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Recently, serotype O has been the most prevalent FMDV serotype in China, and it has evolved into four different lineages: O\/SEA\/Mya-98, O\/ME-SA\/PanAsia, O\/ME-SA\/Ind-2001 and O\/Cathay. PanAsia-2, belonging to the O\/ME-SA topotype, is prevalent in neighbouring countries and poses the risk of cross-border spread in China. This study aimed to develop a promising vaccine candidate strain that can not only provide the best protection against all serotype O FMDVs circulating in China but also be used as an emergency vaccine for the prevention and control of transboundary incursion of PanAsia-2. Here, two chimeric FMDVs (rHN\/TURVP1 and rHN\/NXVP1) featuring substitution of VP1 genes of the O\/TUR\/5\/2009 vaccine strain (PanAsia-2) and O\/NXYCh\/CHA\/2018 epidemic strain (Mya98) were constructed and evaluated. The biological properties of the two chimeric FMDVs were similar to those of the wild-type (wt) virus despite slight differences in plaque sizes observed in BHK-21 cells. The structural protein-specific antibody titres induced by the rHN\/TURVP1 and wt virus vaccines in pigs and cows were higher than those induced by the rHN\/NXVP1 vaccine at 28\u201356\u00a0dpv. The vaccines prepared from the two chimeric viruses and wt virus all induced the production of protective cross-neutralizing antibodies against the viruses of the Mya-98, PanAsia and Ind-2001 lineages in pigs and cattle at 28\u00a0dpv; however, only the animals vaccinated with the rHN\/TURVP1 vaccine produced a protective immune response to the field isolate of the Cathay lineage at 28\u00a0dpv, whereas the animals receiving the wt virus and the rHN\/NXVP1 vaccines did not, although the wt virus and O\/GXCX\/CHA\/2018 both belong to the Cathay topotype. This study will provide very useful information to help develop a potential vaccine candidate for the prevention and control of serotype O FMD in China.<\/jats:p>","DOI":"10.1186\/s13567-022-01072-7","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T12:03:38Z","timestamp":1657281818000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Evaluation of\u00a0immunogenicity and cross-reactive responses of\u00a0\u00a0vaccines prepared from two chimeric serotype O\u00a0foot-and-mouth disease\u00a0viruses in pigs and cattle"],"prefix":"10.1186","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1883-978X","authenticated-orcid":false,"given":"Pinghua","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwen","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyun","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaixin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengjun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"1072_CR1","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1128\/CMR.17.2.465-493.2004","volume":"17","author":"MJ Grubman","year":"2004","unstructured":"Grubman MJ, Baxt B (2004) Foot-and-mouth disease. 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