{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:27:13Z","timestamp":1782401233549,"version":"3.54.5"},"reference-count":128,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No.81970812"],"award-info":[{"award-number":["Grant No.81970812"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biosci"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Neovascular eye disease is characterized by pathological neovascularization, with clinical manifestations such as intraocular exudation, bleeding, and scar formation, ultimately leading to blindness in millions of individuals worldwide. Pathologic ocular angiogenesis often occurs in common fundus diseases including proliferative diabetic retinopathy (PDR), age-related macular degeneration (AMD), and retinopathy of prematurity (ROP). Anti-vascular endothelial growth factor (VEGF) targets the core pathology of ocular angiogenesis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Main body<\/jats:title>\n                <jats:p>In recent years, therapies targeting metabolism to prevent angiogenesis have also rapidly developed, offering assistance to patients with a poor prognosis while receiving anti-VEGF therapy and reducing the side effects associated with long-term VEGF usage. Phosphofructo-2-kinase\/fructose-2,6-bisphosphatase 3 (PFKFB3), a key enzyme in targeted metabolism, has been shown to have great potential, with antiangiogenic effects and multiple protective effects in the treatment of neovascular eye disease. In this review, we summarize the mechanisms of common types of neovascular eye diseases; discuss the protective effect and potential mechanism of targeting PFKFB3, including the related inhibitors of PFKFB3; and look forward to the future exploration directions and therapeutic prospects of PFKFB3 in neovascular eye disease.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Neovascular eye disease, the most common and severely debilitating retinal disease, is largely incurable, necessitating the exploration of new treatment methods. PFKFB3 has been shown to possess various potential protective mechanisms in treating neovascular eye disease. With the development of several drugs targeting PFKFB3 and their gradual entry into clinical research, targeting PFKFB3-mediated glycolysis has emerged as a promising therapeutic approach for the future of neovascular eye disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13578-024-01205-9","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T13:02:51Z","timestamp":1707570171000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["PFKFB3 in neovascular eye disease: unraveling mechanisms and exploring therapeutic strategies"],"prefix":"10.1186","volume":"14","author":[{"given":"Peiyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuchang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,10]]},"reference":[{"issue":"7","key":"1205_CR1","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/s41580-019-0123-5","volume":"20","author":"J Zhu","year":"2019","unstructured":"Zhu J, Thompson CB. Metabolic regulation of cell growth and proliferation. Nat Rev Mol Cell Biol. 2019;20(7):436\u201350. https:\/\/doi.org\/10.1038\/s41580-019-0123-5","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6382","key":"1205_CR2","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1126\/science.aar5557","volume":"359","author":"X Li","year":"2018","unstructured":"Li X, Carmeliet P. Targeting angiogenic metabolism in disease. Science. 2018;359(6382):1335\u20136. https:\/\/doi.org\/10.1126\/science.aar5557","journal-title":"Science"},{"key":"1205_CR3","doi-asserted-by":"publisher","first-page":"17044","DOI":"10.1038\/sigtrans.2017.44","volume":"2","author":"L Shi","year":"2017","unstructured":"Shi L, Pan H, Liu Z, Xie J, Han W. Roles of PFKFB3 in cancer. Signal Transduct Target Ther. 2017;2:17044. https:\/\/doi.org\/10.1038\/sigtrans.2017.44","journal-title":"Signal Transduct Target Ther"},{"key":"1205_CR4","doi-asserted-by":"crossref","unstructured":"Witmer AN, Vrensen GFJM, Van Noorden CJF, Schlingemann RO. Vascular endothelial growth factors and angiogenesis in eye disease. Prog Retin Eye Res. 2003;22(1).","DOI":"10.1016\/S1350-9462(02)00043-5"},{"issue":"10","key":"1205_CR5","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1016\/j.ymthe.2020.06.029","volume":"28","author":"F-L Lin","year":"2020","unstructured":"Lin F-L, Wang P-Y, Chuang Y-F, Wang J-H, Wong VHY, Bui BV, et al. Gene Therapy Intervention in Neovascular Eye Disease: a recent update. Mol Ther. 2020;28(10):2120\u201338. https:\/\/doi.org\/10.1016\/j.ymthe.2020.06.029","journal-title":"Mol Ther"},{"issue":"2","key":"1205_CR6","doi-asserted-by":"publisher","first-page":"CD013775","DOI":"10.1002\/14651858.CD013775.pub2","volume":"2","author":"J Perais","year":"2023","unstructured":"Perais J, Agarwal R, Evans JR, Loveman E, Colquitt JL, Owens D, et al. Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy. Cochrane Database Syst Rev. 2023;2(2):CD013775. https:\/\/doi.org\/10.1002\/14651858.CD013775.pub2","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"1205_CR7","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.gendis.2021.02.009","volume":"9","author":"Y Deng","year":"2022","unstructured":"Deng Y, Qiao L, Du M, Qu C, Wan L, Li J, et al. Age-related macular degeneration: epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy. Genes Dis. 2022;9(1):62\u201379. https:\/\/doi.org\/10.1016\/j.gendis.2021.02.009","journal-title":"Genes Dis"},{"key":"1205_CR8","doi-asserted-by":"publisher","unstructured":"Sabri K, Ells AL, Lee EY, Dutta S, Vinekar A. Retinopathy of Prematurity: A Global Perspective and recent developments. Pediatrics. 2022;150(3). https:\/\/doi.org\/10.1542\/peds.2021-053924","DOI":"10.1542\/peds.2021-053924"},{"key":"1205_CR9","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.2147\/DDDT.S383101","volume":"16","author":"M Xu","year":"2022","unstructured":"Xu M, Fan R, Fan X, Shao Y, Li X. Progress and challenges of Anti-VEGF agents and their sustained-release strategies for retinal angiogenesis. Drug Des Devel Ther. 2022;16:3241\u201362. https:\/\/doi.org\/10.2147\/DDDT.S383101","journal-title":"Drug Des Devel Ther"},{"issue":"2","key":"1205_CR10","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s11739-019-02253-7","volume":"15","author":"M Porta","year":"2020","unstructured":"Porta M, Striglia E. Intravitreal anti-VEGF agents and cardiovascular risk. Intern Emerg Med. 2020;15(2):199\u2013210. https:\/\/doi.org\/10.1007\/s11739-019-02253-7","journal-title":"Intern Emerg Med"},{"issue":"6","key":"1205_CR11","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1038\/s41433-018-0021-7","volume":"32","author":"S Fogli","year":"2018","unstructured":"Fogli S, Del Re M, Rofi E, Posarelli C, Figus M, Danesi R. Clinical pharmacology of intravitreal anti-VEGF drugs. Eye (Lond). 2018;32(6):1010\u201320. https:\/\/doi.org\/10.1038\/s41433-018-0021-7","journal-title":"Eye (Lond)"},{"key":"1205_CR12","doi-asserted-by":"publisher","first-page":"100906","DOI":"10.1016\/j.preteyeres.2020.100906","volume":"82","author":"PS Mettu","year":"2021","unstructured":"Mettu PS, Allingham MJ, Cousins SW. Incomplete response to Anti-VEGF therapy in neovascular AMD: exploring disease mechanisms and therapeutic opportunities. Prog Retin Eye Res. 2021;82:100906. https:\/\/doi.org\/10.1016\/j.preteyeres.2020.100906","journal-title":"Prog Retin Eye Res"},{"key":"1205_CR13","doi-asserted-by":"publisher","unstructured":"Wallsh JO, Gallemore RP. Anti-VEGF-Resistant retinal diseases: a review of the latest treatment options. Cells. 2021;10(5). https:\/\/doi.org\/10.3390\/cells10051049","DOI":"10.3390\/cells10051049"},{"issue":"10","key":"1205_CR14","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s11892-022-01491-y","volume":"22","author":"JA Zehden","year":"2022","unstructured":"Zehden JA, Mortensen XM, Reddy A, Zhang AY. Systemic and ocular adverse events with Intravitreal Anti-VEGF therapy used in the treatment of Diabetic Retinopathy: a review. Curr Diab Rep. 2022;22(10):525\u201336. https:\/\/doi.org\/10.1007\/s11892-022-01491-y","journal-title":"Curr Diab Rep"},{"issue":"2","key":"1205_CR15","first-page":"167","volume":"16","author":"P Fraisl","year":"2009","unstructured":"Fraisl P, Mazzone M, Schmidt T, Carmeliet PJD. Regul Angiogenesis Oxygen Metabolism. 2009;16(2):167\u201379.","journal-title":"Regul Angiogenesis Oxygen Metabolism"},{"issue":"1","key":"1205_CR16","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s13046-020-01765-x","volume":"39","author":"L Cao","year":"2020","unstructured":"Cao L, Wu J, Qu X, Sheng J, Cui M, Liu S, et al. Glycometabolic rearrangements\u2013aerobic glycolysis in pancreatic cancer: causes, characteristics and clinical applications. J Experimental Clin cancer Research: CR. 2020;39(1):267. https:\/\/doi.org\/10.1186\/s13046-020-01765-x","journal-title":"J Experimental Clin cancer Research: CR"},{"key":"1205_CR17","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev-cellbio-092910-154237","volume":"27","author":"SY Lunt","year":"2011","unstructured":"Lunt SY, Vander Heiden MG. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol. 2011;27:441\u201364. https:\/\/doi.org\/10.1146\/annurev-cellbio-092910-154237","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"5","key":"1205_CR18","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nrc3038","volume":"11","author":"WH Koppenol","year":"2011","unstructured":"Koppenol WH, Bounds PL, Dang CV. Otto Warburg\u2019s contributions to current concepts of cancer metabolism. Nat Rev Cancer. 2011;11(5):325\u201337. https:\/\/doi.org\/10.1038\/nrc3038","journal-title":"Nat Rev Cancer"},{"issue":"9","key":"1205_CR19","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.1073\/pnas.1812941116","volume":"116","author":"A Grenell","year":"2019","unstructured":"Grenell A, Wang Y, Yam M, Swarup A, Dilan TL, Hauer A, et al. Loss of MPC1 reprograms retinal metabolism to impair visual function. Proc Natl Acad Sci USA. 2019;116(9):3530\u20135. https:\/\/doi.org\/10.1073\/pnas.1812941116","journal-title":"Proc Natl Acad Sci USA"},{"key":"1205_CR20","doi-asserted-by":"publisher","first-page":"100035","DOI":"10.1194\/jlr.TR120000618","volume":"62","author":"Z Fu","year":"2021","unstructured":"Fu Z, Kern TS, Hellstr\u00f6m A, Smith LEH. Fatty acid oxidation and photoreceptor metabolic needs. J Lipid Res. 2021;62:100035. https:\/\/doi.org\/10.1194\/jlr.TR120000618","journal-title":"J Lipid Res"},{"key":"1205_CR21","doi-asserted-by":"publisher","first-page":"107861","DOI":"10.1016\/j.exer.2019.107861","volume":"190","author":"N Mili\u0107evi\u0107","year":"2020","unstructured":"Mili\u0107evi\u0107 N, Ten Brink JB, Ten Asbroek ALMA, Bergen AA, Felder-Schmittbuhl M-P. The circadian clock regulates RPE-mediated lactate transport via SLC16A1 (MCT1). Exp Eye Res. 2020;190:107861. https:\/\/doi.org\/10.1016\/j.exer.2019.107861","journal-title":"Exp Eye Res"},{"issue":"7","key":"1205_CR22","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1158\/0008-5472.CAN-10-2828","volume":"71","author":"F V\u00e9gran","year":"2011","unstructured":"V\u00e9gran F, Boidot R, Michiels C, Sonveaux P, Feron O. Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-\u03baB\/IL-8 pathway that drives tumor angiogenesis. Cancer Res. 2011;71(7):2550\u201360. https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-2828","journal-title":"Cancer Res"},{"key":"1205_CR23","doi-asserted-by":"publisher","unstructured":"Eelen G, de Zeeuw P, Treps L, Harjes U, Wong BW, Carmeliet P. Endothelial cell metabolism. Physiol Rev. 2018;98(1). https:\/\/doi.org\/10.1152\/physrev.00001.2017","DOI":"10.1152\/physrev.00001.2017"},{"issue":"3","key":"1205_CR24","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1523\/JNEUROSCI.12-03-00840.1992","volume":"12","author":"A Ames","year":"1992","unstructured":"Ames A, Li YY, Heher EC, Kimble CR. Energy metabolism of rabbit retina as related to function: high cost of na\u2009+\u2009transport. J Neurosci. 1992;12(3):840\u201353.","journal-title":"J Neurosci"},{"issue":"8","key":"1205_CR25","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1080\/14728222.2018.1498082","volume":"22","author":"R Bartrons","year":"2018","unstructured":"Bartrons R, Rodr\u00edguez-Garc\u00eda A, Simon-Molas H, Casta\u00f1o E, Manzano A, Navarro-Sabat\u00e9 \u00c0. The potential utility of PFKFB3 as a therapeutic target. Expert Opin Ther Targets. 2018;22(8):659\u201374. https:\/\/doi.org\/10.1080\/14728222.2018.1498082","journal-title":"Expert Opin Ther Targets"},{"key":"1205_CR26","unstructured":"Michaelson IJTOSU. The mode of development of the vascular system in the retina: with some observations on its significance for certain retinal diseases. 1948;68:137\u201380."},{"issue":"8","key":"1205_CR27","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1242\/dev.01732","volume":"132","author":"H West","year":"2005","unstructured":"West H, Richardson WD, Fruttiger M. Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes. Development. 2005;132(8):1855\u201362.","journal-title":"Development"},{"key":"1205_CR28","doi-asserted-by":"publisher","unstructured":"Liu Z, Xu J, Ma Q, Zhang X, Yang Q, Wang L, et al. Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche. Sci Transl Med. 2020;12(555). https:\/\/doi.org\/10.1126\/scitranslmed.aay1371","DOI":"10.1126\/scitranslmed.aay1371"},{"key":"1205_CR29","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3389\/fimmu.2017.00061","volume":"8","author":"PK Langston","year":"2017","unstructured":"Langston PK, Shibata M, Horng T. Metabolism supports macrophage activation. Front Immunol. 2017;8:61. https:\/\/doi.org\/10.3389\/fimmu.2017.00061","journal-title":"Front Immunol"},{"issue":"1","key":"1205_CR30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00441-003-0745-x","volume":"314","author":"H Gerhardt","year":"2003","unstructured":"Gerhardt H, Betsholtz C. Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res. 2003;314(1):15\u201323.","journal-title":"Cell Tissue Res"},{"issue":"5323","key":"1205_CR31","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1126\/science.277.5323.242","volume":"277","author":"P Lindahl","year":"1997","unstructured":"Lindahl P, Johansson BR, Lev\u00e9en P, Betsholtz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science. 1997;277(5323):242\u20135.","journal-title":"Science"},{"issue":"1","key":"1205_CR32","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.ydbio.2003.08.015","volume":"264","author":"DC Darland","year":"2003","unstructured":"Darland DC, Massingham LJ, Smith SR, Piek E, Saint-Geniez M, D\u2019Amore PA. Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. Dev Biol. 2003;264(1):275\u201388.","journal-title":"Dev Biol"},{"issue":"26","key":"1205_CR33","doi-asserted-by":"publisher","first-page":"15859","DOI":"10.1073\/pnas.2136855100","volume":"100","author":"S-C Shih","year":"2003","unstructured":"Shih S-C, Ju M, Liu N, Mo J-R, Ney JJ, Smith LEH. Transforming growth factor beta1 induction of vascular endothelial growth factor receptor 1: mechanism of pericyte-induced vascular survival in vivo. Proc Natl Acad Sci USA. 2003;100(26):15859\u201364.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1205_CR34","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1146\/annurev-physiol-020518-114731","volume":"81","author":"X Li","year":"2019","unstructured":"Li X, Kumar A, Carmeliet P. Metabolic pathways fueling the endothelial cell drive. Annu Rev Physiol. 2019;81:483\u2013503. https:\/\/doi.org\/10.1146\/annurev-physiol-020518-114731","journal-title":"Annu Rev Physiol"},{"issue":"6","key":"1205_CR35","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.ceb.2011.10.002","volume":"23","author":"A Wacker","year":"2011","unstructured":"Wacker A, Gerhardt H. Endothelial development taking shape. Curr Opin Cell Biol. 2011;23(6):676\u201385. https:\/\/doi.org\/10.1016\/j.ceb.2011.10.002","journal-title":"Curr Opin Cell Biol"},{"issue":"6","key":"1205_CR36","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1083\/jcb.200302047","volume":"161","author":"H Gerhardt","year":"2003","unstructured":"Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol. 2003;161(6):1163\u201377.","journal-title":"J Cell Biol"},{"issue":"1","key":"1205_CR37","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2040-2384-2-3","volume":"2","author":"Y Funahashi","year":"2010","unstructured":"Funahashi Y, Shawber CJ, Vorontchikhina M, Sharma A, Outtz HH, Kitajewski J. Notch regulates the angiogenic response via induction of VEGFR-1. J Angiogenes Res. 2010;2(1):3. https:\/\/doi.org\/10.1186\/2040-2384-2-3","journal-title":"J Angiogenes Res"},{"issue":"10","key":"1205_CR38","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/ncb2103","volume":"12","author":"L Jakobsson","year":"2010","unstructured":"Jakobsson L, Franco CA, Bentley K, Collins RT, Ponsioen B, Aspalter IM, et al. Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol. 2010;12(10):943\u201353. https:\/\/doi.org\/10.1038\/ncb2103","journal-title":"Nat Cell Biol"},{"issue":"5","key":"1205_CR39","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.cell.2009.01.020","volume":"136","author":"M Mazzone","year":"2009","unstructured":"Mazzone M, Dettori D, de Oliveira RL, Loges S, Schmidt T, Jonckx B, et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell. 2009;136(5):839\u201351. https:\/\/doi.org\/10.1016\/j.cell.2009.01.020","journal-title":"Cell"},{"key":"1205_CR40","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.preteyeres.2015.06.002","volume":"49","author":"PA Campochiaro","year":"2015","unstructured":"Campochiaro PA. Molecular pathogenesis of retinal and choroidal vascular diseases. Prog Retin Eye Res. 2015;49:67\u201381. https:\/\/doi.org\/10.1016\/j.preteyeres.2015.06.002","journal-title":"Prog Retin Eye Res"},{"key":"1205_CR41","doi-asserted-by":"publisher","first-page":"16012","DOI":"10.1038\/nrdp.2016.12","volume":"2","author":"TY Wong","year":"2016","unstructured":"Wong TY, Cheung CMG, Larsen M, Sharma S, Sim\u00f3 R. Diabetic retinopathy. Nat Rev Dis Primers. 2016;2:16012. https:\/\/doi.org\/10.1038\/nrdp.2016.12","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"1205_CR42","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.cmet.2014.10.008","volume":"20","author":"I Shimizu","year":"2014","unstructured":"Shimizu I, Yoshida Y, Suda M, Minamino T. DNA damage response and metabolic disease. Cell Metab. 2014;20(6):967\u201377. https:\/\/doi.org\/10.1016\/j.cmet.2014.10.008","journal-title":"Cell Metab"},{"issue":"2","key":"1205_CR43","doi-asserted-by":"publisher","first-page":"57","DOI":"10.4239\/wjd.v1.i2.57","volume":"1","author":"M Villarroel","year":"2010","unstructured":"Villarroel M, Ciudin A, Hern\u00e1ndez C, Sim\u00f3 R, Neurodegeneration. An early event of diabetic retinopathy. World J Diabetes. 2010;1(2):57\u201364. https:\/\/doi.org\/10.4239\/wjd.v1.i2.57","journal-title":"World J Diabetes"},{"key":"1205_CR44","doi-asserted-by":"publisher","first-page":"100756","DOI":"10.1016\/j.preteyeres.2019.03.002","volume":"72","author":"IM Nawaz","year":"2019","unstructured":"Nawaz IM, Rezzola S, Cancarini A, Russo A, Costagliola C, Semeraro F, et al. Human vitreous in proliferative diabetic retinopathy: characterization and translational implications. Prog Retin Eye Res. 2019;72:100756. https:\/\/doi.org\/10.1016\/j.preteyeres.2019.03.002","journal-title":"Prog Retin Eye Res"},{"issue":"6","key":"1205_CR45","doi-asserted-by":"publisher","first-page":"3784","DOI":"10.1167\/iovs.10-6386","volume":"52","author":"S Rangasamy","year":"2011","unstructured":"Rangasamy S, Srinivasan R, Maestas J, McGuire PG, Das A. A potential role for angiopoietin 2 in the regulation of the blood-retinal barrier in diabetic retinopathy. Investig Ophthalmol Vis Sci. 2011;52(6):3784\u201391. https:\/\/doi.org\/10.1167\/iovs.10-6386","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"2","key":"1205_CR46","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.canlet.2016.04.036","volume":"377","author":"D Li","year":"2016","unstructured":"Li D, Xie K, Zhang L, Yao X, Li H, Xu Q, et al. Dual blockade of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF-2) exhibits potent anti-angiogenic effects. Cancer Lett. 2016;377(2):164\u201373. https:\/\/doi.org\/10.1016\/j.canlet.2016.04.036","journal-title":"Cancer Lett"},{"issue":"6","key":"1205_CR47","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1161\/CIRCRESAHA.117.311401","volume":"122","author":"SJ Forrester","year":"2018","unstructured":"Forrester SJ, Kikuchi DS, Hernandes MS, Xu Q, Griendling KK. Reactive oxygen species in metabolic and inflammatory signaling. Circ Res. 2018;122(6):877\u2013902. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.311401","journal-title":"Circ Res"},{"issue":"7","key":"1205_CR48","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1172\/JCI18127","volume":"112","author":"X Du","year":"2003","unstructured":"Du X, Matsumura T, Edelstein D, Rossetti L, Zsengell\u00e9r Z, Szab\u00f3 C, et al. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J Clin Invest. 2003;112(7):1049\u201357.","journal-title":"J Clin Invest"},{"issue":"22","key":"1205_CR49","doi-asserted-by":"publisher","first-page":"9287","DOI":"10.1158\/0008-5472.CAN-10-2664","volume":"70","author":"Y Zhao","year":"2010","unstructured":"Zhao Y, McLaughlin D, Robinson E, Harvey AP, Hookham MB, Shah AM, et al. Nox2 NADPH oxidase promotes pathologic cardiac remodeling associated with Doxorubicin chemotherapy. Cancer Res. 2010;70(22):9287\u201397. https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-2664","journal-title":"Cancer Res"},{"issue":"41","key":"1205_CR50","doi-asserted-by":"publisher","first-page":"14782","DOI":"10.1073\/pnas.1417253111","volume":"111","author":"X Jiang","year":"2014","unstructured":"Jiang X, Jiang H, Shen Z, Wang X. Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis. Proc Natl Acad Sci USA. 2014;111(41):14782\u20137. https:\/\/doi.org\/10.1073\/pnas.1417253111","journal-title":"Proc Natl Acad Sci USA"},{"key":"1205_CR51","doi-asserted-by":"publisher","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","volume":"2","author":"T Liu","year":"2017","unstructured":"Liu T, Zhang L, Joo D, Sun S-C. NF-\u03baB signaling in inflammation. Signal Transduct Target Ther. 2017;2:17023. https:\/\/doi.org\/10.1038\/sigtrans.2017.23","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"1205_CR52","doi-asserted-by":"publisher","first-page":"030502","DOI":"10.11613\/BM.2020.030502","volume":"30","author":"S Ka\u0161telan","year":"2020","unstructured":"Ka\u0161telan S, Ore\u0161kovi\u0107 I, Bi\u0161\u0107an F, Ka\u0161telan H, Gverovi\u0107 Antunica A. Inflammatory and angiogenic biomarkers in diabetic retinopathy. Biochem Med (Zagreb). 2020;30(3):030502. https:\/\/doi.org\/10.11613\/BM.2020.030502","journal-title":"Biochem Med (Zagreb)"},{"issue":"2","key":"1205_CR53","doi-asserted-by":"publisher","first-page":"261","DOI":"10.2337\/dbi16-0047","volume":"66","author":"SF Abcouwer","year":"2017","unstructured":"Abcouwer SF. M\u00fcller Cell-Microglia Cross Talk drives Neuroinflammation in Diabetic Retinopathy. Diabetes. 2017;66(2):261\u20133. https:\/\/doi.org\/10.2337\/dbi16-0047","journal-title":"Diabetes"},{"key":"1205_CR54","doi-asserted-by":"publisher","first-page":"24324","DOI":"10.1038\/srep24324","volume":"6","author":"L Chen","year":"2016","unstructured":"Chen L, Zhao J, Tang Q, Li H, Zhang C, Yu R, et al. PFKFB3 control of Cancer Growth by responding to circadian clock outputs. Sci Rep. 2016;6:24324. https:\/\/doi.org\/10.1038\/srep24324","journal-title":"Sci Rep"},{"issue":"1","key":"1205_CR55","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/2049-3002-2-2","volume":"2","author":"AC Klarer","year":"2014","unstructured":"Klarer AC, O\u2019Neal J, Imbert-Fernandez Y, Clem A, Ellis SR, Clark J, et al. Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism. Cancer Metab. 2014;2(1):2. https:\/\/doi.org\/10.1186\/2049-3002-2-2","journal-title":"Cancer Metab"},{"issue":"1","key":"1205_CR56","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13046-016-0481-1","volume":"36","author":"H-M Li","year":"2017","unstructured":"Li H-M, Yang J-G, Liu Z-J, Wang W-M, Yu Z-L, Ren J-G, et al. Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma. J Experimental Clin cancer Research: CR. 2017;36(1):7. https:\/\/doi.org\/10.1186\/s13046-016-0481-1","journal-title":"J Experimental Clin cancer Research: CR"},{"issue":"9","key":"1205_CR57","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/s41419-023-06120-4","volume":"14","author":"F Sneyers","year":"2023","unstructured":"Sneyers F, Kerkhofs M, Speelman-Rooms F, Welkenhuyzen K, La Rovere R, Shemy A, et al. Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing MCL-1-addicted cancer cells. Cell Death Dis. 2023;14(9):600. https:\/\/doi.org\/10.1038\/s41419-023-06120-4","journal-title":"Cell Death Dis"},{"issue":"27","key":"1205_CR58","doi-asserted-by":"publisher","first-page":"13394","DOI":"10.1073\/pnas.1821401116","volume":"116","author":"Y Cao","year":"2019","unstructured":"Cao Y, Zhang X, Wang L, Yang Q, Ma Q, Xu J, et al. PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension. Proc Natl Acad Sci USA. 2019;116(27):13394\u2013403. https:\/\/doi.org\/10.1073\/pnas.1821401116","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"1205_CR59","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1164\/rccm.201812-2290OC","volume":"200","author":"L Kovacs","year":"2019","unstructured":"Kovacs L, Cao Y, Han W, Meadows L, Kovacs-Kasa A, Kondrikov D, et al. PFKFB3 in smooth muscle promotes vascular remodeling in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2019;200(5):617\u201327. https:\/\/doi.org\/10.1164\/rccm.201812-2290OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"1205_CR60","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/s41374-020-0404-9","volume":"100","author":"X Hu","year":"2020","unstructured":"Hu X, Xu Q, Wan H, Hu Y, Xing S, Yang H, et al. PI3K-Akt-mTOR\/PFKFB3 pathway mediated lung fibroblast aerobic glycolysis and collagen synthesis in lipopolysaccharide-induced pulmonary fibrosis. Lab Invest. 2020;100(6):801\u201311. https:\/\/doi.org\/10.1038\/s41374-020-0404-9","journal-title":"Lab Invest"},{"issue":"12","key":"1205_CR61","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1164\/rccm.201504-0780OC","volume":"192","author":"N Xie","year":"2015","unstructured":"Xie N, Tan Z, Banerjee S, Cui H, Ge J, Liu R-M, et al. Glycolytic reprogramming in myofibroblast differentiation and lung fibrosis. Am J Respir Crit Care Med. 2015;192(12):1462\u201374. https:\/\/doi.org\/10.1164\/rccm.201504-0780OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"1205_CR62","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/s41374-021-00701-7","volume":"102","author":"Q Xu","year":"2022","unstructured":"Xu Q, Mei S, Nie F, Zhang Z, Feng J, Zhang J, et al. The role of macrophage-fibroblast interaction in lipopolysaccharide-induced pulmonary fibrosis: an acceleration in lung fibroblast aerobic glycolysis. Lab Invest. 2022;102(4):432\u20139. https:\/\/doi.org\/10.1038\/s41374-021-00701-7","journal-title":"Lab Invest"},{"issue":"1","key":"1205_CR63","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s10456-021-09816-3","volume":"25","author":"P Perrotta","year":"2022","unstructured":"Perrotta P, de Vries MR, Peeters B, Guns P-J, De Meyer GRY, Quax PHA, et al. PFKFB3 gene deletion in endothelial cells inhibits intraplaque angiogenesis and lesion formation in a murine model of venous bypass grafting. Angiogenesis. 2022;25(1):129\u201343. https:\/\/doi.org\/10.1007\/s10456-021-09816-3","journal-title":"Angiogenesis"},{"key":"1205_CR64","doi-asserted-by":"publisher","unstructured":"Perrotta P, Van der Veken B, Van Der Veken P, Pintelon I, Roosens L, Adriaenssens E et al. Partial inhibition of Glycolysis reduces Atherogenesis Independent of Intraplaque Neovascularization in mice. Arteriosclerosis, thrombosis, and vascular biology. 2020;40(5):1168\u201381. https:\/\/doi.org\/10.1161\/ATVBAHA.119.313692","DOI":"10.1161\/ATVBAHA.119.313692"},{"issue":"3","key":"1205_CR65","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.cell.2013.06.037","volume":"154","author":"K De Bock","year":"2013","unstructured":"De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, et al. Role of PFKFB3-driven glycolysis in vessel sprouting. Cell. 2013;154(3):651\u201363. https:\/\/doi.org\/10.1016\/j.cell.2013.06.037","journal-title":"Cell"},{"issue":"1","key":"1205_CR66","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cmet.2013.11.008","volume":"19","author":"S Schoors","year":"2014","unstructured":"Schoors S, De Bock K, Cantelmo AR, Georgiadou M, Ghesqui\u00e8re B, Cauwenberghs S, et al. Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 2014;19(1):37\u201348. https:\/\/doi.org\/10.1016\/j.cmet.2013.11.008","journal-title":"Cell Metab"},{"key":"1205_CR67","doi-asserted-by":"publisher","first-page":"105592","DOI":"10.1016\/j.phrs.2021.105592","volume":"168","author":"A Abdali","year":"2021","unstructured":"Abdali A, Baci D, Damiani I, Belloni F, De Dominicis C, Gelmi ML, et al. In vitro angiogenesis inhibition with selective compounds targeting the key glycolytic enzyme PFKFB3. Pharmacol Res. 2021;168:105592. https:\/\/doi.org\/10.1016\/j.phrs.2021.105592","journal-title":"Pharmacol Res"},{"issue":"1","key":"1205_CR68","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/s41467-017-00551-2","volume":"8","author":"Z Liu","year":"2017","unstructured":"Liu Z, Yan S, Wang J, Xu Y, Wang Y, Zhang S, et al. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun. 2017;8(1):584. https:\/\/doi.org\/10.1038\/s41467-017-00551-2","journal-title":"Nat Commun"},{"issue":"3","key":"1205_CR69","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s10456-020-09760-8","volume":"24","author":"Y Feng","year":"2021","unstructured":"Feng Y, Zou R, Zhang X, Shen M, Chen X, Wang J, et al. YAP promotes ocular neovascularization by modifying PFKFB3-driven endothelial glycolysis. Angiogenesis. 2021;24(3):489\u2013504. https:\/\/doi.org\/10.1007\/s10456-020-09760-8","journal-title":"Angiogenesis"},{"issue":"22","key":"1205_CR70","doi-asserted-by":"publisher","first-page":"5109","DOI":"10.1111\/bph.15925","volume":"179","author":"Z Liu","year":"2022","unstructured":"Liu Z, Mao X, Yang Q, Zhang X, Xu J, Ma Q, et al. Suppression of myeloid PFKFB3-driven glycolysis protects mice from choroidal neovascularization. Br J Pharmacol. 2022;179(22):5109\u201331. https:\/\/doi.org\/10.1111\/bph.15925","journal-title":"Br J Pharmacol"},{"issue":"8","key":"1205_CR71","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.tem.2020.05.009","volume":"31","author":"SJ Dumas","year":"2020","unstructured":"Dumas SJ, Garc\u00eda-Caballero M, Carmeliet P. Metabolic signatures of distinct endothelial phenotypes. Trends Endocrinol Metab. 2020;31(8):580\u201395. https:\/\/doi.org\/10.1016\/j.tem.2020.05.009","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"1205_CR72","doi-asserted-by":"publisher","first-page":"10414","DOI":"10.1038\/s41598-019-46503-2","volume":"9","author":"B Yetkin-Arik","year":"2019","unstructured":"Yetkin-Arik B, Vogels IMC, Neyazi N, van Duinen V, Houtkooper RH, van Noorden CJF, et al. Endothelial tip cells in vitro are less glycolytic and have a more flexible response to metabolic stress than non-tip cells. Sci Rep. 2019;9(1):10414. https:\/\/doi.org\/10.1038\/s41598-019-46503-2","journal-title":"Sci Rep"},{"key":"1205_CR73","doi-asserted-by":"publisher","unstructured":"Kalucka J, Bierhansl L, Conchinha NV, Missiaen R, Elia I, Br\u00fcning U, et al. Quiescent endothelial cells upregulate fatty acid \u03b2-Oxidation for Vasculoprotection via Redox Homeostasis. Cell Metab. 2018;28(6). https:\/\/doi.org\/10.1016\/j.cmet.2018.07.016","DOI":"10.1016\/j.cmet.2018.07.016"},{"issue":"1","key":"1205_CR74","doi-asserted-by":"publisher","first-page":"12608","DOI":"10.1038\/s41598-019-48676-2","volume":"9","author":"B Yetkin-Arik","year":"2019","unstructured":"Yetkin-Arik B, Vogels IMC, Nowak-Sliwinska P, Weiss A, Houtkooper RH, Van Noorden CJF, et al. The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis. Sci Rep. 2019;9(1):12608. https:\/\/doi.org\/10.1038\/s41598-019-48676-2","journal-title":"Sci Rep"},{"key":"1205_CR75","doi-asserted-by":"crossref","unstructured":"Gallop JL. Filopodia and their links with membrane traffic and cell adhesion. Seminars in cell & developmental biology: Elsevier; 2020. p. 81\u2009\u2013\u20099.","DOI":"10.1016\/j.semcdb.2019.11.017"},{"key":"1205_CR76","doi-asserted-by":"publisher","first-page":"12240","DOI":"10.1038\/ncomms12240","volume":"7","author":"B Cruys","year":"2016","unstructured":"Cruys B, Wong BW, Kuchnio A, Verdegem D, Cantelmo AR, Conradi L-C, et al. Glycolytic regulation of cell rearrangement in angiogenesis. Nat Commun. 2016;7:12240. https:\/\/doi.org\/10.1038\/ncomms12240","journal-title":"Nat Commun"},{"key":"1205_CR77","doi-asserted-by":"crossref","unstructured":"Vandekeere S, Dewerchin M, Carmeliet PJM. Angiogenesis revisited: an overlooked role of endothelial cell metabolism in vessel sprouting. 2015;22(7):509\u201317.","DOI":"10.1111\/micc.12229"},{"issue":"4","key":"1205_CR78","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/ncb2926","volume":"16","author":"K Bentley","year":"2014","unstructured":"Bentley K, Franco CA, Philippides A, Blanco R, Dierkes M, Gebala V, et al. The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis. Nat Cell Biol. 2014;16(4):309\u201321. https:\/\/doi.org\/10.1038\/ncb2926","journal-title":"Nat Cell Biol"},{"issue":"6","key":"1205_CR79","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.ccell.2016.10.006","volume":"30","author":"AR Cantelmo","year":"2016","unstructured":"Cantelmo AR, Conradi L-C, Brajic A, Goveia J, Kalucka J, Pircher A, et al. Inhibition of the glycolytic activator PFKFB3 in Endothelium induces Tumor Vessel normalization, Impairs Metastasis, and improves chemotherapy. Cancer Cell. 2016;30(6):968\u201385. https:\/\/doi.org\/10.1016\/j.ccell.2016.10.006","journal-title":"Cancer Cell"},{"key":"1205_CR80","doi-asserted-by":"publisher","first-page":"102530","DOI":"10.1016\/j.redox.2022.102530","volume":"58","author":"S Li","year":"2022","unstructured":"Li S, Deng J, Sun D, Chen S, Yao X, Wang N, et al. FBXW7 alleviates hyperglycemia-induced endothelial oxidative stress injury via ROS and PARP inhibition. Redox Biol. 2022;58:102530. https:\/\/doi.org\/10.1016\/j.redox.2022.102530","journal-title":"Redox Biol"},{"key":"1205_CR81","doi-asserted-by":"publisher","first-page":"102589","DOI":"10.1016\/j.redox.2022.102589","volume":"59","author":"D Sun","year":"2023","unstructured":"Sun D, Chen S, Li S, Wang N, Zhang S, Xu L, et al. Enhancement of glycolysis-dependent DNA repair regulated by FOXO1 knockdown via PFKFB3 attenuates hyperglycemia-induced endothelial oxidative stress injury. Redox Biol. 2023;59:102589. https:\/\/doi.org\/10.1016\/j.redox.2022.102589","journal-title":"Redox Biol"},{"key":"1205_CR82","doi-asserted-by":"publisher","first-page":"101136","DOI":"10.1016\/j.preteyeres.2022.101136","volume":"95","author":"W-K Ju","year":"2023","unstructured":"Ju W-K, Perkins GA, Kim K-Y, Bastola T, Choi W-Y, Choi S-H. Glaucomatous optic neuropathy: mitochondrial dynamics, dysfunction and protection in retinal ganglion cells. Prog Retin Eye Res. 2023;95:101136. https:\/\/doi.org\/10.1016\/j.preteyeres.2022.101136","journal-title":"Prog Retin Eye Res"},{"key":"1205_CR83","doi-asserted-by":"publisher","unstructured":"Sanz-Morello B, Ahmadi H, Vohra R, Saruhanian S, Freude KK, Hamann S, et al. Oxidative stress in Optic neuropathies. Antioxid (Basel Switzerland). 2021;10(10). https:\/\/doi.org\/10.3390\/antiox10101538","DOI":"10.3390\/antiox10101538"},{"issue":"1","key":"1205_CR84","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.tem.2013.09.005","volume":"25","author":"R Sim\u00f3","year":"2014","unstructured":"Sim\u00f3 R, Hern\u00e1ndez C. Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives. Trends Endocrinol Metab. 2014;25(1):23\u201333. https:\/\/doi.org\/10.1016\/j.tem.2013.09.005","journal-title":"Trends Endocrinol Metab"},{"issue":"6","key":"1205_CR85","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/ncb1881","volume":"11","author":"A Herrero-Mendez","year":"2009","unstructured":"Herrero-Mendez A, Almeida A, Fern\u00e1ndez E, Maestre C, Moncada S, Bola\u00f1os JP. The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC\/C-Cdh1. Nat Cell Biol. 2009;11(6):747\u201352. https:\/\/doi.org\/10.1038\/ncb1881","journal-title":"Nat Cell Biol"},{"key":"1205_CR86","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.exer.2015.01.023","volume":"132","author":"AM Abu El-Asrar","year":"2015","unstructured":"Abu El-Asrar AM, De Hertogh G, van den Eynde K, Alam K, Van Raemdonck K, Opdenakker G, et al. Myofibroblasts in proliferative diabetic retinopathy can originate from infiltrating fibrocytes and through endothelial-to-mesenchymal transition (EndoMT). Exp Eye Res. 2015;132:179\u201389. https:\/\/doi.org\/10.1016\/j.exer.2015.01.023","journal-title":"Exp Eye Res"},{"issue":"3","key":"1205_CR87","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1002\/ptr.7401","volume":"36","author":"H Ouyang","year":"2022","unstructured":"Ouyang H, Du A, Zhou L, Zhang T, Lu B, Wang Z, et al. Chlorogenic acid improves diabetic retinopathy by alleviating blood-retinal-barrier dysfunction via inducing Nrf2 activation. Phytother Res. 2022;36(3):1386\u2013401. https:\/\/doi.org\/10.1002\/ptr.7401","journal-title":"Phytother Res"},{"issue":"1","key":"1205_CR88","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1038\/s41392-022-01097-6","volume":"7","author":"H Zeng","year":"2022","unstructured":"Zeng H, Pan T, Zhan M, Hailiwu R, Liu B, Yang H, et al. Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response. Signal Transduct Target Ther. 2022;7(1):303. https:\/\/doi.org\/10.1038\/s41392-022-01097-6","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"1205_CR89","doi-asserted-by":"publisher","first-page":"113221","DOI":"10.1016\/j.yexcr.2022.113221","volume":"417","author":"X Yang","year":"2022","unstructured":"Yang X, Zou R, Dai X, Wu X, Yuan F, Feng Y. YAP is critical to inflammation, endothelial-mesenchymal transition and subretinal fibrosis in experimental choroidal neovascularization. Exp Cell Res. 2022;417(2):113221. https:\/\/doi.org\/10.1016\/j.yexcr.2022.113221","journal-title":"Exp Cell Res"},{"key":"1205_CR90","doi-asserted-by":"publisher","unstructured":"Shu DY, Butcher ER, Saint-Geniez M. Suppression of PGC-1\u03b1 drives metabolic dysfunction in TGF\u03b22-Induced EMT of retinal pigment epithelial cells. Int J Mol Sci. 2021;22(9). https:\/\/doi.org\/10.3390\/ijms22094701","DOI":"10.3390\/ijms22094701"},{"key":"1205_CR91","doi-asserted-by":"publisher","first-page":"109691","DOI":"10.1016\/j.intimp.2023.109691","volume":"115","author":"Y Wang","year":"2023","unstructured":"Wang Y, Han S, Chen J, Sun J, Sun X. PFKFB3 knockdown attenuates amyloid \u03b2-Induced microglial activation and retinal pigment epithelium disorders in mice. Int Immunopharmacol. 2023;115:109691. https:\/\/doi.org\/10.1016\/j.intimp.2023.109691","journal-title":"Int Immunopharmacol"},{"key":"1205_CR92","doi-asserted-by":"publisher","unstructured":"Bailey JD, Diotallevi M, Nicol T, McNeill E, Shaw A, Chuaiphichai S, et al. Nitric oxide modulates metabolic remodeling in inflammatory macrophages through TCA cycle regulation and Itaconate Accumulation. Cell Rep. 2019;28(1). https:\/\/doi.org\/10.1016\/j.celrep.2019.06.018","DOI":"10.1016\/j.celrep.2019.06.018"},{"issue":"1","key":"1205_CR93","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/ncb1080","volume":"6","author":"A Almeida","year":"2004","unstructured":"Almeida A, Moncada S, Bola\u00f1os JP. Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway. Nat Cell Biol. 2004;6(1):45\u201351.","journal-title":"Nat Cell Biol"},{"issue":"1","key":"1205_CR94","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1042\/EBC20220075","volume":"67","author":"A Almeida","year":"2023","unstructured":"Almeida A, Jimenez-Blasco D, Bola\u00f1os JP. Cross-talk between energy and redox metabolism in astrocyte-neuron functional cooperation. Essays Biochem. 2023;67(1):17\u201326. https:\/\/doi.org\/10.1042\/EBC20220075","journal-title":"Essays Biochem"},{"issue":"20","key":"1205_CR95","doi-asserted-by":"publisher","first-page":"12504","DOI":"10.1074\/jbc.M114.618157","volume":"290","author":"W Fu","year":"2015","unstructured":"Fu W, Shi D, Westaway D, Jhamandas JH. Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity. J Biol Chem. 2015;290(20):12504\u201313. https:\/\/doi.org\/10.1074\/jbc.M114.618157","journal-title":"J Biol Chem"},{"key":"1205_CR96","doi-asserted-by":"publisher","first-page":"104292","DOI":"10.1016\/j.phrs.2019.104292","volume":"146","author":"L Wang","year":"2019","unstructured":"Wang L, Cao Y, Gorshkov B, Zhou Y, Yang Q, Xu J, et al. Ablation of endothelial Pfkfb3 protects mice from acute lung injury in LPS-induced endotoxemia. Pharmacol Res. 2019;146:104292. https:\/\/doi.org\/10.1016\/j.phrs.2019.104292","journal-title":"Pharmacol Res"},{"issue":"1","key":"1205_CR97","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1007\/s10753-018-0880-x","volume":"42","author":"R Zhang","year":"2019","unstructured":"Zhang R, Li R, Liu Y, Li L, Tang Y. The glycolytic enzyme PFKFB3 controls TNF-\u03b1-Induced endothelial proinflammatory responses. Inflammation. 2019;42(1):146\u201355. https:\/\/doi.org\/10.1007\/s10753-018-0880-x","journal-title":"Inflammation"},{"key":"1205_CR98","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.bbi.2017.11.015","volume":"69","author":"M Verma","year":"2018","unstructured":"Verma M, Kipari TMJ, Zhang Z, Man TY, Forster T, Homer NZM, et al. 11\u03b2-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation. Brain Behav Immun. 2018;69:223\u201334. https:\/\/doi.org\/10.1016\/j.bbi.2017.11.015","journal-title":"Brain Behav Immun"},{"issue":"6","key":"1205_CR99","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1002\/2211-5463.13174","volume":"11","author":"JA Wik","year":"2021","unstructured":"Wik JA, Phung D, Kolan S, Haraldsen G, Sk\u00e5lhegg BS, Hol Fosse J. Inflammatory activation of endothelial cells increases glycolysis and oxygen consumption despite inhibiting cell proliferation. FEBS Open Bio. 2021;11(6):1719\u201330. https:\/\/doi.org\/10.1002\/2211-5463.13174","journal-title":"FEBS Open Bio"},{"issue":"7","key":"1205_CR100","doi-asserted-by":"publisher","first-page":"e1337","DOI":"10.1038\/cddis.2014.292","volume":"5","author":"A Yalcin","year":"2014","unstructured":"Yalcin A, Clem BF, Imbert-Fernandez Y, Ozcan SC, Peker S, O\u2019Neal J, et al. 6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27. Cell Death Dis. 2014;5(7):e1337. https:\/\/doi.org\/10.1038\/cddis.2014.292","journal-title":"Cell Death Dis"},{"issue":"13","key":"1205_CR101","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1038\/s41388-017-0072-4","volume":"37","author":"W Jia","year":"2018","unstructured":"Jia W, Zhao X, Zhao L, Yan H, Li J, Yang H, et al. Non-canonical roles of PFKFB3 in regulation of cell cycle through binding to CDK4. Oncogene. 2018;37(13):1685\u201398. https:\/\/doi.org\/10.1038\/s41388-017-0072-4","journal-title":"Oncogene"},{"issue":"7","key":"1205_CR102","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1038\/s41416-022-01867-7","volume":"127","author":"S Sarkar Bhattacharya","year":"2022","unstructured":"Sarkar Bhattacharya S, Thirusangu P, Jin L, Staub J, Shridhar V, Molina JR. PFKFB3 works on the FAK-STAT3-SOX2 axis to regulate the stemness in MPM. Br J Cancer. 2022;127(7):1352\u201364. https:\/\/doi.org\/10.1038\/s41416-022-01867-7","journal-title":"Br J Cancer"},{"issue":"Pt 2","key":"1205_CR103","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.semcancer.2020.03.001","volume":"67","author":"MS Schrock","year":"2020","unstructured":"Schrock MS, Stromberg BR, Scarberry L, Summers MK. APC\/C ubiquitin ligase: functions and mechanisms in tumorigenesis. Semin Cancer Biol. 2020;67(Pt 2):80\u201391. https:\/\/doi.org\/10.1016\/j.semcancer.2020.03.001","journal-title":"Semin Cancer Biol"},{"issue":"2","key":"1205_CR104","doi-asserted-by":"publisher","first-page":"945","DOI":"10.3892\/or.2016.4884","volume":"36","author":"KY Hu","year":"2016","unstructured":"Hu KY, Wang DG, Liu PF, Cao YW, Wang YH, Yang XC, et al. Targeting of MCT1 and PFKFB3 influences cell proliferation and apoptosis in bladder cancer by altering the tumor microenvironment. Oncol Rep. 2016;36(2):945\u201351. https:\/\/doi.org\/10.3892\/or.2016.4884","journal-title":"Oncol Rep"},{"issue":"1","key":"1205_CR105","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41467-018-02950-5","volume":"9","author":"F-L Li","year":"2018","unstructured":"Li F-L, Liu J-P, Bao R-X, Yan G, Feng X, Xu Y-P, et al. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018;9(1):508. https:\/\/doi.org\/10.1038\/s41467-018-02950-5","journal-title":"Nat Commun"},{"issue":"1","key":"1205_CR106","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s12967-023-03932-y","volume":"21","author":"K Yang","year":"2023","unstructured":"Yang K, Qiu T, Zhou J, Gong X, Zhang X, Lan Y, et al. Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma. J Transl Med. 2023;21(1):85. https:\/\/doi.org\/10.1186\/s12967-023-03932-y","journal-title":"J Transl Med"},{"issue":"34","key":"1205_CR107","doi-asserted-by":"publisher","first-page":"30778","DOI":"10.1074\/jbc.M205213200","volume":"277","author":"A-S Marsin","year":"2002","unstructured":"Marsin A-S, Bouzin C, Bertrand L, Hue L. The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase. J Biol Chem. 2002;277(34):30778\u201383.","journal-title":"J Biol Chem"},{"issue":"10","key":"1205_CR108","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1271\/bbb.62.2039","volume":"62","author":"N Okamura","year":"1998","unstructured":"Okamura N, Sakakibara R. A common phosphorylation site for cyclic AMP-dependent protein kinase and protein kinase C in human placental 6-phosphofructo-2-kinase\/fructose-2,6-bisphosphatase. Biosci Biotechnol Biochem. 1998;62(10):2039\u201342.","journal-title":"Biosci Biotechnol Biochem"},{"issue":"13","key":"1205_CR109","doi-asserted-by":"publisher","first-page":"9440","DOI":"10.1074\/jbc.M113.529990","volume":"289","author":"Y Imbert-Fernandez","year":"2014","unstructured":"Imbert-Fernandez Y, Clem BF, O\u2019Neal J, Kerr DA, Spaulding R, Lanceta L, et al. Estradiol stimulates glucose metabolism via 6-phosphofructo-2-kinase (PFKFB3). J Biol Chem. 2014;289(13):9440\u20138. https:\/\/doi.org\/10.1074\/jbc.M113.529990","journal-title":"J Biol Chem"},{"issue":"2","key":"1205_CR110","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1042\/BJ20111418","volume":"442","author":"L Novellasdemunt","year":"2012","unstructured":"Novellasdemunt L, Obach M, Mill\u00e1n-Ari\u00f1o L, Manzano A, Ventura F, Rosa JL, et al. Progestins activate 6-phosphofructo-2-kinase\/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells. Biochem J. 2012;442(2):345\u201356. https:\/\/doi.org\/10.1042\/BJ20111418","journal-title":"Biochem J"},{"issue":"16","key":"1205_CR111","doi-asserted-by":"publisher","first-page":"5071","DOI":"10.26355\/eurrev_201808_15699","volume":"22","author":"D Zhang","year":"2018","unstructured":"Zhang D, Lv FL, Wang GH. Effects of HIF-1\u03b1 on diabetic retinopathy angiogenesis and VEGF expression. Eur Rev Med Pharmacol Sci. 2018;22(16):5071\u20136. https:\/\/doi.org\/10.26355\/eurrev_201808_15699","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"38","key":"1205_CR112","doi-asserted-by":"publisher","first-page":"13705","DOI":"10.3748\/wjg.v20.i38.13705","volume":"20","author":"OH Minchenko","year":"2014","unstructured":"Minchenko OH, Tsuchihara K, Minchenko DO, Bikfalvi A, Esumi H. Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells. World J Gastroenterol. 2014;20(38):13705\u201317. https:\/\/doi.org\/10.3748\/wjg.v20.i38.13705","journal-title":"World J Gastroenterol"},{"issue":"4","key":"1205_CR113","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.bbrc.2015.06.068","volume":"463","author":"X Ge","year":"2015","unstructured":"Ge X, Lyu P, Cao Z, Li J, Guo G, Xia W, et al. Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting. Biochem Biophys Res Commun. 2015;463(4):1115\u201321. https:\/\/doi.org\/10.1016\/j.bbrc.2015.06.068","journal-title":"Biochem Biophys Res Commun"},{"key":"1205_CR114","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.ebiom.2019.08.043","volume":"47","author":"SM Wade","year":"2019","unstructured":"Wade SM, Ohnesorge N, McLoughlin H, Biniecka M, Carter SP, Trenkman M, et al. Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis. EBioMedicine. 2019;47:402\u201313. https:\/\/doi.org\/10.1016\/j.ebiom.2019.08.043","journal-title":"EBioMedicine"},{"issue":"22","key":"1205_CR115","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.15252\/embj.201797609","volume":"36","author":"X Zheng","year":"2017","unstructured":"Zheng X, Han H, Liu G-P, Ma Y-X, Pan R-L, Sang L-J, et al. LncRNA wires up Hippo and hedgehog signaling to reprogramme glucose metabolism. EMBO J. 2017;36(22):3325\u201335. https:\/\/doi.org\/10.15252\/embj.201797609","journal-title":"EMBO J"},{"issue":"16","key":"1205_CR116","doi-asserted-by":"publisher","first-page":"4524","DOI":"10.1158\/0008-5472.CAN-17-0385","volume":"78","author":"Z Xing","year":"2018","unstructured":"Xing Z, Zhang Y, Liang K, Yan L, Xiang Y, Li C, et al. Expression of long noncoding RNA YIYA promotes glycolysis in breast Cancer. Cancer Res. 2018;78(16):4524\u201332. https:\/\/doi.org\/10.1158\/0008-5472.CAN-17-0385","journal-title":"Cancer Res"},{"issue":"7585","key":"1205_CR117","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/nature16498","volume":"529","author":"K Wilhelm","year":"2016","unstructured":"Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich MF, Lim R, et al. FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature. 2016;529(7585):216\u201320. https:\/\/doi.org\/10.1038\/nature16498","journal-title":"Nature"},{"key":"1205_CR118","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3389\/fphar.2019.00421","volume":"10","author":"X Huang","year":"2019","unstructured":"Huang X, Sun J, Chen G, Niu C, Wang Y, Zhao C, et al. Resveratrol promotes Diabetic Wound Healing via SIRT1-FOXO1-c-Myc signaling pathway-mediated angiogenesis. Front Pharmacol. 2019;10:421. https:\/\/doi.org\/10.3389\/fphar.2019.00421","journal-title":"Front Pharmacol"},{"key":"1205_CR119","doi-asserted-by":"publisher","unstructured":"Doddaballapur A, Michalik KM, Manavski Y, Lucas T, Houtkooper RH, You X et al. Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3. Arteriosclerosis, thrombosis, and vascular biology. 2015;35(1):137\u201345. https:\/\/doi.org\/10.1161\/atvbaha.114.304277","DOI":"10.1161\/atvbaha.114.304277"},{"key":"1205_CR120","doi-asserted-by":"publisher","first-page":"21643","DOI":"10.1038\/srep21643","volume":"6","author":"RG de Bruin","year":"2016","unstructured":"de Bruin RG, van der Veer EP, Prins J, Lee DH, Dane MJC, Zhang H, et al. The RNA-binding protein quaking maintains endothelial barrier function and affects VE-cadherin and \u03b2-catenin protein expression. Sci Rep. 2016;6:21643. https:\/\/doi.org\/10.1038\/srep21643","journal-title":"Sci Rep"},{"issue":"3","key":"1205_CR121","doi-asserted-by":"publisher","first-page":"e0229395","DOI":"10.1371\/journal.pone.0229395","volume":"15","author":"JA Wik","year":"2020","unstructured":"Wik JA, Lundb\u00e4ck P, la Cour Poulsen L, Haraldsen G, Sk\u00e5lhegg BS, Hol J. 3PO inhibits inflammatory NF\u03baB and stress-activated kinase signaling in primary human endothelial cells independently of its target PFKFB3. PLoS ONE. 2020;15(3):e0229395. https:\/\/doi.org\/10.1371\/journal.pone.0229395","journal-title":"PLoS ONE"},{"issue":"18","key":"1205_CR122","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1002\/1873-3468.13878","volume":"PFKFB3","author":"B Emini Veseli","year":"2020","unstructured":"Emini Veseli B, Perrotta P, Van Wielendaele P, Lambeir A-M, Abdali A, Bellosta S, et al. Small molecule 3PO inhibits glycolysis but does not bind to 6-phosphofructo-2-kinase\/fructose-2,6-bisphosphatase-3 (PFKFB3). FEBS Lett. 2020;594(18):3067-75. https:\/\/doi.org\/10.1002\/1873-3468.13878","journal-title":"FEBS Lett"},{"key":"1205_CR123","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.canlet.2020.12.011","volume":"500","author":"K Matsumoto","year":"2021","unstructured":"Matsumoto K, Noda T, Kobayashi S, Sakano Y, Yokota Y, Iwagami Y, et al. Inhibition of glycolytic activator PFKFB3 suppresses tumor growth and induces tumor vessel normalization in hepatocellular carcinoma. Cancer Lett. 2021;500:29\u201340. https:\/\/doi.org\/10.1016\/j.canlet.2020.12.011","journal-title":"Cancer Lett"},{"issue":"8","key":"1205_CR124","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.1021\/acs.jmedchem.5b00352","volume":"58","author":"S Boyd","year":"2015","unstructured":"Boyd S, Brookfield JL, Critchlow SE, Cumming IA, Curtis NJ, Debreczeni J, et al. Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J Med Chem. 2015;58(8):3611\u201325. https:\/\/doi.org\/10.1021\/acs.jmedchem.5b00352","journal-title":"J Med Chem"},{"key":"1205_CR125","doi-asserted-by":"publisher","unstructured":"Emini Veseli B, Van Wielendaele P, Delibegovic M, Martinet W, De Meyer GRY. The PFKFB3 inhibitor AZ67 inhibits Angiogenesis independently of glycolysis inhibition. Int J Mol Sci. 2021;22(11). https:\/\/doi.org\/10.3390\/ijms22115970","DOI":"10.3390\/ijms22115970"},{"issue":"1","key":"1205_CR126","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/s41467-022-28191-1","volume":"13","author":"I Lopez-Fabuel","year":"2022","unstructured":"Lopez-Fabuel I, Garcia-Macia M, Buondelmonte C, Burmistrova O, Bonora N, Alonso-Batan P, et al. Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis. Nat Commun. 2022;13(1):536. https:\/\/doi.org\/10.1038\/s41467-022-28191-1","journal-title":"Nat Commun"},{"issue":"1","key":"1205_CR127","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1002\/ijc.31868","volume":"144","author":"S Mondal","year":"2019","unstructured":"Mondal S, Roy D, Sarkar Bhattacharya S, Jin L, Jung D, Zhang S, et al. Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers. Int J Cancer. 2019;144(1):178\u201389. https:\/\/doi.org\/10.1002\/ijc.31868","journal-title":"Int J Cancer"},{"issue":"33","key":"1205_CR128","doi-asserted-by":"publisher","first-page":"4003","DOI":"10.1038\/s41388-022-02391-x","volume":"41","author":"P Thirusangu","year":"2022","unstructured":"Thirusangu P, Ray U, Sarkar Bhattacharya S, Oien DB, Jin L, Staub J, et al. PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma. Oncogene. 2022;41(33):4003\u201317. https:\/\/doi.org\/10.1038\/s41388-022-02391-x","journal-title":"Oncogene"}],"container-title":["Cell &amp; Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13578-024-01205-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13578-024-01205-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13578-024-01205-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T13:03:03Z","timestamp":1707570183000},"score":1,"resource":{"primary":{"URL":"https:\/\/cellandbioscience.biomedcentral.com\/articles\/10.1186\/s13578-024-01205-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,10]]},"references-count":128,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1205"],"URL":"https:\/\/doi.org\/10.1186\/s13578-024-01205-9","relation":{},"ISSN":["2045-3701"],"issn-type":[{"value":"2045-3701","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,10]]},"assertion":[{"value":"30 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"21"}}