{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:25:56Z","timestamp":1792801556169,"version":"4.5.0"},"reference-count":196,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Health Science and Technology Innovation Outstanding Young Talents Training Program of Henan Province","award":["YXKC2021027"],"award-info":[{"award-number":["YXKC2021027"]}]},{"name":"Basic Research Project of Henan Eye Institute","award":["20JCZD001"],"award-info":[{"award-number":["20JCZD001"]}],"id":[{"id":"https:\/\/ror.org\/051jybk56","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Basic Research Project of Henan Eye Institute","award":["21JCZD002"],"award-info":[{"award-number":["21JCZD002"]}],"id":[{"id":"https:\/\/ror.org\/051jybk56","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Science and Technology Major Project of Henan Province","award":["221100310200"],"award-info":[{"award-number":["221100310200"]}]},{"name":"Central Plains Science and Technology Leading Talent Fund","award":["224200510013"],"award-info":[{"award-number":["224200510013"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biosci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \/calmodulin-dependent protein kinase II (CaMKII) is a family of broad substrate specificity serine (Ser)\/threonine (Thr) protein kinases that play a crucial role in the Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -dependent signaling pathways. Its significance as an intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    sensor has garnered abundant research interest in the domain of neurodegeneration. Accumulating evidences suggest that CaMKII is implicated in the pathology of degenerative retinopathies such as diabetic retinopathy (DR), age-related macular degeneration (AMD), retinitis pigmentosa (RP) and glaucoma optic neuropathy. CaMKII can induce the aberrant proliferation of retinal blood vessels, influence the synaptic signaling, and exert dual effects on the survival of retinal ganglion cells and pigment epithelial cells. Researchers have put forth multiple therapeutic agents, encompassing small molecules, peptides, and nucleotides that possess the capability to modulate CaMKII activity. Due to its broad range isoforms and splice variants therapeutic strategies seek to inhibit specifically the CaMKII are confronted with considerable challenges. Therefore, it becomes crucial to discern the detrimental and advantageous aspects of CaMKII, thereby facilitating the development of efficacious treatment. In this review, we summarize recent research findings on the cellular and molecular biology of CaMKII, with special emphasis on its metabolic and regulatory mechanisms. We delve into the involvement of CaMKII in the retinal signal transduction pathways and discuss the correlation between CaMKII and calcium overload. Furthermore, we elaborate the therapeutic trials targeting CaMKII, and introduce recent developments in the zone of CaMKII inhibitors. These findings would enrich our knowledge of CaMKII, and shed light on the development of a therapeutic target for degenerative retinopathy.\n                  <\/jats:p>","DOI":"10.1186\/s13578-024-01236-2","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T15:02:20Z","timestamp":1715266940000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Unveiling the role of CaMKII in retinal degeneration: from biological mechanism to therapeutic strategies"],"prefix":"10.1186","volume":"14","author":[{"given":"Yuxin","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongming","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"1236_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.617377","volume":"14","author":"Y Lin","year":"2021","unstructured":"Lin Y, et al. Interaction between mesenchymal stem cells and retinal degenerative microenvironment. Front Neurosci. 2021;14: 617377.","journal-title":"Front Neurosci"},{"key":"1236_CR2","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3389\/fnmol.2019.00206","volume":"12","author":"S Tetenborg","year":"2019","unstructured":"Tetenborg S, et al. Localization of retinal Ca(2+)\/calmodulin-dependent kinase II-\u03b2 (CaMKII-\u03b2) at bipolar cell gap junctions and cross-reactivity of a monoclonal anti-CaMKII-\u03b2 antibody with Connexin36. Front Mol Neurosci. 2019;12:206.","journal-title":"Front Mol Neurosci"},{"issue":"11","key":"1236_CR3","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1016\/j.celrep.2017.05.068","volume":"19","author":"DJ Goodell","year":"2017","unstructured":"Goodell DJ, et al. DAPK1 mediates LTD by making CaMKII\/GluN2B binding LTP specific. Cell Rep. 2017;19(11):2231\u201343.","journal-title":"Cell Rep"},{"key":"1236_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.587072","volume":"14","author":"JR Campbell","year":"2020","unstructured":"Campbell JR, et al. Phosphorylation of the retinal ribbon synapse specific t-SNARE protein Syntaxin3B is regulated by light via a Ca(2 +)-dependent pathway. Front Cell Neurosci. 2020;14: 587072.","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"1236_CR5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/00005072-199001000-00006","volume":"49","author":"AC McKee","year":"1990","unstructured":"McKee AC, et al. Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium\/calmodulin-dependent protein kinase. J Neuropathol Exp Neurol. 1990;49(1):49\u201363.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1","key":"1236_CR6","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1007\/s10620-021-06847-0","volume":"67","author":"W Chen","year":"2022","unstructured":"Chen W, et al. CaMKII mediates TGF\u03b21-induced fibroblasts activation and its cross talk with colon cancer cells. Dig Dis Sci. 2022;67(1):134\u201345.","journal-title":"Dig Dis Sci"},{"issue":"5","key":"1236_CR7","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000101","volume":"7","author":"X Cai","year":"2023","unstructured":"Cai X, et al. TRPM2 regulates cell cycle through the Ca2+-CaM-CaMKII signaling pathway to promote HCC. Hepatol Commun. 2023;7(5): e0101.","journal-title":"Hepatol Commun"},{"issue":"6","key":"1236_CR8","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1161\/CIRCRESAHA.121.319478","volume":"130","author":"Y Yao","year":"2022","unstructured":"Yao Y, et al. Targeting CaMKII-\u03b49 ameliorates cardiac ischemia\/reperfusion injury by inhibiting myocardial inflammation. Circ Res. 2022;130(6):887\u2013903.","journal-title":"Circ Res"},{"key":"1236_CR9","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.bbrc.2022.04.082","volume":"615","author":"D Nie","year":"2022","unstructured":"Nie D, et al. CaMKII inhibition protects against hyperthyroid arrhythmias and adverse myocardial remodeling. Biochem Biophys Res Commun. 2022;615:136\u201342.","journal-title":"Biochem Biophys Res Commun"},{"key":"1236_CR10","doi-asserted-by":"publisher","first-page":"9601046","DOI":"10.1155\/2017\/9601046","volume":"2017","author":"DE Johnson","year":"2017","unstructured":"Johnson DE, Hudmon A. Activation state-dependent substrate gating in Ca(2+)\/calmodulin-dependent protein kinase II. Neural Plast. 2017;2017:9601046.","journal-title":"Neural Plast"},{"issue":"3","key":"1236_CR11","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/nsmb.1751","volume":"17","author":"LH Chao","year":"2010","unstructured":"Chao LH, et al. Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nat Struct Mol Biol. 2010;17(3):264\u201372.","journal-title":"Nat Struct Mol Biol"},{"issue":"6","key":"1236_CR12","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1002\/pro.3869","volume":"29","author":"AP Torres-Ocampo","year":"2020","unstructured":"Torres-Ocampo AP, et al. Characterization of CaMKII\u03b1 holoenzyme stability. Protein Sci. 2020;29(6):1524\u201334.","journal-title":"Protein Sci"},{"issue":"47","key":"1236_CR13","doi-asserted-by":"publisher","first-page":"31555","DOI":"10.1074\/jbc.273.47.31555","volume":"273","author":"SJ Kolb","year":"1998","unstructured":"Kolb SJ, et al. Identification of domains essential for the assembly of calcium\/calmodulin-dependent protein kinase II holoenzymes. J Biol Chem. 1998;273(47):31555\u201364.","journal-title":"J Biol Chem"},{"key":"1236_CR14","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.13405","volume":"5","author":"M Bhattacharyya","year":"2016","unstructured":"Bhattacharyya M, et al. Molecular mechanism of activation-triggered subunit exchange in Ca(2+)\/calmodulin-dependent protein kinase II. Elife. 2016;5: e13405.","journal-title":"Elife"},{"issue":"11","key":"1236_CR15","doi-asserted-by":"publisher","first-page":"4656","DOI":"10.1091\/mbc.e06-03-0252","volume":"17","author":"H O\u2019Leary","year":"2006","unstructured":"O\u2019Leary H, Lasda E, Bayer KU. CaMKII\u03b2 association with the actin cytoskeleton is regulated by alternative splicing. Mol Biol Cell. 2006;17(11):4656\u201365.","journal-title":"Mol Biol Cell"},{"issue":"8","key":"1236_CR16","doi-asserted-by":"publisher","first-page":"6780","DOI":"10.1111\/ejn.14761","volume":"54","author":"R Sloutsky","year":"2021","unstructured":"Sloutsky R, Stratton MM. Functional implications of CaMKII alternative splicing. Eur J Neurosci. 2021;54(8):6780\u201394.","journal-title":"Eur J Neurosci"},{"issue":"2","key":"1236_CR17","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0006-8993(94)91928-3","volume":"634","author":"T Ochiishi","year":"1994","unstructured":"Ochiishi T, et al. Immunohistochemical localization of Ca2+\/calmodulin-dependent protein kinase II in the rat retina. Brain Res. 1994;634(2):257\u201365.","journal-title":"Brain Res"},{"issue":"1\u20132","key":"1236_CR18","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/S0169-328X(00)00203-5","volume":"82","author":"LO Liu","year":"2000","unstructured":"Liu LO, et al. Photoreceptor regulated expression of Ca(2+)\/calmodulin-dependent protein kinase II in the mouse retina. Brain Res Mol Brain Res. 2000;82(1\u20132):150\u201366.","journal-title":"Brain Res Mol Brain Res"},{"issue":"6","key":"1236_CR19","volume":"4","author":"S Ashraf","year":"2019","unstructured":"Ashraf S, et al. CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularization. JCI Insight. 2019;4(6): e122442.","journal-title":"JCI Insight"},{"issue":"6","key":"1236_CR20","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1167\/iovs.10-6574","volume":"52","author":"E Banumathi","year":"2011","unstructured":"Banumathi E, et al. VEGF-induced retinal angiogenic signaling is critically dependent on Ca2+ signaling by Ca2+\/calmodulin-dependent protein kinase II. Invest Ophthalmol Vis Sci. 2011;52(6):3103\u201311.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"1236_CR21","volume":"35","author":"BJ O\u2019Brien","year":"2021","unstructured":"O\u2019Brien BJ, et al. CaMKII\u03b4 is upregulated by pro-inflammatory cytokine IL-6 in a JAK\/STAT3-dependent manner to promote angiogenesis. FASEB J. 2021;35(4): e21437.","journal-title":"FASEB J"},{"issue":"1","key":"1236_CR22","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1002\/dvdy.21005","volume":"236","author":"SC Rothschild","year":"2007","unstructured":"Rothschild SC, Lister JA, Tombes RM. Differential expression of CaMK-II genes during early zebrafish embryogenesis. Dev Dyn. 2007;236(1):295\u2013305.","journal-title":"Dev Dyn"},{"issue":"1","key":"1236_CR23","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1002\/cne.10880","volume":"466","author":"SI Firth","year":"2003","unstructured":"Firth SI, et al. AMPA receptors mediate acetylcholine release from starburst amacrine cells in the rabbit retina. J Comp Neurol. 2003;466(1):80\u201390.","journal-title":"J Comp Neurol"},{"key":"1236_CR24","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3389\/fnmol.2017.00425","volume":"10","author":"S Tetenborg","year":"2017","unstructured":"Tetenborg S, et al. Differential distribution of retinal Ca(2+)\/calmodulin-dependent kinase II (CaMKII) isoforms indicates CaMKII-\u03b2 and -\u03b4 as specific elements of electrical synapses made of Connexin36 (Cx36). Front Mol Neurosci. 2017;10:425.","journal-title":"Front Mol Neurosci"},{"issue":"13","key":"1236_CR25","doi-asserted-by":"publisher","first-page":"12484","DOI":"10.1074\/jbc.M313597200","volume":"279","author":"TR Gaertner","year":"2004","unstructured":"Gaertner TR, et al. Comparative analyses of the three-dimensional structures and enzymatic properties of \u03b1, \u03b2, \u03b3 and \u03b4 isoforms of Ca2+-calmodulin-dependent protein kinase II. J Biol Chem. 2004;279(13):12484\u201394.","journal-title":"J Biol Chem"},{"issue":"8","key":"1236_CR26","doi-asserted-by":"publisher","first-page":"3854","DOI":"10.1167\/iovs.06-1382","volume":"48","author":"W Fan","year":"2007","unstructured":"Fan W, Li X, Cooper NG. CaMKII\u03b1B mediates a survival response in retinal ganglion cells subjected to a glutamate stimulus. Invest Ophthalmol Vis Sci. 2007;48(8):3854\u201363.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"1236_CR27","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.brainres.2005.10.030","volume":"1067","author":"W Fan","year":"2006","unstructured":"Fan W, Agarwal N, Cooper NG. The role of CaMKII in BDNF-mediated neuroprotection of retinal ganglion cells (RGC-5). Brain Res. 2006;1067(1):48\u201357.","journal-title":"Brain Res"},{"issue":"2","key":"1236_CR28","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.molbrainres.2005.06.008","volume":"139","author":"W Fan","year":"2005","unstructured":"Fan W, et al. Retinal ganglion cell death and neuroprotection: involvement of the CaMKII\u03b1 gene. Brain Res Mol Brain Res. 2005;139(2):306\u201316.","journal-title":"Brain Res Mol Brain Res"},{"issue":"23","key":"1236_CR29","doi-asserted-by":"publisher","first-page":"9204","DOI":"10.1523\/JNEUROSCI.21-23-09204.2001","volume":"21","author":"T Mabuchi","year":"2001","unstructured":"Mabuchi T, et al. Phosphorylation of cAMP response element-binding protein in hippocampal neurons as a protective response after exposure to glutamate in vitro and ischemia in vivo. J Neurosci. 2001;21(23):9204\u201313.","journal-title":"J Neurosci"},{"key":"1236_CR30","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.brainres.2008.12.051","volume":"1256","author":"DJ Goebel","year":"2009","unstructured":"Goebel DJ. Selective blockade of CaMKII-\u03b1 inhibits NMDA-induced caspase-3-dependent cell death but does not arrest PARP-1 activation or loss of plasma membrane selectivity in rat retinal neurons. Brain Res. 2009;1256:190\u2013204.","journal-title":"Brain Res"},{"issue":"5","key":"1236_CR31","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1161\/CIRCRESAHA.119.315755","volume":"126","author":"S Lebek","year":"2020","unstructured":"Lebek S, et al. Enhanced CaMKII-dependent late INa induces atrial proarrhythmic activity in patients with sleep-disordered breathing. Circ Res. 2020;126(5):603\u201315.","journal-title":"Circ Res"},{"issue":"1","key":"1236_CR32","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/sms.13828","volume":"31","author":"M Martinez-Canton","year":"2020","unstructured":"Martinez-Canton M, et al. Role of CaMKII and sarcolipin in muscle adaptations to strength training with different levels of fatigue in the set. Scand J Med Sci Sports. 2020;31(1):91\u2013103.","journal-title":"Scand J Med Sci Sports"},{"issue":"3","key":"1236_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092741","volume":"9","author":"C-M Yang","year":"2014","unstructured":"Yang C-M, et al. Adiponectin enhances intercellular adhesion molecule-1 expression and promotes monocyte adhesion in human synovial fibroblasts. PLoS ONE. 2014;9(3): e92741.","journal-title":"PLoS ONE"},{"issue":"4","key":"1236_CR34","doi-asserted-by":"publisher","first-page":"147916412311971","DOI":"10.1177\/14791641231197106","volume":"20","author":"T Liu","year":"2023","unstructured":"Liu T, et al. Dapagliflozin attenuates cardiac remodeling and dysfunction in rats with \u03b2-adrenergic receptor overactivation through restoring calcium handling and suppressing cardiomyocyte apoptosis. Diabetes Vasc Dis Res. 2023;20(4):14791641231197106.","journal-title":"Diabetes Vasc Dis Res"},{"issue":"20","key":"1236_CR35","doi-asserted-by":"publisher","first-page":"6958","DOI":"10.3390\/ijerph20206958","volume":"20","author":"A Alharbi","year":"2023","unstructured":"Alharbi A, et al. The effect of lower limb combined neuromuscular electrical stimulation on skeletal muscle signaling for glucose utilization, myofiber distribution, and metabolic function after spinal cord injury. Int J Environ Res Public Health. 2023;20(20):6958.","journal-title":"Int J Environ Res Public Health"},{"key":"1236_CR36","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.ejphar.2013.10.062","volume":"723","author":"RE Molokie","year":"2014","unstructured":"Molokie RE, et al. Mechanism-driven phase I translational study of trifluoperazine in adults with sickle cell disease. Eur J Pharmacol. 2014;723:419\u201324.","journal-title":"Eur J Pharmacol"},{"issue":"11","key":"1236_CR37","doi-asserted-by":"publisher","first-page":"R1312","DOI":"10.1152\/ajpregu.00364.2015","volume":"310","author":"A Kalsen","year":"2016","unstructured":"Kalsen A, et al. Effect of formoterol, a long-acting \u03b22-adrenergic agonist, on muscle strength and power output, metabolism, and fatigue during maximal sprinting in men. Am J Physiol Regul Integr Comp Physiol. 2016;310(11):R1312\u201321.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"3","key":"1236_CR38","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1002\/jcp.22800","volume":"227","author":"T Kanno","year":"2011","unstructured":"Kanno T, et al. Indomethacin enhances learning and memory potential by interacting with CaMKII. J Cell Physiol. 2011;227(3):919\u201326.","journal-title":"J Cell Physiol"},{"issue":"4","key":"1236_CR39","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s12975-021-00901-9","volume":"12","author":"X Zhang","year":"2021","unstructured":"Zhang X, et al. Calcium\/calmodulin-dependent protein kinase II in cerebrovascular diseases. Transl Stroke Res. 2021;12(4):513\u201329.","journal-title":"Transl Stroke Res"},{"key":"1236_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101779","volume":"37","author":"Y Ozawa","year":"2020","unstructured":"Ozawa Y. Oxidative stress in the light-exposed retina and its implication in age-related macular degeneration. Redox Biol. 2020;37: 101779.","journal-title":"Redox Biol"},{"issue":"3","key":"1236_CR41","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3390\/cells12030401","volume":"12","author":"JAP Rostas","year":"2023","unstructured":"Rostas JAP, Skelding KA. Calcium\/calmodulin-stimulated protein kinase II (CaMKII): different functional outcomes from activation, depending on the cellular microenvironment. Cells. 2023;12(3):401.","journal-title":"Cells"},{"issue":"5","key":"1236_CR42","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1046\/j.1471-4159.1997.68052119.x","volume":"68","author":"S Strack","year":"2002","unstructured":"Strack S, et al. Differential inactivation of postsynaptic density-associated and soluble Ca2+\/calmodulin-dependent protein kinase II by protein phosphatases 1 and 2A. J Neurochem. 2002;68(5):2119\u201328.","journal-title":"J Neurochem"},{"issue":"5140","key":"1236_CR43","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1126\/science.8259515","volume":"262","author":"WE Meador","year":"1993","unstructured":"Meador WE, Means AR, Quiocho FA. Modulation of calmodulin plasticity in molecular recognition on the basis of X-ray structures. Science. 1993;262(5140):1718\u201321.","journal-title":"Science"},{"key":"1236_CR44","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.yjmcc.2014.02.004","volume":"73","author":"ED Luczak","year":"2014","unstructured":"Luczak ED, Anderson ME. CaMKII oxidative activation and the pathogenesis of cardiac disease. J Mol Cell Cardiol. 2014;73:112\u20136.","journal-title":"J Mol Cell Cardiol"},{"issue":"12","key":"1236_CR45","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1038\/nm.2506","volume":"17","author":"BJ He","year":"2011","unstructured":"He BJ, et al. Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med. 2011;17(12):1610\u20138.","journal-title":"Nat Med"},{"issue":"Pt B","key":"1236_CR46","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.yjmcc.2015.10.014","volume":"89","author":"ME Anderson","year":"2015","unstructured":"Anderson ME. Oxidant stress promotes disease by activating CaMKII. J Mol Cell Cardiol. 2015;89(Pt B):160\u20137.","journal-title":"J Mol Cell Cardiol"},{"issue":"9","key":"1236_CR47","doi-asserted-by":"publisher","first-page":"4663","DOI":"10.1172\/JCI133181","volume":"130","author":"K Konstantinidis","year":"2020","unstructured":"Konstantinidis K, et al. MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII. J Clin Invest. 2020;130(9):4663\u201378.","journal-title":"J Clin Invest"},{"issue":"3","key":"1236_CR48","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.cell.2008.02.048","volume":"133","author":"JR Erickson","year":"2008","unstructured":"Erickson JR, et al. A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell. 2008;133(3):462\u201374.","journal-title":"Cell"},{"issue":"3","key":"1236_CR49","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1172\/JCI65268","volume":"123","author":"M Luo","year":"2013","unstructured":"Luo M, et al. Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. J Clin Invest. 2013;123(3):1262\u201374.","journal-title":"J Clin Invest"},{"issue":"4","key":"1236_CR50","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.cardiores.2006.12.003","volume":"73","author":"M Vila-Petroff","year":"2007","unstructured":"Vila-Petroff M, et al. CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury. Cardiovasc Res. 2007;73(4):689\u201398.","journal-title":"Cardiovasc Res"},{"issue":"5","key":"1236_CR51","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/j.yjmcc.2012.01.021","volume":"52","author":"MV Singh","year":"2012","unstructured":"Singh MV, et al. MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction. J Mol Cell Cardiol. 2012;52(5):1135\u201344.","journal-title":"J Mol Cell Cardiol"},{"issue":"7","key":"1236_CR52","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/aps.2011.68","volume":"32","author":"SJ Coultrap","year":"2011","unstructured":"Coultrap SJ, et al. CaMKII in cerebral ischemia. Acta Pharmacol Sin. 2011;32(7):861\u201372.","journal-title":"Acta Pharmacol Sin"},{"issue":"52","key":"1236_CR53","doi-asserted-by":"publisher","first-page":"20964","DOI":"10.1073\/pnas.0805408105","volume":"105","author":"C Alev","year":"2008","unstructured":"Alev C, et al. The neuronal connexin36 interacts with and is phosphorylated by CaMKII in a way similar to CaMKII interaction with glutamate receptors. Proc Natl Acad Sci U S A. 2008;105(52):20964\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"1236_CR54","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1083\/jcb.200505155","volume":"171","author":"A Hudmon","year":"2005","unstructured":"Hudmon A, et al. CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. J Cell Biol. 2005;171(3):537\u201347.","journal-title":"J Cell Biol"},{"issue":"41","key":"1236_CR55","doi-asserted-by":"publisher","first-page":"15791","DOI":"10.1073\/pnas.0804399105","volume":"105","author":"YC Lin","year":"2008","unstructured":"Lin YC, Redmond L. CaMKII\u03b2 binding to stable F-actin in vivo regulates F-actin filament stability. Proc Natl Acad Sci U S A. 2008;105(41):15791\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"1236_CR56","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.bbrc.2013.05.050","volume":"435","author":"MJ Cha","year":"2013","unstructured":"Cha MJ, et al. MicroRNA-145 suppresses ROS-induced Ca2+ overload of cardiomyocytes by targeting CaMKII\u03b4. Biochem Biophys Res Commun. 2013;435(4):720\u20136.","journal-title":"Biochem Biophys Res Commun"},{"issue":"29","key":"1236_CR57","doi-asserted-by":"publisher","first-page":"47565","DOI":"10.18632\/oncotarget.17735","volume":"8","author":"M Shao","year":"2017","unstructured":"Shao M, et al. LncRNA TINCR attenuates cardiac hypertrophy by epigenetically silencing CaMKII. Oncotarget. 2017;8(29):47565\u201373.","journal-title":"Oncotarget"},{"issue":"3","key":"1236_CR58","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.57","volume":"7","author":"Q Xu","year":"2016","unstructured":"Xu Q, et al. Long non-coding RNA C2dat1 regulates CaMKII\u03b4 expression to promote neuronal survival through the NF-\u03baB signaling pathway following cerebral ischemia. Cell Death Dis. 2016;7(3): e2173.","journal-title":"Cell Death Dis"},{"issue":"8","key":"1236_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110398","volume":"38","author":"X Cui","year":"2022","unstructured":"Cui X, et al. Identification and characterization of long non-coding RNA Carip in modulating spatial learning and memory. Cell Rep. 2022;38(8): 110398.","journal-title":"Cell Rep"},{"issue":"4","key":"1236_CR60","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1111\/wrr.12708","volume":"27","author":"Y Zhu","year":"2019","unstructured":"Zhu Y, et al. Roxadustat promotes angiogenesis through HIF-1\u03b1\/VEGF\/VEGFR2 signaling and accelerates cutaneous wound healing in diabetic rats. Wound Repair Regen. 2019;27(4):324\u201334.","journal-title":"Wound Repair Regen"},{"issue":"6","key":"1236_CR61","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.3390\/ijms19061816","volume":"19","author":"W Wang","year":"2018","unstructured":"Wang W, Lo ACY. Diabetic retinopathy: pathophysiology and treatments. Int J Mol Sci. 2018;19(6):1816.","journal-title":"Int J Mol Sci"},{"issue":"6 Suppl","key":"1236_CR62","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1097\/IAE.0b013e3181ad255f","volume":"29","author":"AJ Brucker","year":"2009","unstructured":"Brucker AJ. Age-related macular degeneration. Retina. 2009;29(6 Suppl):S2\u20134.","journal-title":"Retina"},{"issue":"1","key":"1236_CR63","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.jss.2008.12.014","volume":"159","author":"JM Lyons 3rd","year":"2010","unstructured":"Lyons JM 3rd, et al. The role of VEGF pathways in human physiologic and pathologic angiogenesis. J Surg Res. 2010;159(1):517\u201327.","journal-title":"J Surg Res"},{"issue":"18","key":"1236_CR64","doi-asserted-by":"publisher","first-page":"16347","DOI":"10.1074\/jbc.M300259200","volume":"278","author":"RD Meyer","year":"2003","unstructured":"Meyer RD, Latz C, Rahimi N. Recruitment and activation of phospholipase C\u03b31 by vascular endothelial growth factor receptor-2 are required for tubulogenesis and differentiation of endothelial cells. J Biol Chem. 2003;278(18):16347\u201355.","journal-title":"J Biol Chem"},{"issue":"7","key":"1236_CR65","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/sj.bjp.0704956","volume":"137","author":"DS G\u00e9linas","year":"2009","unstructured":"G\u00e9linas DS, et al. Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways. Br J Pharmacol. 2009;137(7):1021\u201330.","journal-title":"Br J Pharmacol"},{"key":"1236_CR66","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3389\/fnmol.2011.00051","volume":"4","author":"J Karar","year":"2011","unstructured":"Karar J, Maity A. PI3K\/AKT\/mTOR pathway in angiogenesis. Front Mol Neurosci. 2011;4:51.","journal-title":"Front Mol Neurosci"},{"key":"1236_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2020.104488","volume":"116","author":"L Wang","year":"2020","unstructured":"Wang L, Liu WX, Huang XG. MicroRNA-199a-3p inhibits angiogenesis by targeting the VEGF\/PI3K\/AKT signalling pathway in an in vitro model of diabetic retinopathy. Exp Mol Pathol. 2020;116: 104488.","journal-title":"Exp Mol Pathol"},{"issue":"16","key":"1236_CR68","doi-asserted-by":"publisher","first-page":"6594","DOI":"10.18632\/aging.204232","volume":"14","author":"R Gong","year":"2022","unstructured":"Gong R, et al. MiR-375 mitigates retinal angiogenesis by depressing the JAK2\/STAT3 pathway. Aging (Albany NY). 2022;14(16):6594\u2013604.","journal-title":"Aging (Albany NY)"},{"issue":"5","key":"1236_CR69","doi-asserted-by":"publisher","first-page":"C589","DOI":"10.1152\/ajpcell.00235.2017","volume":"314","author":"H Alsaffar","year":"2018","unstructured":"Alsaffar H, et al. Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis. Am J Physiol Cell Physiol. 2018;314(5):C589\u2013602.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"14","key":"1236_CR70","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1182\/blood-2012-04-422527","volume":"120","author":"A Stahl","year":"2012","unstructured":"Stahl A, et al. SOCS3 is an endogenous inhibitor of pathologic angiogenesis. Blood. 2012;120(14):2925\u20139.","journal-title":"Blood"},{"key":"1236_CR71","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.714646","volume":"11","author":"B Geng","year":"2021","unstructured":"Geng B, et al. Artesunate suppresses choroidal melanoma vasculogenic mimicry formation and angiogenesis via the Wnt\/CaMKII signaling axis. Front Oncol. 2021;11: 714646.","journal-title":"Front Oncol"},{"issue":"1","key":"1236_CR72","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13045-020-00858-6","volume":"13","author":"Q Luo","year":"2020","unstructured":"Luo Q, et al. Vasculogenic mimicry in carcinogenesis and clinical applications. J Hematol Oncol. 2020;13(1):19.","journal-title":"J Hematol Oncol"},{"issue":"17","key":"1236_CR73","doi-asserted-by":"publisher","first-page":"12701","DOI":"10.1074\/jbc.275.17.12701","volume":"275","author":"M Kuhl","year":"2000","unstructured":"Kuhl M, et al. Ca(2+)\/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J Biol Chem. 2000;275(17):12701\u201311.","journal-title":"J Biol Chem"},{"key":"1236_CR74","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.54056","volume":"9","author":"RO Smith","year":"2020","unstructured":"Smith RO, et al. Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin. Elife. 2020;9: e54056.","journal-title":"Elife"},{"issue":"1","key":"1236_CR75","doi-asserted-by":"publisher","first-page":"20125","DOI":"10.1038\/s41598-022-24414-z","volume":"12","author":"DS Han","year":"2022","unstructured":"Han DS, Lee HJ, Lee EO. Resveratrol suppresses serum-induced vasculogenic mimicry through impairing the EphA2\/twist-VE-cadherin\/AKT pathway in human prostate cancer PC-3 cells. Sci Rep. 2022;12(1):20125.","journal-title":"Sci Rep"},{"issue":"10","key":"1236_CR76","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1007\/s12272-018-1059-6","volume":"41","author":"X Zhu","year":"2018","unstructured":"Zhu X, et al. Paeoniflorin attenuates atRAL-induced oxidative stress, mitochondrial dysfunction and endoplasmic reticulum stress in retinal pigment epithelial cells via triggering Ca(2+)\/CaMKII-dependent activation of AMPK. Arch Pharm Res. 2018;41(10):1009\u201318.","journal-title":"Arch Pharm Res"},{"issue":"2","key":"1236_CR77","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112777","volume":"407","author":"L Liu","year":"2021","unstructured":"Liu L, et al. Proline hydroxylase domain-containing enzymes regulate calcium levels in cardiomyocytes by TRPA1 ion channel. Exp Cell Res. 2021;407(2): 112777.","journal-title":"Exp Cell Res"},{"issue":"10","key":"1236_CR78","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200366RR","volume":"36","author":"J Zou","year":"2022","unstructured":"Zou J, et al. Wnt inhibitory factor 1 ameliorated diabetic retinopathy through the AMPK\/mTOR pathway-mediated mitochondrial function. FASEB J. 2022;36(10): e22531.","journal-title":"FASEB J"},{"issue":"7400","key":"1236_CR79","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nature11066","volume":"485","author":"SM Jeon","year":"2012","unstructured":"Jeon SM, Chandel NS, Hay N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature. 2012;485(7400):661\u20135.","journal-title":"Nature"},{"key":"1236_CR80","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121816","volume":"326","author":"S Yu","year":"2023","unstructured":"Yu S, et al. Patulin alleviates hepatic lipid accumulation by regulating lipogenesis and mitochondrial respiration. Life Sci. 2023;326: 121816.","journal-title":"Life Sci"},{"issue":"6","key":"1236_CR81","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.brainresbull.2003.07.009","volume":"62","author":"A Takahashi","year":"2004","unstructured":"Takahashi A, et al. Oxidative stress-induced apoptosis is associated with alterations in mitochondrial caspase activity and Bcl-2-dependent alterations in mitochondrial pH (pHm). Brain Res Bull. 2004;62(6):497\u2013504.","journal-title":"Brain Res Bull"},{"key":"1236_CR82","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.bbrc.2021.04.082","volume":"559","author":"D Yang","year":"2021","unstructured":"Yang D, et al. CaMK II-induced Drp1 phosphorylation contributes to blue light-induced AIF-mediated necroptosis in retinal R28 cells. Biochem Biophys Res Commun. 2021;559:113\u201320.","journal-title":"Biochem Biophys Res Commun"},{"key":"1236_CR83","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2023.112654","volume":"240","author":"L Wang","year":"2023","unstructured":"Wang L, et al. Long-term blue light exposure impairs mitochondrial dynamics in the retina in light-induced retinal degeneration in vivo and in vitro. J Photochem Photobiol B. 2023;240: 112654.","journal-title":"J Photochem Photobiol B"},{"issue":"6","key":"1236_CR84","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1111\/ceo.13767","volume":"48","author":"E Anitua","year":"2020","unstructured":"Anitua E, et al. Plasma rich in growth factors reduces blue light-induced oxidative damage on retinal pigment epithelial cells and restores their homeostasis by modulating vascular endothelial growth factor and pigment epithelium-derived factor expression. Clin Exp Ophthalmol. 2020;48(6):830\u20138.","journal-title":"Clin Exp Ophthalmol"},{"key":"1236_CR85","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108616","volume":"193","author":"KP Giese","year":"2021","unstructured":"Giese KP. The role of CaMKII autophosphorylation for NMDA receptor-dependent synaptic potentiation. Neuropharmacology. 2021;193: 108616.","journal-title":"Neuropharmacology"},{"key":"1236_CR86","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1007\/s12975-023-01139-3","volume":"15","author":"X Gao","year":"2023","unstructured":"Gao X, et al. Alpha-asarone ameliorates neurological dysfunction of subarachnoid hemorrhagic rats in both acute and recovery phases via regulating the CaMKII-dependent pathways. Transl Stroke Res. 2023;15:476\u201394.","journal-title":"Transl Stroke Res"},{"key":"1236_CR87","first-page":"276","volume":"13","author":"S Wang","year":"2019","unstructured":"Wang S, et al. Pin1 is regulated by CaMKII activation in glutamate-induced retinal neuronal regulated necrosis. Front Cell Neurosci. 2019;13:276.","journal-title":"Front Cell Neurosci"},{"issue":"Suppl 1","key":"1236_CR88","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1186\/1423-0127-17-S1-S5","volume":"17","author":"S Bulley","year":"2010","unstructured":"Bulley S, Shen W. Reciprocal regulation between taurine and glutamate response via Ca2+-dependent pathways in retinal third-order neurons. J Biomed Sci. 2010;17(Suppl 1):S5.","journal-title":"J Biomed Sci"},{"issue":"8","key":"1236_CR89","doi-asserted-by":"publisher","first-page":"5515","DOI":"10.1167\/iovs.10-6870","volume":"52","author":"PS Ganapathy","year":"2011","unstructured":"Ganapathy PS, et al. The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells. Invest Ophthalmol Vis Sci. 2011;52(8):5515\u201324.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1236_CR90","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3389\/fncel.2017.00425","volume":"11","author":"S Wang","year":"2017","unstructured":"Wang S, et al. Pin1 promotes regulated necrosis induced by glutamate in rat retinal neurons via CAST\/Calpain2 pathway. Front Cell Neurosci. 2017;11:425.","journal-title":"Front Cell Neurosci"},{"issue":"5","key":"1236_CR91","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/s11596-016-1639-y","volume":"36","author":"S Chen","year":"2016","unstructured":"Chen S, et al. Inhibition of calpain on oxygen glucose deprivation-induced RGC-5 necroptosis. J Huazhong Univ Sci Technolog Med Sci. 2016;36(5):639\u201345.","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"issue":"5","key":"1236_CR92","doi-asserted-by":"publisher","first-page":"E1133","DOI":"10.1152\/ajpendo.90944.2008","volume":"296","author":"J Chen","year":"2009","unstructured":"Chen J, et al. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein. Am J Physiol Endocrinol Metab. 2009;296(5):E1133\u20139.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"12","key":"1236_CR93","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.3390\/ijms18122720","volume":"18","author":"S Deguchi","year":"2017","unstructured":"Deguchi S, et al. Ophthalmic formulation containing nilvadipine nanoparticles prevents retinal dysfunction in rats injected with streptozotocin. Int J Mol Sci. 2017;18(12):2720.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1236_CR94","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/S0022-5320(58)90050-9","volume":"2","author":"FS Sjostrand","year":"1958","unstructured":"Sjostrand FS. Ultrastructure of retinal rod synapses of the guinea pig eye as revealed by three-dimensional reconstructions from serial sections. J Ultrastruct Res. 1958;2(1):122\u201370.","journal-title":"J Ultrastruct Res"},{"issue":"10","key":"1236_CR95","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1016\/j.bpj.2017.08.012","volume":"113","author":"P Datta","year":"2017","unstructured":"Datta P, et al. Two pools of vesicles associated with synaptic ribbons are molecularly prepared for release. Biophys J. 2017;113(10):2281\u201398.","journal-title":"Biophys J"},{"issue":"6","key":"1236_CR96","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/S0092-8674(00)81404-X","volume":"92","author":"T Weber","year":"1998","unstructured":"Weber T, et al. SNAREpins: minimal machinery for membrane fusion. Cell. 1998;92(6):759\u201372.","journal-title":"Cell"},{"issue":"1","key":"1236_CR97","doi-asserted-by":"publisher","first-page":"9261","DOI":"10.1038\/s41598-022-09654-3","volume":"12","author":"C Gething","year":"2022","unstructured":"Gething C, et al. Conformational change of Syntaxin-3b in regulating SNARE complex assembly in the ribbon synapses. Sci Rep. 2022;12(1):9261.","journal-title":"Sci Rep"},{"issue":"5","key":"1236_CR98","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1002\/cne.21806","volume":"510","author":"LB Curtis","year":"2008","unstructured":"Curtis LB, et al. Syntaxin 3b is a t-SNARE specific for ribbon synapses of the retina. J Comp Neurol. 2008;510(5):550\u20139.","journal-title":"J Comp Neurol"},{"key":"1236_CR99","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.mcn.2014.03.002","volume":"60","author":"X Liu","year":"2014","unstructured":"Liu X, Heidelberger R, Janz R. Phosphorylation of syntaxin 3B by CaMKII regulates the formation of t-SNARE complexes. Mol Cell Neurosci. 2014;60:53\u201362.","journal-title":"Mol Cell Neurosci"},{"key":"1236_CR100","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3389\/fpsyg.2018.00008","volume":"9","author":"A Reeves","year":"2018","unstructured":"Reeves A, Grayhem R, Hwang AD. Rapid adaptation of night vision. Front Psychol. 2018;9:8.","journal-title":"Front Psychol"},{"issue":"Pt 3","key":"1236_CR101","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1111\/j.1469-7793.1997.571ba.x","volume":"505","author":"J Burrone","year":"1997","unstructured":"Burrone J, Lagnado L. Electrical resonance and Ca2+ influx in the synaptic terminal of depolarizing bipolar cells from the goldfish retina. J Physiol. 1997;505(Pt 3):571\u201384.","journal-title":"J Physiol"},{"issue":"11","key":"1236_CR102","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1085\/jgp.201912419","volume":"151","author":"NT Ingram","year":"2019","unstructured":"Ingram NT, Sampath AP, Fain GL. Voltage-clamp recordings of light responses from wild-type and mutant mouse cone photoreceptors. J Gen Physiol. 2019;151(11):1287\u201399.","journal-title":"J Gen Physiol"},{"issue":"4","key":"1236_CR103","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1124\/mol.108.048447","volume":"74","author":"F Binda","year":"2008","unstructured":"Binda F, et al. Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux. Mol Pharmacol. 2008;74(4):1101\u20138.","journal-title":"Mol Pharmacol"},{"key":"1236_CR104","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.brainres.2016.01.039","volume":"1635","author":"Q Li","year":"2016","unstructured":"Li Q, et al. Suppression of outward K+ currents by activating dopamine D1 receptors in rat retinal ganglion cells through PKA and CaMKII signaling pathways. Brain Res. 2016;1635:95\u2013104.","journal-title":"Brain Res"},{"key":"1236_CR105","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.neuropharm.2017.04.027","volume":"124","author":"W-J Qian","year":"2017","unstructured":"Qian W-J, et al. Cannabinoid CB1 and CB2 receptors differentially modulate L- and T-type Ca 2+ channels in rat retinal ganglion cells. Neuropharmacology. 2017;124:143\u201356.","journal-title":"Neuropharmacology"},{"issue":"6","key":"1236_CR106","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1007\/s12264-022-00826-9","volume":"38","author":"T Zhang","year":"2022","unstructured":"Zhang T, et al. Signaling mechanism for modulation by GLP-1 and Exendin-4 of GABA receptors on rat retinal ganglion cells. Neurosci Bull. 2022;38(6):622\u201336.","journal-title":"Neurosci Bull"},{"key":"1236_CR107","doi-asserted-by":"crossref","unstructured":"Musada GR, Carmy-Bennun, T, Hackam AS. Identification of a novel axon regeneration role for noncanonical Wnt signaling in the adult retina after injury. Eneuro. 2022;9(4).","DOI":"10.1523\/ENEURO.0182-22.2022"},{"issue":"18","key":"1236_CR108","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1001\/jama.2014.3192","volume":"311","author":"RN Weinreb","year":"2014","unstructured":"Weinreb RN, Aung T, Medeiros FA. The pathophysiology and treatment of glaucoma: a review. JAMA. 2014;311(18):1901\u201311.","journal-title":"JAMA"},{"issue":"1","key":"1236_CR109","doi-asserted-by":"publisher","first-page":"3209","DOI":"10.1038\/s41467-018-05681-9","volume":"9","author":"H Chen","year":"2018","unstructured":"Chen H, et al. Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma. Nat Commun. 2018;9(1):3209.","journal-title":"Nat Commun"},{"issue":"6","key":"1236_CR110","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.preteyeres.2012.07.001","volume":"31","author":"DJ Calkins","year":"2012","unstructured":"Calkins DJ. Critical pathogenic events underlying progression of neurodegeneration in glaucoma. Prog Retin Eye Res. 2012;31(6):702\u201319.","journal-title":"Prog Retin Eye Res"},{"issue":"16","key":"1236_CR111","doi-asserted-by":"publisher","first-page":"4299","DOI":"10.1016\/j.cell.2021.06.031","volume":"184","author":"X Guo","year":"2021","unstructured":"Guo X, et al. Preservation of vision after CaMKII-mediated protection of retinal ganglion cells. Cell. 2021;184(16):4299-4314.e12.","journal-title":"Cell"},{"issue":"4","key":"1236_CR112","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190930","volume":"217","author":"W Liu","year":"2020","unstructured":"Liu W, et al. Neuronal Epac1 mediates retinal neurodegeneration in mouse models of ocular hypertension. J Exp Med. 2020;217(4): e20190930.","journal-title":"J Exp Med"},{"issue":"2 Pt 3","key":"1236_CR113","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.gene.2015.09.029","volume":"575","author":"K Sugawara","year":"2016","unstructured":"Sugawara K, et al. Structure and functional roles of Epac2 (Rapgef4). Gene. 2016;575(2 Pt 3):577\u201383.","journal-title":"Gene"},{"key":"1236_CR114","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108683","volume":"209","author":"K Ji","year":"2021","unstructured":"Ji K, et al. Resveratrol attenuates retinal ganglion cell loss in a mouse model of retinal ischemia reperfusion injury via multiple pathways. Exp Eye Res. 2021;209: 108683.","journal-title":"Exp Eye Res"},{"issue":"1","key":"1236_CR115","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0896-6273(00)80026-4","volume":"16","author":"K Deisseroth","year":"1996","unstructured":"Deisseroth K, Bito H, Tsien RW. Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron. 1996;16(1):89\u2013101.","journal-title":"Neuron"},{"issue":"Pt C","key":"1236_CR116","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.neuropharm.2013.04.005","volume":"76","author":"G Leal","year":"2014","unstructured":"Leal G, Comprido D, Duarte CB. BDNF-induced local protein synthesis and synaptic plasticity. Neuropharmacology. 2014;76(Pt C):639\u201356.","journal-title":"Neuropharmacology"},{"issue":"4","key":"1236_CR117","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/nrn1078","volume":"4","author":"MV Chao","year":"2003","unstructured":"Chao MV. Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci. 2003;4(4):299\u2013309.","journal-title":"Nat Rev Neurosci"},{"issue":"11","key":"1236_CR118","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1038\/nn1102-1131","volume":"5","author":"G Dechant","year":"2002","unstructured":"Dechant G, Barde Y-A. The neurotrophin receptor p75NTR: novel functions and implications for diseases of the nervous system. Nat Neurosci. 2002;5(11):1131\u20136.","journal-title":"Nat Neurosci"},{"issue":"1","key":"1236_CR119","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1756-6606-2-27","volume":"2","author":"H Koshimizu","year":"2009","unstructured":"Koshimizu H, et al. Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival. Mol Brain. 2009;2(1):27.","journal-title":"Mol Brain"},{"issue":"7","key":"1236_CR120","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1167\/iovs.02-0620","volume":"44","author":"T Shou","year":"2003","unstructured":"Shou T, et al. Differential dendritic shrinkage of \u03b1 and \u03b2 retinal ganglion cells in cats with chronic glaucoma. Invest Ophthalmol Vis Sci. 2003;44(7):3005\u201310.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"1236_CR121","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.037184","volume":"12","author":"HL Park","year":"2019","unstructured":"Park HL, et al. Increased levels of synaptic proteins involved in synaptic plasticity after chronic intraocular pressure elevation and modulation by brain-derived neurotrophic factor in a glaucoma animal model. Dis Model Mech. 2019;12(6): dmm037184.","journal-title":"Dis Model Mech"},{"issue":"1\u20132","key":"1236_CR122","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0006-8993(02)03932-X","volume":"962","author":"H Takano","year":"2003","unstructured":"Takano H, et al. Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization. Brain Res. 2003;962(1\u20132):41\u20137.","journal-title":"Brain Res"},{"issue":"1","key":"1236_CR123","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1096\/fj.02-0157fje","volume":"17","author":"AM Joussen","year":"2003","unstructured":"Joussen AM, et al. Suppression of Fas-FasL-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes. FASEB J. 2003;17(1):76\u20138.","journal-title":"FASEB J"},{"issue":"2","key":"1236_CR124","first-page":"433","volume":"42","author":"B Sander","year":"2001","unstructured":"Sander B, et al. Diabetic macular edema: passive and active transport of fluorescein through the blood-retina barrier. Invest Ophthalmol Vis Sci. 2001;42(2):433\u20138.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"1236_CR125","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1038\/aps.2012.61","volume":"33","author":"J Li","year":"2012","unstructured":"Li J, et al. Calcium mediates high glucose-induced HIF-1\u03b1 and VEGF expression in cultured rat retinal Muller cells through CaMKII-CREB pathway. Acta Pharmacol Sin. 2012;33(8):1030\u20136.","journal-title":"Acta Pharmacol Sin"},{"issue":"11","key":"1236_CR126","doi-asserted-by":"publisher","first-page":"11776","DOI":"10.1096\/fj.201802614RRR","volume":"33","author":"T Zhang","year":"2019","unstructured":"Zhang T, et al. Erianin alleviates diabetic retinopathy by reducing retinal inflammation initiated by microglial cells via inhibiting hyperglycemia-mediated ERK1\/2-NF-\u03baB signaling pathway. FASEB J. 2019;33(11):11776\u201390.","journal-title":"FASEB J"},{"issue":"9","key":"1236_CR127","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1038\/emboj.2008.73","volume":"27","author":"E Mathes","year":"2008","unstructured":"Mathes E, et al. NF-\u03baB dictates the degradation pathway of I\u03baB\u03b1. EMBO J. 2008;27(9):1357\u201367.","journal-title":"EMBO J"},{"key":"1236_CR128","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117146","volume":"241","author":"W-J Liang","year":"2020","unstructured":"Liang W-J, et al. HMGB1 upregulates NF-kB by inhibiting IKB-\u03b1 and associates with diabetic retinopathy. Life Sci. 2020;241: 117146.","journal-title":"Life Sci"},{"issue":"1","key":"1236_CR129","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13578-022-00839-x","volume":"12","author":"D Sbardella","year":"2022","unstructured":"Sbardella D, et al. A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose. Cell Biosci. 2022;12(1):108.","journal-title":"Cell Biosci"},{"issue":"5","key":"1236_CR130","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14084","volume":"46","author":"H Ma","year":"2022","unstructured":"Ma H, Li J. The ginger extract could improve diabetic retinopathy by inhibiting the expression of e\/iNOS and G6PDH, apoptosis, inflammation, and angiogenesis. J Food Biochem. 2022;46(5): e14084.","journal-title":"J Food Biochem"},{"key":"1236_CR131","doi-asserted-by":"publisher","first-page":"3059763","DOI":"10.1155\/2017\/3059763","volume":"2017","author":"W Chen","year":"2017","unstructured":"Chen W, et al. Danhong Huayu Koufuye prevents diabetic retinopathy in streptozotocin-induced diabetic rats via antioxidation and anti-inflammation. Mediators Inflamm. 2017;2017:3059763.","journal-title":"Mediators Inflamm"},{"issue":"11","key":"1236_CR132","doi-asserted-by":"publisher","first-page":"5257","DOI":"10.1167\/iovs.07-0112","volume":"48","author":"EC Leal","year":"2007","unstructured":"Leal EC, et al. Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2007;48(11):5257\u201365.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"1236_CR133","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1159\/000191468","volume":"29","author":"Z Tumur","year":"2009","unstructured":"Tumur Z, Niwa T. Indoxyl sulfate inhibits nitric oxide production and cell viability by inducing oxidative stress in vascular endothelial cells. Am J Nephrol. 2009;29(6):551\u20137.","journal-title":"Am J Nephrol"},{"issue":"3","key":"1236_CR134","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s10059-011-0038-2","volume":"31","author":"YH Kim","year":"2011","unstructured":"Kim YH, et al. CaMKII regulates pericyte loss in the retina of early diabetic mouse. Mol Cells. 2011;31(3):289\u201393.","journal-title":"Mol Cells"},{"issue":"3","key":"1236_CR135","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1159\/000447826","volume":"39","author":"J Li","year":"2016","unstructured":"Li J, et al. Curcumin attenuates retinal vascular leakage by inhibiting calcium\/calmodulin-dependent protein kinase II activity in streptozotocin-induced diabetes. Cell Physiol Biochem. 2016;39(3):1196\u2013208.","journal-title":"Cell Physiol Biochem"},{"key":"1236_CR136","first-page":"2371","volume":"18","author":"J Li","year":"2012","unstructured":"Li J, et al. Calcium entry mediates hyperglycemia-induced apoptosis through Ca(2+)\/calmodulin-dependent kinase II in retinal capillary endothelial cells. Mol Vis. 2012;18:2371\u20139.","journal-title":"Mol Vis"},{"issue":"4","key":"1236_CR137","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1096\/fj.15-279802","volume":"30","author":"F Monickaraj","year":"2016","unstructured":"Monickaraj F, et al. Cathepsin D: an Mvarphi-derived factor mediating increased endothelial cell permeability with implications for alteration of the blood-retinal barrier in diabetic retinopathy. FASEB J. 2016;30(4):1670\u201382.","journal-title":"FASEB J"},{"issue":"5","key":"1236_CR138","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1096\/fj.201700781RR","volume":"32","author":"F Monickaraj","year":"2018","unstructured":"Monickaraj F, McGuire P, Das A. Cathepsin D plays a role in endothelial-pericyte interactions during alteration of the blood-retinal barrier in diabetic retinopathy. FASEB J. 2018;32(5):2539\u201348.","journal-title":"FASEB J"},{"issue":"6294","key":"1236_CR139","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/347677a0","volume":"347","author":"C Bowes","year":"1990","unstructured":"Bowes C, et al. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. Nature. 1990;347(6294):677\u201380.","journal-title":"Nature"},{"issue":"6000","key":"1236_CR140","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/313310a0","volume":"313","author":"EE Fesenko","year":"1985","unstructured":"Fesenko EE, Kolesnikov SS, Lyubarsky AL. Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment. Nature. 1985;313(6000):310\u20133.","journal-title":"Nature"},{"issue":"12","key":"1236_CR141","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0278857","volume":"17","author":"K-W Koch","year":"2022","unstructured":"Koch K-W, et al. The impact of modifier genes on cone-rod dystrophy heterogeneity: an explorative familial pilot study and a hypothesis on neurotransmission impairment. PLoS ONE. 2022;17(12): e0278857.","journal-title":"PLoS ONE"},{"issue":"1","key":"1236_CR142","doi-asserted-by":"publisher","first-page":"19332","DOI":"10.1038\/s41598-021-98677-3","volume":"11","author":"AU Rehman","year":"2021","unstructured":"Rehman AU, et al. Whole exome sequencing in 17 consanguineous Iranian pedigrees expands the mutational spectrum of inherited retinal dystrophies. Sci Rep. 2021;11(1):19332.","journal-title":"Sci Rep"},{"issue":"12","key":"1236_CR143","doi-asserted-by":"publisher","first-page":"4321","DOI":"10.3390\/ijms21124321","volume":"21","author":"C Scimone","year":"2020","unstructured":"Scimone C, et al. Germline mutation enrichment in pathways controlling endothelial cell homeostasis in patients with brain arteriovenous malformation: implication for molecular diagnosis. Int J Mol Sci. 2020;21(12):4321.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"1236_CR144","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1074\/mcp.M500217-MCP200","volume":"5","author":"SM Hauck","year":"2006","unstructured":"Hauck SM, et al. Differential modification of phosducin protein in degenerating rd1 retina is associated with constitutively active Ca2+\/calmodulin kinase II in rod outer segments. Mol Cell Proteomics. 2006;5(2):324\u201336.","journal-title":"Mol Cell Proteomics"},{"issue":"18","key":"1236_CR145","doi-asserted-by":"publisher","first-page":"19149","DOI":"10.1074\/jbc.M311058200","volume":"279","author":"M Sokolov","year":"2004","unstructured":"Sokolov M, et al. Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse. J Biol Chem. 2004;279(18):19149\u201356.","journal-title":"J Biol Chem"},{"issue":"26","key":"1236_CR146","doi-asserted-by":"publisher","first-page":"23805","DOI":"10.1074\/jbc.M101482200","volume":"276","author":"CD Thulin","year":"2001","unstructured":"Thulin CD, et al. Modulation of the G protein regulator phosducin by Ca2+\/calmodulin-dependent protein kinase II phosphorylation and 14-3-3 protein binding. J Biol Chem. 2001;276(26):23805\u201315.","journal-title":"J Biol Chem"},{"issue":"Pt 2","key":"1236_CR147","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.1469-7793.2000.00327.x","volume":"528","author":"RA Shiells","year":"2000","unstructured":"Shiells RA, Falk G. Activation of Ca2+\u2013calmodulin kinase II induces desensitization by background light in dogfish retinal \u2018on\u2019 bipolar cells. J Physiol. 2000;528(Pt 2):327\u201338.","journal-title":"J Physiol"},{"issue":"1","key":"1236_CR148","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1002\/cne.20314","volume":"479","author":"K Schultz","year":"2004","unstructured":"Schultz K, et al. Calcium-binding protein Caldendrin and CaMKII are localized in spinules of the carp retina. J Comp Neurol. 2004;479(1):84\u201393.","journal-title":"J Comp Neurol"},{"issue":"1","key":"1236_CR149","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1167\/iovs.10-5744","volume":"52","author":"AM Fontainhas","year":"2011","unstructured":"Fontainhas AM, Townes-Anderson E. RhoA inactivation prevents photoreceptor axon retraction in an in vitro model of acute retinal detachment. Invest Ophthalmol Vis Sci. 2011;52(1):579\u201387.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"1236_CR150","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1167\/iovs.63.11.11","volume":"63","author":"D Caravaca-Rodriguez","year":"2022","unstructured":"Caravaca-Rodriguez D, et al. Implications of neural plasticity in retinal prosthesis. Invest Ophthalmol Vis Sci. 2022;63(11):11.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"1236_CR151","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.bbrc.2003.12.034","volume":"313","author":"Y Takano","year":"2004","unstructured":"Takano Y, et al. Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse. Biochem Biophys Res Commun. 2004;313(4):1015\u201322.","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"1236_CR152","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1038\/13508","volume":"5","author":"M Frasson","year":"1999","unstructured":"Frasson M, et al. Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse. Nat Med. 1999;5(10):1183\u20137.","journal-title":"Nat Med"},{"issue":"6","key":"1236_CR153","first-page":"1912","volume":"43","author":"BS Pawlyk","year":"2002","unstructured":"Pawlyk BS, et al. Absence of photoreceptor rescue with D-cis-diltiazem in the rd mouse. Invest Ophthalmol Vis Sci. 2002;43(6):1912\u20135.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"1236_CR154","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","volume":"123","author":"BA Holden","year":"2016","unstructured":"Holden BA, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050. Ophthalmology. 2016;123(5):1036\u201342.","journal-title":"Ophthalmology"},{"issue":"7","key":"1236_CR155","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1016\/j.ymthe.2021.02.025","volume":"29","author":"D Li","year":"2021","unstructured":"Li D, et al. Targeting choroidal vascular dysfunction via inhibition of circRNA-FoxO1 for prevention and management of myopic pathology. Mol Ther. 2021;29(7):2268\u201380.","journal-title":"Mol Ther"},{"issue":"12","key":"1236_CR156","doi-asserted-by":"publisher","first-page":"3549","DOI":"10.1007\/s00417-023-06158-2","volume":"261","author":"W Wu","year":"2023","unstructured":"Wu W, Xu Y, Zhang F. Comparisons of the protein expressions between high myopia and moderate myopia on the anterior corneal stroma in human. Graefes Arch Clin Exp Ophthalmol. 2023;261(12):3549\u201358.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"1","key":"1236_CR157","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1038\/s42003-023-05267-2","volume":"6","author":"C Geng","year":"2023","unstructured":"Geng C, et al. Targeting the cochlin\/SFRP1\/CaMKII axis in the ocular posterior pole prevents the progression of nonpathologic myopia. Commun Biol. 2023;6(1):884.","journal-title":"Commun Biol"},{"key":"1236_CR158","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.2147\/IJGM.S354935","volume":"15","author":"W Lai","year":"2022","unstructured":"Lai W, Wu X, Liang H. Identification of the potential key genes and pathways involved in lens changes of high myopia. Int J Gen Med. 2022;15:2867\u201375.","journal-title":"Int J Gen Med"},{"issue":"1","key":"1236_CR159","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1096\/fj.11-192914","volume":"26","author":"Y Lin","year":"2012","unstructured":"Lin Y, et al. Retinoid receptors trigger neuritogenesis in retinal degenerations. FASEB J. 2012;26(1):81\u201392.","journal-title":"FASEB J"},{"issue":"12","key":"1236_CR160","doi-asserted-by":"publisher","first-page":"7139","DOI":"10.1073\/pnas.95.12.7139","volume":"95","author":"R Weiler","year":"1998","unstructured":"Weiler R, et al. Retinoic acid has light-adaptive effects on horizontal cells in the retina. Proc Natl Acad Sci U S A. 1998;95(12):7139\u201344.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1236_CR161","first-page":"9","volume":"5","author":"T Duncan","year":"1999","unstructured":"Duncan T, et al. Levels of retinoic acid and retinaldehyde dehydrogenase expression in eyes of the Mitf-vit mouse model of retinal degeneration. Mol Vis. 1999;5:9.","journal-title":"Mol Vis"},{"issue":"1\u20133","key":"1236_CR162","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.cbi.2012.11.019","volume":"202","author":"R Bchini","year":"2013","unstructured":"Bchini R, et al. Retinoic acid biosynthesis catalyzed by retinal dehydrogenases relies on a rate-limiting conformational transition associated with substrate recognition. Chem Biol Interact. 2013;202(1\u20133):78\u201384.","journal-title":"Chem Biol Interact"},{"issue":"28","key":"1236_CR163","doi-asserted-by":"publisher","first-page":"7567","DOI":"10.1021\/bi800357b","volume":"47","author":"M Kono","year":"2008","unstructured":"Kono M, Goletz PW, Crouch RK. 11-cis- and all-trans-retinols can activate rod opsin: rational design of the visual cycle. Biochemistry. 2008;47(28):7567\u201371.","journal-title":"Biochemistry"},{"issue":"6700","key":"1236_CR164","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/26515","volume":"395","author":"L Solomin","year":"1998","unstructured":"Solomin L, et al. Retinoid-X receptor signalling in the developing spinal cord. Nature. 1998;395(6700):398\u2013402.","journal-title":"Nature"},{"issue":"5","key":"1236_CR165","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1172\/JCI30779","volume":"117","author":"J Si","year":"2007","unstructured":"Si J, Mueller L, Collins SJ. CaMKII regulates retinoic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells. J Clin Invest. 2007;117(5):1412\u201321.","journal-title":"J Clin Invest"},{"key":"1236_CR166","doi-asserted-by":"crossref","unstructured":"Yang YC, et al. Inhibition of oxidative stress-induced epithelial-mesenchymal transition in retinal pigment epithelial cells of age-related macular degeneration model by suppressing ERK activation. J Adv Res 2023.","DOI":"10.1016\/j.jare.2023.06.004"},{"issue":"4","key":"1236_CR167","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/eye.2011.7","volume":"25","author":"L Zhang","year":"2011","unstructured":"Zhang L, et al. Calcium overload is associated with lipofuscin formation in human retinal pigment epithelial cells fed with photoreceptor outer segments. Eye (Lond). 2011;25(4):519\u201327.","journal-title":"Eye (Lond)"},{"issue":"2","key":"1236_CR168","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1167\/iovs.14-15299","volume":"56","author":"IH Yang","year":"2015","unstructured":"Yang IH, et al. Involvement of intracellular calcium mobilization in IL-8 activation in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2015;56(2):761\u20139.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1236_CR169","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1146\/annurev-pharmtox-051421-111814","volume":"63","author":"OE Reyes Gaido","year":"2023","unstructured":"Reyes Gaido OE, et al. CaMKII as a therapeutic target in cardiovascular disease. Annu Rev Pharmacol Toxicol. 2023;63:249\u201372.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"7","key":"1236_CR170","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1007\/s11064-019-02785-6","volume":"44","author":"Y Wei","year":"2019","unstructured":"Wei Y, Wang R, Teng J. Inhibition of calcium\/calmodulin-dependent protein kinase II\u03b1 suppresses oxidative stress in cerebral ischemic rats through targeting glucose 6-phosphate dehydrogenase. Neurochem Res. 2019;44(7):1613\u201320.","journal-title":"Neurochem Res"},{"issue":"10","key":"1236_CR171","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025245","volume":"6","author":"SJ Coultrap","year":"2011","unstructured":"Coultrap SJ, Bayer KU. Improving a natural CaMKII inhibitor by random and rational design. PLoS ONE. 2011;6(10): e25245.","journal-title":"PLoS ONE"},{"issue":"7","key":"1236_CR172","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1016\/j.jmb.2019.02.001","volume":"431","author":"MH Wong","year":"2019","unstructured":"Wong MH, et al. The KN-93 molecule inhibits calcium\/calmodulin-dependent protein kinase II (CaMKII) activity by binding to Ca(2+)\/CaM. J Mol Biol. 2019;431(7):1440\u201359.","journal-title":"J Mol Biol"},{"issue":"6","key":"1236_CR173","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.neuint.2004.12.005","volume":"46","author":"R Paes-de-Carvalho","year":"2005","unstructured":"Paes-de-Carvalho R, et al. Activation of glutamate receptors promotes a calcium-dependent and transporter-mediated release of purines in cultured avian retinal cells: possible involvement of calcium\/calmodulin-dependent protein kinase II. Neurochem Int. 2005;46(6):441\u201351.","journal-title":"Neurochem Int"},{"issue":"4","key":"1236_CR174","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1097\/WNR.0000000000002000","volume":"35","author":"S Li","year":"2024","unstructured":"Li S, et al. Electroacupuncture alleviates streptozotocin-induced diabetic neuropathic pain via suppressing phosphorylated CaMKII\u03b1 in rats. NeuroReport. 2024;35(4):258\u201368.","journal-title":"NeuroReport"},{"key":"1236_CR175","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jare.2022.03.005","volume":"43","author":"C-C Hsieh","year":"2023","unstructured":"Hsieh C-C, et al. TRPM1 promotes tumor progression in acral melanoma by activating the Ca2+\/CaMKII\u03b4\/AKT pathway. J Adv Res. 2023;43:45\u201357.","journal-title":"J Adv Res"},{"key":"1236_CR176","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3389\/fphar.2014.00021","volume":"5","author":"P Pellicena","year":"2014","unstructured":"Pellicena P, Schulman H. CaMKII inhibitors: from research tools to therapeutic agents. Front Pharmacol. 2014;5:21.","journal-title":"Front Pharmacol"},{"issue":"Pt B","key":"1236_CR177","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.yjmcc.2015.10.012","volume":"89","author":"B Hegyi","year":"2015","unstructured":"Hegyi B, et al. KN-93 inhibits IKr in mammalian cardiomyocytes. J Mol Cell Cardiol. 2015;89(Pt B):173\u20136.","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"1236_CR178","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1042\/BJ20121418","volume":"451","author":"Y Gao","year":"2013","unstructured":"Gao Y, et al. A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. Biochem J. 2013;451(2):313\u201328.","journal-title":"Biochem J"},{"key":"1236_CR179","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117016","volume":"318","author":"H Zhang","year":"2024","unstructured":"Zhang H, et al. Jiawei-Xiaoyao pill elicits a rapid antidepressant effect, dependent on activating CaMKII\/mTOR\/BDNF signaling pathway in the hippocampus. J Ethnopharmacol. 2024;318: 117016.","journal-title":"J Ethnopharmacol"},{"issue":"18","key":"1236_CR180","doi-asserted-by":"publisher","first-page":"10890","DOI":"10.1073\/pnas.95.18.10890","volume":"95","author":"BH Chang","year":"1998","unstructured":"Chang BH, Mukherji S, Soderling TR. Characterization of a calmodulin kinase II inhibitor protein in brain. Proc Natl Acad Sci U S A. 1998;95(18):10890\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"1236_CR181","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S0306-4522(00)00520-0","volume":"102","author":"BH Chang","year":"2001","unstructured":"Chang BH, Mukherji S, Soderling TR. Calcium\/calmodulin-dependent protein kinase II inhibitor protein: localization of isoforms in rat brain. Neuroscience. 2001;102(4):767\u201377.","journal-title":"Neuroscience"},{"issue":"12","key":"1236_CR182","doi-asserted-by":"publisher","first-page":"5024","DOI":"10.1091\/mbc.e07-02-0185","volume":"18","author":"RS Vest","year":"2007","unstructured":"Vest RS, et al. Dual mechanism of a natural CaMKII inhibitor. Mol Biol Cell. 2007;18(12):5024\u201333.","journal-title":"Mol Biol Cell"},{"issue":"1","key":"1236_CR183","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s12031-016-0830-8","volume":"61","author":"ME Ahmed","year":"2017","unstructured":"Ahmed ME, et al. Beneficial effects of a CaMKII\u03b1 inhibitor TatCN21 peptide in global cerebral ischemia. J Mol Neurosci. 2017;61(1):42\u201351.","journal-title":"J Mol Neurosci"},{"issue":"6","key":"1236_CR184","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1111\/j.1601-183X.2010.00595.x","volume":"9","author":"K Radwanska","year":"2010","unstructured":"Radwanska K, et al. Differential regulation of CaMKII inhibitor beta protein expression after exposure to a novel context and during contextual fear memory formation. Genes Brain Behav. 2010;9(6):648\u201357.","journal-title":"Genes Brain Behav"},{"issue":"5594","key":"1236_CR185","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1126\/science.1072873","volume":"298","author":"M Aarts","year":"2002","unstructured":"Aarts M, et al. Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions. Science. 2002;298(5594):846\u201350.","journal-title":"Science"},{"issue":"2","key":"1236_CR186","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3390\/ph16020277","volume":"16","author":"X Zhang","year":"2023","unstructured":"Zhang X, et al. Targeting mitochondrial dysfunction in neurodegenerative diseases: expanding the therapeutic approaches by plant-derived natural products. Pharmaceuticals (Basel). 2023;16(2):277.","journal-title":"Pharmaceuticals (Basel)"},{"issue":"8","key":"1236_CR187","doi-asserted-by":"publisher","first-page":"3602","DOI":"10.1167\/iovs.07-0131","volume":"48","author":"KS Shindler","year":"2007","unstructured":"Shindler KS, et al. SIRT1 activation confers neuroprotection in experimental optic neuritis. Invest Ophthalmol Vis Sci. 2007;48(8):3602\u20139.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"1236_CR188","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.neuroscience.2006.02.054","volume":"140","author":"Y Yamagata","year":"2006","unstructured":"Yamagata Y, Imoto K, Obata K. A mechanism for the inactivation of Ca2+\/calmodulin-dependent protein kinase II during prolonged seizure activity and its consequence after the recovery from seizure activity in rats in vivo. Neuroscience. 2006;140(3):981\u201392.","journal-title":"Neuroscience"},{"issue":"7","key":"1236_CR189","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.2337\/db09-1431","volume":"59","author":"YH Kim","year":"2010","unstructured":"Kim YH, et al. Resveratrol inhibits neuronal apoptosis and elevated Ca2+\/calmodulin-dependent protein kinase II activity in diabetic mouse retina. Diabetes. 2010;59(7):1825\u201335.","journal-title":"Diabetes"},{"issue":"7","key":"1236_CR190","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1167\/iovs.64.7.2","volume":"64","author":"K Xiao","year":"2023","unstructured":"Xiao K, et al. Low-dose trans-resveratrol ameliorates diabetes-induced retinal ganglion cell degeneration via TyrRS\/c-Jun pathway. Invest Opthalmol Vis Sci. 2023;64(7):2.","journal-title":"Invest Opthalmol Vis Sci"},{"issue":"1","key":"1236_CR191","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1080\/19768354.2023.2226695","volume":"27","author":"W Yan","year":"2023","unstructured":"Yan W, et al. The impacts of resveratrol on the retinal degeneration in a rat model of retinitis pigmentosa induced by alkylation: an in-vivo study. Anim Cells Syst. 2023;27(1):138\u201348.","journal-title":"Anim Cells Syst"},{"issue":"1","key":"1236_CR192","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1021\/acsnano.2c05824","volume":"17","author":"DD Nguyen","year":"2022","unstructured":"Nguyen DD, et al. Highly retina-permeating and long-acting resveratrol\/metformin nanotherapeutics for enhanced treatment of macular degeneration. ACS Nano. 2022;17(1):168\u201383.","journal-title":"ACS Nano"},{"issue":"2","key":"1236_CR193","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1167\/iovs.10-5966","volume":"52","author":"A Matteucci","year":"2011","unstructured":"Matteucci A, et al. Curcumin protects against NMDA-induced toxicity: a possible role for NR2A subunit. Invest Ophthalmol Vis Sci. 2011;52(2):1070\u20137.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"1236_CR194","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1007\/s10571-018-0595-4","volume":"38","author":"C Mallozzi","year":"2018","unstructured":"Mallozzi C, et al. Curcumin modulates the NMDA receptor subunit composition through a mechanism involving CaMKII and Ser\/Thr protein phosphatases. Cell Mol Neurobiol. 2018;38(6):1315\u201320.","journal-title":"Cell Mol Neurobiol"},{"issue":"10","key":"1236_CR195","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1007\/s00417-023-06082-5","volume":"261","author":"A Ertu\u011frul","year":"2023","unstructured":"Ertu\u011frul A, \u00d6zkaya D, Naz\u0131ro\u011flu M. Curcumin attenuates hydroxychloroquine-mediated apoptosis and oxidative stress via the inhibition of TRPM2 channel signalling pathways in a retinal pigment epithelium cell line. Graefes Arch Clin Exp Ophthalmol. 2023;261(10):2829\u201344.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"1236_CR196","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308635","volume":"11","author":"YC Liu","year":"2024","unstructured":"Liu YC, et al. Injectable, Antioxidative, and Tissue-Adhesive Nanocomposite Hydrogel as a Potential Treatment for Inner Retina Injuries. Advanced Science. 2024;11: e2308635.","journal-title":"Advanced Science"}],"container-title":["Cell &amp; Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13578-024-01236-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13578-024-01236-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13578-024-01236-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T16:31:11Z","timestamp":1715272271000},"score":1,"resource":{"primary":{"URL":"https:\/\/cellandbioscience.biomedcentral.com\/articles\/10.1186\/s13578-024-01236-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,9]]},"references-count":196,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1236"],"URL":"https:\/\/doi.org\/10.1186\/s13578-024-01236-2","relation":{},"ISSN":["2045-3701"],"issn-type":[{"value":"2045-3701","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,9]]},"assertion":[{"value":"6 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"59"}}