{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:54:09Z","timestamp":1790643249206,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":688,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Intensive Care"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1186\/s13613-024-01253-x","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T20:04:00Z","timestamp":1706385840000},"page":"16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Risk factors for bleeding complications in patients undergoing extracorporeal cardiopulmonary resuscitation following out-of-hospital cardiac arrest: a\u00a0secondary\u00a0analysis\u00a0of the\u00a0SAVE-J\u00a0II\u00a0study"],"prefix":"10.1016","volume":"14","author":[{"given":"Shutaro","family":"Isokawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1952-6526","authenticated-orcid":false,"given":"Toru","family":"Hifumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Horie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kijong","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasumi","family":"Shirasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiori","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Otani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1186\/s13613-024-01253-x_bb0010","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/jama.2022.1025","article-title":"Effect of Intra-arrest transport, extracorporeal cardiopulmonary resuscitation, and immediate invasive assessment and treatment on functional neurologic outcome in refractory out-of-hospital cardiac arrest","volume":"327","author":"Belohlavek","year":"2022","journal-title":"JAMA"},{"issue":"10265","key":"10.1186\/s13613-024-01253-x_bb0015","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/S0140-6736(20)32338-2","article-title":"Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): a phase 2, single centre, open-label, randomised controlled trial","volume":"396","author":"Yannopoulos","year":"2020","journal-title":"Lancet"},{"issue":"4","key":"10.1186\/s13613-024-01253-x_bb0020","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1056\/NEJMoa2204511","article-title":"Early extracorporeal CPR for refractory out-of-hospital cardiac arrest","volume":"388","author":"Suverein","year":"2023","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1186\/s13613-024-01253-x_bb0025","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00392-013-0580-3","article-title":"Door-to-implantation time of extracorporeal life support systems predicts mortality in patients with out-of-hospital cardiac arrest","volume":"102","author":"Leick","year":"2013","journal-title":"Clin Res Cardiol"},{"issue":"5","key":"10.1186\/s13613-024-01253-x_bb0030","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1097\/CCM.0b013e31827ca4c8","article-title":"Extracorporeal cardiopulmonary resuscitation for patients with out-of-hospital cardiac arrest of cardiac origin: a propensity-matched study and predictor analysis","volume":"41","author":"Maekawa","year":"2013","journal-title":"Crit Care Med"},{"issue":"5","key":"10.1186\/s13613-024-01253-x_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-014-0535-8","article-title":"An optimal transition time to extracorporeal cardiopulmonary resuscitation for predicting good neurological outcome in patients with out-of-hospital cardiac arrest: a propensity-matched study","volume":"18","author":"Kim","year":"2014","journal-title":"Crit Care"},{"issue":"1","key":"10.1186\/s13613-024-01253-x_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13049-016-0266-8","article-title":"Out-of-hospital cardiac arrest patients treated with cardiopulmonary resuscitation using extracorporeal membrane oxygenation: focus on survival rate and neurologic outcome","volume":"24","author":"Lee","year":"2016","journal-title":"Scand J Trauma Resusc Emerg Med"},{"issue":"2","key":"10.1186\/s13613-024-01253-x_bb0045","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1136\/emermed-2015-204817","article-title":"Clinical outcomes after rescue extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest","volume":"34","author":"Ha","year":"2017","journal-title":"Emerg Med J"},{"issue":"1","key":"10.1186\/s13613-024-01253-x_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12871-016-0293-z","article-title":"Effect of ultrasonography and fluoroscopic guidance on the incidence of complications of cannulation in extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest: a retrospective observational study","volume":"17","author":"Kashiura","year":"2017","journal-title":"BMC Anesthesiol"},{"issue":"6","key":"10.1186\/s13613-024-01253-x_bb0055","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.ajem.2017.11.016","article-title":"D-dimer predicts bleeding complication in out-of-hospital cardiac arrest resuscitated with ECMO","volume":"36","author":"Otani","year":"2018","journal-title":"Am J Emerg Med"},{"issue":"86","key":"10.1186\/s13613-024-01253-x_bb0060","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.resuscitation.2014.09.010","article-title":"Refractory cardiac arrest treated with mechanical CPR, hypothermia, ECMO and early reperfusion (the CHEER trial)","volume":"2015","author":"Stub","year":"2015","journal-title":"Resuscitation"},{"key":"10.1186\/s13613-024-01253-x_bb0065","article-title":"Risk factors and outcomes for patients with bleeding complications receiving extracorporeal membrane oxygenation: An analysis of the Chinese Extracorporeal Life Support Registry","author":"Li","year":"2022","journal-title":"Artif Organs."},{"key":"10.1186\/s13613-024-01253-x_bb0070","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.resuscitation.2020.09.035","article-title":"Traumatic and hemorrhagic complications after extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest","volume":"157","author":"Nguyen","year":"2020","journal-title":"Resuscitation"},{"issue":"1","key":"10.1186\/s13613-024-01253-x_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-022-03998-y","article-title":"Extracorporeal cardiopulmonary resuscitation in adult patients with out-of-hospital cardiac arrest: a retrospective large cohort multicenter study in Japan","volume":"26","author":"Inoue","year":"2022","journal-title":"Crit Care"},{"issue":"17","key":"10.1186\/s13613-024-01253-x_bb0080","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1056\/NEJMsa1600011","article-title":"Public-access defibrillation and out-of-hospital cardiac arrest in Japan","volume":"375","author":"Kitamura","year":"2016","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1186\/s13613-024-01253-x_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ams2.647","article-title":"Variability of extracorporeal cardiopulmonary resuscitation practice in patients with out-of-hospital cardiac arrest from the emergency department to intensive care unit in Japan","volume":"8","author":"Hifumi","year":"2021","journal-title":"Acute Med Surg"},{"issue":"11","key":"10.1186\/s13613-024-01253-x_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm9113588","article-title":"Clinical significance of low-flow time in patients undergoing extracorporeal cardiopulmonary resuscitation: results from the rescue registry","volume":"9","author":"Park","year":"2020","journal-title":"J Clin Med"},{"issue":"2","key":"10.1186\/s13613-024-01253-x_bb0095","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1525-1594.2012.01544.x","article-title":"Single-center experience with extracorporeal life support in 103 nonpostcardiotomy patients","volume":"37","author":"Schopka","year":"2013","journal-title":"Artif Organs"},{"issue":"2","key":"10.1186\/s13613-024-01253-x_bb0100","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jvs.2020.05.071","article-title":"Limb ischemia and bleeding in patients requiring venoarterial extracorporeal membrane oxygenation","volume":"73","author":"Son","year":"2021","journal-title":"J Vasc Surg"},{"issue":"2","key":"10.1186\/s13613-024-01253-x_bb0105","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.athoracsur.2020.02.012","article-title":"Risk factors of bleeding in patients undergoing venoarterial extracorporeal membrane oxygenation","volume":"111","author":"Ellouze","year":"2021","journal-title":"Ann Thorac Surg"},{"key":"10.1186\/s13613-024-01253-x_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13613-016-0196-7","article-title":"Predictive factors of bleeding events in adults undergoing extracorporeal membrane oxygenation","volume":"6","author":"Aubron","year":"2016","journal-title":"Ann Intensive Care."},{"issue":"7","key":"10.1186\/s13613-024-01253-x_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.119.015291","article-title":"Extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest in adult patients","volume":"9","author":"Inoue","year":"2020","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"10.1186\/s13613-024-01253-x_bb0120","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/MAT.0000000000000150","article-title":"Extracorporeal life support: experience with 2,000 patients","volume":"61","author":"Gray","year":"2015","journal-title":"ASAIO J"},{"issue":"5","key":"10.1186\/s13613-024-01253-x_bb0125","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1053\/j.jvca.2019.12.016","article-title":"Extracorporeal cardiopulmonary resuscitation: outcomes and complications at a quaternary referral center","volume":"34","author":"Dalia","year":"2020","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"5","key":"10.1186\/s13613-024-01253-x_bb0130","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s00134-020-05926-6","article-title":"Extracorporeal membrane oxygenation for refractory cardiac arrest: a retrospective multicenter study","volume":"46","author":"Lunz","year":"2020","journal-title":"Intensive Care Med"},{"key":"10.1186\/s13613-024-01253-x_bb0135","unstructured":"Extracorporeal Life Support Organization (ELSO) ELSO Registry Data Definitions. Published 2018. https:\/\/www.elso.org\/portals\/0\/files\/elso registry data definitions 02_13_23.pdf"},{"issue":"1","key":"10.1186\/s13613-024-01253-x_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-019-2320-1","article-title":"Comparison of extracorporeal and conventional cardiopulmonary resuscitation: a retrospective propensity score matched study","volume":"23","author":"Patricio","year":"2019","journal-title":"Crit Care"},{"issue":"132","key":"10.1186\/s13613-024-01253-x_bb0145","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.resuscitation.2018.08.030","article-title":"Surviving refractory out-of-hospital ventricular fibrillation cardiac arrest: critical care and extracorporeal membrane oxygenation management","volume":"2018","author":"Bartos","year":"2018","journal-title":"Resuscitation"},{"key":"10.1186\/s13613-024-01253-x_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13613-016-0196-7","article-title":"Predictive factors of bleeding events in adults undergoing extracorporeal membrane oxygenation","volume":"6","author":"Aubron","year":"2016","journal-title":"Ann Intensive Care."},{"key":"10.1186\/s13613-024-01253-x_bb0155","doi-asserted-by":"crossref","unstructured":"Rossaint R, Afshari A, Bouillon B, et al. The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition. Crit Care. 2023;27(1):1\u201345. doi: https:\/\/doi.org\/10.1186\/s13054-023-04327-7","DOI":"10.1186\/s13054-023-04327-7"},{"key":"10.1186\/s13613-024-01253-x_bb0160","first-page":"1","article-title":"Heparin loading dose in patients undergoing extracorporeal cardiopulmonary resuscitation","volume":"000","author":"Zhang","year":"2023","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"1","key":"10.1186\/s13613-024-01253-x_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40560-015-0098-z","article-title":"Use of a fixed, body weight-unadjusted loading dose of unfractionated heparin for extracorporeal cardiopulmonary resuscitation","volume":"3","author":"Iwashita","year":"2015","journal-title":"J Intensive Care"},{"issue":"6","key":"10.1186\/s13613-024-01253-x_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.116.003732","article-title":"Minnesota Resuscitation Consortium\u2019s advanced perfusion and reperfusion cardiac life support strategy for out-of-hospital refractory ventricular fibrillation","volume":"5","author":"Yannopoulos","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"8","key":"10.1186\/s13613-024-01253-x_bb0175","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/MAT.0000000000001510","article-title":"ELSO interim guidelines for venoarterial extracorporeal membrane oxygenation in adult cardiac patients","volume":"67","author":"Lorusso","year":"2021","journal-title":"ASAIO J"},{"issue":"139","key":"10.1186\/s13613-024-01253-x_bb0180","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.resuscitation.2019.03.021","article-title":"Cost effectiveness and quality of life analysis of extracorporeal cardiopulmonary resuscitation (ECPR) for refractory cardiac arrest","volume":"2019","author":"Dennis","year":"2019","journal-title":"Resuscitation"},{"issue":"126","key":"10.1186\/s13613-024-01253-x_bb0185","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.resuscitation.2017.12.017","article-title":"Coronary lesions in refractory out of hospital cardiac arrest (OHCA) treated by extra corporeal pulmonary resuscitation (ECPR)","volume":"2018","author":"Lamhaut","year":"2018","journal-title":"Resuscitation"},{"issue":"3","key":"10.1186\/s13613-024-01253-x_bb0190","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S0735-1097(00)00779-8","article-title":"Cardiopulmonary cerebral resuscitation using emergency cardiopulmonary bypass, coronary reperfusion therapy and mild hypothermia in patients with cardiac arrest outside the hospital","volume":"36","author":"Nagao","year":"2000","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1186\/s13613-024-01253-x_bb0195","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.athoracsur.2015.10.095","article-title":"The impact of vascular complications on survival of patients on venoarterial extracorporeal membrane oxygenation","volume":"101","author":"Tanaka","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"10.1186\/s13613-024-01253-x_bb0200","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/MAT.0000000000001344","article-title":"Extracorporeal Cardiopulmonary Resuscitation in Adults. Interim Guideline Consensus Statement from the Extracorporeal Life Support Organization","volume":"1","author":"Richardson","year":"2021","journal-title":"ASAIO Journal."},{"issue":"11","key":"10.1186\/s13613-024-01253-x_bb0205","doi-asserted-by":"crossref","first-page":"908","DOI":"10.4070\/kcj.2021.0167","article-title":"Association between a multidisciplinary team approach and clinical outcomes in patients undergoing extracorporeal cardiopulmonary resuscitation in the emergency department","volume":"51","author":"Lee","year":"2021","journal-title":"Kor Circ J"}],"container-title":["Annals of Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13613-024-01253-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13613-024-01253-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025001724?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025001724?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13613-024-01253-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:37:49Z","timestamp":1776670669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2110582025001724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"alternative-id":["S2110582025001724"],"URL":"https:\/\/doi.org\/10.1186\/s13613-024-01253-x","relation":{},"ISSN":["2110-5820"],"issn-type":[{"value":"2110-5820","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk factors for bleeding complications in patients undergoing extracorporeal cardiopulmonary resuscitation following out-of-hospital cardiac arrest: a\u00a0secondary\u00a0analysis\u00a0of the\u00a0SAVE-J\u00a0II\u00a0study","name":"articletitle","label":"Article Title"},{"value":"Annals of Intensive Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1186\/s13613-024-01253-x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2024 The Author(s) 2024. Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}],"article-number":"16"}}