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A hypertonic syrup predominantly comprising <jats:sc>l<\/jats:sc>-arabinose and <jats:sc>d<\/jats:sc>-xylose (20% xylo-oligosaccharides) can be extracted from the hemicellulose of corn husks and cobs. <jats:sc>l<\/jats:sc>-Arabinose and xylo-oligosaccharides have been reported to relieve constipation and improve the gut microbial environment. This study evaluated the bowel cleansing effect of the aforementioned syrup and its influence on the organism and intestinal microbiota after cleansing in comparison with polyethylene glycol-4000 (PEG-4000) in mice. Bowel cleansing was performed using syrup or PEG-4000 in C57BL\/6J mice, and the effect of intestinal preparation and its influence on serum electrolytes and gut microbiota after bowel cleansing were evaluated. The volume of intestinal residual feces in the syrup group was significantly lower than that in the PEG-4000 group. Additionally, syrup disturbed serum electrolytes more mildly than PEG-4000. Alpha diversity in the gut microbiota was significantly higher in the syrup group than in the PEG-4000 group on the first day after bowel cleansing. However, no difference in beta diversity was observed between the two groups. Syrup increased the abundance of <jats:italic>Bifidobacteria<\/jats:italic> and <jats:italic>Christensenella<\/jats:italic> and decreased the abundance of <jats:italic>Akkermansia<\/jats:italic> in comparison with PEG-4000 on the first day after bowel cleansing. Thus, this syrup has potential clinical use as a bowel cleansing agent given the above effects, its benefits and safety, and better taste and acceptability.<\/jats:p>","DOI":"10.1186\/s13568-024-01715-2","type":"journal-article","created":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T16:01:49Z","timestamp":1717257709000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A syrup containing l-arabinose and d-xylose appears superior to PEG-4000 as a bowel cleansing agent"],"prefix":"10.1186","volume":"14","author":[{"given":"Dezhi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingchen","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangli","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianzong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqiu","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongliang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3209-5713","authenticated-orcid":false,"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,1]]},"reference":[{"key":"1715_CR1","doi-asserted-by":"publisher","first-page":"291","DOI":"10.23922\/jarc.2020-104","volume":"5","author":"T Abe","year":"2021","unstructured":"Abe T, Kunimoto M, Hachiro Y, Ohara K, Inagaki M, Hishiyama H, Murakami M (2021) Tolerance and efficacy of polyethylene glycol 4000 in elderly patients with chronic constipation: a retrospective single-center, observational study. 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