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The pathogenesis of infection and the role of bacterial cell wall components in virulence have not been fully elucidated. Lipoproteins, peptidoglycan, as well as lipoteichoic acids (LTA) have all been proposed to contribute to virulence. In the present study, the role of the LTA in the pathogenesis of the infection was evaluated through the characterisation of a mutant of the <jats:italic>S. suis<\/jats:italic> serotype 2 strain P1\/7 lacking the LtaS enzyme, which mediates the polymerization of the LTA poly-glycerolphosphate chain. The <jats:italic>ltaS<\/jats:italic> mutant was confirmed to completely lack LTA and displayed significant morphological defects. Although the bacterial growth of this mutant was not affected, further results showed that LTA is involved in maintaining <jats:italic>S. suis<\/jats:italic> bacterial fitness. However, its role in the pathogenesis of the infection appears limited. Indeed, LTA presence reduces self-agglutination, biofilm formation and even dendritic cell activation, which are important aspects of the pathogenesis of the infection caused by <jats:italic>S. suis<\/jats:italic>. In addition, it does not seem to play a critical role in virulence using a systemic mouse model of infection.<\/jats:p>","DOI":"10.1186\/s13567-024-01287-w","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T16:02:34Z","timestamp":1710864154000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Lipoteichoic acids influence cell shape and bacterial division of Streptococcus suis serotype 2, but play a limited role in the pathogenesis of the infection"],"prefix":"10.1186","volume":"55","author":[{"given":"Servane","family":"Payen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Giroux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Gisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Schombel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahuel","family":"Fittipaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela","family":"Segura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2196-2212","authenticated-orcid":false,"given":"Marcelo","family":"Gottschalk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"1287_CR1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.medmal.2017.10.001","volume":"48","author":"B Haas","year":"2018","unstructured":"Haas B, Grenier D (2018) Understanding the virulence of Streptococcus suis: a veterinary, medical, and economic challenge. 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