{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:57:02Z","timestamp":1785538622817,"version":"3.56.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T00:00:00Z","timestamp":1577404800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003976","name":"Israel National Institute for Health Policy Research","doi-asserted-by":"publisher","award":["17\/2014-R"],"award-info":[{"award-number":["17\/2014-R"]}],"id":[{"id":"10.13039\/501100003976","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Isr J Health Policy Res"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Adherence of primary-care pediatricians to guidelines in pediatric gastroenterology is essential to achieve optimal clinical outcomes. The study aim was to examine adherence of primary-care pediatricians to the European and North American Societies for Pediatric Gastroenterology, Hepatology and Nutrition guidelines on the management of <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infection and celiac disease.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>We conducted a cross-sectional study during March\u2013July 2017 using the survey platform of Maccabi Healthcare Services, the second largest state-mandated health organization in Israel. We sent the study questionnaire to a random sample of 300 pediatricians via electronic mails and to increase the response rate, we performed a telephone interview. Overall, 108 (36%) pediatricians provided completed questionnaires.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Using professional guidelines for the management of <jats:italic>H. pylori<\/jats:italic> infection and celiac disease was reported by 34 and 37% of pediatricians, respectively. Referral to <jats:italic>H. pylori<\/jats:italic> testing was reported by 78 and 52% of pediatricians in children with suspected duodenal ulcer and unexplained iron deficiency anemia, respectively, with the stool antigen enzyme immunoassay being mostly (51%) used as the first choice diagnostic test. Most pediatricians reported prescription of triple therapy; proton pump inhibitors\/clarithromycin\/amoxicillin (59%) or metronidazole (21%). For celiac disease, overall adherence to all guidelines was high both for initial evaluation and for confirmation of diagnosis.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Adherence to the guidelines on management of <jats:italic>H. pylori<\/jats:italic> infection was low, while adherence to the guidelines on celiac disease management was high among primary-care pediatricians. Educational interventions are needed to improve <jats:italic>H. pylori<\/jats:italic> infection management among primary-care pediatricians.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s13584-019-0357-x","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T11:03:06Z","timestamp":1577444586000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A survey of primary-care pediatricians regarding the management of Helicobacter pylori infection and celiac disease"],"prefix":"10.1186","volume":"8","author":[{"given":"Amir","family":"Ben Tov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasef","family":"Na\u2019amnih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amna","family":"Bdair-Amsha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomi","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Tzamir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Chodick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-7559","authenticated-orcid":false,"given":"Khitam","family":"Muhsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,27]]},"reference":[{"key":"357_CR1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jpeds.2016.04.008","volume":"177","author":"ML Lewis","year":"2016","unstructured":"Lewis ML, Palsson OS, Whitehead WE, van Tilburg MAL. Prevalence of functional gastrointestinal disorders in children and adolescents. J Pediatr. 2016;177:39\u201343 e3. https:\/\/doi.org\/10.1016\/j.jpeds.2016.04.008.","journal-title":"J Pediatr"},{"key":"357_CR2","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1097\/MPG.0b013e3182227e90","volume":"53","author":"S Koletzko","year":"2011","unstructured":"Koletzko S, Jones NL, Goodman KJ, Gold B, Rowland M, Cadranel S, et al. Evidence-based guidelines from ESPGHAN and NASPGHAN for helicobacter pylori infection in children. J Pediatr Gastroenterol Nutr. 2011;53:230\u201343. https:\/\/doi.org\/10.1097\/MPG.0b013e3182227e90.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"357_CR3","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1097\/MPG.0000000000001594","volume":"64","author":"NL Jones","year":"2017","unstructured":"Jones NL, Koletzko S, Goodman K, Bontems P, Cadranel S, Casswall T, et al. Joint ESPGHAN\/NASPGHAN guidelines for the management of helicobacter pylori in children and adolescents (update 2016). J Pediatr Gastroenterol Nutr. 2017;64:991\u20131003. https:\/\/doi.org\/10.1097\/MPG.0000000000001594.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"357_CR4","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","volume":"54","author":"S Husby","year":"2012","unstructured":"Husby S, Koletzko S, Korponay-Szabo IR, Mearin ML, Phillips A, Shamir R, et al. European Society for Pediatric Gastroenterology, Hepatology, and nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr. 2012;54:136\u201360. https:\/\/doi.org\/10.1097\/MPG.0b013e31821a23d0.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"357_CR5","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1186\/1471-2458-14-1150","volume":"14","author":"T Harkanen","year":"2014","unstructured":"Harkanen T, Kaikkonen R, Virtala E, Koskinen S. Inverse probability weighting and doubly robust methods in correcting the effects of non-response in the reimbursed medication and self-reported turnout estimates in the ATH survey. BMC Public Health. 2014;14:1150. https:\/\/doi.org\/10.1186\/1471-2458-14-1150.","journal-title":"BMC Public Health"},{"key":"357_CR6","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1097\/00005176-200302000-00015","volume":"36","author":"HY Chang","year":"2003","unstructured":"Chang HY, Sharma VK, Howden CW, Gold BD. Knowledge, attitudes, and practice styles of north American pediatric gastroenterologists: helicobacter pylori infection. J Pediatr Gastroenterol Nutr. 2003;36:235\u201340.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"357_CR7","doi-asserted-by":"publisher","first-page":"550","DOI":"10.3109\/00365521003663688","volume":"45","author":"N Zevit","year":"2010","unstructured":"Zevit N, Levy I, Shmuely H, Samra Z, Yahav J. Antibiotic resistance of helicobacter pylori in Israeli children. Scand J Gastroenterol. 2010;45:550\u20135. https:\/\/doi.org\/10.3109\/00365521003663688.","journal-title":"Scand J Gastroenterol"},{"key":"357_CR8","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jgar.2017.05.017","volume":"10","author":"J Khoury","year":"2017","unstructured":"Khoury J, Geffen Y, Shaul R, Sholy H, Chowers Y, Saadi T. Secondary antibiotic resistance of helicobacter pylori isolates in Israeli children and adults. J Glob Antimicrob Resist. 2017;10:182\u20135. https:\/\/doi.org\/10.1016\/j.jgar.2017.05.017.","journal-title":"J Glob Antimicrob Resist"}],"container-title":["Israel Journal of Health Policy Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13584-019-0357-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13584-019-0357-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13584-019-0357-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T00:04:25Z","timestamp":1608941065000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijhpr.biomedcentral.com\/articles\/10.1186\/s13584-019-0357-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["357"],"URL":"https:\/\/doi.org\/10.1186\/s13584-019-0357-x","relation":{},"ISSN":["2045-4015"],"issn-type":[{"value":"2045-4015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"23 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Helsinki committee of Bayit Balev Medical Center of MHS (number 47\/2014) and the ethics committee of Tel Aviv University approved the study protocol. Informed consent was obtained from all participants included in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"88"}}