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Initially considered a genomic mystery, an increasing number of lncRNAs have been shown to have vital roles in physiological and pathological conditions by regulating gene expression through diverse mechanisms depending on their subcellular localization. Dysregulated angiogenesis is responsible for various vascular oculopathies, including diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration, and corneal neovascularization. While anti-VEGF treatment is available, it is not curative, and long-term outcomes are suboptimal, and some patients are unresponsive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and summary<\/jats:title>\n                    <jats:p>\n                      To better understand these diseases, researchers have investigated the role of lncRNAs in regulating angiogenesis and models of vascular oculopathies. This review summarizes recent research on lncRNAs in ocular angiogenesis, including the pro-angiogenic lncRNAs\n                      <jats:italic>ANRIL<\/jats:italic>\n                      ,\n                      <jats:italic>HOTAIR<\/jats:italic>\n                      ,\n                      <jats:italic>HOTTIP<\/jats:italic>\n                      ,\n                      <jats:italic>H19<\/jats:italic>\n                      ,\n                      <jats:italic>IPW<\/jats:italic>\n                      ,\n                      <jats:italic>MALAT1<\/jats:italic>\n                      ,\n                      <jats:italic>MIAT<\/jats:italic>\n                      ,\n                      <jats:italic>NEAT1<\/jats:italic>\n                      , and\n                      <jats:italic>TUG1<\/jats:italic>\n                      , the anti-angiogenic lncRNAs\n                      <jats:italic>MEG3<\/jats:italic>\n                      and\n                      <jats:italic>PKNY<\/jats:italic>\n                      , and the human\/primate specific lncRNAs\n                      <jats:italic>lncEGFL7OS<\/jats:italic>\n                      , discussing their functions and mechanisms of action in vascular oculopathies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13578-024-01217-5","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T12:01:41Z","timestamp":1711195301000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy"],"prefix":"10.1186","volume":"14","author":[{"given":"Pranali","family":"Gandhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guigang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8841-5432","authenticated-orcid":false,"given":"Shusheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,23]]},"reference":[{"key":"1217_CR1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/978-3-030-43683-4_5","volume-title":"Mechanisms of vascular disease: a Textbook for Vascular specialists","author":"NKP Wong","year":"2020","unstructured":"Wong NKP, et al. 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