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Pullorum in poultry is still unclear. This study was the first to evaluate the safety and anti-<jats:italic>S<\/jats:italic>. Pullorum infection of MccY in specific pathogen-free (SPF) chicks. The safety test showed that the body weight, IgA and IgM levels of serum, and cecal microbiota structure of 3 groups of chicks orally administrated with different doses of MccY (5\u00a0mg\/kg, 10\u00a0mg\/kg, 20\u00a0mg\/kg) for 14\u00a0days were not significantly different from those of the control group. Then, the chicks were randomized into 3 groups for the experiment of anti-<jats:italic>S<\/jats:italic>. Pullorum infection: (I) negative control group (NC), (II) <jats:italic>S<\/jats:italic>. Pullorum-challenged group (SP, 5\u2009\u00d7\u200910<jats:sup>8<\/jats:sup>\u00a0CFU\/bird), (III) MccY-treated group (MccY, 20\u00a0mg\/kg). The results indicated that compared to the SP group, treatment of MccY increased body weight and average daily gain (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), reduced <jats:italic>S<\/jats:italic>. Pullorum burden in feces, liver, and cecum (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), enhanced the thymus, and decreased the spleen and liver index (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Additionally, MccY increased the jejunal villus height, lowered the jejunal and ileal crypt depth (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and upregulated the expression of <jats:italic>IL-4<\/jats:italic>, <jats:italic>IL-10<\/jats:italic>, <jats:italic>ZO-1<\/jats:italic> in the jejunum and ileum, as well as <jats:italic>CLDN-1<\/jats:italic> in the jejunum (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) compared to the SP group. Furthermore, MccY increased probiotic flora (<jats:italic>Barnesiella<\/jats:italic>, etc.), while decreasing (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) the relative abundance of pathogenic flora (<jats:italic>Escherichia<\/jats:italic> and <jats:italic>Salmonella<\/jats:italic>, etc.) compared to the SP group.<\/jats:p>","DOI":"10.1186\/s13567-024-01321-x","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T14:02:13Z","timestamp":1716386533000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of oral administration of microcin Y on growth performance, intestinal barrier function and gut microbiota of chicks challenged with Salmonella Pullorum"],"prefix":"10.1186","volume":"55","author":[{"given":"Wenjing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zepeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saixiang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4546-7133","authenticated-orcid":false,"given":"Weisheng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"1321_CR1","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1080\/03079457.2012.718071","volume":"41","author":"PA Barrow","year":"2012","unstructured":"Barrow PA, Jones MA, Smith AL, Wigley P (2012) The long view: Salmonella\u2014the last forty years. 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