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Iron is an essential nutrient for growth, colonization, and proliferation of <jats:italic>P. multocida<\/jats:italic> during infection of the host, and competition for iron ions in the host is a critical link in the pathogenesis of this pathogen. In recent years, there has been significant progress in the study of the iron uptake system of <jats:italic>P. multocida<\/jats:italic>, including its occurrence and regulatory mechanisms. In order to provide a systematic theoretical basis for the study of the molecular pathogenesis of the <jats:italic>P. multocida<\/jats:italic> iron uptake system, and generate new ideas for the investigation and development of molecular-targeted drugs and subunit vaccines against <jats:italic>P. multocida<\/jats:italic>, the mechanisms of iron uptake by transferrin receptors, heme receptors, and siderophores, and the mechanism of expression and regulation of the <jats:italic>P. multocida<\/jats:italic> iron uptake system are all described.<\/jats:p>","DOI":"10.1186\/s13567-025-01469-0","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T12:44:43Z","timestamp":1739450683000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Study in the iron uptake mechanism of Pasteurella multocida"],"prefix":"10.1186","volume":"56","author":[{"given":"Xiangxiang","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-3945","authenticated-orcid":false,"given":"Zhanqin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"1469_CR1","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.vetmic.2009.04.027","volume":"139","author":"A Bethe","year":"2009","unstructured":"Bethe A, Wieler LH, Selbitz HJ, Ewers C (2009) Genetic diversity of porcine Pasteurella multocida strains from the respiratory tract of healthy and diseased swine. 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