{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:14:52Z","timestamp":1790795692968,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":2879,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"ZonMw","award":["916.13.078"],"award-info":[{"award-number":["916.13.078"]}]},{"name":"ZonMw","award":["91717308"],"award-info":[{"award-number":["91717308"]}]},{"name":"ZonMw","award":["013116358"],"award-info":[{"award-number":["013116358"]}]},{"name":"European Research Council"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Intensive Care"],"published-print":{"date-parts":[[2018]]},"DOI":"10.1186\/s13613-018-0368-8","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T07:45:28Z","timestamp":1518162328000},"page":"20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Delayed cerebral thrombosis complicating pneumococcal meningitis: an autopsy study"],"prefix":"10.1016","volume":"8","author":[{"given":"Joo-Yeon","family":"Engelen-Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7775-7843","authenticated-orcid":false,"given":"Matthijs C.","family":"Brouwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Aronica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diederik","family":"van de Beek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1186\/s13613-018-0368-8_bb0010","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1056\/NEJMoa040845","article-title":"Clinical features and prognostic factors in adults with bacterial meningitis","volume":"351","author":"van de Beek","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1186\/s13613-018-0368-8_bb0015","doi-asserted-by":"crossref","unstructured":"Bijlsma MW, Brouwer MC, Kasanmoentalib ES, et al. Community-acquired bacterial meningitis in adults in the Netherlands, 2006\u20132014: a prospective cohort study. The Lancet Infectious diseases 2015.","DOI":"10.1016\/S1473-3099(15)00430-2"},{"key":"10.1186\/s13613-018-0368-8_bb0020","doi-asserted-by":"crossref","first-page":"16074","DOI":"10.1038\/nrdp.2016.74","article-title":"Community-acquired bacterial meningitis","volume":"2","author":"van de Beek","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1186\/s13613-018-0368-8_bb0025","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1128\/CMR.00008-11","article-title":"Pathogenesis and pathophysiology of pneumococcal meningitis","volume":"24","author":"Mook-Kanamori","year":"2011","journal-title":"Clin Microbiol Rev"},{"key":"10.1186\/s13613-018-0368-8_bb0030","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1056\/NEJMoa021334","article-title":"European dexamethasone in adulthood bacterial meningitis study I. Dexamethasone in adults with bacterial meningitis","volume":"347","author":"de Gans","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1186\/s13613-018-0368-8_bb0035","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1473-3099(04)00937-5","article-title":"Steroids in adults with acute bacterial meningitis: a systematic review","volume":"4","author":"van de Beek","year":"2004","journal-title":"Lancet Infect Dis"},{"key":"10.1186\/s13613-018-0368-8_bb0040","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1212\/WNL.0b013e3181f96297","article-title":"Nationwide implementation of adjunctive dexamethasone therapy for pneumococcal meningitis","volume":"75","author":"Brouwer","year":"2010","journal-title":"Neurology"},{"key":"10.1186\/s13613-018-0368-8_bb0045","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0140-6736(12)61186-6","article-title":"Advances in treatment of bacterial meningitis","volume":"380","author":"van de Beek","year":"2012","journal-title":"Lancet"},{"key":"10.1186\/s13613-018-0368-8_bb0050","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1136\/jnnp.2006.110023","article-title":"Cognitive outcome in adults after bacterial meningitis","volume":"78","author":"Hoogman","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1186\/s13613-018-0368-8_bb0055","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jinf.2016.04.009","article-title":"Neurological sequelae of bacterial meningitis","volume":"73","author":"Lucas","year":"2016","journal-title":"J Infect"},{"key":"10.1186\/s13613-018-0368-8_bb0060","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1056\/NEJMra052116","article-title":"Community-acquired bacterial meningitis in adults","volume":"354","author":"van de Beek","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1186\/s13613-018-0368-8_bb0065","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1007\/s00134-012-2792-9","article-title":"Delayed cerebral thrombosis in bacterial meningitis: a prospective cohort study","volume":"39","author":"Lucas","year":"2013","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-018-0368-8_bb0070","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1212\/WNL.0b013e3181c55d2e","article-title":"Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis","volume":"73","author":"Schut","year":"2009","journal-title":"Neurology"},{"key":"10.1186\/s13613-018-0368-8_bb0075","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/17843286.2016.1146493","article-title":"Delayed cerebral ischaemic injury following apparent recovery from Streptococcus pneumoniae meningitis","volume":"71","author":"Wittebole","year":"2016","journal-title":"Acta Clin Belg"},{"key":"10.1186\/s13613-018-0368-8_bb0080","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1212\/WNL.0b013e3181c55d43","article-title":"Past as prologue: delayed stroke as a parainfectious process of bacterial meningitis?","volume":"73","author":"Steiner","year":"2009","journal-title":"Neurology"},{"key":"10.1186\/s13613-018-0368-8_bb0085","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2176\/nmc.51.302","article-title":"Cerebral arteritis with extremely late onset secondary to bacterial meningitis\u2014case report","volume":"51","author":"Kawaguchi","year":"2011","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"10.1186\/s13613-018-0368-8_bb0090","first-page":"473","article-title":"Cerebral ischaemia in the context of improving, steroid-treated pneumococcal meningitis","volume":"105","author":"Rice","year":"2012","journal-title":"QJM Mon J Assoc Physician"},{"key":"10.1186\/s13613-018-0368-8_bb0095","doi-asserted-by":"crossref","first-page":"647","DOI":"10.2169\/internalmedicine.51.6315","article-title":"Delayed recurrent ischemic stroke after initial good recovery from pneumococcal meningitis","volume":"51","author":"Kato","year":"2012","journal-title":"Intern Med"},{"key":"10.1186\/s13613-018-0368-8_bb0100","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s40478-016-0297-4","article-title":"Pneumococcal meningitis: clinical-pathological correlations (meningene-path)","volume":"4","author":"Engelen-Lee","year":"2016","journal-title":"Acta Neuropathol Commun"},{"key":"10.1186\/s13613-018-0368-8_bb0105","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10143-009-0233-1","article-title":"Intracranial infectious aneurysms: a comprehensive review","volume":"33","author":"Ducruet","year":"2010","journal-title":"Neurosurg Rev"},{"key":"10.1186\/s13613-018-0368-8_bb0110","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.surneu.2006.01.021","article-title":"Different modalities of treatment of intracranial mycotic aneurysms: report of 4 cases","volume":"66","author":"Nakahara","year":"2006","journal-title":"Surg Neurol"},{"key":"10.1186\/s13613-018-0368-8_bb0115","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.eimc.2016.03.008","article-title":"Intracranial mycotic aneurysm in a 5\u00a0month-old infant with pneumococcal meningitis","volume":"35","author":"Palacios","year":"2017","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"10.1186\/s13613-018-0368-8_bb0120","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1159\/000340043","article-title":"Infectious intracranial aneurysm presenting with a series of strokes as a complication of pneumococcal meningitis","volume":"68","author":"Choi","year":"2012","journal-title":"Eur Neurol"},{"key":"10.1186\/s13613-018-0368-8_bb0125","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jns.2006.12.008","article-title":"Spontaneous thrombosis of cerebral aneurysms presenting with ischemic stroke","volume":"254","author":"Cohen","year":"2007","journal-title":"J Neurol Sci"},{"key":"10.1186\/s13613-018-0368-8_bb0130","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12959-015-0047-z","article-title":"Thrombosis in vasculitis: from pathogenesis to treatment","volume":"13","author":"Emmi","year":"2015","journal-title":"Thromb J"},{"key":"10.1186\/s13613-018-0368-8_bb0135","doi-asserted-by":"crossref","first-page":"e45271","DOI":"10.1371\/journal.pone.0045271","article-title":"Intracerebral hemorrhages in adults with community associated bacterial meningitis in adults: should we reconsider anticoagulant therapy?","volume":"7","author":"Mook-Kanamori","year":"2012","journal-title":"PLoS One"},{"key":"10.1186\/s13613-018-0368-8_bb0140","author":"Kumar","year":"2014"},{"key":"10.1186\/s13613-018-0368-8_bb0145","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/modpathol.2013.30","article-title":"Neutrophilic bacterial meningitis: pathology and etiologic diagnosis of fatal cases","volume":"26","author":"Guarner","year":"2013","journal-title":"Mod Pathol"},{"key":"10.1186\/s13613-018-0368-8_bb0150","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1172\/JCI57522","article-title":"Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis","volume":"121","author":"Woehrl","year":"2011","journal-title":"J Clin Invest"}],"container-title":["Annals of Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13613-018-0368-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13613-018-0368-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025007939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025007939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13613-018-0368-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:21:35Z","timestamp":1776669695000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2110582025007939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"alternative-id":["S2110582025007939"],"URL":"https:\/\/doi.org\/10.1186\/s13613-018-0368-8","relation":{},"ISSN":["2110-5820"],"issn-type":[{"value":"2110-5820","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Delayed cerebral thrombosis complicating pneumococcal meningitis: an autopsy study","name":"articletitle","label":"Article Title"},{"value":"Annals of Intensive Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1186\/s13613-018-0368-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 The Author(s) 2018. Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}],"article-number":"20"}}