{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:54:50Z","timestamp":1781628890268,"version":"3.54.5"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["(Grant No. AP09057915)"],"award-info":[{"award-number":["(Grant No. AP09057915)"]}]},{"name":"Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["(Grant No. AP09057915)"],"award-info":[{"award-number":["(Grant No. AP09057915)"]}]},{"name":"Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["(Grant No. AP09057915)"],"award-info":[{"award-number":["(Grant No. AP09057915)"]}]},{"name":"Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["(Grant No. AP09057915)"],"award-info":[{"award-number":["(Grant No. AP09057915)"]}]},{"name":"Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["(Grant No. AP09057915)"],"award-info":[{"award-number":["(Grant No. AP09057915)"]}]},{"name":"Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["(Grant No. AP09057915)"],"award-info":[{"award-number":["(Grant No. AP09057915)"]}]},{"name":"Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["(Grant No. AP09057915)"],"award-info":[{"award-number":["(Grant No. AP09057915)"]}]},{"name":"Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["(Grant No. AP09057915)"],"award-info":[{"award-number":["(Grant No. AP09057915)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AMB Expr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Radioactive compounds, including silicon dioxide (\n                    <jats:sup>31<\/jats:sup>\n                    SiO\n                    <jats:sub>2<\/jats:sub>\n                    ), may enter the environment and affect biological systems, yet their impact on the gut microbiota remains poorly studied. This study aimed to evaluate the effects of radioactive\n                    <jats:sup>31<\/jats:sup>\n                    SiO\n                    <jats:sub>2<\/jats:sub>\n                    , compared to non-radioactive SiO\n                    <jats:sub>2<\/jats:sub>\n                    and gamma irradiation, on the composition and functionality of the gut microbiota in laboratory Wistar rats (n\u2009=\u200928). Gut microbiota analysis of the large intestine, small intestine, and Peyer\u2019s patches was conducted at 90\u00a0min and 72\u00a0h post-exposure using 16S rRNA sequencing. Alpha-diversity results showed increased species richness in Peyer\u2019s patches at 90\u00a0min after exposure to radioactive\n                    <jats:sup>31<\/jats:sup>\n                    SiO\n                    <jats:sub>2<\/jats:sub>\n                    , with elevated\n                    <jats:italic>Bacilli<\/jats:italic>\n                    and Gammaproteobacteria, a trend persisting at 72\u00a0h. In the small intestine, radioactive\n                    <jats:sup>31<\/jats:sup>\n                    SiO\n                    <jats:sub>2<\/jats:sub>\n                    increased\n                    <jats:italic>Bacilli<\/jats:italic>\n                    and\n                    <jats:italic>Clostridia<\/jats:italic>\n                    at 3 days, while Gammaproteobacteria considerably decreased; by 72\u00a0h, Bacilli and\n                    <jats:italic>Clostridia<\/jats:italic>\n                    maintained growth, with\n                    <jats:italic>Gammaproteobacteria<\/jats:italic>\n                    recovering. These findings demonstrate that radioactive\n                    <jats:sup>31<\/jats:sup>\n                    SiO\n                    <jats:sub>2<\/jats:sub>\n                    dynamically alters gut microbiota composition and diversity, highlighting its unique influence on microbial communities.\n                  <\/jats:p>","DOI":"10.1186\/s13568-025-02002-4","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T13:33:57Z","timestamp":1767188037000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multicompartmental analysis of microbiome alterations under radiation stress"],"prefix":"10.1186","volume":"16","author":[{"given":"Nurislam","family":"Mukhanbetzhanov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanzhar","family":"Zhetkenev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta","family":"Vinogradova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shynggys","family":"Sergazy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zharkyn","family":"Jarmukhanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argul","family":"Issilbayeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alibek","family":"Kossumov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliya","family":"Kassenova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bagdaulet","family":"Mukhametuly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Kenessarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassym","family":"Zhumadilov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeriy","family":"Stepanenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktorya","family":"Bogacheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksei","family":"Petukhov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nariaki","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Hoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"issue":"4","key":"2002_CR1","doi-asserted-by":"publisher","first-page":"3208","DOI":"10.3390\/cimb45040209","volume":"45","author":"Z Abishev","year":"2023","unstructured":"Abishev Z, Ruslanova B, Apbassova S, Chaizhunussova N, Shabdarbayeva D, Azimkhanov A, Zhumadilov K, Stepanenko V, Ivanov S, Shegay P, Hoshi M, Fujimoto N (2023) Effects of internal exposure of radioactive 56MnO2 particles on the lung in C57BL mice. Curr Issues Mol Biol 45(4):3208\u20133218. https:\/\/doi.org\/10.3390\/cimb45040209","journal-title":"Curr Issues Mol Biol"},{"issue":"1","key":"2002_CR2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1667\/RR14975.1","volume":"191","author":"F Carbonero","year":"2018","unstructured":"Carbonero F, Mayta A, Bolea M, Yu J-Z, Lindeblad M, Lyubimov A, Neri F, Szilagyi E, Smith B, Halliday L, Bartholomew A (2018) Specific members of the gut microbiota are reliable biomarkers of irradiation intensity and lethality in large animal models of human health. Radiat Res 191(1):107. https:\/\/doi.org\/10.1667\/RR14975.1","journal-title":"Radiat Res"},{"key":"2002_CR3","doi-asserted-by":"publisher","DOI":"10.3402\/mehd.v26.26191","author":"S Carding","year":"2015","unstructured":"Carding S, Verbeke K, Vipond DT, Corfe BM, Owen LJ (2015) Dysbiosis of the gut microbiota in disease. Microb Ecol Health Disease. https:\/\/doi.org\/10.3402\/mehd.v26.26191","journal-title":"Microb Ecol Health Disease"},{"issue":"1","key":"2002_CR4","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s40168-017-0325-z","volume":"5","author":"D Casero","year":"2017","unstructured":"Casero D, Gill K, Sridharan V, Koturbash I, Nelson G, Hauer-Jensen M, Boerma M, Braun J, Cheema AK (2017) Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome. Microbiome 5(1):105. https:\/\/doi.org\/10.1186\/s40168-017-0325-z","journal-title":"Microbiome"},{"key":"2002_CR5","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.impact.2017.07.005","volume":"8","author":"H Chen","year":"2017","unstructured":"Chen H, Zhao R, Wang B, Cai C, Zheng L, Wang H, Wang M, Ouyang H, Zhou X, Chai Z, Zhao Y, Feng W (2017) The effects of orally administered Ag, TiO2 and SiO2 nanoparticles on gut microbiota composition and colitis induction in mice. NanoImpact 8:80\u201388. https:\/\/doi.org\/10.1016\/j.impact.2017.07.005","journal-title":"NanoImpact"},{"issue":"1","key":"2002_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s42523-023-00262-8","volume":"5","author":"W Cui","year":"2023","unstructured":"Cui W, Hull L, Zizzo A, Wang L, Lin B, Zhai M, Xiao M (2023) The gut microbiome changes in wild type and IL-18 knockout mice after 9.0 gy total body irradiation. Anim Microbiome 5(1):42. https:\/\/doi.org\/10.1186\/s42523-023-00262-8","journal-title":"Anim Microbiome"},{"issue":"5","key":"2002_CR7","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1128\/AEM.01226-07","volume":"74","author":"M Derrien","year":"2008","unstructured":"Derrien M, Collado MC, Ben-Amor K, Salminen S, de Vos WM (2008) The mucin degrader Akkermansia muciniphila is an abundant resident of the human intestinal tract. Appl Environ Microbiol 74(5):1646\u20131648. https:\/\/doi.org\/10.1128\/AEM.01226-07","journal-title":"Appl Environ Microbiol"},{"issue":"1","key":"2002_CR8","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s12951-021-00916-2","volume":"19","author":"J Diao","year":"2021","unstructured":"Diao J, Xia Y, Jiang X, Qiu J, Cheng S, Su J, Duan X, Gao M, Qin X, Zhang J, Fan J, Zou Z, Chen C (2021) Silicon dioxide nanoparticles induced neurobehavioral impairments by disrupting microbiota\u2013gut\u2013brain axis. J Nanobiotechnol 19(1):174. https:\/\/doi.org\/10.1186\/s12951-021-00916-2","journal-title":"J Nanobiotechnol"},{"issue":"1","key":"2002_CR9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3109\/01480545.2011.644561","volume":"36","author":"MM Dobrzy\u0144ska","year":"2013","unstructured":"Dobrzy\u0144ska MM, Radzikowska J (2013) Genotoxicity and reproductive toxicity of bisphenol A and X-ray\/bisphenol A combination in male mice. Drug Chem Toxicol 36(1):19\u201326. https:\/\/doi.org\/10.3109\/01480545.2011.644561","journal-title":"Drug Chem Toxicol"},{"issue":"12","key":"2002_CR10","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.1007\/s00204-016-1850-4","volume":"90","author":"C Fruijtier-P\u00f6lloth","year":"2016","unstructured":"Fruijtier-P\u00f6lloth C (2016) The safety of nanostructured synthetic amorphous silica (SAS) as a food additive (E 551). Arch Toxicol 90(12):2885\u20132916. https:\/\/doi.org\/10.1007\/s00204-016-1850-4","journal-title":"Arch Toxicol"},{"issue":"3","key":"2002_CR11","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1667\/RR14306.1","volume":"186","author":"M Goudarzi","year":"2016","unstructured":"Goudarzi M, Mak TD, Jacobs JP, Moon B-H, Strawn SJ, Braun J, Brenner DJ, Fornace AJ, Li H-H (2016) An integrated multi-omic approach to assess radiation injury on the host-microbiome axis. Radiat Res 186(3):219. https:\/\/doi.org\/10.1667\/RR14306.1","journal-title":"Radiat Res"},{"key":"2002_CR12","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay9097","author":"H Guo","year":"2020","unstructured":"Guo H, Chou W-C, Lai Y, Liang K, Tam JW, Brickey WJ, Chen L, Montgomery ND, Li X, Bohannon LM, Sung AD, Chao NJ, Peled JU, Gomes ALC, van den Brink MRM, French MJ, Macintyre AN, Sempowski GD, Tan X, Ting JPY (2020) Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science. https:\/\/doi.org\/10.1126\/science.aay9097","journal-title":"Science"},{"key":"2002_CR13","doi-asserted-by":"publisher","DOI":"10.1667\/RADE-21-00224.1","author":"DF Hamade","year":"2022","unstructured":"Hamade DF, Espinal A, Yu J, Leibowitz BJ, Fisher R, Hou W, Shields D, van Pijkeren J-P, Mukherjee A, Epperly MW, Vlad AM, Coffman L, Wang H, Saiful Huq M, Patel R, Huang J, Greenberger JS (2022) Lactobacillus reuteri releasing IL-22 (LR-IL-22) facilitates intestinal radioprotection for whole-abdomen irradiation (WAI) of ovarian cancer. Radiat Res. https:\/\/doi.org\/10.1667\/RADE-21-00224.1","journal-title":"Radiat Res"},{"key":"2002_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.643283","author":"BA Hollingsworth","year":"2021","unstructured":"Hollingsworth BA, Cassatt DR, DiCarlo AL, Rios CI, Satyamitra MM, Winters TA, Taliaferro LP (2021) Acute radiation syndrome and the microbiome: impact and review. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2021.643283","journal-title":"Front Pharmacol"},{"key":"2002_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113053","volume":"151","author":"Y Huang","year":"2022","unstructured":"Huang Y, Li P, Zhao R, Zhao L, Liu J, Peng S, Fu X, Wang X, Luo R, Wang R, Zhang Z (2022) Silica nanoparticles: biomedical applications and toxicity. Biomed Pharmacother 151:113053. https:\/\/doi.org\/10.1016\/j.biopha.2022.113053","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"2002_CR16","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.3390\/ijms25063339","volume":"25","author":"A Jameus","year":"2024","unstructured":"Jameus A, Dougherty J, Narendrula R, Levert D, Valiquette M, Pirkkanen J, Lalonde C, Bonin P, Gagnon JD, Appanna VD, Tharmalingam S, Thome C (2024) Acute impacts of ionizing radiation exposure on the gastrointestinal tract and gut microbiome in mice. Int J Mol Sci 25(6):3339. https:\/\/doi.org\/10.3390\/ijms25063339","journal-title":"Int J Mol Sci"},{"key":"2002_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.anaerobe.2015.01.004","volume":"33","author":"YS Kim","year":"2015","unstructured":"Kim YS, Kim J, Park S-J (2015) High-throughput 16S rRNA gene sequencing reveals alterations of mouse intestinal microbiota after radiotherapy. Anaerobe 33:1\u20137. https:\/\/doi.org\/10.1016\/j.anaerobe.2015.01.004","journal-title":"Anaerobe"},{"issue":"5","key":"2002_CR18","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1667\/RR2691.1","volume":"177","author":"V Lam","year":"2012","unstructured":"Lam V, Moulder JE, Salzman NH, Dubinsky EA, Andersen GL, Baker JE (2012) Intestinal microbiota as novel biomarkers of prior radiation exposure. Radiat Res 177(5):573. https:\/\/doi.org\/10.1667\/RR2691.1","journal-title":"Radiat Res"},{"issue":"1","key":"2002_CR19","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/toxsci\/kfz144","volume":"171","author":"X Liu","year":"2019","unstructured":"Liu X, Zhou Y, Wang S, Guan H, Hu S, Huang R, Zhou P (2019) Impact of low-dose ionizing radiation on the composition of the gut microbiota of mice. Toxicol Sci 171(1):258\u2013268. https:\/\/doi.org\/10.1093\/toxsci\/kfz144","journal-title":"Toxicol Sci"},{"issue":"1","key":"2002_CR20","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13014-020-01735-9","volume":"16","author":"J Liu","year":"2021","unstructured":"Liu J, Liu C, Yue J (2021) Radiotherapy and the gut microbiome: facts and fiction. Radiat Oncol 16(1):9. https:\/\/doi.org\/10.1186\/s13014-020-01735-9","journal-title":"Radiat Oncol"},{"issue":"1","key":"2002_CR21","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s10020-024-00873-0","volume":"30","author":"L Lu","year":"2024","unstructured":"Lu L, Li F, Gao Y, Kang S, Li J, Guo J (2024) Microbiome in radiotherapy: an emerging approach to enhance treatment efficacy and reduce tissue injury. Mol Med 30(1):105. https:\/\/doi.org\/10.1186\/s10020-024-00873-0","journal-title":"Mol Med"},{"issue":"5","key":"2002_CR22","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1021\/acs.jproteome.9b00101","volume":"18","author":"EL Pannkuk","year":"2019","unstructured":"Pannkuk EL, Laiakis EC, Gill K, Jain SK, Mehta KY, Nishita D, Bujold K, Bakke J, Gahagen J, Authier S, Chang P, Fornace AJ (2019) Liquid chromatography-mass spectrometry-based metabolomics of nonhuman primates after 4 Gy total body radiation exposure: global effects and targeted panels. J Proteome Res 18(5):2260\u20132269. https:\/\/doi.org\/10.1021\/acs.jproteome.9b00101","journal-title":"J Proteome Res"},{"key":"2002_CR23","doi-asserted-by":"publisher","DOI":"10.1136\/bmjos-2020-100115","author":"N Percie du Sert","year":"2020","unstructured":"Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, Lazic SE, Lidster K, MacCallum CJ, Macleod M, Wuerbel H (2020) The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. BMJ Open Sci. https:\/\/doi.org\/10.1136\/bmjos-2020-100115","journal-title":"BMJ Open Sci"},{"key":"2002_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00415","author":"P Sittipo","year":"2020","unstructured":"Sittipo P, Pham HQ, Park CE, Kang G-U, Zhi Y, Ji HJ, Jang A, Seo HS, Shin J-H, Lee YK (2020) Irradiation-induced intestinal damage is recovered by the indigenous gut bacteria Lactobacillus acidophilus. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2020.00415","journal-title":"Front Cell Infect Microbiol"},{"issue":"6","key":"2002_CR25","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1093\/jrr\/rrae063","volume":"65","author":"V Stepanenko","year":"2024","unstructured":"Stepanenko V, Sato H, Kaprin A, Fujimoto N, Kushugulova A, Ivanov S, Shegay P, Bogacheva V, Petukhov A, Zhumadilov K, Ostroumova E, Yasuda H, Kawano N, Ohtaki M, Endo S, Sakaguchi A, Chulenbayeva L, Mukhanbetzhanov N, Hoshi M (2024) Internal radiation dose estimates in organs of Wistar rats exposed to sprayed neutron-activated 31SiO2 microparticles: first results of international multicenter study. J Radiat Res 65(6):744\u2013751. https:\/\/doi.org\/10.1093\/jrr\/rrae063","journal-title":"J Radiat Res"},{"issue":"4","key":"2002_CR26","doi-asserted-by":"publisher","first-page":"653","DOI":"10.3390\/medicina60040653","volume":"60","author":"J Talapko","year":"2024","unstructured":"Talapko J, Talapko D, Katalini\u0107 D, Kotris I, Eri\u0107 I, Beli\u0107 D, Vasilj Mihaljevi\u0107 M, Vasilj A, Eri\u0107 S, Flam J, Beki\u0107 S, Mati\u0107 S, \u0160krlec I (2024) Health effects of ionizing radiation on the human body. Medicina 60(4):653. https:\/\/doi.org\/10.3390\/medicina60040653","journal-title":"Medicina"},{"key":"2002_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122502","volume":"341","author":"M Thandar","year":"2024","unstructured":"Thandar M, Yang X, Zhu Y, Zhang X, Chen Z, Huang S, Chi P (2024) Dysbiosis of gut microbiota and metabolites is associated with radiation-induced colorectal fibrosis and is restored by adipose-derived mesenchymal stem cell therapy. Life Sci 341:122502. https:\/\/doi.org\/10.1016\/j.lfs.2024.122502","journal-title":"Life Sci"},{"issue":"21","key":"2002_CR28","doi-asserted-by":"publisher","first-page":"11808","DOI":"10.3390\/ijms222111808","volume":"22","author":"M Wieckowski","year":"2021","unstructured":"Wieckowski M, Ranga S, Moison D, Messiaen S, Abdallah S, Granon S, Habert R, Rouiller-Fabre V, Livera G, Guerquin M-J (2021) Unexpected interacting effects of physical (radiation) and chemical (Bisphenol A) treatments on male reproductive functions in mice. Int J Mol Sci 22(21):11808. https:\/\/doi.org\/10.3390\/ijms222111808","journal-title":"Int J Mol Sci"},{"key":"2002_CR29","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/j.scitotenv.2016.01.165","volume":"565","author":"Y Yang","year":"2016","unstructured":"Yang Y, Faust JJ, Schoepf J, Hristovski K, Capco DG, Herckes P, Westerhoff P (2016) Survey of food-grade silica dioxide nanomaterial occurrence, characterization, human gut impacts and fate across its lifecycle. Sci Total Environ 565:902\u2013912. https:\/\/doi.org\/10.1016\/j.scitotenv.2016.01.165","journal-title":"Sci Total Environ"},{"issue":"1","key":"2002_CR30","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12967-025-06197-9","volume":"23","author":"P Yang","year":"2025","unstructured":"Yang P, Bai H, Yan T, Xu X, Tang X, Song B, Liu Y, Lu Y, Liu P, Tu W, Shi Y, Zhang S (2025) Integrative multi-omics analysis of radionuclide-induced intestinal injury reveals the radioprotective role of L-citrulline through histone H3-mediated Cxcl3. J Transl Med 23(1):180. https:\/\/doi.org\/10.1186\/s12967-025-06197-9","journal-title":"J Transl Med"},{"key":"2002_CR31","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2018.5088","author":"M Younes","year":"2018","unstructured":"Younes M, Aggett P, Aguilar F, Crebelli R, Dusemund B, Filipi\u010d M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Kuhnle GG, Leblanc J, Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Woutersen RA, Lambr\u00e9 C (2018) Re-evaluation of silicon dioxide (E 551) as a food additive. EFSA J. https:\/\/doi.org\/10.2903\/j.efsa.2018.5088","journal-title":"EFSA J"},{"key":"2002_CR32","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b08475","author":"J Zhang","year":"2019","unstructured":"Zhang J, Wang X, Suo X, Liu X, Liu B, Yuan M, Wang G, Liang C, Shi H (2019) Cellular response of Escherichia coli to photocatalysis: Flagellar assembly variation and beyond. ACS Nano. https:\/\/doi.org\/10.1021\/acsnano.8b08475","journal-title":"ACS Nano"},{"issue":"8","key":"2002_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0286026","volume":"18","author":"L Zhang","year":"2023","unstructured":"Zhang L, Miao Z, Li Y, Xu X, Zhou T, Zhang Y, Liu Y (2023) A potential marker of radiation based on 16S rDNA in the rat model: intestinal flora. PLoS ONE 18(8):e0286026. https:\/\/doi.org\/10.1371\/journal.pone.0286026","journal-title":"PLoS ONE"},{"issue":"13","key":"2002_CR34","doi-asserted-by":"publisher","first-page":"4441","DOI":"10.1093\/nar\/gkm456","volume":"35","author":"K Zhao","year":"2007","unstructured":"Zhao K, Liu M, Burgess RR (2007) Adaptation in bacterial flagellar and motility systems: from regulon members to \u2018foraging\u2019-like behavior in E. coli. Nucleic Acids Res 35(13):4441\u20134452. https:\/\/doi.org\/10.1093\/nar\/gkm456","journal-title":"Nucleic Acids Res"}],"container-title":["AMB Express"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13568-025-02002-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13568-025-02002-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13568-025-02002-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:00:23Z","timestamp":1781625623000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13568-025-02002-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,31]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2002"],"URL":"https:\/\/doi.org\/10.1186\/s13568-025-02002-4","relation":{},"ISSN":["2191-0855"],"issn-type":[{"value":"2191-0855","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,31]]},"assertion":[{"value":"15 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9"}}