume":"406","author":"A Aderem","year":"2000","unstructured":"Aderem A, Ulevitch RJ (2000) Toll-like receptors in the induction of the innate immune response. Nature 406:782\u2013787","journal-title":"Nature"},{"key":"616_CR7","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/39622","volume":"389","author":"RS Jack","year":"1997","unstructured":"Jack RS, Fan X, Bernheiden M, Rune G, Ehlers M, Weber A, Kirsch G, Mentel R, Furll B, Freudenberg M, Schmitz G, Stelter F, Schutt C (1997) Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection. Nature 389:742\u2013745","journal-title":"Nature"},{"key":"616_CR8","doi-asserted-by":"publisher","first-page":"8841","DOI":"10.1073\/pnas.97.16.8841","volume":"97","author":"C Nathan","year":"2000","unstructured":"Nathan C, Shiloh MU (2000) Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc Natl Acad Sci USA 97:8841\u20138848","journal-title":"Proc Natl Acad Sci USA"},{"key":"616_CR9","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0014-5793(91)80803-B","volume":"285","author":"W Fiers","year":"1991","unstructured":"Fiers W (1991) Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level. FEBS Lett 285:199\u2013212","journal-title":"FEBS Lett"},{"key":"616_CR10","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S1359-6101(00)00010-1","volume":"11","author":"SE Dorman","year":"2000","unstructured":"Dorman SE, Holland SM (2000) Interferon-gamma and interleukin-12 pathway defects and human disease. Cytokine Growth Factor Rev 11:321\u2013333","journal-title":"Cytokine Growth Factor Rev"},{"key":"616_CR11","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/S0952-7915(99)80055-7","volume":"11","author":"E Jouanguy","year":"1999","unstructured":"Jouanguy E, Doffinger R, Dupuis S, Pallier A, Altare F, Casanova JL (1999) IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men. Curr Opin Immunol 11:346\u2013351","journal-title":"Curr Opin Immunol"},{"key":"616_CR12","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1128\/IAI.67.3.1432-1438.1999","volume":"67","author":"M Galdiero","year":"1999","unstructured":"Galdiero M, Marcatili A, Cipollaro de l\u2019Ero G, Nuzzo I, Bentivoglio C, Romano Carratelli M, Galdiero C (1999) Effect of transforming growth factor beta on experimental Salmonella typhimurium infection in mice. Infect Immun 67:1432\u20131438","journal-title":"Infect Immun"},{"key":"616_CR13","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/gene.2011.69","volume":"13","author":"R Khan","year":"2012","unstructured":"Khan R, Sancho-Shimizu V, Prendergast C, Roy MF, Loredo-Osti JC, Malo D (2012) Refinement of the genetics of the host response to Salmonella infection in MOLF\/Ei: regulation of type 1 IFN and TRP3 pathways by Ity2. Genes Immun 13:175\u2013183","journal-title":"Genes Immun"},{"key":"616_CR14","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1158\/0008-5472.CAN-11-3382","volume":"72","author":"Y Zwang","year":"2012","unstructured":"Zwang Y, Oren M, Yarden Y (2012) Consistency test of the cell cycle: roles for p53 and EGR1. Cancer Res 72:1051\u20131054","journal-title":"Cancer Res"},{"key":"616_CR15","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1152\/physiolgenomics.00028.2012","volume":"44","author":"PA Apostolidis","year":"2012","unstructured":"Apostolidis PA, Lindsey S, Miller WM, Papoutsakis ET (2012) Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation. Physiol Genomics 44:638\u2013650","journal-title":"Physiol Genomics"},{"key":"616_CR16","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.vetimm.2008.12.027","volume":"130","author":"TE Burkey","year":"2009","unstructured":"Burkey TE, Skjolaas KA, Dritz SS, Minton JE (2009) Expression of porcine Toll-like receptor 2, 4 and 9 gene transcripts in the presence of lipopolysaccharide and Salmonella enterica serovars Typhimurium and Choleraesuis. Vet Immunol Immunopathol 130:96\u2013101","journal-title":"Vet Immunol Immunopathol"},{"key":"616_CR17","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1051\/vetres:2008043","volume":"40","author":"F Meurens","year":"2009","unstructured":"Meurens F, Berri M, Auray G, Melo S, Levast B, Virlogeux-Payant I, Chevaleyre C, Gerdts V, Salmon H (2009) Early immune response following Salmonella enterica subspecies enterica serovar Typhimurium infection in porcine jejunal gut loops. Vet Res 40:5","journal-title":"Vet Res"},{"key":"616_CR18","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.vetimm.2006.01.002","volume":"111","author":"KA Skjolaas","year":"2006","unstructured":"Skjolaas KA, Burkey TE, Dritz SS, Minton JE (2006) Effects of Salmonella enterica serovars Typhimurium (ST) and Choleraesuis (SC) on chemokine and cytokine expression in swine ileum and jejunal epithelial cells. Vet Immunol Immunopathol 111:199\u2013209","journal-title":"Vet Immunol Immunopathol"},{"key":"616_CR19","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/j.molimm.2005.10.011","volume":"43","author":"KA Hyland","year":"2006","unstructured":"Hyland KA, Kohrt L, Vulchanova L, Murtaugh MP (2006) Mucosal innate immune response to intragastric infection by Salmonella enterica serovar Choleraesuis. Mol Immunol 43:1890\u20131899","journal-title":"Mol Immunol"},{"key":"616_CR20","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.vetimm.2006.11.012","volume":"115","author":"TE Burkey","year":"2007","unstructured":"Burkey TE, Skjolaas KA, Dritz SS, Minton JE (2007) Expression of toll-like receptors, interleukin 8, macrophage migration inhibitory factor, and osteopontin in tissues from pigs challenged with Salmonella enterica serovar Typhimurium or serovar Choleraesuis. Vet Immunol Immunopathol 115:309\u2013319","journal-title":"Vet Immunol Immunopathol"},{"key":"616_CR21","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.vetmic.2005.10.042","volume":"114","author":"JJ Uthe","year":"2006","unstructured":"Uthe JJ, Stabel TJ, Zhao SH, Tuggle CK, Bearson SM (2006) Analysis of porcine differential gene expression following challenge with Salmonella enterica serovar Choleraesuis using suppression subtractive hybridization. Vet Microbiol 114:60\u201371","journal-title":"Vet Microbiol"},{"key":"616_CR22","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1051\/vetres\/2009072","volume":"41","author":"M Collado-Romero","year":"2010","unstructured":"Collado-Romero M, Arce C, Ramirez-Boo M, Carvajal A, Garrido JJ (2010) Quantitative analysis of the immune response upon Salmonella typhimurium infection along the porcine intestinal gut. Vet Res 41:23","journal-title":"Vet Res"},{"key":"616_CR23","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1152\/physiolgenomics.00104.2006","volume":"28","author":"CM Dvorak","year":"2006","unstructured":"Dvorak CM, Hirsch GN, Hyland KA, Hendrickson JA, Thompson BS, Rutherford MS, Murtaugh MP (2006) Genomic dissection of mucosal immunobiology in the porcine small intestine. Physiol Genomics 28:5\u201314","journal-title":"Physiol Genomics"},{"key":"616_CR24","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s00335-005-0155-3","volume":"17","author":"SH Zhao","year":"2006","unstructured":"Zhao SH, Kuhar D, Lunney JK, Dawson H, Guidry C, Uthe JJ, Bearson SM, Recknor J, Nettleton D, Tuggle CK (2006) Gene expression profiling in Salmonella Choleraesuis-infected porcine lung using a long oligonucleotide microarray. Mamm Genome 17:777\u2013789","journal-title":"Mamm Genome"},{"key":"616_CR25","doi-asserted-by":"publisher","first-page":"e28768","DOI":"10.1371\/journal.pone.0028768","volume":"6","author":"TH Huang","year":"2011","unstructured":"Huang TH, Uthe JJ, Bearson SM, Demirkale CY, Nettleton D, Knetter S, Christian C, Ramer-Tait AE, Wannemuehler MJ, Tuggle CK (2011) Distinct peripheral blood RNA responses to Salmonella in pigs differing in Salmonella shedding levels: intersection of IFNG. TLR and miRNA pathways. PLoS One 6:e28768","journal-title":"PLoS One"},{"key":"616_CR26","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1016\/j.bbrc.2009.10.145","volume":"390","author":"JS Lim","year":"2009","unstructured":"Lim JS, Na HS, Lee HC, Choy HE, Park SC, Han JM, Cho KA (2009) Caveolae-mediated entry of Salmonella typhimurium in a human M-cell model. Biochem Biophys Res Commun 390:1322\u20131327","journal-title":"Biochem Biophys Res Commun"},{"key":"616_CR27","doi-asserted-by":"publisher","first-page":"e0153444","DOI":"10.1371\/journal.pone.0153444","volume":"11","author":"KC Wang","year":"2016","unstructured":"Wang KC, Huang CH, Huang CJ, Fang SB (2016) Impacts of Salmonella enterica serovar Typhimurium and its speG gene on the transcriptomes of in vitro M cells and Caco-2 cells. PLoS One 11:e0153444","journal-title":"PLoS One"},{"key":"616_CR28","first-page":"74","volume":"3","author":"G Biozzi","year":"1960","unstructured":"Biozzi G, Howard JG, Halpern BN, Stiffel C, Mouton D (1960) The kinetics of blood clearance of isotopically labelled Salmonella entertidis by the reticulo-endothelial system in mice. Immunology 3:74\u201389","journal-title":"Immunology"},{"key":"616_CR29","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/0882-4010(91)90013-Z","volume":"10","author":"NE Dunlap","year":"1991","unstructured":"Dunlap NE, Benjamin WH Jr, McCall RD Jr, Tilden AB, Briles DE (1991) A \u2018safe-site\u2019 for Salmonella typhimurium is within splenic cells during the early phase of infection in mice. Microb Pathog 10:297\u2013310","journal-title":"Microb Pathog"},{"key":"616_CR30","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1051\/vetres\/2009060","volume":"41","author":"A Tomas","year":"2010","unstructured":"Tomas A, Fernandes LT, Sanchez A, Segales J (2010) Time course differential gene expression in response to porcine circovirus type 2 subclinical infection. Vet Res 41:12","journal-title":"Vet Res"},{"key":"616_CR31","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.vetimm.2010.10.006","volume":"138","author":"CK Tuggle","year":"2010","unstructured":"Tuggle CK, Bearson SM, Uthe JJ, Huang TH, Couture OP, Wang YF, Kuhar D, Lunney JK, Honavar V (2010) Methods for transcriptomic analyses of the porcine host immune response: application to Salmonella infection using microarrays. Vet Immunol Immunopathol 138:280\u2013291","journal-title":"Vet Immunol Immunopathol"},{"key":"616_CR32","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1099\/vir.0.009415-0","volume":"90","author":"Z Shi","year":"2009","unstructured":"Shi Z, Sun J, Guo H, Tu C (2009) Genomic expression profiling of peripheral blood leukocytes of pigs infected with highly virulent classical swine fever virus strain Shimen. J Gen Virol 90:1670\u20131680","journal-title":"J Gen Virol"},{"key":"616_CR33","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.virusres.2009.12.004","volume":"148","author":"J Li","year":"2010","unstructured":"Li J, Yu YJ, Feng L, Cai XB, Tang HB, Sun SK, Zhang HY, Liang JJ, Luo TR (2010) Global transcriptional profiles in peripheral blood mononuclear cell during classical swine fever virus infection. Virus Res 148:60\u201370","journal-title":"Virus Res"},{"key":"616_CR34","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.virusres.2010.03.007","volume":"151","author":"DP Gladue","year":"2010","unstructured":"Gladue DP, Zhu J, Holinka LG, Fernandez-Sainz I, Carrillo C, Prarat MV, O\u2019Donnell V, Borca MV (2010) Patterns of gene expression in swine macrophages infected with classical swine fever virus detected by microarray. Virus Res 151:10\u201318","journal-title":"Virus Res"},{"key":"616_CR35","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1051\/vetres\/2009055","volume":"41","author":"P Renson","year":"2010","unstructured":"Renson P, Blanchard Y, Le Dimna M, Felix H, Cariolet R, Jestin A, Le Potier MF (2010) Acute induction of cell death-related IFN stimulated genes (ISG) differentiates highly from moderately virulent CSFV strains. Vet Res 41:7","journal-title":"Vet Res"},{"key":"616_CR36","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.vetimm.2007.10.007","volume":"121","author":"RJ Moser","year":"2008","unstructured":"Moser RJ, Reverter A, Lehnert SA (2008) Gene expression profiling of porcine peripheral blood leukocytes after infection with Actinobacillus pleuropneumoniae. Vet Immunol Immunopathol 121:260\u2013274","journal-title":"Vet Immunol Immunopathol"},{"key":"616_CR37","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1186\/1471-2164-11-292","volume":"11","author":"Y Gao","year":"2010","unstructured":"Gao Y, Flori L, Lecardonnel J, Esquerre D, Hu ZL, Teillaud A, Lemonnier G, Lefevre F, Oswald IP, Rogel-Gaillard C (2010) Transcriptome analysis of porcine PBMCs after in vitro stimulation by LPS or PMA\/ionomycin using an expression array targeting the pig immune response. BMC Genomics 11:292","journal-title":"BMC Genomics"},{"key":"616_CR38","first-page":"185","volume":"132","author":"S Ponsuksili","year":"2008","unstructured":"Ponsuksili S, Murani E, Wimmers K (2008) Porcine genome-wide gene expression in response to tetanus toxoid vaccine. Dev Biol 132:185\u2013195","journal-title":"Dev Biol"},{"key":"616_CR39","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/1297-9686-41-54","volume":"41","author":"M Clapperton","year":"2009","unstructured":"Clapperton M, Diack AB, Matika O, Glass EJ, Gladney CD, Mellencamp MA, Hoste A, Bishop SC (2009) Traits associated with innate and adaptive immunity in pigs: heritability and associations with performance under different health status conditions. Genet Sel Evol 41:54","journal-title":"Genet Sel Evol"},{"key":"616_CR40","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.vetimm.2005.07.006","volume":"108","author":"AM Crawley","year":"2005","unstructured":"Crawley AM, Mallard B, Wilkie BN (2005) Genetic selection for high and low immune response in pigs: effects on immunoglobulin isotype expression. Vet Immunol Immunopathol 108:71\u201376","journal-title":"Vet Immunol Immunopathol"},{"key":"616_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0165-2427(94)90011-6","volume":"40","author":"I Edfors-Lilja","year":"1994","unstructured":"Edfors-Lilja I, Wattrang E, Magnusson U, Fossum C (1994) Genetic variation in parameters reflecting immune competence of swine. Vet Immunol Immunopathol 40:1\u201316","journal-title":"Vet Immunol Immunopathol"},{"key":"616_CR42","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1046\/j.1365-2052.2000.00628.x","volume":"31","author":"I Edfors-Lilja","year":"2000","unstructured":"Edfors-Lilja I, Wattrang E, Andersson L, Fossum C (2000) Mapping quantitative trait loci for stress induced alterations in porcine leukocyte numbers and functions. Anim Genet 31:186\u2013193","journal-title":"Anim Genet"},{"key":"616_CR43","doi-asserted-by":"crossref","first-page":"829","DOI":"10.4049\/jimmunol.161.2.829","volume":"161","author":"I Edfors-Lilja","year":"1998","unstructured":"Edfors-Lilja I, Wattrang E, Marklund L, Moller M, Andersson-Eklund L, Andersson L, Fossum C (1998) Mapping quantitative trait loci for immune capacity in the pig. J Immunol 161:829\u2013835","journal-title":"J Immunol"},{"key":"616_CR44","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/j.1365-2052.2005.01315.x","volume":"36","author":"E Wattrang","year":"2005","unstructured":"Wattrang E, Almqvist M, Johansson A, Fossum C, Wallgren P, Pielberg G, Andersson L, Edfors-Lilja I (2005) Confirmation of QTL on porcine chromosomes 1 and 8 influencing leukocyte numbers, haematological parameters and leukocyte function. Anim Genet 36:337\u2013345","journal-title":"Anim Genet"},{"key":"616_CR45","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0165-2427(02)00165-4","volume":"88","author":"PM Diemen Van","year":"2002","unstructured":"Van Diemen PM, Kreukniet MB, Galina L, Bumstead N, Wallis TS (2002) Characterisation of a resource population of pigs screened for resistance to salmonellosis. Vet Immunol Immunopathol 88:183\u2013196","journal-title":"Vet Immunol Immunopathol"},{"key":"616_CR46","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1111\/j.1365-2052.2009.01916.x","volume":"40","author":"L Galina-Pantoja","year":"2009","unstructured":"Galina-Pantoja L, Siggens K, van Schriek MG, Heuven HC (2009) Mapping markers linked to porcine salmonellosis susceptibility. Anim Genet 40:795\u2013803","journal-title":"Anim Genet"},{"key":"616_CR47","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.vetmic.2008.09.074","volume":"135","author":"JJ Uthe","year":"2009","unstructured":"Uthe JJ, Wang Y, Qu L, Nettleton D, Tuggle CK, Bearson SM (2009) Correlating blood immune parameters and a CCT7 genetic variant with the shedding of Salmonella enterica serovar Typhimurium in swine. Vet Microbiol 135:384\u2013388","journal-title":"Vet Microbiol"},{"key":"616_CR48","doi-asserted-by":"publisher","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","volume":"10","author":"B Langmead","year":"2009","unstructured":"Langmead B, Trapnell C, Pop M, Salzberg SL (2009) Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol 10:R25","journal-title":"Genome Biol"},{"key":"616_CR49","doi-asserted-by":"publisher","first-page":"D733","DOI":"10.1093\/nar\/gkv1189","volume":"44","author":"NA O\u2019Leary","year":"2016","unstructured":"O\u2019Leary NA, Wright MW, Brister JR, Ciufo S, Haddad D, McVeigh R, Rajput B, Robbertse B, Smith-White B, Ako-Adjei D, Astashyn A, Badretdin A, Bao Y, Blinkova O, Brover V, Chetvernin V, Choi J, Cox E, Ermolaeva O, Farrell CM, Goldfarb T, Gupta T, Haft D, Hatcher E, Hlavina W, Joardar VS, Kodali VK, Li W, Maglott D, Masterson P et al (2016) Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation. Nucleic Acids Res 44:D733\u2013745","journal-title":"Nucleic Acids Res"},{"key":"616_CR50","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK (2015) limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43:e47","journal-title":"Nucleic Acids Res"},{"key":"616_CR51","doi-asserted-by":"publisher","first-page":"D991","DOI":"10.1093\/nar\/gks1193","volume":"41","author":"T Barrett","year":"2013","unstructured":"Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, Yefanov A, Lee H, Zhang N, Robertson CL, Serova N, Davis S, Soboleva A (2013) NCBI GEO: archive for functional genomics data sets\u2013update. Nucleic Acids Res 41:D991\u2013995","journal-title":"Nucleic Acids Res"},{"key":"616_CR52","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1534\/genetics.104.036699","volume":"171","author":"Y Benjamini","year":"2005","unstructured":"Benjamini Y, Yekutieli D (2005) Quantitative trait loci analysis using the false discovery rate. Genetics 171:783\u2013790","journal-title":"Genetics"},{"key":"616_CR53","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.4049\/jimmunol.175.4.2570","volume":"175","author":"MM Wurfel","year":"2005","unstructured":"Wurfel MM, Park WY, Radella F, Ruzinski J, Sandstrom A, Strout J, Bumgarner RE, Martin TR (2005) Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity. J Immunol 175:2570\u20132578","journal-title":"J Immunol"},{"key":"616_CR54","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1093\/bioinformatics\/bth078","volume":"20","author":"MJ Hoon de","year":"2004","unstructured":"de Hoon MJ, Imoto S, Nolan J, Miyano S (2004) Open source clustering software. Bioinformatics 20:1453\u20131454","journal-title":"Bioinformatics"},{"key":"616_CR55","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/msb.2008.55","volume":"4","author":"DJ Lynn","year":"2008","unstructured":"Lynn DJ, Winsor GL, Chan C, Richard N, Laird MR, Barsky A, Gardy JL, Roche FM, Chan TH, Shah N, Lo R, Naseer M, Que J, Yau M, Acab M, Tulpan D, Whiteside MD, Chikatamarla A, Mah B, Munzner T, Hokamp K, Hancock RE, Brinkman FS (2008) InnateDB: facilitating systems-level analyses of the mammalian innate immune response. Mol Syst Biol 4:218","journal-title":"Mol Syst Biol"},{"key":"616_CR56","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s00438-015-1146-z","volume":"291","author":"M Yao","year":"2016","unstructured":"Yao M, Gao W, Tao H, Yang J, Liu G, Huang T (2016) Regulation signature of miR-143 and miR-26 in porcine Salmonella infection identified by binding site enrichment analysis. Mol Genet Genomics 291:789\u2013799","journal-title":"Mol Genet Genomics"},{"key":"616_CR57","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/0300-9084(88)90271-4","volume":"70","author":"BB Finlay","year":"1988","unstructured":"Finlay BB, Falkow S (1988) Comparison of the invasion strategies used by Salmonella cholerae-suis, Shigella flexneri and Yersinia enterocolitica to enter cultured animal cells: endosome acidification is not required for bacterial invasion or intracellular replication. Biochimie 70:1089\u20131099","journal-title":"Biochimie"},{"key":"616_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cyto.2009.11.021","volume":"50","author":"B Saha","year":"2010","unstructured":"Saha B, Jyothi Prasanna S, Chandrasekar B, Nandi D (2010) Gene modulation and immunoregulatory roles of interferon gamma. Cytokine 50:1\u201314","journal-title":"Cytokine"},{"key":"616_CR59","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.immuni.2008.08.016","volume":"29","author":"X Hu","year":"2008","unstructured":"Hu X, Chung AY, Wu I, Foldi J, Chen J, Ji JD, Tateya T, Kang YJ, Han J, Gessler M, Kageyama R, Ivashkiv LB (2008) Integrated regulation of toll-like receptor responses by notch and interferon-gamma pathways. Immunity 29:691\u2013703","journal-title":"Immunity"},{"key":"616_CR60","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1073\/pnas.041618998","volume":"98","author":"A Vazquez-Torres","year":"2001","unstructured":"Vazquez-Torres A, Fantuzzi G, Edwards CK 3rd, Dinarello CA, Fang FC (2001) Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages. Proc Natl Acad Sci USA 98:2561\u20132565","journal-title":"Proc Natl Acad Sci USA"},{"key":"616_CR61","doi-asserted-by":"publisher","first-page":"20160183","DOI":"10.1098\/rstb.2016.0183","volume":"372","author":"AR Buskirk","year":"2017","unstructured":"Buskirk AR, Green R (2017) Ribosome pausing, arrest and rescue in bacteria and eukaryotes. Philos Trans R Soc Lond B Biol Sci 372:20160183","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"616_CR62","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.1038\/sj.onc.1208615","volume":"24","author":"SL Harris","year":"2005","unstructured":"Harris SL, Levine AJ (2005) The p53 pathway: positive and negative feedback loops. Oncogene 24:2899\u20132908","journal-title":"Oncogene"},{"key":"616_CR63","doi-asserted-by":"publisher","first-page":"4068","DOI":"10.4161\/cc.9.20.13595","volume":"9","author":"K Schlereth","year":"2010","unstructured":"Schlereth K, Charles JP, Bretz AC, Stiewe T (2010) Life or death: p53-induced apoptosis requires DNA binding cooperativity. Cell Cycle 9:4068\u20134076","journal-title":"Cell Cycle"},{"key":"616_CR64","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/nature01850","volume":"42","author":"A Takaoka","year":"2003","unstructured":"Takaoka A, Hayakawa S, Yanai H, Stoiber D, Negishi H, Kikuchi H, Sasaki S, Imai K, Shibue T, Honda K, Taniguchi T (2003) Integration of interferon-alpha\/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature 42:516","journal-title":"Nature"},{"key":"616_CR65","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1084\/jem.20080383","volume":"205","author":"C Munoz-Fontela","year":"2008","unstructured":"Munoz-Fontela C, Macip S, Martinez-Sobrido L, Brown L, Ashour J, Garcia-Sastre A, Lee SW, Aaronson SA (2008) Transcriptional role of p53 in interferon-mediated antiviral immunity. J Exp Med 205:1929\u20131938","journal-title":"J Exp Med"},{"key":"616_CR66","doi-asserted-by":"publisher","first-page":"36124","DOI":"10.1074\/jbc.M604152200","volume":"281","author":"N Sharma","year":"2006","unstructured":"Sharma N, Timmers C, Trikha P, Saavedra HI, Obery A, Leone G (2006) Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1\/S progression and cellular transformation. J Biol Chem 281:36124\u201336131","journal-title":"J Biol Chem"},{"key":"616_CR67","doi-asserted-by":"publisher","first-page":"577","DOI":"10.4161\/epi.4.8.10217","volume":"4","author":"LF Fehri","year":"2009","unstructured":"Fehri LF, Rechner C, Janssen S, Mak TN, Holland C, Bartfeld S, Bruggemann H, Meyer TF (2009) Helicobacter pylori-induced modification of the histone H3 phosphorylation status in gastric epithelial cells reflects its impact on cell cycle regulation. Epigenetics 4:577\u2013586","journal-title":"Epigenetics"},{"key":"616_CR68","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/nature25492","volume":"554","author":"DVF Tauriello","year":"2018","unstructured":"Tauriello DVF, Palomo-Ponce S, Stork D, Berenguer-Llergo A, Badia-Ramentol J, Iglesias M, Sevillano M, Ibiza S, Canellas A, Hernando-Momblona X, Byrom D, Matarin JA, Calon A, Rivas EI, Nebreda AR, Riera A, Attolini CS, Batlle E (2018) TGFbeta drives immune evasion in genetically reconstituted colon cancer metastasis. Nature 554:538\u2013543","journal-title":"Nature"},{"key":"616_CR69","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.immuni.2017.10.007","volume":"47","author":"X Yu","year":"2017","unstructured":"Yu X, Buttgereit A, Lelios I, Utz SG, Cansever D, Becher B, Greter M (2017) The cytokine TGF-beta promotes the development and homeostasis of alveolar macrophages. Immunity 47:903\u2013912.e904","journal-title":"Immunity"}],"container-title":["Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13567-018-0616-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13567-018-0616-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13567-018-0616-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T02:12:10Z","timestamp":1694484730000},"score":1,"resource":{"primary":{"URL":"https:\/\/veterinaryresearch.biomedcentral.com\/articles\/10.1186\/s13567-018-0616-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["616"],"URL":"https:\/\/doi.org\/10.1186\/s13567-018-0616-9","relation":{},"ISSN":["1297-9716"],"issn-type":[{"value":"1297-9716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"8 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"121"}}