{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:42:31Z","timestamp":1787020951426,"version":"build-2736575974"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100016305","name":"Animal Health and Welfare ERA-Net","doi-asserted-by":"crossref","award":["ID number 119"],"award-info":[{"award-number":["ID number 119"]}],"id":[{"id":"10.13039\/100016305","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["942-2015-766"],"award-info":[{"award-number":["942-2015-766"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Erysipelas, a disease caused by\n                    <jats:italic>Erysipelothrix rhusiopathiae<\/jats:italic>\n                    (ER), is an increasing problem in laying hens housed in cage-free systems. This study aimed to monitor immune responses during ER infection of na\u00efve chickens and chickens vaccinated intra muscularly with a commercial inactivated ER vaccine. Chickens were infected intra muscularly with ER at 30\u00a0days of age and blood leukocyte counts, serum levels of mannose binding lectin (MBL) and ER-specific IgY were monitored until the experiment was terminated at day 15 after infection. ER was detected in blood from more chickens and at higher bacterial counts in the na\u00efve group (day 1: 1 of 7 chickens; day 3: 6 of 6 chickens) than in the vaccinated group (day 1: 0 of 7 chickens; day 3: 1 of 6 chickens). During the acute phase of infection transient increases in circulating heterophil numbers and serum MBL levels were detected in all ER infected chickens but these responses were prolonged in chickens from the na\u00efve group compared to vaccinated chickens. Before infection IgY titers to ER in vaccinated chickens did not differ significantly from those of na\u00efve chickens but vaccinated chickens showed significantly increased IgY titers to ER earlier after infection compared to chickens in the na\u00efve group. In conclusion, the ER infection elicited prompt acute innate responses in all chickens. Vaccinated chickens did not have high IgY titers to ER prior to infection but did however show lower levels of bacteraemia and their acute immune responses were of shorter duration.\n                  <\/jats:p>","DOI":"10.1186\/s13567-020-00830-9","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T06:02:59Z","timestamp":1600063379000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Immune responses upon experimental Erysipelothrix rhusiopathiae infection of na\u00efve and vaccinated chickens"],"prefix":"10.1186","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9804-169X","authenticated-orcid":false,"given":"Eva","family":"Wattrang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Jinnerot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Persson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Bagge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"S\u00f6derlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Naghizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina S\u00f8rensen","family":"Dalgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"830_CR1","volume-title":"Changing diets change egg consumption worldwide. WATT executive guide to world poultry trends","author":"A Conway","year":"2018","unstructured":"Conway A (2018) Changing diets change egg consumption worldwide. WATT executive guide to world poultry trends. WATT Global Media, Rockford"},{"key":"830_CR2","volume-title":"Top poultry countries to add 15 million metric tons by 2027. WATT executive guide to world poultry trends","author":"A Conway","year":"2018","unstructured":"Conway A (2018) Top poultry countries to add 15 million metric tons by 2027. WATT executive guide to world poultry trends. WATT Global Media, Rockford"},{"key":"830_CR3","volume-title":"World egg consumtion continues to rise slowly in 2017. WATT executive guide to world poultry trends","author":"A Conway","year":"2017","unstructured":"Conway A (2017) World egg consumtion continues to rise slowly in 2017. WATT executive guide to world poultry trends. WATT Global Media, Rockford"},{"issue":"4","key":"830_CR4","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1637\/7362-040805R.1","volume":"49","author":"A Mazaheri","year":"2005","unstructured":"Mazaheri A, Lierz M, Hafez HM (2005) Investigations on the pathogenicity of Erysipelothrix rhusiopathiae in laying hens. Avian Dis 49(4):574\u2013576. https:\/\/doi.org\/10.1637\/7362-040805R.1","journal-title":"Avian Dis"},{"issue":"7","key":"830_CR5","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1136\/vr.164.7.203","volume":"164","author":"M Kaufmann-Bart","year":"2009","unstructured":"Kaufmann-Bart M, Hoop RK (2009) Diseases in chicks and laying hens during the first 12\u00a0years after battery cages. Vet Rec 164(7):203\u2013207. https:\/\/doi.org\/10.1136\/vr.164.7.203","journal-title":"Vet Rec"},{"issue":"3","key":"830_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1751-0147-51-3","volume":"51","author":"O Fossum","year":"2009","unstructured":"Fossum O, Jansson DS, Etterlin PE, V\u00e5gsholm I (2009) Causes of mortality in laying hens in different housing systems in 2001 to 2004. Acta Vet Scand 51(3):1\u20139. https:\/\/doi.org\/10.1186\/1751-0147-51-3","journal-title":"Acta Vet Scand"},{"issue":"4","key":"830_CR7","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1637\/9375-041910-Reg.1","volume":"54","author":"NM Stokholm","year":"2010","unstructured":"Stokholm NM, Permin A, Bisgaard M, Christensen JP (2010) Causes of mortality in commercial organic layers in Denmark. Avian Dis 54(4):1241\u20131250. https:\/\/doi.org\/10.1637\/9375-041910-Reg.1","journal-title":"Avian Dis"},{"issue":"6","key":"830_CR8","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1080\/03079457.2010.518313","volume":"39","author":"H Eriksson","year":"2010","unstructured":"Eriksson H, Br\u00e4nnstr\u00f6m S, Skarin H, Chirico J (2010) Characterization of Erysipelothrix rhusiopathiae isolates from laying hens and poultry red mites (Dermanyssus gallinae) from an outbreak of erysipelas. Avian Pathol 39(6):505\u2013509. https:\/\/doi.org\/10.1080\/03079457.2010.518313","journal-title":"Avian Pathol"},{"issue":"1","key":"830_CR9","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1136\/vr.101388","volume":"173","author":"H Eriksson","year":"2013","unstructured":"Eriksson H, Nyman AK, Fellstr\u00f6m C, Wallgren P (2013) Erysipelas in laying hens is associated with housing system. Vet Rec 173(1):18. https:\/\/doi.org\/10.1136\/vr.101388","journal-title":"Vet Rec"},{"issue":"3","key":"830_CR10","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1080\/03079457.2014.907485","volume":"43","author":"H Eriksson","year":"2014","unstructured":"Eriksson H, Bagge E, B\u00e5verud V, Fellstr\u00f6m C, Jansson DS (2014) Erysipelothrix rhusiopathiae contamination in the poultry house environment during erysipelas outbreaks in organic laying hen flocks. Avian Pathol 43(3):231\u2013237. https:\/\/doi.org\/10.1080\/03079457.2014.907485","journal-title":"Avian Pathol"},{"issue":"1","key":"830_CR11","first-page":"59","volume":"4","author":"M Bisgaard","year":"1975","unstructured":"Bisgaard M, Olsen P (1975) Erysipelas in egg-laying chickens: clinical, pathological and bacteriological investigations. Avian Pathol 4(1):59\u201371","journal-title":"Avian Pathol"},{"issue":"3\u20134","key":"830_CR12","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.vetmic.2009.08.012","volume":"140","author":"Q Wang","year":"2010","unstructured":"Wang Q, Chang BJ, Riley TV (2010) Erysipelothrix rhusiopathiae. Vet Microbiol 140(3\u20134):405\u2013417","journal-title":"Vet Microbiol"},{"issue":"7","key":"830_CR13","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3389\/fvets.2020.00174","volume":"15","author":"T Opriessnig","year":"2020","unstructured":"Opriessnig T, Forde T, Shimoji Y (2020) Erysipelothrix Spp.: past, present, and future directions in vaccine research. Front Vet Sci 15(7):174. https:\/\/doi.org\/10.3389\/fvets.2020.00174","journal-title":"Front Vet Sci"},{"issue":"8","key":"830_CR14","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/S1286-4579(00)00397-X","volume":"2","author":"Y Shimoji","year":"2000","unstructured":"Shimoji Y (2000) Pathogenicity of Erysipelothrix rhusiopathiae: virulence factors and protective immunity. Microbes Infect 2(8):965\u2013972. https:\/\/doi.org\/10.1016\/S1286-4579(00)00397-X","journal-title":"Microbes Infect"},{"issue":"4","key":"830_CR15","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s10493-009-9317-4","volume":"50","author":"S Br\u00e4nnstr\u00f6m","year":"2010","unstructured":"Br\u00e4nnstr\u00f6m S, Hansson I, Chirico J (2010) Experimental study on possible transmission of the bacterium Erysipelothrix rhusiopathiae to chickens by the poultry red mite Dermanyssus gallinae. Exp Appl Acarol 50(4):299\u2013307. https:\/\/doi.org\/10.1007\/s10493-009-9317-4","journal-title":"Exp Appl Acarol"},{"issue":"3","key":"830_CR16","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1177\/104063870902100309","volume":"21","author":"K Harada","year":"2009","unstructured":"Harada K, Uchiyama M, Hoshi T, Takahashi T (2009) Comparison of three DNA extraction methods for detection of Erysipelothrix rhusiopathiae in chicken blood by polymerase chain reaction. J Vet Diagn Invest 21(3):354\u2013358. https:\/\/doi.org\/10.1177\/104063870902100309","journal-title":"J Vet Diagn Invest"},{"issue":"2","key":"830_CR17","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0021-9975(97)80031-X","volume":"117","author":"M Shibatani","year":"1997","unstructured":"Shibatani M, Suzuki T, Chujo M, Nakamura K (1997) Disseminated intravascular coagulation in chickens inoculated with Erysipelothrix rhusiopathiae. J Comp Pathol 117(2):147\u2013156. https:\/\/doi.org\/10.1016\/S0021-9975(97)80031-X","journal-title":"J Comp Pathol"},{"issue":"2","key":"830_CR18","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1080\/03079459408418992","volume":"23","author":"T Takahashi","year":"1994","unstructured":"Takahashi T, Takagi M, Yamaoka R, Ohishi K, Norimatsu M, Tamura Y, Nakamura M (1994) Comparison of the pathogenicity for chickens of Erysipelothrix rhusiopathiae and Erysipelothrix tonsillarum. Avian Pathol 23(2):237\u2013245. https:\/\/doi.org\/10.1080\/03079459408418992","journal-title":"Avian Pathol"},{"issue":"461","key":"830_CR19","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1186\/s12864-016-2643-0","volume":"17","author":"T Forde","year":"2016","unstructured":"Forde T, Biek R, Zadoks R, Workentine ML, De Buck J, Kutz S, Opriessnig T, Trewby H, van der Meer F, Orsel K (2016) Genomic analysis of the multi-host pathogen Erysipelothrix rhusiopathiae reveals extensive recombination as well as the existence of three generalist clades with wide geographic distribution. BMC Genomics 17(461):461. https:\/\/doi.org\/10.1186\/s12864-016-2643-0","journal-title":"BMC Genomics"},{"issue":"7","key":"830_CR20","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1099\/jmm.0.001016","volume":"68","author":"E Wattrang","year":"2019","unstructured":"Wattrang E, J\u00e4derblom V, Jinnerot T, Eriksson H, Bagge E, Persson M, Dalgaard TS, S\u00f6derlund R (2019) Detection and quantification of Erysipelothrix rhusiopathiae in blood from infected chickens\u2014addressing challenges with detection of DNA from infectious agents in host species with nucleated red blood cells. J Med Microbiol 68(7):1003\u20131011. https:\/\/doi.org\/10.1099\/jmm.0.001016","journal-title":"J Med Microbiol"},{"issue":"1\u20132","key":"830_CR21","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.vetimm.2011.10.010","volume":"145","author":"C Seliger","year":"2014","unstructured":"Seliger C, Schaerer B, Kohn M, Pendl H, Weigend S, Kaspers B, H\u00e4rtle S (2014) A rapid high-precision flow cytometry based technique for total white blood cell. Vet Immunol Immunopathol 145(1\u20132):86\u201399. https:\/\/doi.org\/10.1016\/j.vetimm.2011.10.010","journal-title":"Vet Immunol Immunopathol"},{"issue":"2","key":"830_CR22","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/ps\/82.2.235","volume":"82","author":"HR Juul-Madsen","year":"2003","unstructured":"Juul-Madsen HR, Handberg KJ, Sorensen P, Johnson AA, Norup LR, Jorgensen PH (2003) Serum levels of mannan-binding lectin in chickens prior to and during experimental infection with avian infectious bronchitis virus. Poult Sci 82(2):235\u2013241","journal-title":"Poult Sci"},{"issue":"11","key":"830_CR23","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.3382\/ps.2007-00238","volume":"86","author":"LR Norup","year":"2007","unstructured":"Norup LR, Juul-Madsen HR (2007) An assay for measuring the mannan-binding lectin pathway of complement activation. Poult Sci 86(11):2322\u20132326","journal-title":"Poult Sci"},{"issue":"3","key":"830_CR24","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.dci.2013.03.021","volume":"41","author":"KJ Genovese","year":"2013","unstructured":"Genovese KJ, He H, Swaggerty CL, Kogut MH (2013) The avian heterophil. Dev Comp Immunol 41(3):334\u2013340. https:\/\/doi.org\/10.1016\/j.dci.2013.03.021","journal-title":"Dev Comp Immunol"},{"issue":"3","key":"830_CR25","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.dci.2013.04.008","volume":"41","author":"P Wigley","year":"2013","unstructured":"Wigley P (2013) Immunity to bacterial infection in the chicken. Dev Comp Immunol 41(3):413\u2013417. https:\/\/doi.org\/10.1016\/j.dci.2013.04.008","journal-title":"Dev Comp Immunol"},{"issue":"4","key":"830_CR26","first-page":"561","volume":"19","author":"J Timoney","year":"1970","unstructured":"Timoney J (1970) The effect of decomplementation on Erysipelothrix rhusiopathiae infection in the mouse. Immunology 19(4):561\u2013567","journal-title":"Immunology"},{"issue":"1","key":"830_CR27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1600-065X.2009.00789.x","volume":"230","author":"WK Ip","year":"2009","unstructured":"Ip WK, Takahashi K, Ezekowitz RA, Stuart LM (2009) Mannose-binding lectin and innate immunity. Immunol Rev 230(1):9\u201321. https:\/\/doi.org\/10.1111\/j.1600-065X.2009.00789.x","journal-title":"Immunol Rev"},{"issue":"7","key":"830_CR28","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.imbio.2008.11.003","volume":"214","author":"AM Kerrigan","year":"2009","unstructured":"Kerrigan AM, Brown GD (2009) C-type lectins and phagocytosis. Immunobiology 214(7):562\u2013575","journal-title":"Immunobiology"},{"issue":"12","key":"830_CR29","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.tim.2015.09.006","volume":"23","author":"SS Foo","year":"2015","unstructured":"Foo SS, Reading PC, Jaillon S, Mantovani A, Mahalingam S (2015) Pentraxins and collectins: friend or foe during pathogen invasion? Trends Microbiol 23(12):799\u2013811. https:\/\/doi.org\/10.1016\/j.tim.2015.09.006","journal-title":"Trends Microbiol"},{"issue":"2\u20133","key":"830_CR30","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0145-305X(99)00066-X","volume":"24","author":"SB Laursen","year":"2000","unstructured":"Laursen SB, Nielsen OL (2000) Mannan-binding lectin (MBL) in chickens: molecular and functional aspects. Dev Comp Immunol 24(2\u20133):85\u2013101","journal-title":"Dev Comp Immunol"},{"issue":"8","key":"830_CR31","doi-asserted-by":"publisher","first-page":"4998","DOI":"10.4049\/jimmunol.174.8.4998","volume":"174","author":"NJ Lynch","year":"2005","unstructured":"Lynch NJ, Khan SU, Stover CM, Sandrini SM, Marston D, Presanis JS, Schwaeble WJ (2005) Composition of the lectin pathway of complement in Gallus gallus: absence ofmannan-binding lectin-associated serine protease-1 in birds. J Immunol 174(8):4998\u20135006","journal-title":"J Immunol"},{"issue":"1\u20132","key":"830_CR32","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.vetimm.2014.11.003","volume":"163","author":"SL Ulrich-Lynge","year":"2015","unstructured":"Ulrich-Lynge SL, Dalgaard TS, Norup LR, Kjaerup RM, Olsen JE, Sorensen P, Juul-Madsen HR (2015) The consequence of low mannose-binding lectin plasma concentration in relation to susceptibility to Salmonella Infantis in chickens. Vet Immunol Immunopathol 163(1\u20132):23\u201332. https:\/\/doi.org\/10.1016\/j.vetimm.2014.11.003","journal-title":"Vet Immunol Immunopathol"},{"issue":"8","key":"830_CR33","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.3382\/ps\/pew101","volume":"95","author":"SL Ulrich-Lynge","year":"2016","unstructured":"Ulrich-Lynge SL, Juul-Madsen HR, Kjaerup RB, Okimoto R, Abrahamsen MS, Maurischat S, Sorensen P, Dalgaard TS (2016) Broilers with low serum Mannose-binding Lectin show increased fecal shedding of Salmonella enterica serovar Montevideo. Poult Sci 95(8):1779\u20131786","journal-title":"Poult Sci"},{"issue":"3","key":"830_CR34","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.cimid.2008.08.010","volume":"33","author":"TW Schou","year":"2010","unstructured":"Schou TW, Permin A, Christensen JP, Cu HP, Juul-Madsen HR (2010) Mannan-binding lectin (MBL) in two chicken breeds and the correlation with. Comp Immunol Microbiol Infect Dis 33(3):183\u2013195. https:\/\/doi.org\/10.1016\/j.cimid.2008.08.010","journal-title":"Comp Immunol Microbiol Infect Dis"},{"issue":"2","key":"830_CR35","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1017\/s1751731107001097","volume":"2","author":"LR Norup","year":"2008","unstructured":"Norup LR, Jensen KF, J\u00f8rgensen E, S\u00f8rensen P, Juul-Madsen HR (2008) Effect of mild heat stress and mild infection pressure on immune responses to an E. coli infection in chickens. Animal 2(2):265\u2013274. https:\/\/doi.org\/10.1017\/s1751731107001097","journal-title":"Animal"},{"issue":"51","key":"830_CR36","doi-asserted-by":"publisher","first-page":"9499","DOI":"10.1016\/j.vaccine.2011.10.016","volume":"29","author":"HR Juul-Madsen","year":"2011","unstructured":"Juul-Madsen HR, Norup LR, Jorgensen PH, Handberg KJ, Wattrang E, Dalgaard TS (2011) Crosstalk between innate and adaptive immune responses to infectious bronchitis virus after vaccination and challenge of chickens varying in serum mannose-binding lectin concentrations. Vaccine 29(51):9499\u20139507","journal-title":"Vaccine"},{"issue":"10","key":"830_CR37","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1089\/vim.2014.0088","volume":"27","author":"RM Kjaerup","year":"2014","unstructured":"Kjaerup RM, Dalgaard TS, Norup LR, Hamzic E, S\u00f8rensen P, Juul-Madsen HR (2014) Characterization of cellular and humoral immune responses after IBV infection in chicken lines differing in MBL serum concentration. Viral Immunol 27(10):529\u2013542","journal-title":"Viral Immunol"},{"issue":"11","key":"830_CR38","doi-asserted-by":"publisher","first-page":"3993","DOI":"10.1128\/IAI.00635-12","volume":"80","author":"F Shi","year":"2012","unstructured":"Shi F, Harada T, Ogawa Y, Ono H, Ohnishi-Kameyama M, Miyamoto T, Eguchi M, Shimoji Y (2012) Capsular polysaccharide of Erysipelothrix rhusiopathiae, the causative agent of swine erysipelas, and its modification with phosphorylcholine. Infect Immun 80(11):3993\u20134003","journal-title":"Infect Immun"},{"issue":"11","key":"830_CR39","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.4049\/jimmunol.147.11.3710","volume":"147","author":"E Paramithiotis","year":"1991","unstructured":"Paramithiotis E, Tkalec L, Ratcliffe MJ (1991) High levels of CD45 are coordinately expressed with CD4 and CD8 on avian thymocytes. J Immunol 147(11):3710\u20133717","journal-title":"J Immunol"},{"issue":"1\u20132","key":"830_CR40","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.vetimm.2007.06.017","volume":"119","author":"BC Viertlboeck","year":"2007","unstructured":"Viertlboeck BC, G\u00f6bel TW (2007) Chicken thrombocytes express the CD51\/CD61 integrin. Vet Immunol Immunopathol 119(1\u20132):137\u2013141. https:\/\/doi.org\/10.1016\/j.vetimm.2007.06.017","journal-title":"Vet Immunol Immunopathol"},{"key":"830_CR41","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.dci.2017.08.013","volume":"77","author":"D Huhle","year":"2017","unstructured":"Huhle D, Hirmer S, G\u00f6bel TW (2017) Splenic gd T cell subsets can be separated by a novel mab specific for two CD45 isoforms. Dev Comp Immunol 77:229\u2013240. https:\/\/doi.org\/10.1016\/j.dci.2017.08.013","journal-title":"Dev Comp Immunol"},{"issue":"3","key":"830_CR42","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.cellsig.2009.10.003","volume":"22","author":"AE Saunders","year":"2010","unstructured":"Saunders AE, Johnson P (2010) Modulation of immune cell signalling by the leukocyte common tyrosine phosphatase, CD45. Cell Signal 22(3):339\u2013348. https:\/\/doi.org\/10.1016\/j.cellsig.2009.10.003","journal-title":"Cell Signal"},{"key":"830_CR43","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.imlet.2018.01.009","volume":"196","author":"A Rheinl\u00e4nder","year":"2018","unstructured":"Rheinl\u00e4nder A, Schraven B, Bommhardt U (2018) CD45 in human physiology and clinical medicine. Immunol Lett 196:22\u201332. https:\/\/doi.org\/10.1016\/j.imlet.2018.01.009","journal-title":"Immunol Lett"},{"issue":"11","key":"830_CR44","doi-asserted-by":"publisher","first-page":"e110330","DOI":"10.1371\/journal.pone.0110330","volume":"9","author":"K Staines","year":"2014","unstructured":"Staines K, Hunt LG, Young JR, Butter C (2014) Evolution of an expanded mannose receptor gene family. PLoS One 9(11):e110330. https:\/\/doi.org\/10.1371\/journal.pone.0110330","journal-title":"PLoS One"},{"issue":"6","key":"830_CR45","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1189\/jlb.0512231","volume":"92","author":"L Martinez-Pomares","year":"2012","unstructured":"Martinez-Pomares L (2012) The mannose receptor. J Leukoc Biol 92(6):1177\u20131186. https:\/\/doi.org\/10.1189\/jlb.0512231","journal-title":"J Leukoc Biol"},{"key":"830_CR46","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.molimm.2017.07.005","volume":"90","author":"MD Kraaij","year":"2017","unstructured":"Kraaij MD, van Dijk A, Haagsman HP (2017) CATH-2 and LL-37 increase mannose receptor expression, antigen presentation and the endocytic capacity of chicken mononuclear phagocytes. Mol Immunol 90:118\u2013125. https:\/\/doi.org\/10.1016\/j.molimm.2017.07.005","journal-title":"Mol Immunol"},{"issue":"3","key":"830_CR47","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.vetimm.2010.05.003","volume":"137","author":"T Sitt","year":"2010","unstructured":"Sitt T, Bowen L, Blanchard MT, Gershwin LJ, Byrne BA, Dold C, McBain J, Stott JL (2010) Cellular immune responses in cetaceans immunized with a porcine erysipelas vaccine. Vet Immunol Immunopathol 137(3):181\u2013189. https:\/\/doi.org\/10.1016\/j.vetimm.2010.05.003","journal-title":"Vet Immunol Immunopathol"}],"container-title":["Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13567-020-00830-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13567-020-00830-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13567-020-00830-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T04:16:40Z","timestamp":1696652200000},"score":1,"resource":{"primary":{"URL":"https:\/\/veterinaryresearch.biomedcentral.com\/articles\/10.1186\/s13567-020-00830-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,14]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["830"],"URL":"https:\/\/doi.org\/10.1186\/s13567-020-00830-9","relation":{},"ISSN":["1297-9716"],"issn-type":[{"value":"1297-9716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,14]]},"assertion":[{"value":"20 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The chicken experiment was carried out at the animal facilities at the National Veterinary Institute, approved for experimental animals by the Swedish Board of Agriculture. The experiment was approved by the Uppsala regional Ethical Committee for Animal Experiments, permit no. C46\/16, according Swedish legislation and directives (SJVFS 2019:9 L 150) based on European Union legislation directive 2010\/63\/EU.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"114"}}