{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T08:38:49Z","timestamp":1776674329536,"version":"3.51.2"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":2149,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Intensive Care"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1186\/s13613-020-00737-w","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T08:02:53Z","timestamp":1600070573000},"page":"121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Potential risks in using midodrine for persistent hypotension after cardiac surgery: a comparative cohort study"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8322-2087","authenticated-orcid":false,"given":"Jan-Alexis","family":"Tremblay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Laram\u00e9e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoan","family":"Lamarche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Denault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Beaubien-Souligny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Julie","family":"Frenette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loay","family":"Kontar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Serri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Charbonney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1186\/s13613-020-00737-w_bb0010","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ejcts.2003.11.032","article-title":"Risk factors and outcomes for 'vasoplegia syndrome' following cardiac transplantation","volume":"25","author":"Byrne","year":"2004","journal-title":"Eur J Cardiothorac Surg"},{"issue":"5","key":"10.1186\/s13613-020-00737-w_bb0015","first-page":"619","article-title":"Vasoplegic syndrome after open heart surgery","volume":"39","author":"Gomes","year":"1998","journal-title":"J Cardiovasc Surg (Torino)"},{"issue":"6","key":"10.1186\/s13613-020-00737-w_bb0020","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1093\/icvts\/ivy352","article-title":"Risk factors for vasoplegia after cardiac surgery: a meta-analysis","volume":"28","author":"Dayan","year":"2019","journal-title":"Inter Cardiovasc Thor Surg."},{"issue":"2","key":"10.1186\/s13613-020-00737-w_bb0025","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1053\/j.semtcvs.2010.09.007","article-title":"Vasoplegia during cardiac surgery: current concepts and management","volume":"22","author":"Fischer","year":"2010","journal-title":"Semin Thorac Cardiovasc Surg"},{"issue":"5","key":"10.1186\/s13613-020-00737-w_bb0030","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1053\/j.jvca.2018.02.006","article-title":"Postoperative vasoplegic syndrome is associated with impaired endothelial vasomotor response in cardiac surgery: a prospective, observational study","volume":"32","author":"Abou-Arab","year":"2018","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"Suppl 1","key":"10.1186\/s13613-020-00737-w_bb0035","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/00005344-199600001-00004","article-title":"Initiation of white cell activation during cardiopulmonary bypass: cytokines and receptors","volume":"27","author":"Cameron","year":"1996","journal-title":"J Cardiovasc Pharmacol"},{"issue":"3","key":"10.1186\/s13613-020-00737-w_bb0040","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1378\/chest.112.3.676","article-title":"Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies","volume":"112","author":"Wan","year":"1997","journal-title":"Chest"},{"issue":"6","key":"10.1186\/s13613-020-00737-w_bb0045","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1097\/00003246-199906000-00033","article-title":"Low systemic vascular resistance state in patients undergoing cardiopulmonary bypass","volume":"27","author":"Kristof","year":"1999","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1186\/s13613-020-00737-w_bb0050","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0022-5223(98)70049-2","article-title":"Management of vasodilatory shock after cardiac surgery: identification of predisposing factors and use of a novel pressor agent","volume":"116","author":"Argenziano","year":"1998","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"4","key":"10.1186\/s13613-020-00737-w_bb0055","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1159\/000455061","article-title":"Perioperative hemodynamic instability and fluid overload are associated with increasing acute kidney injury severity and worse outcome after cardiac surgery","volume":"43","author":"Haase-Fielitz","year":"2017","journal-title":"Blood Purif"},{"issue":"1","key":"10.1186\/s13613-020-00737-w_bb0060","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/ALN.0000000000001434","article-title":"Vasopressin versus norepinephrine in patients with vasoplegic shock after cardiac surgery: the VANCS randomized controlled trial","volume":"126","author":"Hajjar","year":"2017","journal-title":"Anesthesiology"},{"issue":"2","key":"10.1186\/s13613-020-00737-w_bb0065","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0003-4975(03)01510-8","article-title":"Methylene blue reduces mortality and morbidity in vasoplegic patients after cardiac surgery","volume":"77","author":"Levin","year":"2004","journal-title":"The Annals of thoracic surgery"},{"issue":"2","key":"10.1186\/s13613-020-00737-w_bb0070","doi-asserted-by":"crossref","first-page":"178","DOI":"10.4103\/aca.ACA_237_16","article-title":"Methylene blue for postcardiopulmonary bypass vasoplegic syndrome: a cohort study","volume":"20","author":"Mazzeffi","year":"2017","journal-title":"Ann Card Anaesth"},{"issue":"1","key":"10.1186\/s13613-020-00737-w_bb0075","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0002-9343(93)90230-M","article-title":"Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine","volume":"95","author":"Jankovic","year":"1993","journal-title":"Am J Med"},{"issue":"2","key":"10.1186\/s13613-020-00737-w_bb0080","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jhep.2006.09.012","article-title":"Effects of a 7-day treatment with midodrine in non-azotemic cirrhotic patients with and without ascites","volume":"46","author":"Kalambokis","year":"2007","journal-title":"J Hepatol"},{"issue":"9","key":"10.1186\/s13613-020-00737-w_bb0085","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.clinthera.2008.09.001","article-title":"Pharmacokinetic and pharmacodynamic effects of midodrine on blood pressure, the autonomic nervous system, and plasma natriuretic peptides: a prospective, randomized, single-blind, two-period, crossover, placebo-controlled study","volume":"30","author":"Lamarre-Cliche","year":"2008","journal-title":"Clin Ther"},{"issue":"13","key":"10.1186\/s13613-020-00737-w_bb0090","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1001\/jama.1997.03540370036033","article-title":"Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study Midodrine Study Group","volume":"277","author":"Low","year":"1997","journal-title":"JAMA"},{"issue":"10","key":"10.1186\/s13613-020-00737-w_bb0095","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1093\/ndt\/gfh420","article-title":"Midodrine appears to be safe and effective for dialysis-induced hypotension: a systematic review","volume":"19","author":"Prakash","year":"2004","journal-title":"Nephrol Dial Transpl"},{"issue":"2","key":"10.1186\/s13613-020-00737-w_bb0100","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1177\/1074248408317709","article-title":"Oral midodrine is effective for the treatment of hypotension associated with carotid artery stenting","volume":"13","author":"Sharma","year":"2008","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"1","key":"10.1186\/s13613-020-00737-w_bb0105","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1212\/WNL.51.1.120","article-title":"A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension","volume":"51","author":"Wright","year":"1998","journal-title":"Neurology"},{"issue":"6","key":"10.1186\/s13613-020-00737-w_bb0110","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/hep.510290629","article-title":"Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide","volume":"29","author":"Angeli","year":"1999","journal-title":"Hepatology"},{"issue":"5","key":"10.1186\/s13613-020-00737-w_bb0115","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1159\/000494806","article-title":"The Impact of Midodrine on Outcomes in Patients with Intradialytic Hypotension","volume":"48","author":"Brunelli","year":"2018","journal-title":"Am J Nephrol"},{"issue":"7","key":"10.1186\/s13613-020-00737-w_bb0120","doi-asserted-by":"crossref","first-page":"e628","DOI":"10.1097\/CCM.0000000000003121","article-title":"Trends in Use of Midodrine in the ICU: A Single-Center Retrospective Case Series","volume":"46","author":"Rizvi","year":"2018","journal-title":"Crit Care Med"},{"issue":"8","key":"10.1186\/s13613-020-00737-w_bb0125","doi-asserted-by":"crossref","first-page":"e648","DOI":"10.1097\/CCM.0000000000003814","article-title":"Continuation of Newly Initiated Midodrine Therapy After Intensive Care and Hospital Discharge: A Single-Center Retrospective Study","volume":"47","author":"Rizvi","year":"2019","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1186\/s13613-020-00737-w_bb0130","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.chest.2016.02.657","article-title":"Feasibility, Utility, and Safety of Midodrine During Recovery Phase From Septic Shock","volume":"149","author":"Whitson","year":"2016","journal-title":"Chest"},{"issue":"5","key":"10.1186\/s13613-020-00737-w_bb0135","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.jcrc.2013.05.021","article-title":"Oral midodrine treatment accelerates the liberation of intensive care unit patients from intravenous vasopressor infusions","volume":"28","author":"Levine","year":"2013","journal-title":"J Crit Care"},{"issue":"3","key":"10.1186\/s13613-020-00737-w_bb0140","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/jcpt.12375","article-title":"Midodrine for the weaning of vasopressor infusions","volume":"41","author":"Poveromo","year":"2016","journal-title":"J Clin Pharm Ther"},{"issue":"1","key":"10.1186\/s13613-020-00737-w_bb0145","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12871-017-0339-x","article-title":"Midodrine as adjunctive support for treatment of refractory hypotension in the intensive care unit: a multicenter, randomized, placebo controlled trial (the MIDAS trial)","volume":"17","author":"Anstey","year":"2017","journal-title":"BMC Anesthesiol"},{"key":"10.1186\/s13613-020-00737-w_bb0150","doi-asserted-by":"crossref","unstructured":"Hammond DA, Smith MN, Peksa GD, Trivedi AP, Balk RA, Menich BE. Midodrine as an adjuvant to intravenous vasopressor agents in adults with resolving shock: systematic review and meta-analysis. J Intensive Care Med. 2019:885066619843279.","DOI":"10.1177\/0885066619843279"},{"issue":"2","key":"10.1186\/s13613-020-00737-w_bb0155","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bja.2018.09.028","article-title":"High postoperative portal venous flow pulsatility indicates right ventricular dysfunction and predicts complications in cardiac surgery patients","volume":"122","author":"Eljaiek","year":"2019","journal-title":"Br J Anaesth"},{"issue":"19","key":"10.1186\/s13613-020-00737-w_bb0160","doi-asserted-by":"crossref","first-page":"e009961","DOI":"10.1161\/JAHA.118.009961","article-title":"Alterations in portal vein flow and intrarenal venous flow are associated with acute kidney injury after cardiac surgery: a prospective observational cohort study","volume":"7","author":"Beaubien-Souligny","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"10.1186\/s13613-020-00737-w_bb0165","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/ejcts\/ezs043","article-title":"EuroSCORE II","volume":"41","author":"Nashef","year":"2012","journal-title":"Eur J Cardio-thor Surg"},{"issue":"12","key":"10.1186\/s13613-020-00737-w_bb0170","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1007\/s00134-018-5463-7","article-title":"Polymyxin B hemoperfusion in endotoxemic septic shock patients without extreme endotoxemia: a post hoc analysis of the EUPHRATES trial","volume":"44","author":"Klein","year":"2018","journal-title":"Intensive Care Med"},{"issue":"12","key":"10.1186\/s13613-020-00737-w_bb0175","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1007\/s00134-008-1193-6","article-title":"Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis","volume":"34","author":"Trzeciak","year":"2008","journal-title":"Intensive Care Med"},{"issue":"2","key":"10.1186\/s13613-020-00737-w_bb0180","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.resuscitation.2012.06.011","article-title":"The effect of hypothermia \"dose\" on vasopressor requirements and outcome after cardiac arrest","volume":"84","author":"Huynh","year":"2013","journal-title":"Resuscitation"},{"issue":"1","key":"10.1186\/s13613-020-00737-w_bb0185","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/cc11454","article-title":"Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1)","volume":"17","author":"Kellum JA, Lameire N, Group KAGW","year":"2013","journal-title":"Critical care (London, England)"},{"key":"10.1186\/s13613-020-00737-w_bb0190","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1749-8090-9-20","article-title":"Impact of cardiopulmonary bypass on acute kidney injury following coronary artery bypass grafting: a matched pair analysis","volume":"9","author":"Schopka","year":"2014","journal-title":"J Cardiothorac Surg"},{"issue":"4","key":"10.1186\/s13613-020-00737-w_bb0195","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jcrc.2012.12.008","article-title":"Acute kidney injury after cardiac surgery according to Risk\/Injury\/Failure\/Loss\/End-stage, Acute Kidney Injury Network, and Kidney Disease: Improving Global Outcomes classifications","volume":"28","author":"Bastin","year":"2013","journal-title":"J Crit Care"},{"issue":"14","key":"10.1186\/s13613-020-00737-w_bb0200","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1001\/jama.2017.2841","article-title":"Association between US norepinephrine shortage and mortality among patients with septic shock","volume":"317","author":"Vail","year":"2017","journal-title":"JAMA"},{"issue":"3","key":"10.1186\/s13613-020-00737-w_bb0205","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/pds.1357","article-title":"Immortal time bias in observational studies of drug effects","volume":"16","author":"Suissa","year":"2007","journal-title":"Pharmacoepidemiol Drug Saf"}],"container-title":["Annals of Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13613-020-00737-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13613-020-00737-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025011586?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025011586?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13613-020-00737-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:41:38Z","timestamp":1776670898000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2110582025011586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020]]}},"alternative-id":["S2110582025011586"],"URL":"https:\/\/doi.org\/10.1186\/s13613-020-00737-w","relation":{},"ISSN":["2110-5820"],"issn-type":[{"value":"2110-5820","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential risks in using midodrine for persistent hypotension after cardiac surgery: a comparative cohort study","name":"articletitle","label":"Article Title"},{"value":"Annals of Intensive Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1186\/s13613-020-00737-w","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 The Author(s) 2020. Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}],"article-number":"121"}}