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Here, we used genomics approaches to characterize 251\n                    <jats:italic>S. suis<\/jats:italic>\n                    isolates recovered from diseased pigs across Belgium, France, Germany, Hungary, the Netherlands, Spain, and the United Kingdom. We identified 13 serotypes, being serotypes 9 and 2 the most prevalent, and 34 sequence types (STs), including 16 novel STs, although ST16 and ST1 dominated the strain population. Phylogenetic analysis revealed complex genetic relationships, notable geographic clustering, and potential differential capacity for capsular switching among serotype 9 isolates. We found antimicrobial resistance (AMR) genes in 85.3% of the isolates, with high frequencies of genes conferring resistance to tetracyclines and macrolides. Specifically, 49.4% of the isolates harbored the\n                    <jats:italic>tetO<\/jats:italic>\n                    gene, and 64.9% possessed the\n                    <jats:italic>ermB<\/jats:italic>\n                    gene. Additionally, we observed a diverse array of virulence-associated genes (VAGs), including the classical VAGs\n                    <jats:italic>mrp<\/jats:italic>\n                    ,\n                    <jats:italic>epf<\/jats:italic>\n                    , and\n                    <jats:italic>sly<\/jats:italic>\n                    , with variable presence across different genotypes. The high genetic diversity among European\n                    <jats:italic>S. suis<\/jats:italic>\n                    isolates highlights the importance of targeted antimicrobial use and flexible vaccine strategies. Rapid strain characterization is crucial for optimizing swine health management, enabling tailored interventions like the development of autovaccines to mitigate\n                    <jats:italic>S. suis<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.1186\/s13567-024-01366-y","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T06:02:04Z","timestamp":1727416924000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Molecular characterization of Streptococcus suis isolates recovered from diseased pigs in Europe"],"prefix":"10.1186","volume":"55","author":[{"given":"Kevin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Lacouture","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Lewandowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Thibault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Gantelet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Gottschalk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1063-7983","authenticated-orcid":false,"given":"Nahuel","family":"Fittipaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"1366_CR1","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1002\/9781119350927.ch61","volume-title":"Diseases of swine","author":"M Gottschalk","year":"2019","unstructured":"Gottschalk M, Segura M (2019) Streptococcosis. 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