{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:40:09Z","timestamp":1785526809831,"version":"3.56.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Scientific and Technological research project of Henan province","award":["No. 232102110093"],"award-info":[{"award-number":["No. 232102110093"]}]},{"name":"Doctoral Specialty Foundation of Nanyang Normal University","award":["No. 2022ZX032-218310"],"award-info":[{"award-number":["No. 2022ZX032-218310"]}]},{"name":"Key Scientific Research Projects of Colleges and Universities in Henan Province of China","award":["No. 23A230002"],"award-info":[{"award-number":["No. 23A230002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Swine acute diarrhoea syndrome coronavirus (SADS-CoV), which originates from zoonotic transmission of bat coronaviruses in the HKU2 lineage, causes severe illness in pigs and carries a high risk of spreading to humans. At present, there are no licenced therapeutics for the treatment of SADS-CoV. In this study, we examined the effectiveness of recombinant porcine interferon delta 8 (IFN-\u03b48) against SADS-CoV both in vitro and in vivo. In vitro experiments showed that IFN-\u03b48 inhibited SADS-CoV proliferation in a concentration-dependent manner, with complete inhibition occurring at a concentration of 5\u00a0\u03bcg\/mL. In vivo experiments demonstrated that two 50\u00a0\u03bcg\/kg doses of IFN-\u03b48 injected intraperitoneally protected piglets against lethal challenge, blocked viral shedding, attenuated intestinal damage, and decreased the viral load in the jejunum and ileum. Further findings suggested that IFN-\u03b48 inhibited SADS-CoV infection by increasing the expression of IFN-stimulated genes. These results indicate that IFN-\u03b48 shows promise as a biological macromolecule drug against SADS-CoV infection.<\/jats:p>","DOI":"10.1186\/s13567-024-01346-2","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T09:02:56Z","timestamp":1721811776000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Recombinant porcine interferon delta 8 inhibits swine acute diarrhoea syndrome coronavirus infection in vitro and in vivo"],"prefix":"10.1186","volume":"55","author":[{"given":"Teng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jucai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kankan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8530-5732","authenticated-orcid":false,"given":"Lunguang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"1346_CR1","doi-asserted-by":"publisher","first-page":"2332653","DOI":"10.1080\/22221751.2024.2332653","volume":"13","author":"J Guo","year":"2024","unstructured":"Guo J, Lai Y, Yang Z, Song W, Zhou J, Li Z, Su W, Xiao S, Fang L (2024) Coinfection and nonrandom recombination drive the evolution of swine enteric coronaviruses. 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All animals received humane care in compliance with good animal practice according to the animal ethics procedures and guidelines of the Institutional Animal Care and Use Committee. All efforts were made to alleviate and minimise animal suffering.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent for publication was obtained from all participants (Teng Zhang, Jiale Yao, Zhuan Yang, Jucai Wang, Kankan Yang, Lunguang Yao, Junru Wang, Xiufen He, and Bo Chen).","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"92"}}