{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:37:24Z","timestamp":1793054244699,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":688,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016545","name":"Roche Diagnostics","doi-asserted-by":"crossref","award":["n.a."],"award-info":[{"award-number":["n.a."]}],"id":[{"id":"10.13039\/100016545","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sedana Medical Research Foundation","award":["n.a."],"award-info":[{"award-number":["n.a."]}]},{"DOI":"10.13039\/501100008307","name":"Promedica Stiftung","doi-asserted-by":"publisher","award":["n.a."],"award-info":[{"award-number":["n.a."]}],"id":[{"id":"10.13039\/501100008307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008949","name":"Uniscientia Stiftung","doi-asserted-by":"publisher","award":["n.a."],"award-info":[{"award-number":["n.a."]}],"id":[{"id":"10.13039\/501100008949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Intensive Care"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1186\/s13613-024-01276-4","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T03:04:38Z","timestamp":1711508678000},"page":"41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Early sevoflurane sedation in severe COVID-19-related lung injury patients. A pilot randomized controlled trial"],"prefix":"10.1016","volume":"14","author":[{"given":"Beatrice","family":"Beck-Schimmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Schadde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Pietsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miodrag","family":"Filipovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seraina","family":"D\u00fcbendorfer-Dalbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Fodor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"H\u00fcbner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Schuepbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Steiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard D.","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Neff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4288-7124","authenticated-orcid":false,"given":"Martin","family":"Schl\u00e4pfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1186\/s13613-024-01276-4_bb0010","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1097\/SLA.0b013e318272df7c","article-title":"Protection of pharmacological postconditioning in liver surgery: results of a prospective randomized controlled trial","volume":"256","author":"Beck-Schimmer","year":"2012","journal-title":"Ann Surg"},{"issue":"6","key":"10.1186\/s13613-024-01276-4_bb0015","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1097\/SLA.0b013e31818f3dda","article-title":"A randomized controlled trial on pharmacological preconditioning in liver surgery using a volatile anesthetic","volume":"248","author":"Beck-Schimmer","year":"2008","journal-title":"Ann Surg"},{"issue":"6","key":"10.1186\/s13613-024-01276-4_bb0020","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1097\/ALN.0b013e3181a10731","article-title":"Anesthetic-induced improvement of the inflammatory response to one-lung ventilation","volume":"110","author":"De Conno","year":"2009","journal-title":"Anesthesiology"},{"issue":"5","key":"10.1186\/s13613-024-01276-4_bb0025","doi-asserted-by":"crossref","first-page":"R191","DOI":"10.1186\/cc11676","article-title":"Late pharmacologic conditioning with volatile anesthetics after cardiac surgery","volume":"16","author":"Steurer","year":"2012","journal-title":"Crit Care"},{"issue":"14","key":"10.1186\/s13613-024-01276-4_bb0030","doi-asserted-by":"crossref","first-page":"340","DOI":"10.21037\/atm.2019.06.76","article-title":"Effect of sevoflurane and propofol on acute kidney injury in pediatric living donor liver transplantation","volume":"7","author":"Li","year":"2019","journal-title":"Annals Translational Med"},{"issue":"8","key":"10.1186\/s13613-024-01276-4_bb0035","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1097\/TP.0000000000000644","article-title":"Conditioning with sevoflurane in liver transplantation: results of a Multicenter Randomized Controlled Trial","volume":"99","author":"Beck-Schimmer","year":"2015","journal-title":"Transplantation"},{"issue":"6","key":"10.1186\/s13613-024-01276-4_bb0040","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1164\/rccm.201604-0686OC","article-title":"Sevoflurane for Sedation in Acute Respiratory Distress Syndrome. A Randomized Controlled Pilot Study","volume":"195","author":"Jabaudon","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1186\/s13613-024-01276-4_bb0045","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1213\/ANE.0000000000001634","article-title":"Safety and Efficacy of Volatile Anesthetic agents compared with Standard Intravenous Midazolam\/Propofol Sedation in ventilated critical care patients: a Meta-analysis and systematic review of prospective trials","volume":"124","author":"Jerath","year":"2017","journal-title":"Anesth Analg"},{"issue":"7","key":"10.1186\/s13613-024-01276-4_bb0050","doi-asserted-by":"crossref","first-page":"737","DOI":"10.23736\/S0375-9393.17.11735-9","article-title":"Halogenated volatile anesthetics in the intensive care unit: current knowledge on an upcoming practice","volume":"83","author":"Laferriere-Langlois","year":"2017","journal-title":"Minerva Anestesiol"},{"key":"10.1186\/s13613-024-01276-4_bb0055","doi-asserted-by":"crossref","unstructured":"Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020.","DOI":"10.1016\/S2213-2600(20)30079-5"},{"key":"10.1186\/s13613-024-01276-4_bb0060","doi-asserted-by":"crossref","unstructured":"Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020.","DOI":"10.1007\/s00134-020-05991-x"},{"issue":"10229","key":"10.1186\/s13613-024-01276-4_bb0065","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"issue":"8","key":"10.1186\/s13613-024-01276-4_bb0070","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S2213-2600(20)30267-8","article-title":"Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities","volume":"8","author":"Mehta","year":"2020","journal-title":"Lancet Respiratory Med"},{"issue":"10","key":"10.1186\/s13613-024-01276-4_bb0075","doi-asserted-by":"crossref","first-page":"a016295","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1186\/s13613-024-01276-4_bb0080","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1741-7015-8-18","article-title":"CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials","volume":"8","author":"Schulz","year":"2010","journal-title":"BMC Med"},{"key":"10.1186\/s13613-024-01276-4_bb0085","doi-asserted-by":"crossref","unstructured":"Pregernig A, M\u00fcller M, Held U, Beck-Schimmer B. Prediction of mortality in adult patients with sepsis using six biomarkers: a systematic review and meta-analysis. Ann Intensiv Care. 2019;9(1).","DOI":"10.1186\/s13613-019-0600-1"},{"key":"10.1186\/s13613-024-01276-4_bb0090","doi-asserted-by":"crossref","unstructured":"Lineberry N, Berlin JA, Mansi B, Glasser S, Berkwits M, Klem C et al. Recommendations to improve adverse event reporting in clinical trial publications: a joint pharmaceutical industry\/journal editor perspective. BMJ. 2016.","DOI":"10.1136\/bmj.i5078"},{"issue":"4","key":"10.1186\/s13613-024-01276-4_bb0095","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO Clinical Practice guidelines for Acute kidney Injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron Clin Pract"},{"key":"10.1186\/s13613-024-01276-4_bb0100","doi-asserted-by":"crossref","unstructured":"Kellum JA, Bellomo R, Ronco C. The Concept of Acute Kidney Injury and the RIFLE Criteria. Acute Kidney Injury. Contributions to Nephrology2007. p. 10 \u2013 6.","DOI":"10.1159\/000102010"},{"issue":"10201","key":"10.1186\/s13613-024-01276-4_bb0105","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0140-6736(19)31894-X","article-title":"Acute liver failure","volume":"394","author":"Stravitz","year":"2019","journal-title":"Lancet"},{"issue":"10223","key":"10.1186\/s13613-024-01276-4_bb0110","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"10.1186\/s13613-024-01276-4_bb0115","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1213\/ANE.0000000000001530","article-title":"Sevoflurane abolishes oxygenation impairment in a long-term rat model of Acute Lung Injury","volume":"124","author":"Kellner","year":"2017","journal-title":"Anesth Analg"},{"issue":"1","key":"10.1186\/s13613-024-01276-4_bb0120","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-2249.2012.04562.x","article-title":"Sevoflurane reduces severity of acute lung injury possibly by impairing formation of alveolar oedema","volume":"168","author":"Schlapfer","year":"2012","journal-title":"Clin Exp Immunol"},{"issue":"6","key":"10.1186\/s13613-024-01276-4_bb0125","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1097\/ALN.0b013e3181bdf857","article-title":"Sevoflurane ameliorates gas exchange and attenuates lung damage in experimental lipopolysaccharide-induced lung injury","volume":"111","author":"Voigtsberger","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1186\/s13613-024-01276-4_bb0130","doi-asserted-by":"crossref","unstructured":"Ikeda K, Osuru HP, Thiele RH. Intraoperative administration of isoflurane improves survival in rats exposed to caecal ligation and puncture. BJA Open. 2022;2.","DOI":"10.1016\/j.bjao.2022.100014"},{"key":"10.1186\/s13613-024-01276-4_bb0135","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13054-015-0751-x","article-title":"Propofol increases morbidity and mortality in a rat model of sepsis","volume":"19","author":"Schlapfer","year":"2015","journal-title":"Crit Care"},{"issue":"6","key":"10.1186\/s13613-024-01276-4_bb0140","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1097\/00000542-200306000-00004","article-title":"Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: a double-blinded, placebo-controlled, multicenter study","volume":"98","author":"Julier","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1186\/s13613-024-01276-4_bb0145","doi-asserted-by":"crossref","first-page":"692734","DOI":"10.3389\/fsurg.2021.692734","article-title":"The effects of Sevoflurane vs. Propofol for inflammatory responses in patients undergoing lung resection: a Meta-analysis of Randomized controlled trials","volume":"8","author":"Yuan","year":"2021","journal-title":"Front Surg"},{"key":"10.1186\/s13613-024-01276-4_bb0150","first-page":"930487","article-title":"The influence of pharmacological preconditioning with sevoflurane on incidence of early allograft dysfunction in liver transplant recipients","volume":"2012","author":"Minou","year":"2012","journal-title":"Anesthesiol Res Pract"},{"issue":"2","key":"10.1186\/s13613-024-01276-4_bb0155","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/ALN.0000000000001164","article-title":"Which anesthesia regimen is best to reduce morbidity and mortality in lung surgery? A Multicenter Randomized Controlled Trial","volume":"125","author":"Beck-Schimmer","year":"2016","journal-title":"Anesthesiology"},{"issue":"13","key":"10.1186\/s13613-024-01276-4_bb0160","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1056\/NEJMoa1816476","article-title":"Volatile anesthetics versus total intravenous anesthesia for cardiac surgery","volume":"380","author":"Landoni","year":"2019","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1186\/s13613-024-01276-4_bb0165","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/jmv.26232","article-title":"The cytokine storm and COVID-19","volume":"93","author":"Hu","year":"2021","journal-title":"J Med Virol"},{"issue":"10","key":"10.1186\/s13613-024-01276-4_bb0170","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1038\/s41591-021-01500-9","article-title":"Calming the cytokine storm in COVID-19","volume":"27","author":"Cron","year":"2021","journal-title":"Nat Med"},{"issue":"7","key":"10.1186\/s13613-024-01276-4_bb0175","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1513\/AnnalsATS.202008-1026OC","article-title":"COVID-19 versus Non\u2013COVID-19 Acute Respiratory Distress Syndrome: comparison of demographics, physiologic parameters, inflammatory biomarkers, and clinical outcomes","volume":"18","author":"Bain","year":"2021","journal-title":"Annals Am Thorac Soc"},{"key":"10.1186\/s13613-024-01276-4_bb0180","doi-asserted-by":"crossref","unstructured":"Sinha P, Matthay MA, Calfee CS. Is a cytokine storm relevant to COVID-19? JAMA Intern Med. 2020;180(9).","DOI":"10.1001\/jamainternmed.2020.3313"},{"issue":"9","key":"10.1186\/s13613-024-01276-4_bb0185","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.1002\/jmv.27099","article-title":"Evaluation of the relationship between KIM-1 and suPAR levels and clinical severity in COVID\u201019 patients: a different perspective on suPAR","volume":"93","author":"Kerget","year":"2021","journal-title":"J Med Virol"},{"issue":"10","key":"10.1186\/s13613-024-01276-4_bb0190","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1038\/s41591-021-01569-2","article-title":"Author correction: early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial","volume":"27","author":"Kyriazopoulou","year":"2021","journal-title":"Nat Med"},{"issue":"11","key":"10.1186\/s13613-024-01276-4_bb0195","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1681\/ASN.2020060829","article-title":"Soluble urokinase receptor (SuPAR) in COVID-19\u2013Related AKI","volume":"31","author":"Azam","year":"2020","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"10.1186\/s13613-024-01276-4_bb0200","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000524965","article-title":"suPAR: an inflammatory mediator for kidneys","volume":"8","author":"Sudhini","year":"2022","journal-title":"Kidney Dis"},{"issue":"6","key":"10.1186\/s13613-024-01276-4_bb0205","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1213\/ane.0b013e3181a1988b","article-title":"Renal integrity in sevoflurane sedation in the intensive care unit with the anesthetic-conserving device: a comparison with intravenous propofol sedation","volume":"108","author":"Rohm","year":"2009","journal-title":"Anesth Analg"},{"key":"10.1186\/s13613-024-01276-4_bb0210","doi-asserted-by":"crossref","unstructured":"Tzotzos SJ, Fischer B, Fischer H, Zeitlinger M. Incidence of ARDS and outcomes in hospitalized patients with COVID-19: a global literature survey. Crit Care. 2020;24(1).","DOI":"10.1186\/s13054-020-03240-7"},{"issue":"5","key":"10.1186\/s13613-024-01276-4_bb0215","doi-asserted-by":"crossref","first-page":"613","DOI":"10.7326\/M20-5327","article-title":"Characteristics, outcomes, and trends of patients with COVID-19\u2013Related critical illness at a Learning Health System in the United States","volume":"174","author":"Anesi","year":"2021","journal-title":"Ann Intern Med"},{"key":"10.1186\/s13613-024-01276-4_bb0220","unstructured":"Wendel Garcia PD, Fumeaux T, Guerci P, Heuberger DM, Montomoli J, Roche-Campo F et al. Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: initial report of the international RISC-19-ICU prospective observational cohort. EClinicalMedicine. 2020;25."}],"updated-by":[{"DOI":"10.1186\/s13613-024-01322-1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000}},{"DOI":"10.1186\/s13613-024-01322-1","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000}}],"container-title":["Annals of Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13613-024-01276-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13613-024-01276-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025001943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025001943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13613-024-01276-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:44:28Z","timestamp":1776671068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2110582025001943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"alternative-id":["S2110582025001943"],"URL":"https:\/\/doi.org\/10.1186\/s13613-024-01276-4","relation":{},"ISSN":["2110-5820"],"issn-type":[{"value":"2110-5820","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early sevoflurane sedation in severe COVID-19-related lung injury patients. A pilot randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Annals of Intensive Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1186\/s13613-024-01276-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2024 The Author(s) 2024. Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}],"article-number":"41"}}