{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:55:40Z","timestamp":1793836540152,"version":"4.6.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2020B1212060052"],"award-info":[{"award-number":["2020B1212060052"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biosci"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Ototoxicity is a major side effect of many broadly used aminoglycoside antibiotics (AGs) and no FDA-approved otoprotective drug is available currently. The zebrafish has recently become a valuable model to investigate AG-induced hair cell toxicity and an expanding list of otoprotective compounds that block the uptake of AGs have been identified from zebrafish-based screening; however, it remains to be established whether inhibiting intracellular cell death pathway(s) constitutes an effective strategy to protect against AG-induced ototoxicity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We used the zebrafish model as well as in vitro cell-based assays to investigate AG-induced cell death and found that ferroptosis is the dominant type of cell death induced by neomycin. Neomycin stimulates lipid reactive oxygen species (ROS) accumulation through mitochondrial pathway and blocking mitochondrial ferroptosis pathway effectively protects neomycin-induced cell death. We screened an alkaloid natural compound library and identified seven small compounds that protect neomycin-induced ototoxicity by targeting ferroptosis pathway: six of them are radical-trapping agents (RTAs) while the other one (ellipticine) regulates intracellular iron homeostasis, which is essential for the generation of lipid ROS to stimulate ferroptosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our study demonstrates that blocking intracellular ferroptosis pathway is an alternative strategy to ameliorate neomycin-induced ototoxicity and provides multiple hit compounds for further otoprotective drug development.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13578-024-01258-w","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T11:54:18Z","timestamp":1717588458000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chemical screen in zebrafish lateral line identified compounds that ameliorate neomycin-induced ototoxicity by inhibiting ferroptosis pathway"],"prefix":"10.1186","volume":"14","author":[{"given":"Yipu","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dajiang","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9145-7887","authenticated-orcid":false,"given":"Xiaodong","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"1258_CR1","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3389\/fncel.2017.00325","volume":"11","author":"ME O\u2019Sullivan","year":"2017","unstructured":"O\u2019Sullivan ME, Perez A, Lin R, Sajjadi A, Ricci AJ, Cheng AG. Towards the Prevention of Aminoglycoside-related hearing loss. Front Cell Neurosci. 2017;11:325.","journal-title":"Front Cell Neurosci"},{"issue":"11","key":"1258_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1101\/cshperspect.a033548","volume":"9","author":"CJ Kros","year":"2019","unstructured":"Kros CJ, Steyger PS. Aminoglycoside- and Cisplatin-Induced Ototoxicity: mechanisms and otoprotective strategies. Cold Spring Harbor Perspect Med. 2019;9(11):1\u201318.","journal-title":"Cold Spring Harbor Perspect Med"},{"key":"1258_CR3","doi-asserted-by":"publisher","first-page":"103722","DOI":"10.1016\/j.mcn.2022.103722","volume":"120","author":"J Kim","year":"2022","unstructured":"Kim J, Hemachandran S, Cheng AG, Ricci AJ. Identifying targets to prevent aminoglycoside ototoxicity. Mol Cell Neurosci. 2022;120:103722.","journal-title":"Mol Cell Neurosci"},{"key":"1258_CR4","doi-asserted-by":"publisher","first-page":"692762","DOI":"10.3389\/fncel.2021.692762","volume":"15","author":"X Fu","year":"2021","unstructured":"Fu X, Wan P, Li P, Wang J, Guo S, Zhang Y, An Y, Ye C, Liu Z, Gao J, et al. Mechanism and Prevention of Ototoxicity Induced by aminoglycosides. Front Cell Neurosci. 2021;15:692762.","journal-title":"Front Cell Neurosci"},{"issue":"3S","key":"1258_CR5","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1044\/2021_AJA-21-00006","volume":"30","author":"PS Steyger","year":"2021","unstructured":"Steyger PS. Mechanisms of Aminoglycoside- and Cisplatin-Induced Ototoxicity. Am J Audiol. 2021;30(3S):887\u2013900.","journal-title":"Am J Audiol"},{"key":"1258_CR6","doi-asserted-by":"publisher","first-page":"108783","DOI":"10.1016\/j.heares.2023.108783","volume":"434","author":"WJT Tan","year":"2023","unstructured":"Tan WJT, Song L. Role of mitochondrial dysfunction and oxidative stress in sensorineural hearing loss. Hear Res. 2023;434:108783.","journal-title":"Hear Res"},{"issue":"6","key":"1258_CR7","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.tcb.2020.02.009","volume":"30","author":"BR Stockwell","year":"2020","unstructured":"Stockwell BR, Jiang X, Gu W. Emerging mechanisms and Disease Relevance of Ferroptosis. Trends Cell Biol. 2020;30(6):478\u201390.","journal-title":"Trends Cell Biol"},{"issue":"6","key":"1258_CR8","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","volume":"32","author":"J Zheng","year":"2020","unstructured":"Zheng J, Conrad M. The metabolic underpinnings of Ferroptosis. Cell Metabol. 2020;32(6):920\u201337.","journal-title":"Cell Metabol"},{"issue":"2","key":"1258_CR9","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","volume":"31","author":"D Tang","year":"2021","unstructured":"Tang D, Chen X, Kang R, Kroemer G. Ferroptosis: molecular mechanisms and health implications. Cell Res. 2021;31(2):107\u201325.","journal-title":"Cell Res"},{"issue":"5","key":"1258_CR10","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060\u201372.","journal-title":"Cell"},{"key":"1258_CR11","doi-asserted-by":"crossref","unstructured":"Gan B. Mitochondrial regulation of ferroptosis. J Cell Biol 2021, 220(9).","DOI":"10.1083\/jcb.202105043"},{"issue":"4","key":"1258_CR12","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.chembiol.2020.03.013","volume":"27","author":"BR Stockwell","year":"2020","unstructured":"Stockwell BR, Jiang X. The Chemistry and Biology of Ferroptosis. Cell Chem Biology. 2020;27(4):365\u201375.","journal-title":"Cell Chem Biology"},{"issue":"1\u20132","key":"1258_CR13","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0378-5955(02)00338-6","volume":"169","author":"N Dehne","year":"2002","unstructured":"Dehne N, Rauen U, de Groot H, Lautermann J. Involvement of the mitochondrial permeability transition in gentamicin ototoxicity. Hear Res. 2002;169(1\u20132):47\u201355.","journal-title":"Hear Res"},{"issue":"1\u20132","key":"1258_CR14","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0378-5955(96)00003-2","volume":"94","author":"BB Song","year":"1996","unstructured":"Song BB, Schacht J. Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo. Hear Res. 1996;94(1\u20132):87\u201393.","journal-title":"Hear Res"},{"issue":"2","key":"1258_CR15","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1097\/00005537-199802000-00023","volume":"108","author":"BJ Conlon","year":"1998","unstructured":"Conlon BJ, Perry BP, Smith DW. Attenuation of neomycin ototoxicity by iron chelation. Laryngoscope. 1998;108(2):284\u20137.","journal-title":"Laryngoscope"},{"issue":"3","key":"1258_CR16","doi-asserted-by":"publisher","first-page":"e0151557","DOI":"10.1371\/journal.pone.0151557","volume":"11","author":"J Chang","year":"2016","unstructured":"Chang J, Choi J, Rah YC, Yoo MH, Oh KH, Im GJ, Lee SH, Kwon SY, Park HC, Chae SW, et al. Sodium Selenite acts as an otoprotectant against neomycin-Induced Hair cell damage in a zebrafish model. PLoS ONE. 2016;11(3):e0151557.","journal-title":"PLoS ONE"},{"key":"1258_CR17","doi-asserted-by":"crossref","unstructured":"Zheng Z, Tang D, Zhao L, Li W, Han J, Hu B, Nie G, He Y. Liproxstatin-1 Protects Hair Cell-Like HEI-OC1 Cells and Cochlear Hair Cells against Neomycin Ototoxicity. Oxidative medicine and cellular longevity 2020, 2020:1782659.","DOI":"10.1155\/2020\/1782659"},{"key":"1258_CR18","doi-asserted-by":"publisher","first-page":"1085225","DOI":"10.3389\/fcell.2022.1085225","volume":"10","author":"A Barrallo-Gimeno","year":"2022","unstructured":"Barrallo-Gimeno A, Llorens J. Hair cell toxicology: with the help of a little fish. Front cell Dev Biology. 2022;10:1085225.","journal-title":"Front cell Dev Biology"},{"issue":"2","key":"1258_CR19","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s10162-002-3022-x","volume":"4","author":"JA Harris","year":"2003","unstructured":"Harris JA, Cheng AG, Cunningham LL, MacDonald G, Raible DW, Rubel EW. Neomycin-induced hair cell death and rapid regeneration in the lateral line of zebrafish (Danio rerio). J Association Res Otolaryngology: JARO. 2003;4(2):219\u201334.","journal-title":"J Association Res Otolaryngology: JARO"},{"issue":"1\u20132","key":"1258_CR20","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.heares.2005.05.005","volume":"208","author":"C Ton","year":"2005","unstructured":"Ton C, Parng C. The use of zebrafish for assessing ototoxic and otoprotective agents. Hear Res. 2005;208(1\u20132):79\u201388.","journal-title":"Hear Res"},{"issue":"4","key":"1258_CR21","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1002\/cne.21345","volume":"502","author":"KN Owens","year":"2007","unstructured":"Owens KN, Cunningham DE, MacDonald G, Rubel EW, Raible DW, Pujol R. Ultrastructural analysis of aminoglycoside-induced hair cell death in the zebrafish lateral line reveals an early mitochondrial response. J Comp Neurol. 2007;502(4):522\u201343.","journal-title":"J Comp Neurol"},{"issue":"9","key":"1258_CR22","doi-asserted-by":"publisher","first-page":"3556","DOI":"10.1172\/JCI84939","volume":"126","author":"R Esterberg","year":"2016","unstructured":"Esterberg R, Linbo T, Pickett SB, Wu P, Ou HC, Rubel EW, Raible DW. Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death. J Clin Investig. 2016;126(9):3556\u201366.","journal-title":"J Clin Investig"},{"issue":"4","key":"1258_CR23","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3342\/ceo.2013.6.4.219","volume":"6","author":"J Chang","year":"2013","unstructured":"Chang J, Im GJ, Chae SW, Lee SH, Kwon SY, Jung HH, Chung AY, Park HC, Choi J. Protective role of Trimetazidine against neomycin-induced hair cell damage in zebrafish. Clin Exp Otorhinolaryngol. 2013;6(4):219\u201325.","journal-title":"Clin Exp Otorhinolaryngol"},{"issue":"5","key":"1258_CR24","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1002\/jat.2964","volume":"34","author":"J Choi","year":"2014","unstructured":"Choi J, Chang J, Jun HJ, Im GJ, Chae SW, Lee SH, Kwon SY, Jung HH, Chung AY, Park HC. Protective role of edaravone against neomycin-induced ototoxicity in zebrafish. J Appl Toxicology: JAT. 2014;34(5):554\u201361.","journal-title":"J Appl Toxicology: JAT"},{"issue":"2","key":"1258_CR25","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s00204-013-1124-3","volume":"88","author":"JJ Song","year":"2014","unstructured":"Song JJ, Chang J, Choi J, Im GJ, Chae SW, Lee SH, Kwon SY, Jung HH, Chung AY, Park HC, et al. Protective role of NecroX-5 against neomycin-induced hair cell damage in zebrafish. Arch Toxicol. 2014;88(2):435\u201341.","journal-title":"Arch Toxicol"},{"key":"1258_CR26","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.freeradbiomed.2015.11.007","volume":"89","author":"YC Rah","year":"2015","unstructured":"Rah YC, Choi J, Yoo MH, Yum G, Park S, Oh KH, Lee SH, Kwon SY, Cho SH, Kim S, et al. Ecabet sodium alleviates neomycin-induced hair cell damage. Free Radic Biol Med. 2015;89:1176\u201383.","journal-title":"Free Radic Biol Med"},{"key":"1258_CR27","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.heares.2016.10.001","volume":"342","author":"Y Hirose","year":"2016","unstructured":"Hirose Y, Sugahara K, Kanagawa E, Takemoto Y, Hashimoto M, Yamashita H. Quercetin protects against hair cell loss in the zebrafish lateral line and guinea pig cochlea. Hear Res. 2016;342:80\u20135.","journal-title":"Hear Res"},{"key":"1258_CR28","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3389\/fncel.2016.00083","volume":"10","author":"M Kruger","year":"2016","unstructured":"Kruger M, Boney R, Ordoobadi AJ, Sommers TF, Trapani JG, Coffin AB. Natural bizbenzoquinoline derivatives protect zebrafish lateral line sensory hair cells from Aminoglycoside Toxicity. Front Cell Neurosci. 2016;10:83.","journal-title":"Front Cell Neurosci"},{"key":"1258_CR29","doi-asserted-by":"publisher","first-page":"234","DOI":"10.3389\/fncel.2020.00234","volume":"14","author":"AM Hudson","year":"2020","unstructured":"Hudson AM, Lockard GM, Namjoshi OA, Wilson JW, Kindt KS, Blough BE, Coffin AB. Berbamine analogs exhibit Differential Protective effects from Aminoglycoside-Induced Hair Cell Death. Front Cell Neurosci. 2020;14:234.","journal-title":"Front Cell Neurosci"},{"key":"1258_CR30","doi-asserted-by":"publisher","first-page":"262","DOI":"10.3389\/fncel.2017.00262","volume":"11","author":"NK Kirkwood","year":"2017","unstructured":"Kirkwood NK, O\u2019Reilly M, Derudas M, Kenyon EJ, Huckvale R, van Netten SM, Ward SE, Richardson GP, Kros CJ. d-Tubocurarine and Berbamine: Alkaloids that are permeant blockers of the Hair Cell\u2019s Mechano-Electrical Transducer Channel and protect from Aminoglycoside Toxicity. Front Cell Neurosci. 2017;11:262.","journal-title":"Front Cell Neurosci"},{"key":"1258_CR31","doi-asserted-by":"crossref","unstructured":"Kitcher SR, Kirkwood NK, Camci ED, Wu P, Gibson RM, Redila VA, Simon JA, Rubel EW, Raible DW, Richardson GP et al. ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity. JCI Insight 2019, 4(15).","DOI":"10.1172\/jci.insight.126764"},{"issue":"2","key":"1258_CR32","doi-asserted-by":"publisher","first-page":"e1000020","DOI":"10.1371\/journal.pgen.1000020","volume":"4","author":"KN Owens","year":"2008","unstructured":"Owens KN, Santos F, Roberts B, Linbo T, Coffin AB, Knisely AJ, Simon JA, Rubel EW, Raible DW. Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death. PLoS Genet. 2008;4(2):e1000020.","journal-title":"PLoS Genet"},{"issue":"2","key":"1258_CR33","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s10162-009-0158-y","volume":"10","author":"HC Ou","year":"2009","unstructured":"Ou HC, Cunningham LL, Francis SP, Brandon CS, Simon JA, Raible DW, Rubel EW. Identification of FDA-approved drugs and bioactives that protect hair cells in the zebrafish (Danio rerio) lateral line and mouse (Mus musculus) utricle. J Association Res Otolaryngology: JARO. 2009;10(2):191\u2013203.","journal-title":"J Association Res Otolaryngology: JARO"},{"issue":"1\u20132","key":"1258_CR34","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.heares.2012.08.002","volume":"294","author":"AL Vlasits","year":"2012","unstructured":"Vlasits AL, Simon JA, Raible DW, Rubel EW, Owens KN. Screen of FDA-approved drug library reveals compounds that protect hair cells from aminoglycosides and cisplatin. Hear Res. 2012;294(1\u20132):153\u201365.","journal-title":"Hear Res"},{"key":"1258_CR35","doi-asserted-by":"crossref","unstructured":"Kenyon EJ, Kirkwood NK, Kitcher SR, O\u2019Reilly M, Derudas M, Cantillon DM, Goodyear RJ, Secker A, Baxendale S, Bull JC et al. Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death. JCI insight : 2017, 2(24).","DOI":"10.1172\/jci.insight.96773"},{"key":"1258_CR36","doi-asserted-by":"crossref","unstructured":"Kenyon EJ, Kirkwood NK, Kitcher SR, Goodyear RJ, Derudas M, Cantillon DM, de la Baxendale S, Mahieu VN, Osgood RT et al. Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity. JCI insight : 2021, 6(7).","DOI":"10.1172\/jci.insight.145704"},{"key":"1258_CR37","doi-asserted-by":"crossref","unstructured":"Zallocchi M, Hati S, Xu Z, Hausman W, Liu H, He DZ, Zuo J. Characterization of quinoxaline derivatives for protection against iatrogenically induced hearing loss. JCI Insight 2021, 6(5).","DOI":"10.1172\/jci.insight.141561"},{"issue":"12","key":"1258_CR38","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/ncb3064","volume":"16","author":"JP Friedmann Angeli","year":"2014","unstructured":"Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014;16(12):1180\u201391.","journal-title":"Nat Cell Biol"},{"key":"1258_CR39","first-page":"1473","volume":"17","author":"CY Gregory-Evans","year":"2011","unstructured":"Gregory-Evans CY, Moosajee M, Shan X, Gregory-Evans K. Gene-specific differential response to anti-apoptotic therapies in zebrafish models of ocular coloboma. Mol Vis. 2011;17:1473\u201384.","journal-title":"Mol Vis"},{"issue":"10","key":"1258_CR40","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1093\/hmg\/dds056","volume":"21","author":"IA Viringipurampeer","year":"2012","unstructured":"Viringipurampeer IA, Ferreira T, DeMaria S, Yoon JJ, Shan X, Moosajee M, Gregory-Evans K, Ngai J, Gregory-Evans CY. Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development. Hum Mol Genet. 2012;21(10):2357\u201369.","journal-title":"Hum Mol Genet"},{"issue":"1\u20132","key":"1258_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.heares.2005.10.015","volume":"213","author":"PP Hernandez","year":"2006","unstructured":"Hernandez PP, Moreno V, Olivari FA, Allende ML. Sub-lethal concentrations of waterborne copper are toxic to lateral line neuromasts in zebrafish (Danio rerio). Hear Res. 2006;213(1\u20132):1\u201310.","journal-title":"Hear Res"},{"issue":"2","key":"1258_CR42","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1021\/tx0496946","volume":"18","author":"W Lesniak","year":"2005","unstructured":"Lesniak W, Pecoraro VL, Schacht J. Ternary complexes of gentamicin with iron and lipid catalyze formation of reactive oxygen species. Chem Res Toxicol. 2005;18(2):357\u201364.","journal-title":"Chem Res Toxicol"},{"issue":"7860","key":"1258_CR43","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","volume":"593","author":"C Mao","year":"2021","unstructured":"Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021;593(7860):586\u201390.","journal-title":"Nature"},{"issue":"11","key":"1258_CR44","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1038\/s41419-022-05447-8","volume":"13","author":"Y Fan","year":"2022","unstructured":"Fan Y, Zhang Y, Shi K, Cheng S, Pei D, Shu X. Identification of a group of bisbenzylisoquinoline (BBIQ) compounds as ferroptosis inhibitors. Cell Death Dis. 2022;13(11):1000.","journal-title":"Cell Death Dis"},{"key":"1258_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2008.09.050","volume":"1244","author":"FA Olivari","year":"2008","unstructured":"Olivari FA, Hernandez PP, Allende ML. Acute copper exposure induces oxidative stress and cell death in lateral line hair cells of zebrafish larvae. Brain Res. 2008;1244:1\u201312.","journal-title":"Brain Res"},{"issue":"4","key":"1258_CR46","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1016\/j.bbrc.2020.10.019","volume":"533","author":"B Hu","year":"2020","unstructured":"Hu B, Liu Y, Chen X, Zhao J, Han J, Dong H, Zheng Q, Nie G. Ferrostatin-1 protects auditory hair cells from cisplatin-induced ototoxicity in vitro and in vivo. Biochem Biophys Res Commun. 2020;533(4):1442\u20138.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1\u20132","key":"1258_CR47","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.heares.2009.03.001","volume":"253","author":"KN Owens","year":"2009","unstructured":"Owens KN, Coffin AB, Hong LS, Bennett KO, Rubel EW, Raible DW. Response of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways. Hear Res. 2009;253(1\u20132):32\u201341.","journal-title":"Hear Res"},{"issue":"5","key":"1258_CR48","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s10162-013-0404-1","volume":"14","author":"AB Coffin","year":"2013","unstructured":"Coffin AB, Rubel EW, Raible DW. Bax, Bcl2, and p53 differentially regulate neomycin- and gentamicin-induced hair cell death in the zebrafish lateral line. J Association Res Otolaryngology: JARO. 2013;14(5):645\u201359.","journal-title":"J Association Res Otolaryngology: JARO"},{"issue":"4","key":"1258_CR49","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s10495-013-0816-8","volume":"18","author":"AB Coffin","year":"2013","unstructured":"Coffin AB, Williamson KL, Mamiya A, Raible DW, Rubel EW. Profiling drug-induced cell death pathways in the zebrafish lateral line. Apoptosis: Int J Program cell Death. 2013;18(4):393\u2013408.","journal-title":"Apoptosis: Int J Program cell Death"}],"container-title":["Cell &amp; Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13578-024-01258-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13578-024-01258-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13578-024-01258-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T12:00:09Z","timestamp":1717588809000},"score":1,"resource":{"primary":{"URL":"https:\/\/cellandbioscience.biomedcentral.com\/articles\/10.1186\/s13578-024-01258-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,5]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1258"],"URL":"https:\/\/doi.org\/10.1186\/s13578-024-01258-w","relation":{},"ISSN":["2045-3701"],"issn-type":[{"value":"2045-3701","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,5]]},"assertion":[{"value":"23 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"<b>Not applicable<\/b>.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"<b>Not applicable<\/b>.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"71"}}