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Intensive Care"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Compared to other life-threatening infection survivors, long-term health-related quality of life (QOL) of patients surviving necrotizing soft-tissue infections (NSTI) and its determinants are little known.<\/jats:p>\n                    <jats:p>In this monocentric prospective cohort including NSTI survivors admitted between 2014 and 2017, QOL was assessed during a phone interview using the 36-Item Short-Form Health Survey (SF-36), the Hospital Anxiety and Depression (HAD), the activity of daily living (ADL), instrumental ADL (IADL) scales and the Impact of Event Scale-Revised (IES-R). The primary outcome measure was the SF-36 physical component summary (PCS). NSTI patients were compared according to intensive care unit (ICU) admission status. ICU survivors were matched on SAPS II with non-NSTI related septic shock survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty-nine NSTI survivors were phone-interviewed and included in the study. Median PCS was decreased compared to the reference population [\u2212\u00a00.97 (\u2212\u00a02.27; \u2212\u00a00.08) SD]. Previous cardiac disease was the only variable associated with PCS alteration [multivariate regression coefficient: \u2212\u00a08.86 (\u2212\u00a017.64; \u2212\u00a00.07),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009 0.048]. Of NSTI survivors, 15.2% had a HAD-D score \u2009\u2265\u2009 5 and 61.2% an IES-R score \u2009\u2265\u2009 33. ICU admission was not associated with lower PCS [35.21 (25.49\u201346.54) versus (vs) 41.82 (24.12\u201351.01),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009 0.516], but with higher IES-R score [14 (7.5\u201334) vs 7 (3\u201318),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009 0.035] and a higher proportion of HAD-D score \u2009\u2265\u2009 5 (28.6 vs 4.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009 0.036). Compared to non-NSTI septic shock-matched controls, NSTI patients had similar PCS [33.81 (24.58; \u2212\u00a044.39) vs 44.87 (26.71; \u2212\u00a056.01),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009= \u20090.706] but higher HAD-D [3.5 (1\u20137) vs 3 (1.5\u20136),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009 0.048] and IES-R scores [18 (8\u201335) vs 8 (3\u201319),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009 0.049].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long-term QOL in NSTI survivors is severely impaired, similarly to that of non-NSTI septic shock patients for physical compartments, but with more frequent depressive and\/or post-traumatic stress disorders. Only ICU admission and previous cardiac disease were predictive of QOL impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13613-021-00891-9","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T04:03:07Z","timestamp":1625198587000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Long-term quality of life in necrotizing soft-tissue infection survivors: a monocentric prospective cohort study"],"prefix":"10.1016","volume":"11","author":[{"given":"Tomas","family":"Urbina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Canoui-Poitrine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Layese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachida","family":"Ouedraogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Bosc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Sbidian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Chosidow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand Mekontso","family":"Dessap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4833-4320","authenticated-orcid":false,"given":"Nicolas","family":"de Prost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Henri Mondor Hospital Necrotizing Fasciitis Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Bosc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Chosidow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"de Prost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Lepeule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Luciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Nakad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Tomberli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Urbina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul-Louis","family":"Woerther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","published-online":{"date-parts":[[2021,7,2]]},"reference":[{"key":"891_CR1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2019.277","author":"Z Al-Qurayshi","year":"2020","unstructured":"Al-Qurayshi Z, Nichols RL, Killackey MT, Kandil E. 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