{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:33:23Z","timestamp":1740166403271,"version":"3.37.3"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Isr J Health Policy Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Clinical trial registration is critical for research transparency and integrity. Since 2005, the Declaration of Helsinki has required prospective registration of trials before subject recruitment. In Israel, the MyTrial registry was established in 2015 to register interventional trials and became mandatory in 2016 for ethical approval. The study aimed to analyze the registration practices, challenges, and trends in clinical trial registration in Israel using the local registry \u201cMyTrial\u201d.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 3,895 clinical trial records from 2011 to December 2022 were retrieved from the MyTrial platform and subjected to descriptive analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A significant increase occurred from 2016 to 2021 due to mandated registration, with a peak in 2020 (733 trials) and a decrease in 2022 (462 trials), likely due to COVID-19. Most of the trials included drugs (56%) or medical devices (33%). Geographically, 53% were from central Israel. Only 39% of the patients were registered at both MyTrial and ClinicalTrials.gov. 65% had no blinding. 47% featured unregistered products. 56% had not started recruitment. Since 2016, the number of advanced therapy trials has steadily increased, reaching 19 in 2022. There are gaps between registered trials and official government reports.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>These findings provide valuable insights into the current landscape of clinical trial registration in Israel and highlight the need for improvements in compliance with prospective registration and adherence to the WHO-ICTRP standards.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13584-024-00643-7","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T08:03:52Z","timestamp":1729757032000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trends in Israeli clinical trials registration \u201cMyTrial\u201d"],"prefix":"10.1186","volume":"13","author":[{"given":"Anat","family":"Engel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4919-8807","authenticated-orcid":false,"given":"Ornit","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"643_CR1","doi-asserted-by":"crossref","unstructured":"Ndwandwe DE, Runeyi S, Pienaar E, Mathebula L, Hohlfeld A, Wiysonge CS. Practices, and trends in clinical trial registration in the Pan African clinical trials Registry (PACTR): a descriptive analysis of registration data. BMJ Open. 2022;12(1).","DOI":"10.1136\/bmjopen-2021-057474"},{"key":"643_CR2","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3325\/cmj.2009.50.105","volume":"50","author":"K Krle\u017ea-Jeri\u0107","year":"2009","unstructured":"Krle\u017ea-Jeri\u0107 K, Lemmens T. 7th revision of the declaration of Helsinki: good news for the transparency of clinical trials. Croatian Med J. 2009;50:105\u201310.","journal-title":"Croatian Med J"},{"key":"643_CR3","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Gonz\u00e1lez L. Registering transparency: the making of the international clinical trial registry platform by the World Health Organization (2004\u20132006). 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Practical, and conceptual issues of clinical trial registration for Brazilian researchers. Sao Paulo Med J. 2015;134(1):28\u201333.","journal-title":"Sao Paulo Med J"},{"issue":"1","key":"643_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5001\/omj.2014.01","volume":"29","author":"LJJ John","year":"2014","unstructured":"John LJJ, Muttappallymyalil J. Clinical Trial Registration in the Eastern Mediterranean Region. Oman Med J. 2014;29(1):1\u20132.","journal-title":"Oman Med J"},{"key":"643_CR11","doi-asserted-by":"crossref","unstructured":"G\u00fclmezoglu AM, Sim I. International clinical trial registration: Any progress? Vol. 118, Wiener Klinische Wochenschrift. Springer Wien; 2006. pp. 1\u20132.","DOI":"10.1007\/s00508-006-0525-1"},{"key":"643_CR12","unstructured":"Cui M. Data integrity and data quality in application submissions [Internet]. 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ClinicalTrials.gov [Internet]. 2005 [cited 2005 Jan 1]. https:\/\/clinicaltrials.gov\/"}],"container-title":["Israel Journal of Health Policy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13584-024-00643-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13584-024-00643-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13584-024-00643-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T08:07:33Z","timestamp":1729757253000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijhpr.biomedcentral.com\/articles\/10.1186\/s13584-024-00643-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,24]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["643"],"URL":"https:\/\/doi.org\/10.1186\/s13584-024-00643-7","relation":{},"ISSN":["2045-4015"],"issn-type":[{"type":"electronic","value":"2045-4015"}],"subject":[],"published":{"date-parts":[[2024,10,24]]},"assertion":[{"value":"21 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no conflicts of interest relevant to this article to disclose. There are no prior publications or submissions with any overlapping information, including studies and patients.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing of interest"}}],"article-number":"62"}}