{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T06:36:15Z","timestamp":1793860575330,"version":"4.6.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":2149,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"FONDECYT Chile","award":["1170043"],"award-info":[{"award-number":["1170043"]}]}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Intensive Care"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1186\/s13613-020-00767-4","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T13:02:52Z","timestamp":1604322172000},"page":"150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Effects of capillary refill time-vs. lactate-targeted fluid resuscitation on regional, microcirculatory and hypoxia-related perfusion parameters in septic shock: a randomized controlled trial"],"prefix":"10.1016","volume":"10","author":[{"given":"Ricardo","family":"Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Kattan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Ferri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Pairumani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio Daniel","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Alegr\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Oviedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Pavez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagoberto","family":"Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Vera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Santis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brusela","family":"Astudillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Alicia","family":"Cid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Ospina-Tasc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3032-4087","authenticated-orcid":false,"given":"Glenn","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1186\/s13613-020-00767-4_bb0010","first-page":"280","article-title":"The holistic view on perfusion monitoring in septic shock","volume":"18","author":"Hernandez","year":"2012","journal-title":"Curr Opin Crit Care"},{"key":"10.1186\/s13613-020-00767-4_bb0015","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/CCM.0000000000002255","article-title":"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016","volume":"45","author":"Rhodes","year":"2017","journal-title":"Crit Care Med"},{"key":"10.1186\/s13613-020-00767-4_bb0020","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13613-014-0030-z","article-title":"When to stop septic shock resuscitation: clues from a dynamic perfusion monitoring","volume":"4","author":"Hernandez","year":"2014","journal-title":"Ann Intensive Care."},{"key":"10.1186\/s13613-020-00767-4_bb0025","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s00134-018-5213-x","article-title":"The ten pitfalls of lactate clearance in sepsis","volume":"45","author":"Hernandez","year":"2019","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-020-00767-4_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/cc6916","article-title":"A positive fluid balance is associated with a worse outcome in patients with acute renal failure","volume":"12","author":"Payen","year":"2008","journal-title":"Crit Care"},{"key":"10.1186\/s13613-020-00767-4_bb0035","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/CCM.0b013e3181feeb15","article-title":"Fluid resuscitation in septic shock: A positive fluid balance and elevated central venous pressure are associated with increased mortality","volume":"39","author":"Boyd","year":"2011","journal-title":"Crit Care Med"},{"key":"10.1186\/s13613-020-00767-4_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/cc6948","article-title":"Fluid balance as a biomarker : impact of fluid overload on outcome in critically ill patients with acute kidney injury","volume":"12","author":"Bagshaw","year":"2008","journal-title":"Crit Care"},{"key":"10.1186\/s13613-020-00767-4_bb0045","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jcrc.2011.05.024","article-title":"Evolution of peripheral vs metabolic perfusion parameters during septic shock resuscitation A clinical-physiologic study","volume":"27","author":"Hernandez","year":"2012","journal-title":"J Crit Care"},{"key":"10.1186\/s13613-020-00767-4_bb0050","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1097\/CCM.0b013e31819869db","article-title":"The prognostic value of the subjective assessment of peripheral perfusion in critically ill patients","volume":"37","author":"Lima","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1186\/s13613-020-00767-4_bb0055","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1164\/rccm.201408-1575LE","article-title":"Early peripheral perfusion-guided fluid therapy in patients with septic shock","volume":"191","author":"Van Genderen","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1186\/s13613-020-00767-4_bb0060","doi-asserted-by":"crossref","first-page":"e0188548","DOI":"10.1371\/journal.pone.0188548","article-title":"Capillary refill time during fluid resuscitation in patients with sepsis-related hyperlactatemia at the emergency department is related to mortality","volume":"12","author":"Lara","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1186\/s13613-020-00767-4_bb0065","first-page":"253","article-title":"Statistical analysis plan for early goal-directed therapy using a physiological holistic view - The andromeda-shock: A randomized controlled trial","volume":"30","author":"Hern\u00e1ndez","year":"2018","journal-title":"Rev Bras Ter Intensiva"},{"key":"10.1186\/s13613-020-00767-4_bb0070","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13613-018-0398-2","article-title":"Early goal-directed therapy using a physiological holistic view: the ANDROMEDA-SHOCK\u2014a randomized controlled trial","volume":"8","author":"Hern\u00e1ndez","year":"2018","journal-title":"Ann Intensive Care"},{"key":"10.1186\/s13613-020-00767-4_bb0075","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1001\/jama.2019.0071","article-title":"Effect of a resuscitation strategy targeting peripheral perfusion status vs serum lactate levels on 28-day mortality among patients with septic shock The andromeda-shock randomized Clinical Trial","volume":"321","author":"Hernandez","year":"2019","journal-title":"JAMA"},{"key":"10.1186\/s13613-020-00767-4_bb0080","article-title":"Effect of a resuscitation strategy targeting peripheral perfusion status vs serum lactate levels on 28-day mortality among patients with septic shock: a bayesian reanalysis of the andromeda-shock trial","author":"Zampieri","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1186\/s13613-020-00767-4_bb0085","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1186\/s13613-020-00767-4_bb0090","first-page":"190","article-title":"Assessment of fluid responsiveness: recent advances","volume":"24","author":"Monnet","year":"2018","journal-title":"Curr Opin Crit Care"},{"key":"10.1186\/s13613-020-00767-4_bb0095","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13054-020-2732-y","article-title":"Systematic assessment of fluid responsiveness during early septic shock resuscitation: Secondary analysis of the ANDROMEDA-SHOCK trial","volume":"24","author":"Kattan","year":"2020","journal-title":"Crit Care"},{"key":"10.1186\/s13613-020-00767-4_bb0100","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13054-018-1959-3","article-title":"Should we measure the central venous pressure to guide fluid management? Ten answers to 10 questions","volume":"22","author":"De Backer","year":"2018","journal-title":"Crit Care"},{"key":"10.1186\/s13613-020-00767-4_bb0105","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/CCM.0000000000000553","article-title":"International study on microcirculatory shock occurrence in acutely Ill patients*","volume":"43","author":"Vellinga","year":"2015","journal-title":"Crit Care Med"},{"key":"10.1186\/s13613-020-00767-4_bb0110","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s00134-013-2982-0","article-title":"Effects of dobutamine on systemic, regional and microcirculatory perfusion parameters in septic shock: A randomized, placebo-controlled, double-blind, crossover study","volume":"39","author":"Hernandez","year":"2013","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-020-00767-4_bb0115","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1111\/aas.12406","article-title":"Indocyanine green plasma disappearance rate as dynamic liver function test in critically ill patients","volume":"58","author":"Halle","year":"2014","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1186\/s13613-020-00767-4_bb0120","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jcrc.2008.11.012","article-title":"Prognostic value of indocyanine green elimination assessed with LiMON in septic patients","volume":"24","author":"Inal","year":"2009","journal-title":"J Crit Care"},{"key":"10.1186\/s13613-020-00767-4_bb0125","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1097\/CCM.0b013e3182186675","article-title":"The relation of near-infrared spectroscopy with changes in peripheral circulation in critically ill patients","volume":"39","author":"Lima","year":"2011","journal-title":"Crit Care Med"},{"key":"10.1186\/s13613-020-00767-4_bb0130","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1007\/s00134-016-4233-7","article-title":"Understanding the venous\u2013arterial CO2 to arterial\u2013venous O2 content difference ratio","volume":"42","author":"Ospina-Tasc\u00f3n","year":"2016","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-020-00767-4_bb0135","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jcrc.2018.09.030","article-title":"Venous-arterial CO2 to arterial-venous O2 differences: A physiological meaning debate","volume":"48","author":"Ospina-Tasc\u00f3n","year":"2018","journal-title":"J Crit Care"},{"key":"10.1186\/s13613-020-00767-4_bb0140","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.21037\/jtd.2019.07.10","article-title":"How can CO2-derived indices guide resuscitation in critically ill patients?","volume":"11","author":"Gavelli","year":"2019","journal-title":"J Thorac Dis"},{"key":"10.1186\/s13613-020-00767-4_bb0145","doi-asserted-by":"crossref","unstructured":"Rimachi R, Bruzzi De Carvahlo F, OrellanoJimenez C, Cotton F, Vincent JL, De Backer D. Lactate\/pyruvate ratio as a marker of tissue hypoxia in circulatory and septic shock. Anaesth Intensive Care. 2012. 40:427\u201332.","DOI":"10.1177\/0310057X1204000307"},{"key":"10.1186\/s13613-020-00767-4_bb0150","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jcrc.2016.05.007","article-title":"Changes in peripheral perfusion relate to visceral organ perfusion in early septic shock: A pilot study","volume":"35","author":"Brunauer","year":"2016","journal-title":"J Crit Care"},{"key":"10.1186\/s13613-020-00767-4_bb0155","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00134-011-2163-y","article-title":"Mottling score predicts survival in septic shock","volume":"37","author":"Ait-Oufella","year":"2011","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-020-00767-4_bb0160","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s00134-012-2555-7","article-title":"Knee area tissue oxygen saturation is predictive of 14-day mortality in septic shock","volume":"38","author":"Ait-Oufella","year":"2012","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-020-00767-4_bb0165","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13613-016-0164-2","article-title":"Toe-to-room temperature gradient correlates with tissue perfusion and predicts outcome in selected critically ill patients with severe infections","volume":"6","author":"Bourcier","year":"2016","journal-title":"Ann Intensive Care"},{"key":"10.1186\/s13613-020-00767-4_bb0170","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.4187\/respcare.03357","article-title":"Tissue hypoxia: Implications for the respiratory clinician","volume":"59","author":"Macintyre","year":"2014","journal-title":"Respir Care"},{"key":"10.1186\/s13613-020-00767-4_bb0175","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s00134-015-3720-6","article-title":"Combination of arterial lactate levels and venous-arterial CO2 to arterial-venous O2 content difference ratio as markers of resuscitation in patients with septic shock","volume":"41","author":"Ospina-Tasc\u00f3n","year":"2015","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-020-00767-4_bb0180","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/00005373-200004000-00009","article-title":"Tissue Hemoglobin O2 Saturation during Resuscitation of Traumatic Shock Monitored Using Near Infrared Spectrometry","volume":"48","author":"McKinley","year":"2000","journal-title":"J Trauma Inj Infect Crit Care"}],"container-title":["Annals of Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13613-020-00767-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13613-020-00767-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025011884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025011884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13613-020-00767-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:47:37Z","timestamp":1776671257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2110582025011884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020]]}},"alternative-id":["S2110582025011884"],"URL":"https:\/\/doi.org\/10.1186\/s13613-020-00767-4","relation":{},"ISSN":["2110-5820"],"issn-type":[{"value":"2110-5820","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of capillary refill time-vs. lactate-targeted fluid resuscitation on regional, microcirculatory and hypoxia-related perfusion parameters in septic shock: a randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Annals of Intensive Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1186\/s13613-020-00767-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 The Author(s) 2020. Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}],"article-number":"150"}}