{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:22:47Z","timestamp":1790338967069,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":3244,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Intensive Care"],"published-print":{"date-parts":[[2017]]},"DOI":"10.1186\/s13613-017-0255-8","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T01:11:31Z","timestamp":1490145091000},"page":"34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Systematic overdosing of oxa- and cloxacillin in severe infections treated in ICU: risk factors and side effects"],"prefix":"10.1016","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1774-6509","authenticated-orcid":false,"given":"Mathilde","family":"Neuville","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najoua","family":"El-Helali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Magalhaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aguila","family":"Radjou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Smonig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Soubirou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Voiriot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Le Monnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Ruckly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila","family":"Bouadma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Sonneville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Timsit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Mourvillier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1186\/s13613-017-0255-8_bb0010","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1093\/jac\/dkq228","article-title":"Antibiotic use in 530 French hospitals: results from a surveillance network at hospital and ward levels in 2007","volume":"65","author":"Dumartin","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"10.1186\/s13613-017-0255-8_bb0015","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1007\/s00134-004-2436-9","article-title":"Infective endocarditis in the intensive care unit: clinical spectrum and prognostic factors in 228 consecutive patients","volume":"30","author":"Mourvillier","year":"2004","journal-title":"Intensive Care Med."},{"key":"10.1186\/s13613-017-0255-8_bb0020","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1001\/jama.293.24.3012","article-title":"Staphylococcus aureus endocarditis: a consequence of medical progress","volume":"293","author":"Fowler","year":"2005","journal-title":"JAMA"},{"key":"10.1186\/s13613-017-0255-8_bb0025","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1093\/cid\/cis199","article-title":"Preeminence of Staphylococcus aureus in infective endocarditis: a 1-year population-based survey","volume":"54","author":"AEPEI Study Group","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1186\/s13613-017-0255-8_bb0030","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1093\/eurheartj\/ehv319","volume":"36","author":"Habib","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1186\/s13613-017-0255-8_bb0035","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2125.2011.04080.x","article-title":"Therapeutic drug monitoring of antimicrobials","volume":"73","author":"Roberts","year":"2012","journal-title":"Br J Clin Pharmacol"},{"key":"10.1186\/s13613-017-0255-8_bb0040","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1097\/CCM.0b013e318180fe62","article-title":"Antibiotic resistance\u2014what\u2019s dosing got to do with it?","volume":"36","author":"Roberts","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1186\/s13613-017-0255-8_bb0045","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1007\/s00134-013-3088-4","article-title":"Clinical implications of antibiotic pharmacokinetic principles in the critically ill","volume":"39","author":"Udy","year":"2013","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-017-0255-8_bb0050","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1097\/CCM.0b013e3181961bff","article-title":"Pharmacokinetic issues for antibiotics in the critically ill patient","volume":"37","author":"Roberts","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1186\/s13613-017-0255-8_bb0055","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1378\/chest.11-1671","article-title":"Subtherapeutic initial \u03b2-lactam concentrations in select critically ill patients: association between augmented renal clearance and low trough drug concentrations","volume":"142","author":"Udy","year":"2012","journal-title":"Chest"},{"key":"10.1186\/s13613-017-0255-8_bb0060","doi-asserted-by":"crossref","first-page":"e394","DOI":"10.1161\/01.CIR.0000153812.64956.EF","volume":"111","author":"Baddour","year":"2005","journal-title":"Circulation"},{"key":"10.1186\/s13613-017-0255-8_bb0065","unstructured":"Haute Autorit\u00e9 de Sant\u00e9\u2014BRISTOPEN. http:\/\/www.has-sante.fr\/portail\/jcms\/c_1234501\/fr\/bristopen."},{"key":"10.1186\/s13613-017-0255-8_bb0070","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1056\/NEJM197702242960817","article-title":"Neurotoxic reaction to oxacillin","volume":"296","author":"Malone","year":"1977","journal-title":"N Engl J Med"},{"key":"10.1186\/s13613-017-0255-8_bb0075","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1136\/pgmj.44.518.891","article-title":"Penicillin encephalopathy","volume":"44","author":"Conway","year":"1968","journal-title":"Postgrad Med J"},{"key":"10.1186\/s13613-017-0255-8_bb0080","doi-asserted-by":"crossref","first-page":"497","DOI":"10.7326\/0003-4819-89-4-497","article-title":"Hepatitis from intravenous high-dose oxacillin therapy: findings in an adult inpatient population","volume":"89","author":"Onorato","year":"1978","journal-title":"Ann Intern Med"},{"key":"10.1186\/s13613-017-0255-8_bb0085","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/clinids\/19.5.981","article-title":"Cloxacillin-induced cholestasis","volume":"19","author":"Lotric","year":"1994","journal-title":"Clin Infect Dis"},{"key":"10.1186\/s13613-017-0255-8_bb0090","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0168-8278(92)90029-O","article-title":"Liver damage from flucloxacillin, cloxacillin and dicloxacillin","volume":"15","author":"Olsson","year":"1992","journal-title":"J Hepatol"},{"key":"10.1186\/s13613-017-0255-8_bb0095","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1093\/ndt\/gfs458","article-title":"Renal impairment after high-dose flucloxacillin and single-dose gentamicin prophylaxis in patients undergoing elective hip and knee replacement","volume":"28","author":"Challagundla","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"10.1186\/s13613-017-0255-8_bb0100","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1177\/106002809202601010","article-title":"Cloxacillin-induced acute tubulo interstitial nephritis","volume":"26","author":"Garc\u00eda-Ortiz","year":"1992","journal-title":"Ann Pharmacother"},{"key":"10.1186\/s13613-017-0255-8_bb0105","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01709751","article-title":"The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction\/failure. On behalf of the working group on sepsis-related problems of the European society of intensive care medicine","volume":"22","author":"Vincent","year":"1996","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-017-0255-8_bb0110","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1001\/jama.1993.03510240069035","article-title":"A new simplified acute physiology score (SAPS II) based on a European\/North American multicenter study","volume":"270","author":"Le Gall","year":"1993","journal-title":"JAMA"},{"key":"10.1186\/s13613-017-0255-8_bb0115","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin Pharmacol Ther"},{"key":"10.1186\/s13613-017-0255-8_bb0120","unstructured":"Eucast2. http:\/\/mic.eucast.org\/Eucast2\/."},{"key":"10.1186\/s13613-017-0255-8_bb0125","author":"Brunton","year":"2011"},{"key":"10.1186\/s13613-017-0255-8_bb0130","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1093\/jac\/dkq184","article-title":"Flucloxacillin dosing in critically ill patients with hypoalbuminaemia: special emphasis on unbound pharmacokinetics","volume":"65","author":"Ulldemolins","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"10.1186\/s13613-017-0255-8_bb0135","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1469-0691.2005.01289.x","article-title":"Evolving trends in infective endocarditis","volume":"12","author":"Hill","year":"2006","journal-title":"Clin Microbiol Infect"},{"key":"10.1186\/s13613-017-0255-8_bb0140","year":"2010"},{"key":"10.1186\/s13613-017-0255-8_bb0145","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000221464","article-title":"Pharmacokinetics of cloxacillin in patients on chronic intermittent haemodialysis and in healthy subjects","volume":"19","author":"Nauta","year":"1973","journal-title":"Chemotherapy"},{"key":"10.1186\/s13613-017-0255-8_bb0150","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/BF00542548","article-title":"The metabolic disposition of flucloxacillin in patients with impaired kidney function","volume":"22","author":"Thijssen","year":"1982","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1186\/s13613-017-0255-8_bb0155","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ijantimicag.2010.06.008","article-title":"Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept","volume":"36","author":"Roberts","year":"2010","journal-title":"Int J Antimicrob Agents"},{"key":"10.1186\/s13613-017-0255-8_bb0160","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1179\/joc.2011.23.5.277","article-title":"Assessment of interindividual variability of plasma concentrations after administration of high doses of intravenous amoxicillin or cloxacillin in critically ill patients","volume":"23","author":"Verdier","year":"2011","journal-title":"J Chemother"},{"key":"10.1186\/s13613-017-0255-8_bb0165","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/clinids\/17.3.491","article-title":"Clinical pharmacokinetics of continuous intravenous administration of penicillins","volume":"17","author":"Visser","year":"1993","journal-title":"Clin Infect Dis"},{"key":"10.1186\/s13613-017-0255-8_bb0170","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.nephro.2008.10.004","article-title":"Recommended dosage adaptation based on renal function is not always sufficient to avoid betalactam antibiotics side effects","volume":"5","author":"Lemaire-Hurtel","year":"2009","journal-title":"N\u00e9phrol Th\u00e9r"},{"key":"10.1186\/s13613-017-0255-8_bb0175","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1469-0691.2004.01030.x","article-title":"Use of high-performance liquid chromatography (HPLC) to monitor \u03b2-lactam plasma concentrations during the treatment of endocarditis","volume":"11","author":"Tattevin","year":"2005","journal-title":"Clin Microbiol Infect"},{"key":"10.1186\/s13613-017-0255-8_bb0180","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1056\/NEJMoa1301372","article-title":"Long-term cognitive impairment after critical illness","volume":"369","author":"BRAIN-ICU Study Investigators","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1186\/s13613-017-0255-8_bb0185","doi-asserted-by":"crossref","first-page":"h2538","DOI":"10.1136\/bmj.h2538","article-title":"Outcome of delirium in critically ill patients: systematic review and meta-analysis","volume":"350","author":"Salluh","year":"2015","journal-title":"BMJ"},{"key":"10.1186\/s13613-017-0255-8_bb0190","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2125.1975.tb01566.x","article-title":"Pharmacokinetics of flucloxacillin and cloxacillin in healthy subjects and patients on chronic intermittent haemodialysis","volume":"2","author":"Nauta","year":"1975","journal-title":"Br J Clin Pharmacol"},{"key":"10.1186\/s13613-017-0255-8_bb0195","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1001\/jama.1964.03060180005001","article-title":"Effect of uremia on methicillin and oxacillin blood levels","volume":"187","author":"Bulger","year":"1964","journal-title":"JAMA"},{"key":"10.1186\/s13613-017-0255-8_bb0200","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1128\/AAC.10.3.441","article-title":"Active metabolites of isoxazolylpencillins in humans","volume":"10","author":"Thijssen","year":"1976","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1186\/s13613-017-0255-8_bb0205","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1067\/mcp.2002.121829","article-title":"Changes in plasma protein binding have little clinical relevance","volume":"71","author":"Benet","year":"2002","journal-title":"Clin Pharmacol Ther"},{"key":"10.1186\/s13613-017-0255-8_bb0210","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ijantimicag.2012.10.002","article-title":"\u03b2-Lactam therapeutic drug monitoring in the critically ill: optimising drug exposure in patients with fluctuating renal function and hypoalbuminaemia","volume":"41","author":"Hayashi","year":"2013","journal-title":"Int J Antimicrob Agents"}],"container-title":["Annals of Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13613-017-0255-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13613-017-0255-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025019247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025019247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13613-017-0255-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:35:26Z","timestamp":1776670526000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2110582025019247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"alternative-id":["S2110582025019247"],"URL":"https:\/\/doi.org\/10.1186\/s13613-017-0255-8","relation":{},"ISSN":["2110-5820"],"issn-type":[{"value":"2110-5820","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic overdosing of oxa- and cloxacillin in severe infections treated in ICU: risk factors and side effects","name":"articletitle","label":"Article Title"},{"value":"Annals of Intensive Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1186\/s13613-017-0255-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 The Author(s) 2017. Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}],"article-number":"34"}}