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This genus includes both edible and non-edible species, several of which hold significant nutritional and pharmacological value. Many of these edible mushrooms are well explored for their medicinal properties.\n                    <jats:italic>Agaricus flocculosipes<\/jats:italic>\n                    , is a recent addition in this genus introduced as an edible mushroom, but remains less explored for its therapeutic ability and commercial cultivation. This study for the first time explores medicinal properties of this mushroom. In the present study,\n                    <jats:italic>A. flocculosipes<\/jats:italic>\n                    exhibited selective inhibitory activity against Gram-positive pathogens, with the chloroform extract recording both Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values at 50\u00a0\u00b5g\/mL against\n                    <jats:italic>Streptococcus pyogenes<\/jats:italic>\n                    . Biofilm inhibition assays further demonstrated over 85% reduction in\n                    <jats:italic>S. pyogenes<\/jats:italic>\n                    biofilm formation at a concentration of 46\u00a0\u00b5g\/mL. The chloroform extract also displayed potent anticancer activity, characterized by nuclear condensation, activation of caspase-9 and caspase-7, cleavage of Poly (ADP-ribose) polymerase (PARP), and upregulation of Bax, thereby inducing apoptosis in cancer cells. Metabolomic profiling of the chloroform fraction revealed a diverse array of bioactive compounds likely contributing to these observed biological effects. Collectively, these findings position\n                    <jats:italic>A. flocculosipes<\/jats:italic>\n                    as a promising medicinal mushroom with significant potential for future pharmacological and biotechnological research.\n                  <\/jats:p>","DOI":"10.1186\/s13568-026-02028-2","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T23:34:44Z","timestamp":1772667284000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First report of therapeutic investigation and metabolic profiling of edible mushroom Agaricus flocculosipes"],"prefix":"10.1186","volume":"16","author":[{"given":"Divya","family":"Sreekala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipin Mohan","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gama Mohan M.","family":"Geetha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arya","family":"Chamaparambath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anagha","family":"Bindu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajith","family":"Raghunandanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chittethu Kunjan","family":"Pradeep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"issue":"3","key":"2028_CR1","first-page":"21","volume":"65","author":"AA Abdalla","year":"2025","unstructured":"Abdalla AA, Dawoud ME, Mohamed MSM, Mahmoud MS, Bakr AA (2025) Evaluation of the effect of gamma irradiation on the antimicrobial compounds of Pleurotus ostreatus. 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