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A rapid and sensitive immunochromatographic strip (ICS) based on Eu (III) nanoparticles (EuNPs) was developed for the detection of<jats:italic>Trichinella spiralis<\/jats:italic>(<jats:italic>T. spiralis<\/jats:italic>) infection in pigs.<jats:italic>T. spiralis<\/jats:italic>muscle larvae excretory secretory or preadult worm excretory secretory (ML-ES or PAW-ES) antigens were conjugated with EuNPs probes to capture<jats:italic>T. spiralis<\/jats:italic>-specific antibodies in pig sera, after which the complex bound to mouse anti-pig IgG deposited on the test line (T-line), producing a fluorescent signal. In the pigs infected with 100, 1000 and 10\u00a0000 ML, seroconversion was first detectable for the EuNPs-ML-ES ICS at 30, 25 and 21\u00a0days post-infection (dpi) and for the EuNPs-PAW-ES ICS at 25, 21 and 17\u00a0dpi. These results show that EuNPs-PAW-ES ICS detects anti-<jats:italic>Trichinella<\/jats:italic>IgG in pigs 4\u20135\u00a0days earlier that test using ML-ES antigens. Our ICS have no cross reaction with other parasite infection sera. Furthermore, the detection process could be completed in 10\u00a0min. This study indicated that our ICS can be used for the detection of the circulating antibodies in early<jats:italic>T. spiralis<\/jats:italic>infection and provide a novel method for on-site detection of<jats:italic>T. spiralis<\/jats:italic>infection in pigs<jats:italic>.<\/jats:italic><\/jats:p>","DOI":"10.1186\/s13567-021-00951-9","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T20:02:36Z","timestamp":1623441756000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Development of a rapid and sensitive immunochromatographic strip based on EuNPs-ES fluorescent probe for the detection of early Trichinella spiralis-specific IgG antibody in pigs"],"prefix":"10.1186","volume":"52","author":[{"given":"Xinyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijian","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangdong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quangang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"951_CR1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0304-4017(00)00341-1","volume":"93","author":"J Dupouy-Camet","year":"2000","unstructured":"Dupouy-Camet J (2000) Trichinellosis: a worldwide zoonosis. 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