{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:44:35Z","timestamp":1771328675918,"version":"3.50.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003008","name":"Ministry of Higher Education, Egypt","doi-asserted-by":"publisher","award":["40437"],"award-info":[{"award-number":["40437"]}],"id":[{"id":"10.13039\/501100003008","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K17468"],"award-info":[{"award-number":["20K17468"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H03184"],"award-info":[{"award-number":["21H03184"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Numerous infectious diseases in cattle lead to reductions in body weight, milk production, and reproductive performance. Cattle are primarily vaccinated using inactivated vaccines due to their increased safety. However, inactivated vaccines generally result in weaker immunity compared with live attenuated vaccines, which may be insufficient in certain cases. Over the last few decades, there has been extensive research on the use of the Newcastle disease virus (NDV) as a live vaccine vector for economically significant livestock diseases. A single vaccination dose of NDV can sufficiently induce immunity; therefore, a booster vaccination dose is expected to yield limited induction of further immune response. We previously developed recombinant chimeric NDV (rNDV-2F2HN), in which its hemagglutinin-neuraminidase (HN) and fusion (F) proteins were replaced with those of avian paramyxovirus 2 (APMV-2). In vitro analysis revealed that rNDV-2F2HN expressing human interferon-gamma had potential as a cancer therapeutic tool, particularly for immunized individuals. In the present study, we constructed rNDV-2F2HN expressing the bovine rotavirus antigen VP6 (rNDV-2F2HN-VP6) and evaluated its immune response in mice previously immunized with NDV. Mice primarily inoculated with recombinant wild-type NDV expressing VP6 (rNDV-WT-VP6), followed by a booster inoculation of rNDV-2F2HN-VP6, showed a significantly stronger immune response than that in mice that received rNDV-WT-VP6 as both primary and booster inoculations. Therefore, our findings suggest that robust immunity could be obtained from the effects of chimeric rNDV-2F2HN expressing the same or a different antigen of a particular pathogen as a live attenuated vaccine vector.<\/jats:p>","DOI":"10.1186\/s13567-024-01271-4","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T15:05:41Z","timestamp":1707145541000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Use of live attenuated recombinant Newcastle disease virus carrying avian paramyxovirus 2 HN and F protein genes to enhance immune responses against species A rotavirus VP6 protein"],"prefix":"10.1186","volume":"55","author":[{"given":"Rofaida Mostafa","family":"Soliman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Nishioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumi","family":"Murakoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7513-6186","authenticated-orcid":false,"given":"Takaaki","family":"Nakaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"1271_CR1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.livsci.2010.02.009","volume":"130","author":"B Gummow","year":"2010","unstructured":"Gummow B (2010) Challenges posed by new and re-emerging infectious diseases in livestock production, wildlife and humans. Livest Sci 130:41\u201346","journal-title":"Livest Sci"},{"key":"1271_CR2","doi-asserted-by":"publisher","first-page":"100238","DOI":"10.1016\/j.vas.2022.100238","volume":"15","author":"GU Maier","year":"2022","unstructured":"Maier GU, Breitenbuecher J, Gomez JP, Samah F, Fausak E, Van Noord M (2022) Vaccination for the prevention of neonatal calf diarrhea in cow-calf operations: a scoping review. Vet Anim Sci 15:100238","journal-title":"Vet Anim Sci"},{"key":"1271_CR3","doi-asserted-by":"publisher","first-page":"4054","DOI":"10.1016\/j.vaccine.2004.12.010","volume":"23","author":"JR Patel","year":"2005","unstructured":"Patel JR (2005) Relative efficacy of inactivated bovine herpesvirus-1 (BHV-1) vaccines. Vaccine 23:4054\u20134061","journal-title":"Vaccine"},{"key":"1271_CR4","doi-asserted-by":"publisher","first-page":"4508","DOI":"10.1016\/j.vaccine.2009.05.012","volume":"27","author":"R Platt","year":"2009","unstructured":"Platt R, Widel PW, Kesl LD, Roth JA (2009) Comparison of humoral and cellular immune responses to a pentavalent modified live virus vaccine in three age groups of calves with maternal antibodies, before and after BVDV type 2 challenge. Vaccine 27:4508\u20134519","journal-title":"Vaccine"},{"key":"1271_CR5","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S1045-1056(03)00025-3","volume":"31","author":"I Greiser-Wilke","year":"2003","unstructured":"Greiser-Wilke I, Grummer B, Moennig V (2003) Bovine viral diarrhoea eradication and control programmes in Europe. Biologicals 31:113\u2013118","journal-title":"Biologicals"},{"key":"1271_CR6","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/978-981-15-2651-0_8","volume":"2020","author":"AN Vlasova","year":"2020","unstructured":"Vlasova AN, Deol P, Sircar S, Ghosh S, Jakab S, B\u00e1nyai K, Dhama K, Amimo JO, Saif LJ, Malik YS (2020) Animal rotaviruses. Animal-Origin Viral Zoonoses 2020:163\u2013202","journal-title":"Animal-Origin Viral Zoonoses"},{"key":"1271_CR7","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12985-017-0910-6","volume":"15","author":"Z Guo","year":"2018","unstructured":"Guo Z, Chen XX, Li R, Qiao S, Zhang G (2018) The prevalent status and genetic diversity of porcine reproductive and respiratory syndrome virus in China: a molecular epidemiological perspective. Virol J 15:2","journal-title":"Virol J"},{"key":"1271_CR8","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.biori.2017.10.001","volume":"1","author":"S Jorge","year":"2017","unstructured":"Jorge S, Dellagostin OA (2017) The development of veterinary vaccines: a review of traditional methods and modern biotechnology approaches. Biotechnol Res Innov 1:6\u201313","journal-title":"Biotechnol Res Innov"},{"key":"1271_CR9","doi-asserted-by":"publisher","first-page":"5974","DOI":"10.1016\/j.vaccine.2017.09.008","volume":"35","author":"J Mayers","year":"2017","unstructured":"Mayers J, Mansfield KL, Brown IH (2017) The role of vaccination in risk mitigation and control of Newcastle disease in poultry. Vaccine 35:5974\u20135980","journal-title":"Vaccine"},{"key":"1271_CR10","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1016\/j.vaccine.2015.03.091","volume":"33","author":"J Ge","year":"2015","unstructured":"Ge J, Wang X, Tian M, Gao Y, Wen Z, Yu G, Zhou W, Zu S, Bu Z (2015) Recombinant Newcastle disease viral vector expressing hemagglutinin or fusion of canine distemper virus is safe and immunogenic in minks. Vaccine 33:2457\u20132462","journal-title":"Vaccine"},{"key":"1271_CR11","doi-asserted-by":"publisher","first-page":"NP83","DOI":"10.1177\/1533034615601521","volume":"15","author":"G Ren","year":"2016","unstructured":"Ren G, Tian G, Liu Y, He J, Gao X, Yu Y, Liu X, Zhang X, Sun T, Liu S, Yin J, Li D (2016) Recombinant Newcastle disease virus encoding IL-12 and\/or IL-2 as potential candidate for hepatoma carcinoma therapy. Technol Cancer Res Treat 15:NP83-94","journal-title":"Technol Cancer Res Treat"},{"key":"1271_CR12","doi-asserted-by":"publisher","first-page":"11868","DOI":"10.1128\/JVI.75.23.11868-11873.2001","volume":"75","author":"T Nakaya","year":"2001","unstructured":"Nakaya T, Cros J, Park MS, Nakaya Y, Zheng H, Sagrera A, Villar E, Garcia-Sastre A, Palese P (2001) Recombinant Newcastle disease virus as a vaccine vector. J Virol 75:11868\u201311873","journal-title":"J Virol"},{"key":"1271_CR13","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ejphar.2017.02.042","volume":"802","author":"Y Wu","year":"2017","unstructured":"Wu Y, He J, Geng J, An Y, Ye X, Yan S, Yu Q, Yin J, Zhang Z, Li D (2017) Recombinant Newcastle disease virus expressing human TRAIL as a potential candidate for hepatoma therapy. Eur J Pharmacol 802:85\u201392","journal-title":"Eur J Pharmacol"},{"key":"1271_CR14","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12985-016-0481-y","volume":"13","author":"M Zhang","year":"2016","unstructured":"Zhang M, Ge J, Li X, Chen W, Wang X, Wen Z, Bu Z (2016) Protective efficacy of a recombinant Newcastle disease virus expressing glycoprotein of vesicular stomatitis virus in mice. Virol J 13:31","journal-title":"Virol J"},{"key":"1271_CR15","doi-asserted-by":"publisher","first-page":"347","DOI":"10.2217\/fmb.12.4","volume":"7","author":"D Zamarin","year":"2012","unstructured":"Zamarin D, Palese P (2012) Oncolytic Newcastle disease virus for cancer therapy: old challenges and new directions. Future Microbiol 7:347\u2013367","journal-title":"Future Microbiol"},{"key":"1271_CR16","doi-asserted-by":"publisher","first-page":"3159","DOI":"10.1016\/j.vaccine.2010.02.051","volume":"28","author":"SK Khattar","year":"2010","unstructured":"Khattar SK, Collins PL, Samal SK (2010) Immunization of cattle with recombinant Newcastle disease virus expressing bovine herpesvirus-1 (BHV-1) glycoprotein D induces mucosal and serum antibody responses and provides partial protection against BHV-1. Vaccine 28:3159\u20133170","journal-title":"Vaccine"},{"key":"1271_CR17","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s00705-016-3078-2","volume":"162","author":"M Zhang","year":"2017","unstructured":"Zhang M, Ge J, Wen Z, Chen W, Wang X, Liu R, Bu Z (2017) Characterization of a recombinant Newcastle disease virus expressing the glycoprotein of bovine ephemeral fever virus. Arch Virol 162:359\u2013367","journal-title":"Arch Virol"},{"key":"1271_CR18","doi-asserted-by":"publisher","first-page":"6197","DOI":"10.1038\/s41467-021-26499-y","volume":"12","author":"W Sun","year":"2021","unstructured":"Sun W, Liu Y, Amanat F, Gonzalez-Dominguez I, McCroskery S, Slamanig S, Coughlan L, Rosado V, Lemus N, Jangra S, Rathnasinghe R, Schotsaert M, Martinez JL, Sano K, Mena I, Innis BL, Wirachwong P, Thai DH, Oliveira RDN, Scharf R, Hjorth R, Raghunandan R, Krammer F, Garcia-Sastre A, Palese P (2021) A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responses. Nat Commun 12:6197","journal-title":"Nat Commun"},{"key":"1271_CR19","doi-asserted-by":"publisher","first-page":"e0153822","DOI":"10.1128\/spectrum.01538-22","volume":"10","author":"I Gonzalez-Dominguez","year":"2022","unstructured":"Gonzalez-Dominguez I, Martinez JL, Slamanig S, Lemus N, Liu Y, Lai TY, Carreno JM, Singh G, Singh G, Schotsaert M, Mena I, McCroskery S, Coughlan L, Krammer F, Garc\u00eda-Sastre A, Palese P, Sun W (2022) Trivalent NDV-HXP-S vaccine protects against phylogenetically distant SARS-CoV-2 variants of concern in mice. Microbiol Spectr 10:e0153822","journal-title":"Microbiol Spectr"},{"key":"1271_CR20","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1128\/JVI.01514-06","volume":"81","author":"J Ge","year":"2007","unstructured":"Ge J, Deng G, Wen Z, Tian G, Wang Y, Shi J, Wang X, Li Y, Hu S, Jiang Y, Yang C, Yu K, Bu Z, Chen H (2007) Newcastle disease virus-based live attenuated vaccine completely protects chickens and mice from lethal challenge of homologous and heterologous H5N1 avian influenza viruses. J Virol 81:150\u2013158","journal-title":"J Virol"},{"key":"1271_CR21","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1128\/JVI.01946-09","volume":"84","author":"JM DiNapoli","year":"2010","unstructured":"DiNapoli JM, Nayak B, Yang L, Finneyfrock BW, Cook A, Andersen H, Torres-Velez F, Murphy BR, Samal SK, Collins PL, Bukreyev A (2010) Newcastle disease virus-vectored vaccines expressing the hemagglutinin or neuraminidase protein of H5N1 highly pathogenic avian influenza virus protect against virus challenge in monkeys. J Virol 84:1489\u20131503","journal-title":"J Virol"},{"key":"1271_CR22","doi-asserted-by":"publisher","first-page":"8241","DOI":"10.1128\/JVI.00519-11","volume":"85","author":"J Ge","year":"2011","unstructured":"Ge J, Wang X, Tao L, Wen Z, Feng N, Yang S, Xia X, Yang C, Chen H, Bu Z (2011) Newcastle disease virus-vectored rabies vaccine is safe, highly immunogenic, and provides long-lasting protection in dogs and cats. J Virol 85:8241\u20138252","journal-title":"J Virol"},{"key":"1271_CR23","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.virol.2012.06.001","volume":"432","author":"D Kong","year":"2012","unstructured":"Kong D, Wen Z, Su H, Ge J, Chen W, Wang X, Wu C, Yang C, Chen H, Bu Z (2012) Newcastle disease virus-vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long-lasting neutralizing antibodies in pigs. Virology 432:327\u2013335","journal-title":"Virology"},{"key":"1271_CR24","doi-asserted-by":"publisher","first-page":"8582","DOI":"10.1128\/JVI.00652-11","volume":"85","author":"SH Kim","year":"2011","unstructured":"Kim SH, Subbiah M, Samuel AS, Collins PL, Samal SK (2011) Roles of the fusion and hemagglutinin-neuraminidase proteins in replication, tropism, and pathogenicity of avian paramyxoviruses. J Virol 85:8582\u20138596","journal-title":"J Virol"},{"key":"1271_CR25","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.virol.2017.01.006","volume":"503","author":"SH Kim","year":"2017","unstructured":"Kim SH, Paldurai A, Samal SK (2017) A novel chimeric Newcastle disease virus vectored vaccine against highly pathogenic avian influenza virus. Virology 503:31\u201336","journal-title":"Virology"},{"key":"1271_CR26","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3390\/biomedicines11020455","volume":"11","author":"RM Soliman","year":"2023","unstructured":"Soliman RM, Nishioka K, Daidoji T, Noyori O, Nakaya T (2023) Chimeric Newcastle disease virus vectors expressing human IFN-gamma mediate target immune responses and enable multifaceted treatments. Biomedicines 11:455","journal-title":"Biomedicines"},{"key":"1271_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4142\/jvs.2014.15.1.1","volume":"15","author":"YI Cho","year":"2014","unstructured":"Cho YI, Yoon KJ (2014) An overview of calf diarrhea\u2014infectious etiology, diagnosis, and intervention. J Vet Sci 15:1\u201317","journal-title":"J Vet Sci"},{"key":"1271_CR28","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.3390\/ani11041014","volume":"11","author":"M Brunauer","year":"2021","unstructured":"Brunauer M, Roch FF, Conrady B (2021) Prevalence of worldwide neonatal calf diarrhoea caused by bovine rotavirus in combination with bovine coronavirus, Escherichia coli K99 and Cryptosporidium spp.: a meta-analysis. Animals (Basel) 11:1014","journal-title":"Animals (Basel)"},{"key":"1271_CR29","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s00418-009-0648-3","volume":"133","author":"K Miyazawa","year":"2010","unstructured":"Miyazawa K, Hondo T, Kanaya T, Tanaka S, Takakura I, Itani W, Rose MT, Kitazawa H, Yamaguchi T, Aso H (2010) Characterization of newly established bovine intestinal epithelial cell line. Histochem Cell Biol 133:125\u2013134","journal-title":"Histochem Cell Biol"},{"key":"1271_CR30","doi-asserted-by":"publisher","first-page":"12285","DOI":"10.1128\/JVI.00969-10","volume":"84","author":"K Miyazawa","year":"2010","unstructured":"Miyazawa K, Kanaya T, Takakura I, Tanaka S, Hondo T, Watanabe H, Rose MT, Kitazawa H, Yamaguchi T, Katamine S, Nishida N, Aso H (2010) Transcytosis of murine-adapted bovine spongiform encephalopathy agents in an in vitro bovine M cell model. J Virol 84:12285\u201312291","journal-title":"J Virol"},{"key":"1271_CR31","first-page":"Unit 15C.3","volume":"15","author":"M Arnold","year":"2009","unstructured":"Arnold M, Patton JT, McDonald SM (2009) Culturing, storage, and quantification of rotaviruses. Curr Protoc Microbiol Chapter 15:Unit 15C.3","journal-title":"Curr Protoc Microbiol Chapter"},{"key":"1271_CR32","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jviromet.2006.01.003","volume":"134","author":"AF Payne","year":"2006","unstructured":"Payne AF, Binduga-Gajewska I, Kauffman EB, Kramer LD (2006) Quantitation of flaviviruses by fluorescent focus assay. J Virol Methods 134:183\u2013189","journal-title":"J Virol Methods"},{"key":"1271_CR33","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1006\/viro.2000.0618","volume":"278","author":"S Krishnamurthy","year":"2000","unstructured":"Krishnamurthy S, Huang Z, Samal SK (2000) Recovery of a virulent strain of Newcastle disease virus from cloned cDNA: expression of a foreign gene results in growth retardation and attenuation. Virology 278:168\u2013182","journal-title":"Virology"},{"key":"1271_CR34","doi-asserted-by":"publisher","first-page":"198659","DOI":"10.1016\/j.virusres.2021.198659","volume":"309","author":"K Nishioka","year":"2022","unstructured":"Nishioka K, Daidoji T, Nakaya T (2022) Downregulation of calcium-regulated heat stable protein 1 expression by low-temperature stimulation causes reduction of interferon-beta expression and sensitivity to influenza viral infection. Virus Res 309:198659","journal-title":"Virus Res"},{"key":"1271_CR35","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.virol.2004.10.016","volume":"331","author":"P Zhao","year":"2005","unstructured":"Zhao P, Cao J, Zhao LJ, Qin ZL, Ke JS, Pan W, Ren H, Yu JG, Qi ZT (2005) Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine. Virology 331:128\u2013135","journal-title":"Virology"},{"key":"1271_CR36","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1128\/CVI.00135-10","volume":"17","author":"S Lee","year":"2010","unstructured":"Lee S, Belitsky BR, Brinker JP, Kerstein KO, Brown DW, Clements JD, Keusch GT, Tzipori S, Sonenshein AL, Herrmann JE (2010) Development of a Bacillus subtilis-based rotavirus vaccine. Clin Vaccine Immunol 17:1647\u20131655","journal-title":"Clin Vaccine Immunol"},{"key":"1271_CR37","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1007\/s00705-015-2461-8","volume":"160","author":"S Lappalainen","year":"2015","unstructured":"Lappalainen S, Pastor AR, Malm M, Lopez-Guerrero V, Esquivel-Guadarrama F, Palomares LA, Vesikari T, Blazevic V (2015) Protection against live rotavirus challenge in mice induced by parenteral and mucosal delivery of VP6 subunit rotavirus vaccine. Arch Virol 160:2075\u20132078","journal-title":"Arch Virol"},{"key":"1271_CR38","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s00705-022-05407-9","volume":"167","author":"Z Shoja","year":"2022","unstructured":"Shoja Z, Jalilvand S, Latifi T, Roohvand F (2022) Rotavirus VP6: involvement in immunogenicity, adjuvant activity, and use as a vector for heterologous peptides, drug delivery, and production of nano-biomaterials. Arch Virol 167:1013\u20131023","journal-title":"Arch Virol"},{"key":"1271_CR39","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1590\/S1679-45082016RB3582","volume":"14","author":"A Luchs","year":"2016","unstructured":"Luchs A, Timenetsky MdCST (2016) Group A rotavirus gastroenteritis: post-vaccine era, genotypes and zoonotic transmission. Einstein (S\u00e3o Paulo) 14:278\u2013287","journal-title":"Einstein (S\u00e3o Paulo)"},{"key":"1271_CR40","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3390\/v8070183","volume":"8","author":"SH Kim","year":"2016","unstructured":"Kim SH, Samal SK (2016) Newcastle disease virus as a vaccine vector for development of human and veterinary vaccines. Viruses 8:183","journal-title":"Viruses"},{"key":"1271_CR41","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3389\/fmicb.2020.00769","volume":"11","author":"L He","year":"2020","unstructured":"He L, Zhang Z, Yu Q (2020) Expression of two foreign genes by a Newcastle disease virus vector from the optimal insertion sites through a combination of the ITU and IRES-dependent expression approaches. Front Microbiol 11:769","journal-title":"Front Microbiol"},{"key":"1271_CR42","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3390\/vaccines8020222","volume":"8","author":"Z Hu","year":"2020","unstructured":"Hu Z, Ni J, Cao Y, Liu X (2020) Newcastle disease virus as a vaccine vector for 20 years: A focus on maternally derived antibody interference. Vaccines (Basel) 8:222","journal-title":"Vaccines (Basel)"},{"key":"1271_CR43","doi-asserted-by":"publisher","first-page":"451","DOI":"10.3390\/v12040451","volume":"12","author":"MB Bello","year":"2020","unstructured":"Bello MB, Yusoff K, Ideris A, Hair-Bejo M, Jibril AH, Peeters BPH, Omar AR (2020) Exploring the prospects of engineered Newcastle disease virus in modern vaccinology. Viruses 12:451","journal-title":"Viruses"},{"key":"1271_CR44","doi-asserted-by":"publisher","first-page":"9366","DOI":"10.1128\/JVI.78.17.9366-9375.2004","volume":"78","author":"Y Nakaya","year":"2004","unstructured":"Nakaya Y, Nakaya T, Park MS, Cros J, Imanishi J, Palese P, Garcia-Sastre A (2004) Induction of cellular immune responses to simian immunodeficiency virus gag by two recombinant negative-strand RNA virus vectors. J Virol 78:9366\u20139375","journal-title":"J Virol"},{"key":"1271_CR45","doi-asserted-by":"publisher","first-page":"e1008732","DOI":"10.1371\/journal.ppat.1008732","volume":"16","author":"SL Caddy","year":"2020","unstructured":"Caddy SL, Vaysburd M, Wing M, Foss S, Andersen JT, O\u2019Connell K, Mayes K, Higginson K, Iturriza-Gomara M, Desselberger U, James LC (2020) Intracellular neutralisation of rotavirus by VP6-specific IgG. PLoS Pathog 16:e1008732","journal-title":"PLoS Pathog"},{"key":"1271_CR46","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.semcdb.2021.10.010","volume":"126","author":"M Bottermann","year":"2022","unstructured":"Bottermann M, Caddy SL (2022) Virus neutralisation by intracellular antibodies. Semin Cell Dev Biol 126:108\u2013116","journal-title":"Semin Cell Dev Biol"},{"key":"1271_CR47","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.vetimm.2010.04.015","volume":"137","author":"DD Gonzalez","year":"2010","unstructured":"Gonzalez DD, Mozgovoj MV, Bellido D, Rodriguez DV, Fernandez FM, Wigdorovitz A, Parreno VG, Dus Santos MJ (2010) Evaluation of a bovine rotavirus VP6 vaccine efficacy in the calf model of infection and disease. Vet Immunol Immunopathol 137:155\u2013160","journal-title":"Vet Immunol Immunopathol"},{"key":"1271_CR48","doi-asserted-by":"publisher","first-page":"e2027","DOI":"10.1002\/rmv.2027","volume":"29","author":"A Afchangi","year":"2019","unstructured":"Afchangi A, Jalilvand S, Mohajel N, Marashi SM, Shoja Z (2019) Rotavirus VP6 as a potential vaccine candidate. Rev Med Virol 29:e2027","journal-title":"Rev Med Virol"},{"key":"1271_CR49","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.1007\/s00705-018-4016-2","volume":"163","author":"J Liu","year":"2018","unstructured":"Liu J, Xue L, Hu S, Cheng H, Deng Y, Hu Z, Wang X, Liu X (2018) Chimeric Newcastle disease virus-vectored vaccine protects chickens against H9N2 avian influenza virus in the presence of pre-existing NDV immunity. Arch Virol 163:3365\u20133371","journal-title":"Arch Virol"},{"key":"1271_CR50","doi-asserted-by":"publisher","first-page":"e1011670","DOI":"10.1371\/journal.ppat.1011670","volume":"19","author":"TL Chandler","year":"2023","unstructured":"Chandler TL, Yang A, Otero CE, Permar SR, Caddy SL (2023) Protective mechanisms of nonneutralizing antiviral antibodies. PLoS Pathog 19:e1011670","journal-title":"PLoS Pathog"},{"key":"1271_CR51","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1172\/JCI14397","volume":"109","author":"N Feng","year":"2002","unstructured":"Feng N, Lawton JA, Gilbert J, Kuklin N, Vo P, Prasad BVV, Greenberg HB (2002) Inhibition of rotavirus replication by a non-neutralizing, rotavirus VP6\u2013specific IgA mAb. J Clin Invest 109:1203\u20131213","journal-title":"J Clin Invest"},{"key":"1271_CR52","doi-asserted-by":"publisher","first-page":"3281","DOI":"10.1016\/j.vaccine.2015.05.026","volume":"33","author":"S Jalilvand","year":"2015","unstructured":"Jalilvand S, Marashi SM, Shoja Z (2015) Rotavirus VP6 preparations as a non-replicating vaccine candidates. Vaccine 33:3281\u20133287","journal-title":"Vaccine"},{"key":"1271_CR53","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.4161\/hv.28858","volume":"10","author":"S Lappalainen","year":"2014","unstructured":"Lappalainen S, Pastor AR, Tamminen K, Lopez-Guerrero V, Esquivel-Guadarrama F, Palomares LA, Vesikari T, Blazevic V (2014) Immune responses elicited against rotavirus middle layer protein VP6 inhibit viral replication in vitro and in vivo. Hum Vaccin Immunother 10:2039\u20132047","journal-title":"Hum Vaccin Immunother"},{"key":"1271_CR54","doi-asserted-by":"publisher","first-page":"6639701","DOI":"10.1155\/2021\/6639701","volume":"2021","author":"US Geletu","year":"2021","unstructured":"Geletu US, Usmael MA, Bari FD (2021) Rotavirus in calves and its zoonotic importance. Vet Med Int 2021:6639701","journal-title":"Vet Med Int"}],"container-title":["Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13567-024-01271-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13567-024-01271-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13567-024-01271-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T18:09:02Z","timestamp":1707156542000},"score":1,"resource":{"primary":{"URL":"https:\/\/veterinaryresearch.biomedcentral.com\/articles\/10.1186\/s13567-024-01271-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,5]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1271"],"URL":"https:\/\/doi.org\/10.1186\/s13567-024-01271-4","relation":{},"ISSN":["1297-9716"],"issn-type":[{"value":"1297-9716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,5]]},"assertion":[{"value":"13 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experiments involving mice were conducted according to the guidelines and recommendations of the Institutional Animal Ethics Committee of the Animal Center of KPUM (Approval Number: M2022-541).\u00a0","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16"}}