{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:16:54Z","timestamp":1792001814617,"version":"4.4.0"},"reference-count":14,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":3244,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Intensive Care"],"published-print":{"date-parts":[[2017]]},"DOI":"10.1186\/s13613-017-0253-x","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T21:09:05Z","timestamp":1489007345000},"page":"29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["A hypoperfusion context may aid to interpret hyperlactatemia in sepsis-3 septic shock patients: a proof-of-concept study"],"prefix":"10.1016","volume":"7","author":[{"given":"Leyla","family":"Alegr\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Vera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Dreyse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Carpio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Henriquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Gajardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Araneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Kattan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Ospina-Tasc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Teboul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1186\/s13613-017-0253-x_bb0010","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1186\/s13613-017-0253-x_bb0015","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/CCM.0b013e31827e83af","article-title":"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012","volume":"41","author":"Dellinger","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1186\/s13613-017-0253-x_bb0020","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s13054-014-0503-3","article-title":"Sepsis-associated hyperlactatemia","volume":"18","author":"Garcia-Alvarez","year":"2014","journal-title":"Crit Care"},{"key":"10.1186\/s13613-017-0253-x_bb0025","first-page":"280","article-title":"The holistic view on perfusion monitoring in septic shock","volume":"18","author":"Hernandez","year":"2012","journal-title":"Curr Opinion Crit Care"},{"key":"10.1186\/s13613-017-0253-x_bb0030","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s13054-015-0928-3","article-title":"Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion","volume":"19","author":"Tapia","year":"2015","journal-title":"Crit Care"},{"key":"10.1186\/s13613-017-0253-x_bb0035","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1007\/s00134-014-3525-z","article-title":"Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine","volume":"40","author":"Cecconi","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-017-0253-x_bb0040","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1164\/rccm.200912-1918OC","article-title":"Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial","volume":"182","author":"Jansen","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1186\/s13613-017-0253-x_bb0045","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s00134-015-3720-6","article-title":"Combination of arterial lactate levels and venous-arterial CO2 to arterial-venous O2 content difference ratio as markers of resuscitation in patients with septic shock","volume":"41","author":"Ospina-Tascon","year":"2015","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-017-0253-x_bb0050","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13613-014-0030-z","article-title":"When to stop septic shock resuscitation: clues from a dynamic perfusion monitoring","volume":"4","author":"Hernandez","year":"2014","journal-title":"Ann Intensive Care"},{"key":"10.1186\/s13613-017-0253-x_bb0055","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1164\/rccm.201408-1575LE","article-title":"Early peripheral perfusion-guided fluid therapy in patients with septic shock","volume":"191","author":"van Genderen","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1186\/s13613-017-0253-x_bb0060","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa010307","article-title":"Early goal-directed therapy in the treatment of severe sepsis and septic shock","volume":"345","author":"Rivers","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1186\/s13613-017-0253-x_bb0065","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1007\/s00134-008-1199-0","article-title":"Central venous-to-arterial carbon dioxide difference: An additional target for goal-directed therapy in septic shock?","volume":"34","author":"Vall\u00e9e","year":"2008","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-017-0253-x_bb0070","doi-asserted-by":"crossref","first-page":"R294","DOI":"10.1186\/cc13160","article-title":"Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock","volume":"17","author":"Ospina-Tasc\u00f3n","year":"2013","journal-title":"Crit Care"},{"key":"10.1186\/s13613-017-0253-x_bb0075","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jcrc.2011.05.024","article-title":"Evolution of peripheral vs metabolic perfusion parameters during septic shock resuscitation: a clinical-physiologic study","volume":"27","author":"Hernandez","year":"2012","journal-title":"J Crit Care"}],"container-title":["Annals of Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13613-017-0253-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13613-017-0253-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025019223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025019223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13613-017-0253-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:30:46Z","timestamp":1776670246000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2110582025019223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"alternative-id":["S2110582025019223"],"URL":"https:\/\/doi.org\/10.1186\/s13613-017-0253-x","relation":{},"ISSN":["2110-5820"],"issn-type":[{"value":"2110-5820","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A hypoperfusion context may aid to interpret hyperlactatemia in sepsis-3 septic shock patients: a proof-of-concept study","name":"articletitle","label":"Article Title"},{"value":"Annals of Intensive Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1186\/s13613-017-0253-x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 The Author(s) 2017. Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}],"article-number":"29"}}