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KWH\n                    <jats:sub>2<\/jats:sub>\n                    , a novel peptide demonstrating potent antimicrobial activity, holds translational potential for enteric disease control. This study evaluated KWH\n                    <jats:sub>2<\/jats:sub>\n                    \u2019s therapeutic efficacy in weaned piglets challenged with\n                    <jats:italic>Salmonella choleraesuis<\/jats:italic>\n                    \u2014a clinically relevant model of intestinal infection and immunity. KWH\n                    <jats:sub>2<\/jats:sub>\n                    supplementation significantly improved clinical outcomes during infection, including restoring growth performance, reducing diarrhea severity, and enhancing intestinal barrier integrity. Transcriptomic analysis revealed KWH\n                    <jats:sub>2<\/jats:sub>\n                    \u2019s modulation of key pathways in intestinal immunity, inflammation, and cellular stress responses. Mechanistically, KWH\n                    <jats:sub>2<\/jats:sub>\n                    targeted the\n                    <jats:italic>GSK-3\u03b2<\/jats:italic>\n                    signaling axis, suppressing inflammatory activation and promoting epithelial repair through GSK-3\u03b2 phosphorylation. These results establish KWH\n                    <jats:sub>2<\/jats:sub>\n                    as a dual-function therapeutic candidate that enhances intestinal resilience against infection by integrating antimicrobial activity with host-directed immunometabolic regulation. Its efficacy in a production-relevant porcine model supports KWH\n                    <jats:sub>2<\/jats:sub>\n                    \u2019s potential for developing veterinary therapeutics targeting enteric pathogens.\n                  <\/jats:p>","DOI":"10.1186\/s13567-025-01682-x","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T19:03:16Z","timestamp":1773774196000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual-action peptide KWH2 protects against Salmonella choleraesuis diarrhea in weaned piglets by enhancing intestinal barrier integrity and modulating GSK-3\u03b2\/Myc signaling"],"prefix":"10.1186","volume":"57","author":[{"given":"Yunhui","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaikai","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziye","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueyang","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongpeng","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"1682_CR1","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/s12276-024-01179-1","volume":"56","author":"J Choi","year":"2024","unstructured":"Choi J, Augenlicht LH (2024) Intestinal stem cells: guardians of homeostasis in health and aging amid environmental challenges. 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