{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:12:02Z","timestamp":1792098722741,"version":"4.4.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":1418,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013347","name":"European Society of Intensive Care Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013347","id-type":"DOI","asserted-by":"crossref"}]},{"name":"St Michael\u2019s Hospital, Toronto, Canada"},{"DOI":"10.13039\/501100002954","name":"Universit\u00e0 degli Studi di Milano-Bicocca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002954","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Intensive Care"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1186\/s13613-022-01015-7","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T02:02:45Z","timestamp":1653098565000},"page":"42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Presence of comorbidities alters management and worsens outcome of patients with acute respiratory distress syndrome: insights from the LUNG SAFE study"],"prefix":"10.1016","volume":"12","clinical-trial-number":[{"clinical-trial-number":"nct02010073","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Emanuele","family":"Rezoagli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bairbre A.","family":"McNicholas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Madotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e0i","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Bellani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1246-9573","authenticated-orcid":false,"given":"John G.","family":"Laffey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1186\/s13613-022-01015-7_bb0010","doi-asserted-by":"crossref","DOI":"10.4187\/respcare.06034","article-title":"Influence of clinical factors and exclusion criteria on mortality in ARDS observational studies and randomized controlled trials","author":"Pais","year":"2018","journal-title":"Respir Care"},{"key":"10.1186\/s13613-022-01015-7_bb0015","article-title":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome","author":"Acute Respiratory Distress Syndrome Network","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1186\/s13613-022-01015-7_bb0020","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa1214103","article-title":"Prone positioning in severe acute respiratory distress syndrome","author":"Guerin","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1186\/s13613-022-01015-7_bb0025","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa1005372","article-title":"Neuromuscular blockers in early acute respiratory distress syndrome","author":"Papazian","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1186\/s13613-022-01015-7_bb0030","doi-asserted-by":"crossref","DOI":"10.1007\/s00134-021-06370-w","article-title":"Between-trial heterogeneity in ARDS research","author":"Juschten","year":"2021","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-022-01015-7_bb0035","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2016.0291","article-title":"Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries","author":"Bellani","year":"2016","journal-title":"JAMA"},{"key":"10.1186\/s13613-022-01015-7_bb0040","doi-asserted-by":"crossref","DOI":"10.1007\/s00134-018-5152-6","article-title":"Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study","author":"Madotto","year":"2018","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-022-01015-7_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.chest.2020.05.605","article-title":"Patterns and impact of arterial CO2 management in patients with acute respiratory distress syndrome: insights from the LUNG SAFE study","author":"Madotto","year":"2020","journal-title":"Chest"},{"key":"10.1186\/s13613-022-01015-7_bb0050","doi-asserted-by":"crossref","DOI":"10.1007\/s00134-016-4571-5","article-title":"Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study","author":"Laffey","year":"2016","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-022-01015-7_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.chest.2020.01.041","article-title":"Patterns of use of adjunctive therapies in patients with early moderate to severe ARDS: insights from the LUNG SAFE study","author":"Duggal","year":"2020","journal-title":"Chest"},{"key":"10.1186\/s13613-022-01015-7_bb0060","doi-asserted-by":"crossref","DOI":"10.1007\/s00134-018-5209-6","article-title":"Management and outcomes of acute respiratory distress syndrome patients with and without comorbid conditions","author":"Azoulay","year":"2018","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-022-01015-7_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/S2213-2600(14)70097-9","article-title":"Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials","author":"Calfee","year":"2014","journal-title":"Lancet Respir Med"},{"key":"10.1186\/s13613-022-01015-7_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/S2213-2600(18)30177-2","article-title":"Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial","author":"Calfee","year":"2018","journal-title":"Lancet Respir Med"},{"key":"10.1186\/s13613-022-01015-7_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/S2213-2600(19)30138-9","article-title":"Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial","author":"Constantin","year":"2019","journal-title":"Lancet Respir Med"},{"key":"10.1186\/s13613-022-01015-7_bb0080","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.201001-0024WS","article-title":"Beyond mortality: future clinical research in acute lung injury","author":"Spragg","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1186\/s13613-022-01015-7_bb0085","article-title":"Lessons to learn from epidemiologic studies in ARDS","author":"McNicholas","year":"2018","journal-title":"Curr Opin Crit Care"},{"key":"10.1186\/s13613-022-01015-7_bb0090","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-019-2695-z","article-title":"How I set up positive end-expiratory pressure: evidence- and physiology-based!","author":"Rezoagli","year":"2019","journal-title":"Crit Care"},{"key":"10.1186\/s13613-022-01015-7_bb0095","doi-asserted-by":"crossref","DOI":"10.1186\/s13613-019-0540-9","article-title":"Formal guidelines: management of acute respiratory distress syndrome","author":"Papazian","year":"2019","journal-title":"Ann Intensive Care"}],"container-title":["Annals of Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13613-022-01015-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13613-022-01015-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025006132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025006132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13613-022-01015-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:40:42Z","timestamp":1776670842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2110582025006132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"alternative-id":["S2110582025006132"],"URL":"https:\/\/doi.org\/10.1186\/s13613-022-01015-7","relation":{},"ISSN":["2110-5820"],"issn-type":[{"value":"2110-5820","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Presence of comorbidities alters management and worsens outcome of patients with acute respiratory distress syndrome: insights from the LUNG SAFE study","name":"articletitle","label":"Article Title"},{"value":"Annals of Intensive Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1186\/s13613-022-01015-7","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 The Author(s) 2022. Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}],"article-number":"42"}}